Pediatric COVID-19 in Argentina: A comprehensive analysis of disease and economic burden through official data and a systematic literature review

Autores
Bardach, Ariel Esteban; Ruvinsky, Silvina Denise; Moreno, Carolina; Perelli, Lucas; Kyaw, Moe H.; Spinardi, Julia; Mendoza, Carlos Fernando; Carballo, Carolina M.; Roel, Macarena; Espinola, Natalia Micaela
Año de publicación
2024
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Background: Limited data are available on the clinical impact and economic burden of COVID-19 in the pediatric population in Argentina. We aimed to estimate the disease and economic burden of COVID-19 on children and adolescents.Methods: We analyzed official national databases and conducted a supplemental systematic review of the published literature with meta-analysis in children aged 0-18. The period of interest was from March 2020 to August 2021, before the introduction of vaccination in this age group as a national strategic plan. In addition, we used a cost of illness analysis to estimate the direct medical costs associated with COVID-19. All costs are reported in US dollars 2023.Results: A total of 450,503 confirmed COVID-19 cases and 180 multisystem inflammatory syndrome (MIS-C) were reported in Argentina in the study period. Fourteen observational clinical studies were identified. The meta-analyses of severity level from hospital patients showed that according to different studies 15%-28% of cases were asymptomatic, 68%-88% were mild or moderate, and 3%-10% were severe or critical. About 28% of children had an underlying disease. In addition, the estimated economic burden associated with COVID-19 was 80 million dollars and 4 million dollars corresponded to MISC.Conclusion: Significant impact of COVID-19 on the healthcare system and substantial economic implications for the pediatric population in Argentina were identified. The findings should help policymakers to make informed decisions and allocate resources effectively.
Fil: Bardach, Ariel Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Ruvinsky, Silvina Denise. Instituto de Efectividad Clínica y Sanitaria; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
Fil: Moreno, Carolina. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Perelli, Lucas. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Kyaw, Moe H.. Pfizer Inc.; Estados Unidos
Fil: Spinardi, Julia. Pfizer Inc.; Brasil
Fil: Mendoza, Carlos Fernando. Pfizer Inc.; México
Fil: Carballo, Carolina M.. Pfizer Inc.; Argentina
Fil: Roel, Macarena. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
Fil: Espinola, Natalia Micaela. Instituto de Efectividad Clínica y Sanitaria; Argentina
Materia
ARGENTINA
COVID-19
COST OF ILLNESS
META-ANALYSIS
SYSTEMATIC REVIEW
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/265117
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/265117
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Pediatric COVID-19 in Argentina: A comprehensive analysis of disease and economic burden through official data and a systematic literature reviewBardach, Ariel EstebanRuvinsky, Silvina DeniseMoreno, CarolinaPerelli, LucasKyaw, Moe H.Spinardi, JuliaMendoza, Carlos FernandoCarballo, Carolina M.Roel, MacarenaEspinola, Natalia MicaelaARGENTINACOVID-19COST OF ILLNESSMETA-ANALYSISSYSTEMATIC REVIEWhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Background: Limited data are available on the clinical impact and economic burden of COVID-19 in the pediatric population in Argentina. We aimed to estimate the disease and economic burden of COVID-19 on children and adolescents.Methods: We analyzed official national databases and conducted a supplemental systematic review of the published literature with meta-analysis in children aged 0-18. The period of interest was from March 2020 to August 2021, before the introduction of vaccination in this age group as a national strategic plan. In addition, we used a cost of illness analysis to estimate the direct medical costs associated with COVID-19. All costs are reported in US dollars 2023.Results: A total of 450,503 confirmed COVID-19 cases and 180 multisystem inflammatory syndrome (MIS-C) were reported in Argentina in the study period. Fourteen