Herpes zoster epidemiology in Latin America: A systematic review and meta-analysis

Autores
Bardach, Ariel Esteban; Palermo, Carolina; Alconada, Tomás; Sandoval, Macarena; Balan, Darío Javier; Guevara, Javier Nieto; Gómez, Jorge; Ciapponi, Agustín
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The epidemiology and burden of Herpes Zoster (HZ) are largely unknown, and there are no recent reviews summarizing the available evidence from the Latin America and Caribbean (LAC) region. We conducted a systematic review and meta-analysis to characterize the epidemiology and burden of HZ in LAC. Bibliographic databases and grey literature sources were consulted to find studies published (January 2000 ?February 2020) with epidemiological endpoints: cumulative incidence and incidence density (HZ cases per 100,000 person-years), prevalence, case-fatality rates, HZ mortality, hospitalization rates, and rates of each HZ complication. Twenty-six studies were included with most studies coming from Brazil. No studies reported the incidence of HZ in the general population. In population at higher risk, the cumulative incidence ranged from 318?3,423 cases of HZ per 100,000 persons per year of follow-up. The incidence density was 6.4?36.5 cases per 1,000 person-years. Age was identified as a major risk factor towards HZ incidence which increase significantly in people >50 years of age. Hospitalization rates ranged from 3%?35.7%. The in-hospital HZ mortality rate ranged from 0%?36%. Overall, HZ mortality rates were found to be higher in females across all age groups and countries. The incidence of HZ complications (such as post-herpetic neuralgia, ophthalmic herpes zoster, and Ramsay Hunt syndrome) was higher in the immunosuppressed compared to the immunocompetent population. Acyclovir was the most frequently used therapy. Epidemiological data from Ministry of Health databases (Argentina, Brazil, Colombia, Chile y Mexico) and Institute for Health Metrics and Evaluation?s Global Burden of Disease project reported stable rates of hospitalizations and deaths over the last 10 years. High-risk groups for HZ impose a considerable burden in LAC. They could benefit from directed healthcare initiatives, including adult immunization, to prevent HZ occurrence and its complications.
Fil: Bardach, Ariel Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina
Fil: Palermo, Carolina. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Alconada, Tomás. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Sandoval, Macarena. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Balan, Darío Javier. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Guevara, Javier Nieto. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Gómez, Jorge. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Ciapponi, Agustín. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina
Materia
Herpes zoster
Latin America
Systematic review
Meta-analysis
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/211998
Acceder
id CONICETDig_2b9777b0509554d46eb747d31602e232
oai_identifier_str oai:ri.conicet.gov.ar:11336/211998
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Herpes zoster epidemiology in Latin America: A systematic review and meta-analysisBardach, Ariel EstebanPalermo, CarolinaAlconada, TomásSandoval, MacarenaBalan, Darío JavierGuevara, Javier NietoGómez, JorgeCiapponi, AgustínHerpes zosterLatin AmericaSystematic reviewMeta-analysishttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3The epidemiology and burden of Herpes Zoster (HZ) are largely unknown, and there are no recent reviews summarizing the available evidence from the Latin America and Caribbean (LAC) region. We conducted a systematic review and meta-analysis to characterize the epidemiology and burden of HZ in LAC. Bibliographic databases and grey literature sources were consulted to find studies published (January 2000 ?February 2020) with epidemiological endpoints: cumulative incidence and incidence density (HZ cases per 100,000 person-years), prevalence, case-fatality rates, HZ mortality, hospitalization rates, and rates of each HZ complication. Twenty-six studies were included with most studies coming from Brazil. No studies reported the incidence of HZ in the general population. In population at higher risk, the cumulative incidence ranged from 318?3,423 cases of HZ per 100,000 persons per year of follow-up. The incidence density was 6.4?36.5 cases per 1,000 person-years. Age was identified as a major risk factor towards HZ incidence which increase significantly in people >50 years of age. Hospitalization rates ranged from 3%?35.7%. The in-hospital HZ mortality rate ranged from 0%?36%. Overall, HZ mortality rates were found to be higher in females across all age groups and countries. The incidence of HZ complications (such as post-herpetic neuralgia, ophthalmic herpes zoster, and Ramsay Hunt syndrome) was higher in the immunosuppressed compared to the immunocompetent population. Acyclovir was the most frequently used therapy. Epidemiological data from Ministry of Health databases (Argentina, Brazil, Colombia, Chile y Mexico) and Institute for Health Metrics and Evaluation?s Global Burden of