Neuroprotective role of hypothermia in hypoxic-ischemic brain injury : combined therapies using estrogen

Autores
Toro-Urrego, Nicolás; Vesga-Jiménez, Diego Julián; Herrera, María Inés; Luaces, Juan Pablo; Capani, Francisco
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión aceptada
Descripción
Fil: Toro-Urrego, Nicolás. Universidad de Buenos Aires. Instituto de Investigaciones Cardiológicas. Laboratorio de Citoarquitectura y Plasticidad Neuronal; Argentina
Fil: Toro-Urrego, Nicolás. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Vesga-Jiménez, Diego Julián. Pontificia Universidad Javeriana. Facultad de Ciencias. Departamento de Nutrición y Bioquímica; Colombia
Fil: Herrera, María Inés. Universidad de Buenos Aires. Instituto de Investigaciones Cardiológicas. Laboratorio de Citoarquitectura y Plasticidad Neuronal; Argentina
Fil: Herrera, María Inés. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Herrera, María Inés. Pontificia Universidad Católica Argentina. Facultad de Psicología y Psicopedagogía. Centro de Investigaciones en Psicología y Psicopedagogía; Argentina
Fil: Luaces, Juan Pablo. Universidad de Buenos Aires. Instituto de Investigaciones Cardiológicas. Laboratorio de Citoarquitectura y Plasticidad Neuronal; Argentina
Fil: Luaces, Juan Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Capani, Francisco. Universidad de Buenos Aires. Instituto de Investigaciones Cardiológicas. Laboratorio de Citoarquitectura y Plasticidad Neuronal; Argentina
Fil: Capani, Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Capani, Francisco. Pontificia Universidad Católica Argentina. Facultad de Psicología y Psicopedagogía. Centro de Investigaciones en Psicología y Psicopedagogía; Argentina
Fil: Capani, Francisco. Universidad Argentina JF Kennedy. Departamento de Biología; Argentina
Fil: Capani, Francisco. Universidad Autónoma de Chile; Chile
Abstract: Hypoxic-ischemic brain injury is a complex network of factors, which is mainly characterized by a decrease in levels of oxygen concentration and blood flow, which lead to an inefficient supply of nutrients to the brain. Hypoxic-ischemic brain injury can be found in perinatal asphyxia and ischemic-stroke, which represent one of the main causes of mortality and morbidity in children and adults worldwide. Therefore, knowledge of underlying mechanisms triggering these insults may help establish neuroprotective treatments. Selective Estrogen Receptor Modulators and Selective Tissue Estrogenic Activity Regulators exert several neuroprotective effects, including a decrease of reactive oxygen species, maintenance of cell viability, mitochondrial survival, among others. However, these strategies represent a traditional approach of targeting a single factor of pathology without satisfactory results. Hence, combined therapies, such as the administration of therapeutic hypothermia with a complementary neuroprotective agent, constitute a promising alternative. In this sense, the present review summarizes the underlying mechanisms of hypoxic-ischemic brain injury and compiles several neuroprotective strategies, including Selective Estrogen Receptor Modulators and Selective Tissue Estrogenic Activity Regulators, which represent putative agents for combined therapies with therapeutic hypothermia.
Fuente
Current Neuropharmacology. 2019, 17(9)
Materia
ESTROGENO
ISQUEMIA
LESION CEREBRAL
NEUROPROTECCION
ENCEFALOPATIAS
HIPOTERMIA
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/4.0/
Repositorio
Repositorio Institucional (UCA)
Institución
Pontificia Universidad Católica Argentina
OAI Identificador
oai:ucacris:123456789/9869
Acceder
id RIUCA_6a096c1dbde211f53d55c2ba03296d36
oai_identifier_str oai:ucacris:123456789/9869
network_acronym_str RIUCA
repository_id_str 2585
network_name_str Repositorio Institucional (UCA)
spelling Neuroprotective role of hypothermia in hypoxic-ischemic brain injury : combined therapies using estrogenToro-Urrego, NicolásVesga-Jiménez, Diego JuliánHerrera, María InésLuaces, Juan PabloCapani, FranciscoESTROGENOISQUEMIALESION CEREBRALNEUROPROTECCIONENCEFALOPATIASHIPOTERMIAFil: Toro-Urrego, Nicolás. Universidad de Buenos Aires. Instituto de Investigaciones Cardiológicas. Laboratorio de Citoarquitectura y Plasticidad Neuronal; ArgentinaFil: Toro-Urrego, Nicolás. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Vesga-Jiménez, Diego Julián. Pontificia Universidad Javeriana. Facultad de Ciencias. Departamento de Nutrición y Bioquímica; ColombiaFil: Herrera, María Inés. Universidad de Buenos Aires. Instituto de Investigaciones Cardiológicas. Laboratorio de Citoarquitectura y Plasticidad Neuronal; ArgentinaFil: Herrera, María Inés. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Herrera, María Inés. Pontificia Universidad Católica Argentina. Facultad de Psicología y Psicopedagogía. Centro de Investigaciones en Psicología y Psicopedagogía; ArgentinaFil: Luaces, Juan Pablo. Universidad de Buenos Aires. Instituto de Investigaciones Cardiológicas. Laboratorio de Citoarquitectura y Plasticidad Neuronal; ArgentinaFil: Luaces, Juan Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Capani, Francisco. Universidad de Buenos Aires. Instituto de Investigaciones Cardiológicas. Laboratorio de Citoarquitectura y Plasticidad Neuronal; ArgentinaFil: Capani, Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Capani, Francisco. Pontificia Universidad Católica Argentina. Facultad de Psicología y Psicopedagogía. Centro de Investigaciones en Psicología y Psicopedagogía; ArgentinaFil: Capani, Francisco. Universidad Argentina JF Kennedy. Departamento de Biología; ArgentinaFil: Capani, Francisco. Universidad Autónoma de Chile; ChileAbstract: Hypoxic-ischemic brain injury is a complex network of factors, which is mainly characterized by a decrease in levels of oxygen concentration and blood flow, which lead to an inefficient supply of nutrients to the brain. Hypoxic-ischemic brain injury can be found in perinatal asphyxia and ischemic-stroke, which represent one of the main causes of mortality and morbidity in children and adults worldwide. Therefore, knowledge of underlying mechanisms triggering these insults may help establish neuroprotective treatments. Selective Estrogen Receptor Modulators and Selective Tissue Estrogenic Activity Regulators exert several neuroprotective effects, including a decrease of reactive oxygen species, maintenance of cell viability, mitochondrial survival, among others. However, these strategies represent a traditional approach of targeting a single factor of pathology without satisfactory results. Hence, combined therapies, such as the administration of therapeutic hypothermia with a complementary neuroprotective agent, constitute a promising alternative. In this sense, the present review summarizes the underlying mechanisms of hypoxic-ischemic brain injury and compiles several neuroprotective strategies, including Selective Estrogen Receptor Modulators and Selective Tissue Estrogenic Activity Regulators, which represent putative agents for combined therapies with therapeutic hypothermia.Bentham Science Publishers2019info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttps://repositorio.uca.edu.ar/handle/123456789/98691570-159X (impreso)1875-6190 (online)10.2174/1570159X1766618120610131430520375Toro-Urrego, N. Neuroprotective role of hypothermia in hypoxic-ischemic brain injury : combined therapies using estrogen [en línea]. Current Neuropharmacology. 2019, 17(9). doi:10.2174/1570159X17666181206101314 Disponible en: https://repositorio.uca.edu.ar/handle/123456789/9869Current Neuropharmacology. 2019, 17(9)reponame:Repositorio Institucional (UCA)instname:Pontificia Universidad Católica Argentinaenginfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/4.0/2025-07-03T10:57:19Zoai:ucacris:123456789/9869instacron:UCAInstitucionalhttps://repositorio.uca.edu.ar/Universidad privadaNo correspondehttps://repositorio.uca.edu.ar/oaiclaudia_fernandez@uca.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:25852025-07-03 10:57:19.529Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentinafalse
dc.title.none.fl_str_mv Neuroprotective role of hypothermia in hypoxic-ischemic brain injury : combined therapies using estrogen
title Neuroprotective role of hypothermia in hypoxic-ischemic brain injury : combined therapies using estrogen
spellingShingle Neuroprotective role of hypothermia in hypoxic-ischemic brain injury : combined therapies using estrogen
Toro-Urrego, Nicolás
ESTROGENO
ISQUEMIA
LESION CEREBRAL
NEUROPROTECCION
ENCEFALOPATIAS
HIPOTERMIA
title_short Neuroprotective role of hypothermia in hypoxic-ischemic brain injury : combined therapies using estrogen
title_full Neuroprotective role of hypothermia in hypoxic-ischemic brain injury : combined therapies using estrogen
title_fullStr Neuroprotective role of hypothermia in hypoxic-ischemic brain injury : combined therapies using estrogen
title_full_unstemmed Neuroprotective role of hypothermia in hypoxic-ischemic brain injury : combined therapies using estrogen
title_sort Neuroprotective role of hypothermia in hypoxic-ischemic brain injury : combined therapies using estrogen
dc.creator.none.fl_str_mv Toro-Urrego, Nicolás
Vesga-Jiménez, Diego Julián
Herrera, María Inés
Luaces, Juan Pablo
Capani, Francisco
author Toro-Urrego, Nicolás
author_facet Toro-Urrego, Nicolás
Vesga-Jiménez, Diego Julián
Herrera, María Inés
Luaces, Juan Pablo
Capani, Francisco
author_role author
author2 Vesga-Jiménez, Diego Julián
Herrera, María Inés
Luaces, Juan Pablo
Capani, Francisco
author2_role author
author
author
author
dc.subject.none.fl_str_mv ESTROGENO
ISQUEMIA
LESION CEREBRAL
NEUROPROTECCION
ENCEFALOPATIAS
HIPOTERMIA
topic ESTROGENO
ISQUEMIA
LESION CEREBRAL
NEUROPROTECCION
ENCEFALOPATIAS
HIPOTERMIA
