Respiratory syncytial virus disease burden in children and adults from Latin America: a systematic review and meta-analysis

Autores
Ciapponi, Agustín; Palermo, María Carolina; Sandoval, María Macarena; Baumeister, Elsa; Ruvinsky, Silvina Denise; Ulloa Gutierrez, Rolando; Stegelmann, Katharina; Ruesjas, Sofía Ardiles; Cantos, Joaquín; LaRotta, Jorge; de Almeida, Rodrigo Sini; Bardach, Ariel Esteban
Año de publicación
2024
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Background: Respiratory Syncytial Virus (RSV) is a common cause of lowerrespiratory tract infections (LRTI) and hospitalization worldwide. The impact of RSVin Latin America and the Caribbean (LAC) including expensive treatment options,such as palivizumab, have been extensively discussed. However, publications on theimpact of RSV disease burden in the region are scarce. This systematic review aimedto determine the incidence and prevalence of RSV in LAC by age and RSV subtype.Methods: We conducted a systematic review following Cochrane methodsto evaluate the disease burden of RSV in LAC countries. We searched studiesfrom January 2012 to January 2023 in literature databases and grey literaturewithout language restrictions. We included guidelines, observational, economic,and surveillance studies from LAC countries. Pairs of reviewers independentlyselected, and extracted data from included studies. The risk of bias was assessedusing the Study Quality Assessment Tools (NHLBI) and AGREE-II. We performedproportion meta-analyses using methods to stabilize the variance. The protocolwas registered in PROSPERO (CRD42023393731).Results: We included 156 studies, mainly from Brazil (25%), Colombia (14.5%),and Argentina (13.8%), as well as four clinical practice guidelines. Most studieswere cross-sectional (76.9%) and were classified as low risk of bias (52.6%). Themajority included inpatients (85.6%), pediatric (73.7%), and normal-risk patients(67.1%). The highest pooled prevalence was estimated in patients <1 year old(58%), with type A and B prevalence of 52 and 34%, respectively. The RSV-LRTIincidence was 15/100 symptomatic infants aged <2 years old, and the ICUadmission was 42%. The RSV-LRTI lethality was 0.6, 3% in patients aged <2 and0–5 years old, respectively, and 23% among >65 years old high-risk patients.The identified guidelines lack methodological rigor and have limitations in theirapplicability. The seasonality was more evident in South America than in CentralAmerica and The Caribbean, with a clear gap during the pandemic.Conclusion: This is the most exhaustive and updated body of evidence describing a significant burden of RSV in LAC, particularly at the extremes of life, and its seasonality patterns. Our findings could contribute could contribute facilitating effective prevention and treatment strategies for this significant public health problem.
Fil: Ciapponi, Agustín. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina
Fil: Palermo, María Carolina. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Sandoval, María Macarena. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Baumeister, Elsa. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas; Argentina
Fil: Ruvinsky, Silvina Denise. Instituto de Efectividad Clínica y Sanitaria; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
Fil: Ulloa Gutierrez, Rolando. Hospital Nacional de Niños "Dr. Carlos Sáenz Herrera"; Costa Rica. Universidad de Ciencias Médicas; Costa Rica. Instituto de Investigación en Ciencias Médicas; Costa Rica
Fil: Stegelmann, Katharina. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Ruesjas, Sofía Ardiles. Universidad de Barcelona; España
Fil: Cantos, Joaquín. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: LaRotta, Jorge. Pfizer; Colombia
Fil: de Almeida, Rodrigo Sini. Pfizer; Estados Unidos
Fil: Bardach, Ariel Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina
Materia
RESPIRATORY SYNCYTIAL VIRUS
LATIN AMERICA
SYSTEMATIC REVIEW
META-ANALYSIS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/266783
Acceder
id CONICETDig_7b5ef28bbfc47f5172847545bfb9332c
oai_identifier_str oai:ri.conicet.gov.ar:11336/266783