Disease project reported stable rates of hospitalizations and deaths over the last 10 years. High-risk groups for HZ impose a considerable burden in LAC. They could benefit from directed healthcare initiatives, including adult immunization, to prevent HZ occurrence and its complications.Fil: Bardach, Ariel Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; ArgentinaFil: Palermo, Carolina. Instituto de Efectividad Clínica y Sanitaria; ArgentinaFil: Alconada, Tomás. Instituto de Efectividad Clínica y Sanitaria; ArgentinaFil: Sandoval, Macarena. Instituto de Efectividad Clínica y Sanitaria; ArgentinaFil: Balan, Darío Javier. Instituto de Efectividad Clínica y Sanitaria; ArgentinaFil: Guevara, Javier Nieto. Instituto de Efectividad Clínica y Sanitaria; ArgentinaFil: Gómez, Jorge. Instituto de Efectividad Clínica y Sanitaria; ArgentinaFil: Ciapponi, Agustín. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; ArgentinaPublic Library of Science2021-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/211998Bardach, Ariel Esteban; Palermo, Carolina; Alconada, Tomás; Sandoval, Macarena; Balan, Darío Javier; et al.; Herpes zoster epidemiology in Latin America: A systematic review and meta-analysis; Public Library of Science; Plos One; 16; 8-2021; 1-191932-6203CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0255877info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0255877info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-17T11:07:28Zoai:ri.conicet.gov.ar:11336/211998instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-17 11:07:28.706CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Herpes zoster epidemiology in Latin America: A systematic review and meta-analysis
title Herpes zoster epidemiology in Latin America: A systematic review and meta-analysis
spellingShingle Herpes zoster epidemiology in Latin America: A systematic review and meta-analysis
Bardach, Ariel Esteban
Herpes zoster
Latin America
Systematic review
Meta-analysis
title_short Herpes zoster epidemiology in Latin America: A systematic review and meta-analysis
title_full Herpes zoster epidemiology in Latin America: A systematic review and meta-analysis
title_fullStr Herpes zoster epidemiology in Latin America: A systematic review and meta-analysis
title_full_unstemmed Herpes zoster epidemiology in Latin America: A systematic review and meta-analysis
title_sort Herpes zoster epidemiology in Latin America: A systematic review and meta-analysis
dc.creator.none.fl_str_mv Bardach, Ariel Esteban
Palermo, Carolina
Alconada, Tomás
Sandoval, Macarena
Balan, Darío Javier
Guevara, Javier Nieto
Gómez, Jorge
Ciapponi, Agustín
author Bardach, Ariel Esteban
author_facet Bardach, Ariel Esteban
Palermo, Carolina
Alconada, Tomás
Sandoval, Macarena
Balan, Darío Javier
Guevara, Javier Nieto
Gómez, Jorge
Ciapponi, Agustín
author_role author
author2 Palermo, Carolina
Alconada, Tomás
Sandoval, Macarena
Balan, Darío Javier
Guevara, Javier Nieto
Gómez, Jorge
Ciapponi, Agustín
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Herpes zoster
Latin America
Systematic review
Meta-analysis
topic Herpes zoster
Latin America
Systematic review
Meta-analysis
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The epidemiology and burden of Herpes Zoster (HZ) are largely unknown, and there are no recent reviews summarizing the available evidence from the Latin America and Caribbean (LAC) region. We conducted a systematic review and meta-analysis to characterize the epidemiology and burden of HZ in LAC. Bibliographic databases and grey literature sources were consulted to find studies published (January 2000 ?February 2020) with epidemiological endpoints: cumulative incidence and incidence density (HZ cases per 100,000 person-years), prevalence, case-fatality rates, HZ mortality, hospitalization rates, and rates of each HZ complication. Twenty-six studies were included with most studies coming from Brazil. No studies reported the incidence of HZ in the general population. In population at higher risk, the cumulative incidence ranged from 318?3,423 cases of HZ per 100,000 persons per year of follow-up. The incidence density was 6.4?36.5 cases per 1,000 person-years. Age was identified as a major risk factor towards HZ incidence which increase significantly in people >50 years of age. Hospitalization rates ranged from 3%?35.7%. The in-hospital HZ mortality rate ranged from 0%?36%. Overall, HZ mortality rates were found to be higher in females across all age groups and countries. The incidence of HZ complications (such as post-herpetic neuralgia, ophthalmic herpes zoster, and Ramsay Hunt syndrome) was higher in the immunosuppressed compared to the immunocompetent population. Acyclovir was the most frequently used therapy. Epidemiological data from Ministry of Health databases (Argentina, Brazil, Colombia, Chile y Mexico) and Institute for Health Metrics and Evaluation?s Global Burden of Disease project reported stable rates of hospitalizations and deaths over the last 10 years. High-risk groups for HZ impose a considerable burden in LAC. They could benefit from directed healthcare initiatives, including adult immunization, to prevent HZ occurrence and its complications.
