Analysis of an Indian colorectal cancer faecal microbiome collection demonstrates universal colorectal cancer-associated patterns, but closest correlation with other Indian cohorts

Autores
Bose, Mayilvahanan; Wood, Henry M.; Young, Caroline; Van Nang, Pham; Van Doi, Mai; Vaccaro, Carlos Alberto; Piñero, Tamara Alejandra; Arguero, Julieta; Melendez, Luis Contreras; Valladares, Camilo Tapia; Quirke, Philip; Seshadri, Ramakrishan Ayloor
Año de publicación
2023
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
It is increasingly being recognised that changes in the gut microbiome have either a causative or associative relationship with colorectal cancer (CRC). However, most of this research has been carried out in a small number of developed countries with high CRC incidence. It is unknown if lower incidence countries such as India have similar microbial associations. Having previously established protocols to facilitate microbiome research in regions with developing research infrastructure, we have now collected and sequenced microbial samples from a larger cohort study of 46 Indian CRC patients and 43 healthy volunteers. When comparing to previous global collections, these samples resemble other Asian samples, with relatively high levels of Prevotella. Predicting cancer status between cohorts shows good concordance. When compared to a previous collection of Indian CRC patients, there was similar concordance, despite different sequencing technologies between cohorts. These results show that there does seem to be a global CRC microbiome, and that some inference between studies is reasonable. However, we also demonstrate that there is definite regional variation, with more similarities between location-matched comparisons. This emphasises the importance of developing protocols and advancing infrastructure to allow as many countries as possible to contribute to microbiome studies of their own populations.
Fil: Bose, Mayilvahanan. Cancer Institute; India
Fil: Wood, Henry M.. University of Leeds; Reino Unido
Fil: Young, Caroline. University of Leeds; Reino Unido
Fil: Van Nang, Pham. International C. R. C. Microbiome Network; Reino Unido
Fil: Van Doi, Mai. International C. R. C. Microbiome Network; Reino Unido
Fil: Vaccaro, Carlos Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Medicina Traslacional e Ingeniería Biomédica - Hospital Italiano. Instituto de Medicina Traslacional e Ingeniería Biomédica.- Instituto Universitario Hospital Italiano de Buenos Aires. Instituto de Medicina Traslacional e Ingeniería Biomédica; Argentina
Fil: Piñero, Tamara Alejandra. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Medicina Traslacional E Ingenieria Biomedica. - Hospital Italiano. Instituto de Medicina Traslacional E Ingenieria Biomedica. - Instituto Universitario Hospital Italiano de Buenos Aires. Instituto de Medicina Traslacional E Ingenieria Biomedica.; Argentina
Fil: Arguero, Julieta. Hospital Italiano; Argentina
Fil: Melendez, Luis Contreras. Universidad de Los Andes.; Chile
Fil: Valladares, Camilo Tapia. Universidad de Los Andes.; Chile
Fil: Quirke, Philip. University of Leeds; Reino Unido
Fil: Seshadri, Ramakrishan Ayloor. Cancer Institute; India
Materia
CANCER MICROBIOME
COLORECTAL CANCER
INDIAN MICROBIOME
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/227944
Acceder
id CONICETDig_fff66564de5f73dc78f58719e18a946f
oai_identifier_str oai:ri.conicet.gov.ar:11336/227944
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Analysis of an Indian colorectal cancer faecal microbiome collection demonstrates universal colorectal cancer-associated patterns, but closest correlation with other Indian cohortsBose, MayilvahananWood, Henry M.Young, CarolineVan Nang, PhamVan Doi, MaiVaccaro, Carlos AlbertoPiñero, Tamara AlejandraArguero, JulietaMelendez, Luis ContrerasValladares, Camilo TapiaQuirke, PhilipSeshadri, Ramakrishan AyloorCANCER MICROBIOMECOLORECTAL CANCERINDIAN MICROBIOMEhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3It is increasingly being recognised that changes in the gut microbiome have either a causative or associative relationship with colorectal cancer (CRC). However, most of this research has been carried out in a small number of developed countries with high CRC incidence. It is unknown if lower incidence countries such as India have similar microbial associations. Having previously established protocols to facilitate microbiome research in regions with developing research infrastructure, we have now collected and sequenced microbial samples from a larger cohort study of 46 Indian CRC patients and 43 healthy volunteers. When comparing to previous global collections, these samples resemble other Asian samples, with relatively high levels of Prevotella. Predicting cancer status between cohorts shows good concordance. When compared to a