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Respiratory syncytial virus disease burden in children and adults from Latin America: a systematic review and meta-analysisCiapponi, AgustínPalermo, María CarolinaSandoval, María MacarenaBaumeister, ElsaRuvinsky, Silvina DeniseUlloa Gutierrez, RolandoStegelmann, KatharinaRuesjas, Sofía ArdilesCantos, JoaquínLaRotta, Jorgede Almeida, Rodrigo SiniBardach, Ariel EstebanRESPIRATORY SYNCYTIAL VIRUSLATIN AMERICASYSTEMATIC REVIEWMETA-ANALYSIShttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Background: Respiratory Syncytial Virus (RSV) is a common cause of lowerrespiratory tract infections (LRTI) and hospitalization worldwide. The impact of RSVin Latin America and the Caribbean (LAC) including expensive treatment options,such as palivizumab, have been extensively discussed. However, publications on theimpact of RSV disease burden in the region are scarce. This systematic review aimedto determine the incidence and prevalence of RSV in LAC by age and RSV subtype.Methods: We conducted a systematic review following Cochrane methodsto evaluate the disease burden of RSV in LAC countries. We searched studiesfrom January 2012 to January 2023 in literature databases and grey literaturewithout language restrictions. We included guidelines, observational, economic,and surveillance studies from LAC countries. Pairs of reviewers independentlyselected, and extracted data from included studies. The risk of bias was assessedusing the Study Quality Assessment Tools (NHLBI) and AGREE-II. We performedproportion meta-analyses using methods to stabilize the variance. The protocolwas registered in PROSPERO (CRD42023393731).Results: We included 156 studies, mainly from Brazil (25%), Colombia (14.5%),and Argentina (13.8%), as well as four clinical practice guidelines. Most studieswere cross-sectional (76.9%) and were classified as low risk of bias (52.6%). Themajority included inpatients (85.6%), pediatric (73.7%), and normal-risk patients(67.1%). The highest pooled prevalence was estimated in patients <1 year old(58%), with type A and B prevalence of 52 and 34%, respectively. The RSV-LRTIincidence was 15/100 symptomatic infants aged <2 years old, and the ICUadmission was 42%. The RSV-LRTI lethality was 0.6, 3% in patients aged <2 and0–5 years old, respectively, and 23% among >65 years old high-risk patients.The identified guidelines lack methodological rigor and have limitations in theirapplicability. The seasonality was more evident in South America than in CentralAmerica and The Caribbean, with a clear gap during the pandemic.Conclusion: This is the most exhaustive and updated body of evidence describing a significant burden of RSV in LAC, particularly at the extremes of life, and its seasonality patterns. Our findings could contribute could contribute facilitating effective prevention and treatment strategies for this significant public health problem.Fil: Ciapponi, Agustín. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; ArgentinaFil: Palermo, María Carolina. Instituto de Efectividad Clínica y Sanitaria; ArgentinaFil: Sandoval, María Macarena. Instituto de Efectividad Clínica y Sanitaria; ArgentinaFil: Baumeister, Elsa. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas; ArgentinaFil: Ruvinsky, Silvina Denise. Instituto de Efectividad Clínica y Sanitaria; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; ArgentinaFil: Ulloa Gutierrez, Rolando. Hospital Nacional de Niños "Dr. Carlos Sáenz Herrera"; Costa Rica. Universidad de Ciencias Médicas; Costa Rica. Instituto de Investigación en Ciencias Médicas; Costa RicaFil: Stegelmann, Katharina. Instituto de Efectividad Clínica y Sanitaria; ArgentinaFil: Ruesjas, Sofía Ardiles. Universidad de Barcelona; EspañaFil: Cantos, Joaquín. Instituto de Efectividad Clínica y Sanitaria; ArgentinaFil: LaRotta, Jorge. Pfizer; ColombiaFil: de Almeida, Rodrigo Sini. Pfizer; Estados UnidosFil: Bardach, Ariel Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; ArgentinaFrontiers Media2024-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/266783Ciapponi, Agustín; Palermo, María Carolina; Sandoval, María Macarena; Baumeister, Elsa; Ruvinsky, Silvina Denise; et al.; Respiratory syncytial virus disease burden in children and adults from Latin America: a systematic review and meta-analysis; Frontiers Media; Frontiers in Public Health; 12; 10-2024; 1-132296-2565CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fpubh.2024.1377968/fullinfo:eu-repo/semantics/altIdentifier/doi/10.3389/fpubh.2024.1377968info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:48:32Zoai:ri.conicet.gov.ar:11336/266783instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:48:32.95CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Respiratory syncytial virus disease burden in children and adults from Latin America: a systematic review and meta-analysis