Fil: Bardach, Ariel Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina
Fil: Palermo, Carolina. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Alconada, Tomás. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Sandoval, Macarena. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Balan, Darío Javier. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Guevara, Javier Nieto. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Gómez, Jorge. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Ciapponi, Agustín. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina
description The epidemiology and burden of Herpes Zoster (HZ) are largely unknown, and there are no recent reviews summarizing the available evidence from the Latin America and Caribbean (LAC) region. We conducted a systematic review and meta-analysis to characterize the epidemiology and burden of HZ in LAC. Bibliographic databases and grey literature sources were consulted to find studies published (January 2000 ?February 2020) with epidemiological endpoints: cumulative incidence and incidence density (HZ cases per 100,000 person-years), prevalence, case-fatality rates, HZ mortality, hospitalization rates, and rates of each HZ complication. Twenty-six studies were included with most studies coming from Brazil. No studies reported the incidence of HZ in the general population. In population at higher risk, the cumulative incidence ranged from 318?3,423 cases of HZ per 100,000 persons per year of follow-up. The incidence density was 6.4?36.5 cases per 1,000 person-years. Age was identified as a major risk factor towards HZ incidence which increase significantly in people >50 years of age. Hospitalization rates ranged from 3%?35.7%. The in-hospital HZ mortality rate ranged from 0%?36%. Overall, HZ mortality rates were found to be higher in females across all age groups and countries. The incidence of HZ complications (such as post-herpetic neuralgia, ophthalmic herpes zoster, and Ramsay Hunt syndrome) was higher in the immunosuppressed compared to the immunocompetent population. Acyclovir was the most frequently used therapy. Epidemiological data from Ministry of Health databases (Argentina, Brazil, Colombia, Chile y Mexico) and Institute for Health Metrics and Evaluation?s Global Burden of Disease project reported stable rates of hospitalizations and deaths over the last 10 years. High-risk groups for HZ impose a considerable burden in LAC. They could benefit from directed healthcare initiatives, including adult immunization, to prevent HZ occurrence and its complications.
publishDate 2021
dc.date.none.fl_str_mv 2021-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/211998
Bardach, Ariel Esteban; Palermo, Carolina; Alconada, Tomás; Sandoval, Macarena; Balan, Darío Javier; et al.; Herpes zoster epidemiology in Latin America: A systematic review and meta-analysis; Public Library of Science; Plos One; 16; 8-2021; 1-19
1932-6203
CONICET Digital
CONICET
url http://hdl.handle.net/11336/211998
identifier_str_mv Bardach, Ariel Esteban; Palermo, Carolina; Alconada, Tomás; Sandoval, Macarena; Balan, Darío Javier; et al.; Herpes zoster epidemiology in Latin America: A systematic review and meta-analysis; Public Library of Science; Plos One; 16; 8-2021; 1-19
1932-6203
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0255877
info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0255877
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
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eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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