previous collection of Indian CRC patients, there was similar concordance, despite different sequencing technologies between cohorts. These results show that there does seem to be a global CRC microbiome, and that some inference between studies is reasonable. However, we also demonstrate that there is definite regional variation, with more similarities between location-matched comparisons. This emphasises the importance of developing protocols and advancing infrastructure to allow as many countries as possible to contribute to microbiome studies of their own populations.Fil: Bose, Mayilvahanan. Cancer Institute; IndiaFil: Wood, Henry M.. University of Leeds; Reino UnidoFil: Young, Caroline. University of Leeds; Reino UnidoFil: Van Nang, Pham. International C. R. C. Microbiome Network; Reino UnidoFil: Van Doi, Mai. International C. R. C. Microbiome Network; Reino UnidoFil: Vaccaro, Carlos Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Medicina Traslacional e Ingeniería Biomédica - Hospital Italiano. Instituto de Medicina Traslacional e Ingeniería Biomédica.- Instituto Universitario Hospital Italiano de Buenos Aires. Instituto de Medicina Traslacional e Ingeniería Biomédica; ArgentinaFil: Piñero, Tamara Alejandra. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Medicina Traslacional E Ingenieria Biomedica. - Hospital Italiano. Instituto de Medicina Traslacional E Ingenieria Biomedica. - Instituto Universitario Hospital Italiano de Buenos Aires. Instituto de Medicina Traslacional E Ingenieria Biomedica.; ArgentinaFil: Arguero, Julieta. Hospital Italiano; ArgentinaFil: Melendez, Luis Contreras. Universidad de Los Andes.; ChileFil: Valladares, Camilo Tapia. Universidad de Los Andes.; ChileFil: Quirke, Philip. University of Leeds; Reino UnidoFil: Seshadri, Ramakrishan Ayloor. Cancer Institute; IndiaBioMed Central2023-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/227944Bose, Mayilvahanan; Wood, Henry M.; Young, Caroline; Van Nang, Pham; Van Doi, Mai; et al.; Analysis of an Indian colorectal cancer faecal microbiome collection demonstrates universal colorectal cancer-associated patterns, but closest correlation with other Indian cohorts; BioMed Central; BMC Microbiology; 23; 1; 12-2023; 1-131471-2180CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://bmcmicrobiol.biomedcentral.com/articles/10.1186/s12866-023-02805-0info:eu-repo/semantics/altIdentifier/doi/10.1186/s12866-023-02805-0info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:59:20Zoai:ri.conicet.gov.ar:11336/227944instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:59:20.507CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Analysis of an Indian colorectal cancer faecal microbiome collection demonstrates universal colorectal cancer-associated patterns, but closest correlation with other Indian cohorts
title Analysis of an Indian colorectal cancer faecal microbiome collection demonstrates universal colorectal cancer-associated patterns, but closest correlation with other Indian cohorts
spellingShingle Analysis of an Indian colorectal cancer faecal microbiome collection demonstrates universal colorectal cancer-associated patterns, but closest correlation with other Indian cohorts
Bose, Mayilvahanan
CANCER MICROBIOME
COLORECTAL CANCER
INDIAN MICROBIOME
title_short Analysis of an Indian colorectal cancer faecal microbiome collection demonstrates universal colorectal cancer-associated patterns, but closest correlation with other Indian cohorts
title_full Analysis of an Indian colorectal cancer faecal microbiome collection demonstrates universal colorectal cancer-associated patterns, but closest correlation with other Indian cohorts
title_fullStr Analysis of an Indian colorectal cancer faecal microbiome collection demonstrates universal colorectal cancer-associated patterns, but closest correlation with other Indian cohorts
title_full_unstemmed Analysis of an Indian colorectal cancer faecal microbiome collection demonstrates universal colorectal cancer-associated patterns, but closest correlation with other Indian cohorts
title_sort Analysis of an Indian colorectal cancer faecal microbiome collection demonstrates universal colorectal cancer-associated patterns, but closest correlation with other Indian cohorts
dc.creator.none.fl_str_mv Bose, Mayilvahanan
Wood, Henry M.
Young, Caroline
Van Nang, Pham
Van Doi, Mai
Vaccaro, Carlos Alberto
Piñero, Tamara Alejandra
Arguero, Julieta
Melendez, Luis Contreras
Valladares, Camilo Tapia
Quirke, Philip
Seshadri, Ramakrishan Ayloor
author Bose, Mayilvahanan
author_facet Bose, Mayilvahanan
Wood, Henry M.
Young, Caroline
Van Nang, Pham
Van Doi, Mai
Vaccaro, Carlos Alberto
Piñero, Tamara Alejandra
Arguero, Julieta
Melendez, Luis Contreras
Valladares, Camilo Tapia
Quirke, Philip
Seshadri, Ramakrishan Ayloor
author_role author
author2 Wood, Henry M.