title Respiratory syncytial virus disease burden in children and adults from Latin America: a systematic review and meta-analysis
spellingShingle Respiratory syncytial virus disease burden in children and adults from Latin America: a systematic review and meta-analysis
Ciapponi, Agustín
RESPIRATORY SYNCYTIAL VIRUS
LATIN AMERICA
SYSTEMATIC REVIEW
META-ANALYSIS
title_short Respiratory syncytial virus disease burden in children and adults from Latin America: a systematic review and meta-analysis
title_full Respiratory syncytial virus disease burden in children and adults from Latin America: a systematic review and meta-analysis
title_fullStr Respiratory syncytial virus disease burden in children and adults from Latin America: a systematic review and meta-analysis
title_full_unstemmed Respiratory syncytial virus disease burden in children and adults from Latin America: a systematic review and meta-analysis
title_sort Respiratory syncytial virus disease burden in children and adults from Latin America: a systematic review and meta-analysis
dc.creator.none.fl_str_mv Ciapponi, Agustín
Palermo, María Carolina
Sandoval, María Macarena
Baumeister, Elsa
Ruvinsky, Silvina Denise
Ulloa Gutierrez, Rolando
Stegelmann, Katharina
Ruesjas, Sofía Ardiles
Cantos, Joaquín
LaRotta, Jorge
de Almeida, Rodrigo Sini
Bardach, Ariel Esteban
author Ciapponi, Agustín
author_facet Ciapponi, Agustín
Palermo, María Carolina
Sandoval, María Macarena
Baumeister, Elsa
Ruvinsky, Silvina Denise
Ulloa Gutierrez, Rolando
Stegelmann, Katharina
Ruesjas, Sofía Ardiles
Cantos, Joaquín
LaRotta, Jorge
de Almeida, Rodrigo Sini
Bardach, Ariel Esteban
author_role author
author2 Palermo, María Carolina
Sandoval, María Macarena
Baumeister, Elsa
Ruvinsky, Silvina Denise
Ulloa Gutierrez, Rolando
Stegelmann, Katharina
Ruesjas, Sofía Ardiles
Cantos, Joaquín
LaRotta, Jorge
de Almeida, Rodrigo Sini
Bardach, Ariel Esteban
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv RESPIRATORY SYNCYTIAL VIRUS
LATIN AMERICA
SYSTEMATIC REVIEW
META-ANALYSIS
topic RESPIRATORY SYNCYTIAL VIRUS
LATIN AMERICA
SYSTEMATIC REVIEW
META-ANALYSIS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Background: Respiratory Syncytial Virus (RSV) is a common cause of lowerrespiratory tract infections (LRTI) and hospitalization worldwide. The impact of RSVin Latin America and the Caribbean (LAC) including expensive treatment options,such as palivizumab, have been extensively discussed. However, publications on theimpact of RSV disease burden in the region are scarce. This systematic review aimedto determine the incidence and prevalence of RSV in LAC by age and RSV subtype.Methods: We conducted a systematic review following Cochrane methodsto evaluate the disease burden of RSV in LAC countries. We searched studiesfrom January 2012 to January 2023 in literature databases and grey literaturewithout language restrictions. We included guidelines, observational, economic,and surveillance studies from LAC countries. Pairs of reviewers independentlyselected, and extracted data from included studies. The risk of bias was assessedusing the Study Quality Assessment Tools (NHLBI) and AGREE-II. We performedproportion meta-analyses using methods to stabilize the variance. The protocolwas registered in PROSPERO (CRD42023393731).Results: We included 156 studies, mainly from Brazil (25%), Colombia (14.5%),and Argentina (13.8%), as well as four clinical practice guidelines. Most studieswere cross-sectional (76.9%) and were classified as low risk of bias (52.6%). Themajority included inpatients (85.6%), pediatric (73.7%), and normal-risk patients(67.1%). The highest pooled prevalence was estimated in patients <1 year old(58%), with type A and B prevalence of 52 and 34%, respectively. The RSV-LRTIincidence was 15/100 symptomatic infants aged <2 years old, and the ICUadmission was 42%. The RSV-LRTI lethality was 0.6, 3% in patients aged <2 and0–5 years old, respectively, and 23% among >65 years old high-risk patients.The identified guidelines lack methodological rigor and have limitations in theirapplicability. The seasonality was more evident in South America than in CentralAmerica and The Caribbean, with a clear gap during the pandemic.Conclusion: This is the most exhaustive and updated body of evidence describing a significant burden of RSV in LAC, particularly at the extremes of life, and its seasonality patterns. Our findings could contribute could contribute facilitating effective prevention and treatment strategies for this significant public health problem.