observational clinical studies were identified. The meta-analyses of severity level from hospital patients showed that according to different studies 15%-28% of cases were asymptomatic, 68%-88% were mild or moderate, and 3%-10% were severe or critical. About 28% of children had an underlying disease. In addition, the estimated economic burden associated with COVID-19 was 80 million dollars and 4 million dollars corresponded to MISC.Conclusion: Significant impact of COVID-19 on the healthcare system and substantial economic implications for the pediatric population in Argentina were identified. The findings should help policymakers to make informed decisions and allocate resources effectively.Fil: Bardach, Ariel Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina. Instituto de Efectividad Clínica y Sanitaria; ArgentinaFil: Ruvinsky, Silvina Denise. Instituto de Efectividad Clínica y Sanitaria; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; ArgentinaFil: Moreno, Carolina. Instituto de Efectividad Clínica y Sanitaria; ArgentinaFil: Perelli, Lucas. Instituto de Efectividad Clínica y Sanitaria; ArgentinaFil: Kyaw, Moe H.. Pfizer Inc.; Estados UnidosFil: Spinardi, Julia. Pfizer Inc.; BrasilFil: Mendoza, Carlos Fernando. Pfizer Inc.; MéxicoFil: Carballo, Carolina M.. Pfizer Inc.; ArgentinaFil: Roel, Macarena. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; ArgentinaFil: Espinola, Natalia Micaela. Instituto de Efectividad Clínica y Sanitaria; ArgentinaFrontiers Media2024-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/265117Bardach, Ariel Esteban; Ruvinsky, Silvina Denise; Moreno, Carolina; Perelli, Lucas; Kyaw, Moe H.; et al.; Pediatric COVID-19 in Argentina: A comprehensive analysis of disease and economic burden through official data and a systematic literature review; Frontiers Media; Frontiers in Pediatrics; 12; 3-2024; 1-112296-2360CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fped.2024.1352260/fullinfo:eu-repo/semantics/altIdentifier/doi/10.3389/fped.2024.1352260info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:48:18Zoai:ri.conicet.gov.ar:11336/265117instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:48:18.654CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Pediatric COVID-19 in Argentina: A comprehensive analysis of disease and economic burden through official data and a systematic literature review
title Pediatric COVID-19 in Argentina: A comprehensive analysis of disease and economic burden through official data and a systematic literature review
spellingShingle Pediatric COVID-19 in Argentina: A comprehensive analysis of disease and economic burden through official data and a systematic literature review
Bardach, Ariel Esteban
ARGENTINA
COVID-19
COST OF ILLNESS
META-ANALYSIS
SYSTEMATIC REVIEW
title_short Pediatric COVID-19 in Argentina: A comprehensive analysis of disease and economic burden through official data and a systematic literature review
title_full Pediatric COVID-19 in Argentina: A comprehensive analysis of disease and economic burden through official data and a systematic literature review
title_fullStr Pediatric COVID-19 in Argentina: A comprehensive analysis of disease and economic burden through official data and a systematic literature review
title_full_unstemmed Pediatric COVID-19 in Argentina: A comprehensive analysis of disease and economic burden through official data and a systematic literature review
title_sort Pediatric COVID-19 in Argentina: A comprehensive analysis of disease and economic burden through official data and a systematic literature review
dc.creator.none.fl_str_mv Bardach, Ariel Esteban
Ruvinsky, Silvina Denise
Moreno, Carolina
Perelli, Lucas
Kyaw, Moe H.
Spinardi, Julia
Mendoza, Carlos Fernando
Carballo, Carolina M.
Roel, Macarena
Espinola, Natalia Micaela
author Bardach, Ariel Esteban
author_facet Bardach, Ariel Esteban
Ruvinsky, Silvina Denise
Moreno, Carolina
Perelli, Lucas
Kyaw, Moe H.
Spinardi, Julia
Mendoza, Carlos Fernando
Carballo, Carolina M.
Roel, Macarena
Espinola, Natalia Micaela
author_role author
author2 Ruvinsky, Silvina Denise
Moreno, Carolina
Perelli, Lucas
Kyaw, Moe H.
Spinardi, Julia
Mendoza, Carlos Fernando
Carballo, Carolina M.
