Coxiella endosymbiont of rhipicephalus microplus modulates tick physiology with a major impact in blood feeding capacity
- Autores
- Garcia Guizzo, Melina; Tirloni, Lucas; Gonzalez, Sergio Alberto; Farber, Marisa Diana; Braz, Glória; Parizi, Luís Fernando; Dedavid e Silva, Lucas Andre; Da Silva Vaz, Itabajara; Oliveira, Pedro L.
- Año de publicación
- 2022
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- In the past decade, metagenomics studies exploring tick microbiota have revealed widespread interactions between bacteria and arthropods, including symbiotic interactions. Functional studies showed that obligate endosymbionts contribute to tick biology, affecting reproductive fitness and molting. Understanding the molecular basis of the interaction between ticks and their mutualist endosymbionts may help to develop control methods based on microbiome manipulation. Previously, we showed that Rhipicephalus microplus larvae with reduced levels of Coxiella endosymbiont of R. microplus (CERM) were arrested at the metanymph life stage (partially engorged nymph) and did not molt into adults. In this study, we performed a transcriptomic differential analysis of the R. microplus metanymph in the presence and absence of its mutualist endosymbiont. The lack of CERM resulted in an altered expression profile of transcripts from several functional categories. Gene products such as DA-P36, protease inhibitors, metalloproteases, and evasins, which are involved in blood feeding capacity, were underexpressed in CERM-free metanymphs. Disregulation in genes related to extracellular matrix remodeling was also observed in the absence of the symbiont. Taken together, the observed alterations in gene expression may explain the blockage of development at the metanymph stage and reveal a novel physiological aspect of the symbiont-tick-vertebrate host interaction.
Instituto de Biotecnología
Fil: Garcia Guizzo, Melina. National Institute of Allergy and Infectious Diseases. Laboratory of Malaria and Vector Research. Vector Biology Section; Estados Unidos
Fil: Garcia Guizzo, Melina. Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo de Meis; Brasil
Fil: Tirloni, Lucas. National Institute of Allergy and Infectious Diseases. Rocky Mountain Laboratories. Laboratory of Bacteriology. Tick-Pathogen Transmission Unit; Estados Unidos
Fil: Gonzalez, Sergio Alberto. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnologia y Biologia Molecular; Argentina
Fil: Gonzalez, Sergio Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Farber, Marisa Diana. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnologia y Biologia Molecular; Argentina
Fil: Farber, Marisa Diana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Braz, Glória. Universidade Federal do Rio de Janeiro. Instituto de Química; Brasil
Fil: Parizi, Luís Fernando. Universidade Federal do Rio Grande do Sul. Centro de Biotecnologia; Brasil
Fil: Dedavid e Silva, Lucas Andre. Universidade Federal do Rio Grande do Sul. Centro de Biotecnologia; Brasil
Fil: Da Silva Vaz, Itabajara. Universidade Federal do Rio Grande do Sul. Centro de Biotecnologia; Brasil
Fil: Da Silva Vaz, Itabajara. Universidade Federal do Rio Grande do Sul. Faculdade de Veterinária; Brasil
Fil: Da Silva Vaz, Itabajara. Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular; Brasil
Fil: Oliveira, Pedro L. Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo de Meis; Brasil
Fil: Oliveira, Pedro L. Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular; Brasil - Fuente
- Frontiers in Microbiology 13 : 868575 (Mayo 2022)
- Materia
-
Coxiella
Simbiontico
Transcriptomas
Microbiomas
Sanidad Animal
Symbionts
Rhipicephalus
Transcriptome
Microbiomes
Animal Health
Rhipicephalus microplus - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- http://creativecommons.org/licenses/by-nc-sa/4.0/
- Repositorio
- Institución
- Instituto Nacional de Tecnología Agropecuaria
- OAI Identificador
- oai:localhost:20.500.12123/12156