Fil: Ciapponi, Agustín. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina
Fil: Palermo, María Carolina. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Sandoval, María Macarena. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Baumeister, Elsa. Dirección Nacional de Institutos de Investigación. Administración Nacional de Laboratorios e Institutos de Salud. Instituto Nacional de Enfermedades Infecciosas; Argentina
Fil: Ruvinsky, Silvina Denise. Instituto de Efectividad Clínica y Sanitaria; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital de Pediatría "Juan P. Garrahan"; Argentina
Fil: Ulloa Gutierrez, Rolando. Hospital Nacional de Niños "Dr. Carlos Sáenz Herrera"; Costa Rica. Universidad de Ciencias Médicas; Costa Rica. Instituto de Investigación en Ciencias Médicas; Costa Rica
Fil: Stegelmann, Katharina. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Ruesjas, Sofía Ardiles. Universidad de Barcelona; España
Fil: Cantos, Joaquín. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: LaRotta, Jorge. Pfizer; Colombia
Fil: de Almeida, Rodrigo Sini. Pfizer; Estados Unidos
Fil: Bardach, Ariel Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina
description Background: Respiratory Syncytial Virus (RSV) is a common cause of lowerrespiratory tract infections (LRTI) and hospitalization worldwide. The impact of RSVin Latin America and the Caribbean (LAC) including expensive treatment options,such as palivizumab, have been extensively discussed. However, publications on theimpact of RSV disease burden in the region are scarce. This systematic review aimedto determine the incidence and prevalence of RSV in LAC by age and RSV subtype.Methods: We conducted a systematic review following Cochrane methodsto evaluate the disease burden of RSV in LAC countries. We searched studiesfrom January 2012 to January 2023 in literature databases and grey literaturewithout language restrictions. We included guidelines, observational, economic,and surveillance studies from LAC countries. Pairs of reviewers independentlyselected, and extracted data from included studies. The risk of bias was assessedusing the Study Quality Assessment Tools (NHLBI) and AGREE-II. We performedproportion meta-analyses using methods to stabilize the variance. The protocolwas registered in PROSPERO (CRD42023393731).Results: We included 156 studies, mainly from Brazil (25%), Colombia (14.5%),and Argentina (13.8%), as well as four clinical practice guidelines. Most studieswere cross-sectional (76.9%) and were classified as low risk of bias (52.6%). Themajority included inpatients (85.6%), pediatric (73.7%), and normal-risk patients(67.1%). The highest pooled prevalence was estimated in patients <1 year old(58%), with type A and B prevalence of 52 and 34%, respectively. The RSV-LRTIincidence was 15/100 symptomatic infants aged <2 years old, and the ICUadmission was 42%. The RSV-LRTI lethality was 0.6, 3% in patients aged <2 and0–5 years old, respectively, and 23% among >65 years old high-risk patients.The identified guidelines lack methodological rigor and have limitations in theirapplicability. The seasonality was more evident in South America than in CentralAmerica and The Caribbean, with a clear gap during the pandemic.Conclusion: This is the most exhaustive and updated body of evidence describing a significant burden of RSV in LAC, particularly at the extremes of life, and its seasonality patterns. Our findings could contribute could contribute facilitating effective prevention and treatment strategies for this significant public health problem.
publishDate 2024
dc.date.none.fl_str_mv 2024-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/266783
Ciapponi, Agustín; Palermo, María Carolina; Sandoval, María Macarena; Baumeister, Elsa; Ruvinsky, Silvina Denise; et al.; Respiratory syncytial virus disease burden in children and adults from Latin America: a systematic review and meta-analysis; Frontiers Media; Frontiers in Public Health; 12; 10-2024; 1-13
2296-2565
CONICET Digital
CONICET
url http://hdl.handle.net/11336/266783
identifier_str_mv Ciapponi, Agustín; Palermo, María Carolina; Sandoval, María Macarena; Baumeister, Elsa; Ruvinsky, Silvina Denise; et al.; Respiratory syncytial virus disease burden in children and adults from Latin America: a systematic review and meta-analysis; Frontiers Media; Frontiers in Public Health; 12; 10-2024; 1-13
2296-2565
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fpubh.2024.1377968/full
info:eu-repo/semantics/altIdentifier/doi/10.3389/fpubh.2024.1377968
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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