Young, Caroline
Van Nang, Pham
Van Doi, Mai
Vaccaro, Carlos Alberto
Piñero, Tamara Alejandra
Arguero, Julieta
Melendez, Luis Contreras
Valladares, Camilo Tapia
Quirke, Philip
Seshadri, Ramakrishan Ayloor
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv CANCER MICROBIOME
COLORECTAL CANCER
INDIAN MICROBIOME
topic CANCER MICROBIOME
COLORECTAL CANCER
INDIAN MICROBIOME
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv It is increasingly being recognised that changes in the gut microbiome have either a causative or associative relationship with colorectal cancer (CRC). However, most of this research has been carried out in a small number of developed countries with high CRC incidence. It is unknown if lower incidence countries such as India have similar microbial associations. Having previously established protocols to facilitate microbiome research in regions with developing research infrastructure, we have now collected and sequenced microbial samples from a larger cohort study of 46 Indian CRC patients and 43 healthy volunteers. When comparing to previous global collections, these samples resemble other Asian samples, with relatively high levels of Prevotella. Predicting cancer status between cohorts shows good concordance. When compared to a previous collection of Indian CRC patients, there was similar concordance, despite different sequencing technologies between cohorts. These results show that there does seem to be a global CRC microbiome, and that some inference between studies is reasonable. However, we also demonstrate that there is definite regional variation, with more similarities between location-matched comparisons. This emphasises the importance of developing protocols and advancing infrastructure to allow as many countries as possible to contribute to microbiome studies of their own populations.
Fil: Bose, Mayilvahanan. Cancer Institute; India
Fil: Wood, Henry M.. University of Leeds; Reino Unido
Fil: Young, Caroline. University of Leeds; Reino Unido
Fil: Van Nang, Pham. International C. R. C. Microbiome Network; Reino Unido
Fil: Van Doi, Mai. International C. R. C. Microbiome Network; Reino Unido
Fil: Vaccaro, Carlos Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Medicina Traslacional e Ingeniería Biomédica - Hospital Italiano. Instituto de Medicina Traslacional e Ingeniería Biomédica.- Instituto Universitario Hospital Italiano de Buenos Aires. Instituto de Medicina Traslacional e Ingeniería Biomédica; Argentina
Fil: Piñero, Tamara Alejandra. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Medicina Traslacional E Ingenieria Biomedica. - Hospital Italiano. Instituto de Medicina Traslacional E Ingenieria Biomedica. - Instituto Universitario Hospital Italiano de Buenos Aires. Instituto de Medicina Traslacional E Ingenieria Biomedica.; Argentina
Fil: Arguero, Julieta. Hospital Italiano; Argentina
Fil: Melendez, Luis Contreras. Universidad de Los Andes.; Chile
Fil: Valladares, Camilo Tapia. Universidad de Los Andes.; Chile
Fil: Quirke, Philip. University of Leeds; Reino Unido
Fil: Seshadri, Ramakrishan Ayloor. Cancer Institute; India
description It is increasingly being recognised that changes in the gut microbiome have either a causative or associative relationship with colorectal cancer (CRC). However, most of this research has been carried out in a small number of developed countries with high CRC incidence. It is unknown if lower incidence countries such as India have similar microbial associations. Having previously established protocols to facilitate microbiome research in regions with developing research infrastructure, we have now collected and sequenced microbial samples from a larger cohort study of 46 Indian CRC patients and 43 healthy volunteers. When comparing to previous global collections, these samples resemble other Asian samples, with relatively high levels of Prevotella. Predicting cancer status between cohorts shows good concordance. When compared to a previous collection of Indian CRC patients, there was similar concordance, despite different sequencing technologies between cohorts. These results show that there does seem to be a global CRC microbiome, and that some inference between studies is reasonable. However, we also demonstrate that there is definite regional variation, with more similarities between location-matched comparisons. This emphasises the importance of developing protocols and advancing infrastructure to allow as many countries as possible to contribute to microbiome studies of their own populations.
publishDate 2023
dc.date.none.fl_str_mv 2023-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/227944
Bose, Mayilvahanan; Wood, Henry M.; Young, Caroline; Van Nang, Pham; Van Doi, Mai; et al.; Analysis of an Indian colorectal cancer faecal microbiome collection demonstrates universal colorectal cancer-associated patterns, but closest correlation with other Indian cohorts; BioMed Central; BMC Microbiology; 23; 1; 12-2023; 1-13
1471-2180
CONICET Digital
CONICET
url http://hdl.handle.net/11336/227944
identifier_str_mv Bose, Mayilvahanan; Wood, Henry M.; Young, Caroline; Van Nang, Pham; Van Doi, Mai; et al.; Analysis of an Indian colorectal cancer faecal microbiome collection demonstrates universal colorectal cancer-associated patterns, but closest correlation with other Indian cohorts; BioMed Central; BMC Microbiology; 23; 1; 12-2023; 1-13
1471-2180
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://bmcmicrobiol.biomedcentral.com/articles/10.1186/s12866-023-02805-0
info:eu-repo/semantics/altIdentifier/doi/10.1186/s12866-023-02805-0
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269576489861120
score 13.13397

Publicaciones similares