Clinical Implications of Epigenetic Dysregulation in Perinatal Hypoxic-Ischemic Brain Damage

Autores
Bustelo, Martí; Barkhuizen, Melinda; van den Hove, Daniel L. A.; Steinbusch, Harry Wilhelm. M.; Bruno, Martin; Loidl, Cesar Fabian; Gavilanes, Antonio W. Danilo
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Placental and fetal hypoxia caused by perinatal hypoxic-ischemic events are major causes of stillbirth, neonatal morbidity, and long-term neurological sequelae among surviving neonates. Brain hypoxia and associated pathological processes such as excitotoxicity, apoptosis, necrosis, and inflammation, are associated with lasting disruptions in epigenetic control of gene expression contributing to neurological dysfunction. Recent studies have pointed to DNA (de)methylation, histone modifications, and non-coding RNAs as crucial components of hypoxic-ischemic encephalopathy (HIE). The understanding of epigenetic dysregulation in HIE is essential in the development of new clinical interventions for perinatal HIE. Here, we summarize our current understanding of epigenetic mechanisms underlying the molecular pathology of HI brain damage and its clinical implications in terms of new diagnostic, prognostic, and therapeutic tools.
Fil: Bustelo, Martí. Universidad de Buenos Aires; Argentina. Maastricht University Medical Center; Países Bajos. Universidad Católica de Cuyo - Sede San Juan; Argentina
Fil: Barkhuizen, Melinda. Maastricht University Medical Center; Países Bajos
Fil: van den Hove, Daniel L. A.. Universiteit Maastricht.; Países Bajos
Fil: Steinbusch, Harry Wilhelm. M.. Universiteit Maastricht.; Países Bajos
Fil: Bruno, Martin. Universidad Católica de Cuyo - Sede San Juan; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan; Argentina
Fil: Loidl, Cesar Fabian. Universidad Catolica de Cuyo - Sede San Luis; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; Argentina
Fil: Gavilanes, Antonio W. Danilo. Maastricht University Medical Cente; Países Bajos
Materia
BIOMARKER
DNA METHYLATION
HISTONE MODIFICATIONS
HYPOXIA
HYPOXIC-ISCHEMIC ENCEPHALOPATHY
ISCHEMIA
MICRORNAS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/152583

id CONICETDig_482c837ad93a9b1169c0e6e7802d702f
oai_identifier_str oai:ri.conicet.gov.ar:11336/152583
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Clinical Implications of Epigenetic Dysregulation in Perinatal Hypoxic-Ischemic Brain DamageBustelo, MartíBarkhuizen, Melindavan den Hove, Daniel L. A.Steinbusch, Harry Wilhelm. M.Bruno, MartinLoidl, Cesar FabianGavilanes, Antonio W. DaniloBIOMARKERDNA METHYLATIONHISTONE MODIFICATIONSHYPOXIAHYPOXIC-ISCHEMIC ENCEPHALOPATHYISCHEMIAMICRORNAShttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Placental and fetal hypoxia caused by perinatal hypoxic-ischemic events are major causes of stillbirth, neonatal morbidity, and long-term neurological sequelae among surviving neonates. Brain hypoxia and associated pathological processes such as excitotoxicity, apoptosis, necrosis, and inflammation, are associated with lasting disruptions in epigenetic control of gene expression contributing to neurological dysfunction. Recent studies have pointed to DNA (de)methylation, histone modifications, and non-coding RNAs as crucial components of hypoxic-ischemic encephalopathy (HIE). The understanding of epigenetic dysregulation in HIE is essential in the development of new clinical interventions for perinatal HIE. Here, we summarize our current understanding of epigenetic mechanisms underlying the molecular pathology of HI brain damage and its clinical implications in terms of new diagnostic, prognostic, and therapeutic tools.Fil: Bustelo, Martí. Universidad de Buenos Aires; Argentina. Maastricht University Medical Center; Países Bajos. Universidad Católica de Cuyo - Sede San Juan; ArgentinaFil: Barkhuizen, Melinda. Maastricht University Medical Center; Países BajosFil: van den Hove, Daniel L. A.. Universiteit Maastricht.; Países BajosFil: Steinbusch, Harry Wilhelm. M.. Universiteit Maastricht.; Países BajosFil: Bruno, Martin. Universidad Católica de Cuyo - Sede San Juan; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan; ArgentinaFil: Loidl, Cesar Fabian. Universidad Catolica de Cuyo - Sede San Luis; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; ArgentinaFil: Gavilanes, Antonio W. Danilo. Maastricht University Medical Cente; Países BajosFrontiers Media2020-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/152583Bustelo, Martí; Barkhuizen, Melinda; van den Hove, Daniel L. A.; Steinbusch, Harry Wilhelm. M.; Bruno, Martin; et al.; Clinical Implications of Epigenetic Dysregulation in Perinatal Hypoxic-Ischemic Brain Damage; Frontiers Media; Frontiers in Neurology; 11; 6-2020; 1-151664-2295CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.3389/fneur.2020.00483info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:37:53Zoai:ri.conicet.gov.ar:11336/152583instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:37:53.735CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Clinical Implications of Epigenetic Dysregulation in Perinatal Hypoxic-Ischemic Brain Damage
title Clinical Implications of Epigenetic Dysregulation in Perinatal Hypoxic-Ischemic Brain Damage
spellingShingle Clinical Implications of Epigenetic Dysregulation in Perinatal Hypoxic-Ischemic Brain Damage
Bustelo, Martí
BIOMARKER
DNA METHYLATION
HISTONE MODIFICATIONS
HYPOXIA
HYPOXIC-ISCHEMIC ENCEPHALOPATHY
ISCHEMIA
MICRORNAS
title_short Clinical Implications of Epigenetic Dysregulation in Perinatal Hypoxic-Ischemic Brain Damage
title_full Clinical Implications of Epigenetic Dysregulation in Perinatal Hypoxic-Ischemic Brain Damage
title_fullStr Clinical Implications of Epigenetic Dysregulation in Perinatal Hypoxic-Ischemic Brain Damage
title_full_unstemmed Clinical Implications of Epigenetic Dysregulation in Perinatal Hypoxic-Ischemic Brain Damage
title_sort Clinical Implications of Epigenetic Dysregulation in Perinatal Hypoxic-Ischemic Brain Damage
dc.creator.none.fl_str_mv Bustelo, Martí
Barkhuizen, Melinda
van den Hove, Daniel L. A.