Roel, Macarena
Espinola, Natalia Micaela
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv ARGENTINA
COVID-19
COST OF ILLNESS
META-ANALYSIS
SYSTEMATIC REVIEW
topic ARGENTINA
COVID-19
COST OF ILLNESS
META-ANALYSIS
SYSTEMATIC REVIEW
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Background: Limited data are available on the clinical impact and economic burden of COVID-19 in the pediatric population in Argentina. We aimed to estimate the disease and economic burden of COVID-19 on children and adolescents.Methods: We analyzed official national databases and conducted a supplemental systematic review of the published literature with meta-analysis in children aged 0-18. The period of interest was from March 2020 to August 2021, before the introduction of vaccination in this age group as a national strategic plan. In addition, we used a cost of illness analysis to estimate the direct medical costs associated with COVID-19. All costs are reported in US dollars 2023.Results: A total of 450,503 confirmed COVID-19 cases and 180 multisystem inflammatory syndrome (MIS-C) were reported in Argentina in the study period. Fourteen observational clinical studies were identified. The meta-analyses of severity level from hospital patients showed that according to different studies 15%-28% of cases were asymptomatic, 68%-88% were mild or moderate, and 3%-10% were severe or critical. About 28% of children had an underlying disease. In addition, the estimated economic burden associated with COVID-19 was 80 million dollars and 4 million dollars corresponded to MISC.Conclusion: Significant impact of COVID-19 on the healthcare system and substantial economic implications for the pediatric population in Argentina were identified. The findings should help policymakers to make informed decisions and allocate resources effectively.
Fil: Bardach, Ariel Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Ruvinsky, Silvina Denise. Instituto de Efectividad Clínica y Sanitaria; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
Fil: Moreno, Carolina. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Perelli, Lucas. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Kyaw, Moe H.. Pfizer Inc.; Estados Unidos
Fil: Spinardi, Julia. Pfizer Inc.; Brasil
Fil: Mendoza, Carlos Fernando. Pfizer Inc.; México
Fil: Carballo, Carolina M.. Pfizer Inc.; Argentina
Fil: Roel, Macarena. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
Fil: Espinola, Natalia Micaela. Instituto de Efectividad Clínica y Sanitaria; Argentina
description Background: Limited data are available on the clinical impact and economic burden of COVID-19 in the pediatric population in Argentina. We aimed to estimate the disease and economic burden of COVID-19 on children and adolescents.Methods: We analyzed official national databases and conducted a supplemental systematic review of the published literature with meta-analysis in children aged 0-18. The period of interest was from March 2020 to August 2021, before the introduction of vaccination in this age group as a national strategic plan. In addition, we used a cost of illness analysis to estimate the direct medical costs associated with COVID-19. All costs are reported in US dollars 2023.Results: A total of 450,503 confirmed COVID-19 cases and 180 multisystem inflammatory syndrome (MIS-C) were reported in Argentina in the study period. Fourteen observational clinical studies were identified. The meta-analyses of severity level from hospital patients showed that according to different studies 15%-28% of cases were asymptomatic, 68%-88% were mild or moderate, and 3%-10% were severe or critical. About 28% of children had an underlying disease. In addition, the estimated economic burden associated with COVID-19 was 80 million dollars and 4 million dollars corresponded to MISC.Conclusion: Significant impact of COVID-19 on the healthcare system and substantial economic implications for the pediatric population in Argentina were identified. The findings should help policymakers to make informed decisions and allocate resources effectively.
publishDate 2024
dc.date.none.fl_str_mv 2024-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/265117
Bardach, Ariel Esteban; Ruvinsky, Silvina Denise; Moreno, Carolina; Perelli, Lucas; Kyaw, Moe H.; et al.; Pediatric COVID-19 in Argentina: A comprehensive analysis of disease and economic burden through official data and a systematic literature review; Frontiers Media; Frontiers in Pediatrics; 12; 3-2024; 1-11
2296-2360
CONICET Digital
CONICET
url http://hdl.handle.net/11336/265117
identifier_str_mv Bardach, Ariel Esteban; Ruvinsky, Silvina Denise; Moreno, Carolina; Perelli, Lucas; Kyaw, Moe H.; et al.; Pediatric COVID-19 in Argentina: A comprehensive analysis of disease and economic burden through official data and a systematic literature review; Frontiers Media; Frontiers in Pediatrics; 12; 3-2024; 1-11
2296-2360
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fped.2024.1352260/full
info:eu-repo/semantics/altIdentifier/doi/10.3389/fped.2024.1352260
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.885934

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