dc.description.none.fl_txt_mv Fil: Toro-Urrego, Nicolás. Universidad de Buenos Aires. Instituto de Investigaciones Cardiológicas. Laboratorio de Citoarquitectura y Plasticidad Neuronal; Argentina
Fil: Toro-Urrego, Nicolás. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Vesga-Jiménez, Diego Julián. Pontificia Universidad Javeriana. Facultad de Ciencias. Departamento de Nutrición y Bioquímica; Colombia
Fil: Herrera, María Inés. Universidad de Buenos Aires. Instituto de Investigaciones Cardiológicas. Laboratorio de Citoarquitectura y Plasticidad Neuronal; Argentina
Fil: Herrera, María Inés. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Herrera, María Inés. Pontificia Universidad Católica Argentina. Facultad de Psicología y Psicopedagogía. Centro de Investigaciones en Psicología y Psicopedagogía; Argentina
Fil: Luaces, Juan Pablo. Universidad de Buenos Aires. Instituto de Investigaciones Cardiológicas. Laboratorio de Citoarquitectura y Plasticidad Neuronal; Argentina
Fil: Luaces, Juan Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Capani, Francisco. Universidad de Buenos Aires. Instituto de Investigaciones Cardiológicas. Laboratorio de Citoarquitectura y Plasticidad Neuronal; Argentina
Fil: Capani, Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Capani, Francisco. Pontificia Universidad Católica Argentina. Facultad de Psicología y Psicopedagogía. Centro de Investigaciones en Psicología y Psicopedagogía; Argentina
Fil: Capani, Francisco. Universidad Argentina JF Kennedy. Departamento de Biología; Argentina
Fil: Capani, Francisco. Universidad Autónoma de Chile; Chile
Abstract: Hypoxic-ischemic brain injury is a complex network of factors, which is mainly characterized by a decrease in levels of oxygen concentration and blood flow, which lead to an inefficient supply of nutrients to the brain. Hypoxic-ischemic brain injury can be found in perinatal asphyxia and ischemic-stroke, which represent one of the main causes of mortality and morbidity in children and adults worldwide. Therefore, knowledge of underlying mechanisms triggering these insults may help establish neuroprotective treatments. Selective Estrogen Receptor Modulators and Selective Tissue Estrogenic Activity Regulators exert several neuroprotective effects, including a decrease of reactive oxygen species, maintenance of cell viability, mitochondrial survival, among others. However, these strategies represent a traditional approach of targeting a single factor of pathology without satisfactory results. Hence, combined therapies, such as the administration of therapeutic hypothermia with a complementary neuroprotective agent, constitute a promising alternative. In this sense, the present review summarizes the underlying mechanisms of hypoxic-ischemic brain injury and compiles several neuroprotective strategies, including Selective Estrogen Receptor Modulators and Selective Tissue Estrogenic Activity Regulators, which represent putative agents for combined therapies with therapeutic hypothermia.
description Fil: Toro-Urrego, Nicolás. Universidad de Buenos Aires. Instituto de Investigaciones Cardiológicas. Laboratorio de Citoarquitectura y Plasticidad Neuronal; Argentina
publishDate 2019
dc.date.none.fl_str_mv 2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://repositorio.uca.edu.ar/handle/123456789/9869
1570-159X (impreso)
1875-6190 (online)
10.2174/1570159X17666181206101314
30520375
Toro-Urrego, N. Neuroprotective role of hypothermia in hypoxic-ischemic brain injury : combined therapies using estrogen [en línea]. Current Neuropharmacology. 2019, 17(9). doi:10.2174/1570159X17666181206101314 Disponible en: https://repositorio.uca.edu.ar/handle/123456789/9869
url https://repositorio.uca.edu.ar/handle/123456789/9869
identifier_str_mv 1570-159X (impreso)
1875-6190 (online)
10.2174/1570159X17666181206101314
30520375
Toro-Urrego, N. Neuroprotective role of hypothermia in hypoxic-ischemic brain injury : combined therapies using estrogen [en línea]. Current Neuropharmacology. 2019, 17(9). doi:10.2174/1570159X17666181206101314 Disponible en: https://repositorio.uca.edu.ar/handle/123456789/9869
dc.language.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/4.0/
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Bentham Science Publishers
publisher.none.fl_str_mv Bentham Science Publishers
dc.source.none.fl_str_mv Current Neuropharmacology. 2019, 17(9)
reponame:Repositorio Institucional (UCA)
instname:Pontificia Universidad Católica Argentina
reponame_str Repositorio Institucional (UCA)
collection Repositorio Institucional (UCA)
instname_str Pontificia Universidad Católica Argentina
repository.name.fl_str_mv Repositorio Institucional (UCA) - Pontificia Universidad Católica Argentina
repository.mail.fl_str_mv claudia_fernandez@uca.edu.ar
_version_ 1836638350884208640
score 13.13397

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