Clinical Implications of Epigenetic Dysregulation in Perinatal Hypoxic-Ischemic Brain Damage
- Autores
- Bustelo, Martí; Barkhuizen, Melinda; van den Hove, Daniel L. A.; Steinbusch, Harry Wilhelm. M.; Bruno, Martin; Loidl, Cesar Fabian; Gavilanes, Antonio W. Danilo
- Año de publicación
- 2020
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Placental and fetal hypoxia caused by perinatal hypoxic-ischemic events are major causes of stillbirth, neonatal morbidity, and long-term neurological sequelae among surviving neonates. Brain hypoxia and associated pathological processes such as excitotoxicity, apoptosis, necrosis, and inflammation, are associated with lasting disruptions in epigenetic control of gene expression contributing to neurological dysfunction. Recent studies have pointed to DNA (de)methylation, histone modifications, and non-coding RNAs as crucial components of hypoxic-ischemic encephalopathy (HIE). The understanding of epigenetic dysregulation in HIE is essential in the development of new clinical interventions for perinatal HIE. Here, we summarize our current understanding of epigenetic mechanisms underlying the molecular pathology of HI brain damage and its clinical implications in terms of new diagnostic, prognostic, and therapeutic tools.
Fil: Bustelo, Martí. Universidad de Buenos Aires; Argentina. Maastricht University Medical Center; Países Bajos. Universidad Católica de Cuyo - Sede San Juan; Argentina
Fil: Barkhuizen, Melinda. Maastricht University Medical Center; Países Bajos
Fil: van den Hove, Daniel L. A.. Universiteit Maastricht.; Países Bajos
Fil: Steinbusch, Harry Wilhelm. M.. Universiteit Maastricht.; Países Bajos
Fil: Bruno, Martin. Universidad Católica de Cuyo - Sede San Juan; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan; Argentina
Fil: Loidl, Cesar Fabian. Universidad Catolica de Cuyo - Sede San Luis; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; Argentina
Fil: Gavilanes, Antonio W. Danilo. Maastricht University Medical Cente; Países Bajos - Materia
-
BIOMARKER
DNA METHYLATION
HISTONE MODIFICATIONS
HYPOXIA
HYPOXIC-ISCHEMIC ENCEPHALOPATHY
ISCHEMIA
MICRORNAS - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/152583
Ver los metadatos del registro completo
id |
CONICETDig_482c837ad93a9b1169c0e6e7802d702f |
---|---|
oai_identifier_str |
oai:ri.conicet.gov.ar:11336/152583 |
network_acronym_str |
CONICETDig |
repository_id_str |
3498 |
network_name_str |
CONICET Digital (CONICET) |
spelling |
Clinical Implications of Epigenetic Dysregulation in Perinatal Hypoxic-Ischemic Brain DamageBustelo, MartíBarkhuizen, Melindavan den Hove, Daniel L. A.Steinbusch, Harry Wilhelm. M.Bruno, MartinLoidl, Cesar FabianGavilanes, Antonio W. DaniloBIOMARKERDNA METHYLATIONHISTONE MODIFICATIONSHYPOXIAHYPOXIC-ISCHEMIC ENCEPHALOPATHYISCHEMIAMICRORNAShttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Placental and fetal hypoxia caused by perinatal hypoxic-ischemic events are major causes of stillbirth, neonatal morbidity, and long-term neurological sequelae among surviving neonates. Brain hypoxia and associated pathological processes such as excitotoxicity, apoptosis, necrosis, and inflammation, are associated with lasting disruptions in epigenetic control of gene expression contributing to neurological dysfunction. Recent studies have pointed to DNA (de)methylation, histone modifications, and non-coding RNAs as crucial components of hypoxic-ischemic encephalopathy (HIE). The understanding of epigenetic dysregulation in HIE is essential in the development of new clinical interventions for perinatal HIE. Here, we summarize our current understanding of epigenetic mechanisms underlying the molecular pathology of HI brain damage and its clinical implications in terms of new diagnostic, prognostic, and therapeutic tools.Fil: Bustelo, Martí. Universidad de Buenos Aires; Argentina. Maastricht University Medical Center; Países Bajos. Universidad Católica de Cuyo - Sede San Juan; ArgentinaFil: Barkhuizen, Melinda. Maastricht University Medical Center; Países BajosFil: van den Hove, Daniel L. A.. Universiteit Maastricht.; Países BajosFil: Steinbusch, Harry Wilhelm. M.. Universiteit Maastricht.; Países BajosFil: Bruno, Martin. Universidad Católica de Cuyo - Sede San Juan; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan; ArgentinaFil: Loidl, Cesar Fabian. Universidad Catolica de Cuyo - Sede San Luis; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; ArgentinaFil: Gavilanes, Antonio W. Danilo. Maastricht University Medical Cente; Países BajosFrontiers Media2020-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/152583Bustelo, Martí; Barkhuizen, Melinda; van den Hove, Daniel L. A.; Steinbusch, Harry Wilhelm. M.; Bruno, Martin; et al.; Clinical Implications of Epigenetic Dysregulation in Perinatal Hypoxic-Ischemic Brain Damage; Frontiers Media; Frontiers in Neurology; 11; 6-2020; 1-151664-2295CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.3389/fneur.2020.00483info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:37:53Zoai:ri.conicet.gov.ar:11336/152583instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:37:53.735CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Clinical Implications of Epigenetic Dysregulation in Perinatal Hypoxic-Ischemic Brain Damage |
title |
Clinical Implications of Epigenetic Dysregulation in Perinatal Hypoxic-Ischemic Brain Damage |