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Coxiella endosymbiont of rhipicephalus microplus modulates tick physiology with a major impact in blood feeding capacityGarcia Guizzo, MelinaTirloni, LucasGonzalez, Sergio AlbertoFarber, Marisa DianaBraz, GlóriaParizi, Luís FernandoDedavid e Silva, Lucas AndreDa Silva Vaz, ItabajaraOliveira, Pedro L.CoxiellaSimbionticoTranscriptomasMicrobiomasSanidad AnimalSymbiontsRhipicephalusTranscriptomeMicrobiomesAnimal HealthRhipicephalus microplusIn the past decade, metagenomics studies exploring tick microbiota have revealed widespread interactions between bacteria and arthropods, including symbiotic interactions. Functional studies showed that obligate endosymbionts contribute to tick biology, affecting reproductive fitness and molting. Understanding the molecular basis of the interaction between ticks and their mutualist endosymbionts may help to develop control methods based on microbiome manipulation. Previously, we showed that Rhipicephalus microplus larvae with reduced levels of Coxiella endosymbiont of R. microplus (CERM) were arrested at the metanymph life stage (partially engorged nymph) and did not molt into adults. In this study, we performed a transcriptomic differential analysis of the R. microplus metanymph in the presence and absence of its mutualist endosymbiont. The lack of CERM resulted in an altered expression profile of transcripts from several functional categories. Gene products such as DA-P36, protease inhibitors, metalloproteases, and evasins, which are involved in blood feeding capacity, were underexpressed in CERM-free metanymphs. Disregulation in genes related to extracellular matrix remodeling was also observed in the absence of the symbiont. Taken together, the observed alterations in gene expression may explain the blockage of development at the metanymph stage and reveal a novel physiological aspect of the symbiont-tick-vertebrate host interaction.Instituto de BiotecnologíaFil: Garcia Guizzo, Melina. National Institute of Allergy and Infectious Diseases. Laboratory of Malaria and Vector Research. Vector Biology Section; Estados UnidosFil: Garcia Guizzo, Melina. Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo de Meis; BrasilFil: Tirloni, Lucas. National Institute of Allergy and Infectious Diseases. Rocky Mountain Laboratories. Laboratory of Bacteriology. Tick-Pathogen Transmission Unit; Estados UnidosFil: Gonzalez, Sergio Alberto. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnologia y Biologia Molecular; ArgentinaFil: Gonzalez, Sergio Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Farber, Marisa Diana. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnologia y Biologia Molecular; ArgentinaFil: Farber, Marisa Diana. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Braz, Glória. Universidade Federal do Rio de Janeiro. Instituto de Química; BrasilFil: Parizi, Luís Fernando. Universidade Federal do Rio Grande do Sul. Centro de Biotecnologia; BrasilFil: Dedavid e Silva, Lucas Andre. Universidade Federal do Rio Grande do Sul. Centro de Biotecnologia; BrasilFil: Da Silva Vaz, Itabajara. Universidade Federal do Rio Grande do Sul. Centro de Biotecnologia; BrasilFil: Da Silva Vaz, Itabajara. Universidade Federal do Rio Grande do Sul. Faculdade de Veterinária; BrasilFil: Da Silva Vaz, Itabajara. Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular; BrasilFil: Oliveira, Pedro L. Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo de Meis; BrasilFil: Oliveira, Pedro L. Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular; BrasilFrontiers Media2022-06-24T10:31:46Z2022-06-24T10:31:46Z2022-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://hdl.handle.net/20.500.12123/12156https://www.frontiersin.org/articles/10.3389/fmicb.2022.868575/full1664-302Xhttps://doi.org/10.3389/fmicb.2022.868575Frontiers in Microbiology 13 : 868575 (Mayo 2022)reponame:INTA Digital (INTA)instname:Instituto Nacional de Tecnología Agropecuariaenginfo:eu-repograntAgreement/INTA/PNBIO-1131043/AR./Bioinformática y Estadística Genómica.info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-sa/4.0/Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)2025-10-16T09:30:47Zoai:localhost:20.500.12123/12156instacron:INTAInstitucionalhttp://repositorio.inta.gob.ar/Organismo científico-tecnológicoNo correspondehttp://repositorio.inta.gob.ar/oai/requesttripaldi.nicolas@inta.gob.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:l2025-10-16 09:30:47.701INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuariafalse |
dc.title.none.fl_str_mv |
Coxiella endosymbiont of rhipicephalus microplus modulates tick physiology with a major impact in blood feeding capacity |
title |
Coxiella endosymbiont of rhipicephalus microplus modulates tick physiology with a major impact in blood feeding capacity |
spellingShingle |
Coxiella endosymbiont of rhipicephalus microplus modulates tick physiology with a major impact in blood feeding capacity Garcia Guizzo, Melina Coxiella Simbiontico Transcriptomas Microbiomas Sanidad Animal Symbionts Rhipicephalus Transcriptome Microbiomes Animal Health Rhipicephalus microplus |
title_short |
Coxiella endosymbiont of rhipicephalus microplus modulates tick physiology with a major impact in blood feeding capacity |
title_full |
Coxiella endosymbiont of rhipicephalus microplus modulates tick physiology with a major impact in blood feeding capacity |
title_fullStr |
Coxiella endosymbiont of rhipicephalus microplus modulates tick physiology with a major impact in blood feeding capacity |
title_full_unstemmed |
Coxiella endosymbiont of rhipicephalus microplus modulates tick physiology with a major impact in blood feeding capacity |
title_sort |
Coxiella endosymbiont of rhipicephalus microplus modulates tick physiology with a major impact in blood feeding capacity |
dc.creator.none.fl_str_mv |
Garcia Guizzo, Melina Tirloni, Lucas Gonzalez, Sergio Alberto Farber, Marisa Diana Braz, Glória Parizi, Luís Fernando Dedavid e Silva, Lucas Andre Da Silva Vaz, Itabajara Oliveira, Pedro L. |
author |
Garcia Guizzo, Melina |
author_facet |
Garcia Guizzo, Melina Tirloni, Lucas Gonzalez, Sergio Alberto Farber, Marisa Diana Braz, Glória Parizi, Luís Fernando Dedavid e Silva, Lucas Andre Da Silva Vaz, Itabajara Oliveira, Pedro L. |
author_role |
author |
author2 |
Tirloni, Lucas Gonzalez, Sergio Alberto Farber, Marisa Diana Braz, Glória Parizi, Luís Fernando Dedavid e Silva, Lucas Andre Da Silva Vaz, Itabajara Oliveira, Pedro L. |
author2_role |
author author author author author author author author |
dc.subject.none.fl_str_mv |
Coxiella Simbiontico Transcriptomas Microbiomas Sanidad Animal Symbionts Rhipicephalus Transcriptome Microbiomes Animal Health Rhipicephalus microplus |
topic |
Coxiella Simbiontico Transcriptomas Microbiomas Sanidad Animal Symbionts Rhipicephalus Transcriptome Microbiomes Animal Health Rhipicephalus microplus |
dc.description.none.fl_txt_mv |
In the past decade, metagenomics studies exploring tick microbiota have revealed widespread interactions between bacteria and arthropods, including symbiotic interactions. Functional studies showed that obligate endosymbionts contribute to tick biology, affecting reproductive fitness and molting. Understanding the molecular basis of the interaction between ticks and their mutualist endosymbionts may help to develop control methods based on microbiome manipulation. Previously, we showed that Rhipicephalus microplus larvae with reduced levels of Coxiella endosymbiont of R. microplus (CERM) were arrested at the metanymph life stage (partially engorged nymph) and did not molt into adults. In this study, we performed a transcriptomic differential analysis of the R. microplus metanymph in the presence and absence of its mutualist endosymbiont. The lack of CERM resulted in an altered expression profile of transcripts from several functional categories. Gene products such as DA-P36, protease inhibitors, metalloproteases, and evasins, which are involved in blood feeding capacity, were underexpressed in CERM-free metanymphs. Disregulation in genes related to extracellular matrix remodeling was also observed in the absence of the symbiont. Taken together, the observed alterations in gene expression may explain the blockage of development at the metanymph stage and reveal a novel physiological aspect of the symbiont-tick-vertebrate host interaction. Instituto de Biotecnología Fil: Garcia Guizzo, Melina. National Institute of Allergy and Infectious Diseases. Laboratory of Malaria and Vector Research. Vector Biology Section; Estados Unidos Fil: Garcia Guizzo, Melina. Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo de Meis; Brasil Fil: Tirloni, Lucas. National Institute of Allergy and Infectious Diseases. Rocky Mountain Laboratories. Laboratory of Bacteriology. Tick-Pathogen Transmission Unit; Estados Unidos Fil: Gonzalez, Sergio Alberto. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnologia y Biologia Molecular; Argentina Fil: Gonzalez, Sergio Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Farber, Marisa Diana. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Agrobiotecnologia y Biologia Molecular; Argentina Fil: Farber, Marisa Diana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Braz, Glória. Universidade Federal do Rio de Janeiro. Instituto de Química; Brasil Fil: Parizi, Luís Fernando. Universidade Federal do Rio Grande do Sul. Centro de Biotecnologia; Brasil Fil: Dedavid e Silva, Lucas Andre. Universidade Federal do Rio Grande do Sul. Centro de Biotecnologia; Brasil Fil: Da Silva Vaz, Itabajara. Universidade Federal do Rio Grande do Sul. Centro de Biotecnologia; Brasil Fil: Da Silva Vaz, Itabajara. Universidade Federal do Rio Grande do Sul. Faculdade de Veterinária; Brasil Fil: Da Silva Vaz, Itabajara. Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular; Brasil Fil: Oliveira, Pedro L. Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo de Meis; Brasil Fil: Oliveira, Pedro L. Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular; Brasil |
description |
In the past decade, metagenomics studies exploring tick microbiota have revealed widespread interactions between bacteria and arthropods, including symbiotic interactions. Functional studies showed that obligate endosymbionts contribute to tick biology, affecting reproductive fitness and molting. Understanding the molecular basis of the interaction between ticks and their mutualist endosymbionts may help to develop control methods based on microbiome manipulation. Previously, we showed that Rhipicephalus microplus larvae with reduced levels of Coxiella endosymbiont of R. microplus (CERM) were arrested at the metanymph life stage (partially engorged nymph) and did not molt into adults. In this study, we performed a transcriptomic differential analysis of the R. microplus metanymph in the presence and absence of its mutualist endosymbiont. The lack of CERM resulted in an altered expression profile of transcripts from several functional categories. Gene products such as DA-P36, protease inhibitors, metalloproteases, and evasins, which are involved in blood feeding capacity, were underexpressed in CERM-free metanymphs. Disregulation in genes related to extracellular matrix remodeling was also observed in the absence of the symbiont. Taken together, the observed alterations in gene expression may explain the blockage of development at the metanymph stage and reveal a novel physiological aspect of the symbiont-tick-vertebrate host interaction. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-06-24T10:31:46Z 2022-06-24T10:31:46Z 2022-05 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/20.500.12123/12156 https://www.frontiersin.org/articles/10.3389/fmicb.2022.868575/full 1664-302X https://doi.org/10.3389/fmicb.2022.868575 |
url |
http://hdl.handle.net/20.500.12123/12156 https://www.frontiersin.org/articles/10.3389/fmicb.2022.868575/full https://doi.org/10.3389/fmicb.2022.868575 |
identifier_str_mv |
1664-302X |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repograntAgreement/INTA/PNBIO-1131043/AR./Bioinformática y Estadística Genómica. |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
http://creativecommons.org/licenses/by-nc-sa/4.0/ Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Frontiers Media |
publisher.none.fl_str_mv |
Frontiers Media |
dc.source.none.fl_str_mv |
Frontiers in Microbiology 13 : 868575 (Mayo 2022) reponame:INTA Digital (INTA) instname:Instituto Nacional de Tecnología Agropecuaria |
reponame_str |
INTA Digital (INTA) |
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INTA Digital (INTA) |
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Instituto Nacional de Tecnología Agropecuaria |
repository.name.fl_str_mv |
INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuaria |
repository.mail.fl_str_mv |
tripaldi.nicolas@inta.gob.ar |
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