Steinbusch, Harry Wilhelm. M.
Bruno, Martin
Loidl, Cesar Fabian
Gavilanes, Antonio W. Danilo
author Bustelo, Martí
author_facet Bustelo, Martí
Barkhuizen, Melinda
van den Hove, Daniel L. A.
Steinbusch, Harry Wilhelm. M.
Bruno, Martin
Loidl, Cesar Fabian
Gavilanes, Antonio W. Danilo
author_role author
author2 Barkhuizen, Melinda
van den Hove, Daniel L. A.
Steinbusch, Harry Wilhelm. M.
Bruno, Martin
Loidl, Cesar Fabian
Gavilanes, Antonio W. Danilo
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv BIOMARKER
DNA METHYLATION
HISTONE MODIFICATIONS
HYPOXIA
HYPOXIC-ISCHEMIC ENCEPHALOPATHY
ISCHEMIA
MICRORNAS
topic BIOMARKER
DNA METHYLATION
HISTONE MODIFICATIONS
HYPOXIA
HYPOXIC-ISCHEMIC ENCEPHALOPATHY
ISCHEMIA
MICRORNAS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Placental and fetal hypoxia caused by perinatal hypoxic-ischemic events are major causes of stillbirth, neonatal morbidity, and long-term neurological sequelae among surviving neonates. Brain hypoxia and associated pathological processes such as excitotoxicity, apoptosis, necrosis, and inflammation, are associated with lasting disruptions in epigenetic control of gene expression contributing to neurological dysfunction. Recent studies have pointed to DNA (de)methylation, histone modifications, and non-coding RNAs as crucial components of hypoxic-ischemic encephalopathy (HIE). The understanding of epigenetic dysregulation in HIE is essential in the development of new clinical interventions for perinatal HIE. Here, we summarize our current understanding of epigenetic mechanisms underlying the molecular pathology of HI brain damage and its clinical implications in terms of new diagnostic, prognostic, and therapeutic tools.
Fil: Bustelo, Martí. Universidad de Buenos Aires; Argentina. Maastricht University Medical Center; Países Bajos. Universidad Católica de Cuyo - Sede San Juan; Argentina
Fil: Barkhuizen, Melinda. Maastricht University Medical Center; Países Bajos
Fil: van den Hove, Daniel L. A.. Universiteit Maastricht.; Países Bajos
Fil: Steinbusch, Harry Wilhelm. M.. Universiteit Maastricht.; Países Bajos
Fil: Bruno, Martin. Universidad Católica de Cuyo - Sede San Juan; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan; Argentina
Fil: Loidl, Cesar Fabian. Universidad Catolica de Cuyo - Sede San Luis; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; Argentina
Fil: Gavilanes, Antonio W. Danilo. Maastricht University Medical Cente; Países Bajos
description Placental and fetal hypoxia caused by perinatal hypoxic-ischemic events are major causes of stillbirth, neonatal morbidity, and long-term neurological sequelae among surviving neonates. Brain hypoxia and associated pathological processes such as excitotoxicity, apoptosis, necrosis, and inflammation, are associated with lasting disruptions in epigenetic control of gene expression contributing to neurological dysfunction. Recent studies have pointed to DNA (de)methylation, histone modifications, and non-coding RNAs as crucial components of hypoxic-ischemic encephalopathy (HIE). The understanding of epigenetic dysregulation in HIE is essential in the development of new clinical interventions for perinatal HIE. Here, we summarize our current understanding of epigenetic mechanisms underlying the molecular pathology of HI brain damage and its clinical implications in terms of new diagnostic, prognostic, and therapeutic tools.
publishDate 2020
dc.date.none.fl_str_mv 2020-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/152583
Bustelo, Martí; Barkhuizen, Melinda; van den Hove, Daniel L. A.; Steinbusch, Harry Wilhelm. M.; Bruno, Martin; et al.; Clinical Implications of Epigenetic Dysregulation in Perinatal Hypoxic-Ischemic Brain Damage; Frontiers Media; Frontiers in Neurology; 11; 6-2020; 1-15
1664-2295
CONICET Digital
CONICET
url http://hdl.handle.net/11336/152583
identifier_str_mv Bustelo, Martí; Barkhuizen, Melinda; van den Hove, Daniel L. A.; Steinbusch, Harry Wilhelm. M.; Bruno, Martin; et al.; Clinical Implications of Epigenetic Dysregulation in Perinatal Hypoxic-Ischemic Brain Damage; Frontiers Media; Frontiers in Neurology; 11; 6-2020; 1-15
1664-2295
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.3389/fneur.2020.00483
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844614400186515456
score 13.070432