spellingShingle |
Clinical Implications of Epigenetic Dysregulation in Perinatal Hypoxic-Ischemic Brain Damage Bustelo, Martí BIOMARKER DNA METHYLATION HISTONE MODIFICATIONS HYPOXIA HYPOXIC-ISCHEMIC ENCEPHALOPATHY ISCHEMIA MICRORNAS |
title_short |
Clinical Implications of Epigenetic Dysregulation in Perinatal Hypoxic-Ischemic Brain Damage |
title_full |
Clinical Implications of Epigenetic Dysregulation in Perinatal Hypoxic-Ischemic Brain Damage |
title_fullStr |
Clinical Implications of Epigenetic Dysregulation in Perinatal Hypoxic-Ischemic Brain Damage |
title_full_unstemmed |
Clinical Implications of Epigenetic Dysregulation in Perinatal Hypoxic-Ischemic Brain Damage |
title_sort |
Clinical Implications of Epigenetic Dysregulation in Perinatal Hypoxic-Ischemic Brain Damage |
dc.creator.none.fl_str_mv |
Bustelo, Martí Barkhuizen, Melinda van den Hove, Daniel L. A. Steinbusch, Harry Wilhelm. M. Bruno, Martin Loidl, Cesar Fabian Gavilanes, Antonio W. Danilo |
author |
Bustelo, Martí |
author_facet |
Bustelo, Martí Barkhuizen, Melinda van den Hove, Daniel L. A. Steinbusch, Harry Wilhelm. M. Bruno, Martin Loidl, Cesar Fabian Gavilanes, Antonio W. Danilo |
author_role |
author |
author2 |
Barkhuizen, Melinda van den Hove, Daniel L. A. Steinbusch, Harry Wilhelm. M. Bruno, Martin Loidl, Cesar Fabian Gavilanes, Antonio W. Danilo |
author2_role |
author author author author author author |
dc.subject.none.fl_str_mv |
BIOMARKER DNA METHYLATION HISTONE MODIFICATIONS HYPOXIA HYPOXIC-ISCHEMIC ENCEPHALOPATHY ISCHEMIA MICRORNAS |
topic |
BIOMARKER DNA METHYLATION HISTONE MODIFICATIONS HYPOXIA HYPOXIC-ISCHEMIC ENCEPHALOPATHY ISCHEMIA MICRORNAS |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Placental and fetal hypoxia caused by perinatal hypoxic-ischemic events are major causes of stillbirth, neonatal morbidity, and long-term neurological sequelae among surviving neonates. Brain hypoxia and associated pathological processes such as excitotoxicity, apoptosis, necrosis, and inflammation, are associated with lasting disruptions in epigenetic control of gene expression contributing to neurological dysfunction. Recent studies have pointed to DNA (de)methylation, histone modifications, and non-coding RNAs as crucial components of hypoxic-ischemic encephalopathy (HIE). The understanding of epigenetic dysregulation in HIE is essential in the development of new clinical interventions for perinatal HIE. Here, we summarize our current understanding of epigenetic mechanisms underlying the molecular pathology of HI brain damage and its clinical implications in terms of new diagnostic, prognostic, and therapeutic tools. Fil: Bustelo, Martí. Universidad de Buenos Aires; Argentina. Maastricht University Medical Center; Países Bajos. Universidad Católica de Cuyo - Sede San Juan; Argentina Fil: Barkhuizen, Melinda. Maastricht University Medical Center; Países Bajos Fil: van den Hove, Daniel L. A.. Universiteit Maastricht.; Países Bajos Fil: Steinbusch, Harry Wilhelm. M.. Universiteit Maastricht.; Países Bajos Fil: Bruno, Martin. Universidad Católica de Cuyo - Sede San Juan; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan; Argentina Fil: Loidl, Cesar Fabian. Universidad Catolica de Cuyo - Sede San Luis; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; Argentina Fil: Gavilanes, Antonio W. Danilo. Maastricht University Medical Cente; Países Bajos |
description |
Placental and fetal hypoxia caused by perinatal hypoxic-ischemic events are major causes of stillbirth, neonatal morbidity, and long-term neurological sequelae among surviving neonates. Brain hypoxia and associated pathological processes such as excitotoxicity, apoptosis, necrosis, and inflammation, are associated with lasting disruptions in epigenetic control of gene expression contributing to neurological dysfunction. Recent studies have pointed to DNA (de)methylation, histone modifications, and non-coding RNAs as crucial components of hypoxic-ischemic encephalopathy (HIE). The understanding of epigenetic dysregulation in HIE is essential in the development of new clinical interventions for perinatal HIE. Here, we summarize our current understanding of epigenetic mechanisms underlying the molecular pathology of HI brain damage and its clinical implications in terms of new diagnostic, prognostic, and therapeutic tools. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-06 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/152583 Bustelo, Martí; Barkhuizen, Melinda; van den Hove, Daniel L. A.; Steinbusch, Harry Wilhelm. M.; Bruno, Martin; et al.; Clinical Implications of Epigenetic Dysregulation in Perinatal Hypoxic-Ischemic Brain Damage; Frontiers Media; Frontiers in Neurology; 11; 6-2020; 1-15 1664-2295 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/152583 |
identifier_str_mv |
Bustelo, Martí; Barkhuizen, Melinda; van den Hove, Daniel L. A.; Steinbusch, Harry Wilhelm. M.; Bruno, Martin; et al.; Clinical Implications of Epigenetic Dysregulation in Perinatal Hypoxic-Ischemic Brain Damage; Frontiers Media; Frontiers in Neurology; 11; 6-2020; 1-15 1664-2295 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.3389/fneur.2020.00483 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Frontiers Media |
publisher.none.fl_str_mv |
Frontiers Media |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
_version_ |
1844614400186515456 |
score |
13.070432 |