Burden of Disease of Gonorrhoea in Latin America: Systematic Review and Meta-analysis

Autores
Bardach, Ariel Esteban; Alconada, Tomás; Palermo, Carolina; Rojas Roque, Carlos; Sandoval, María Macarena; Gomez, Jorge; Pinto, Thatiana; Ciapponi, Agustín
Año de publicación
2023
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Introduction: Neisseria gonorrhoeae causes gonorrhoea, a globally neglected but increasing disease. This systematic review and meta-analysis reviewed the epidemiology and economic burden of gonorrhoea in Latin America and the Caribbean (LAC). Methods: We searched PubMed, EMBase, Cochrane Library, EconLIT, CINAHL, CRD, LILACS, Global Health, Global Dissertations and Theses, SciELO, Web of Science databases, countries’ ministries of health, and the IHME’s Global Burden of Disease databases. Studies published in the last 10 years (20 years for economic studies) were included if conducted in any LAC country, without language restrictions. The main outcome measures were incidence/prevalence, proportion of co-infections, case fatality rates, specific mortality/hospitalisation rates, direct/indirect costs, and impact of gonorrhoea on quality of life. To assess evidence quality, we used a checklist developed by the US National Heart, Lung, and Blood Institute for observational studies and trial control arms, the Cochrane Effective Practice Organization of Care Group tool for randomised controlled trials, and the CICERO checklist for economic studies. Results: We identified 1290 articles; 115 included epidemiological studies and one included an economic study. Ministry of health data from Argentina, Brazil, Chile, Colombia, Mexico, and Uruguay were identified. Gonorrhoea prevalence was 1.46% (95% confidence interval [CI] 1.00–2.00%) from 48 studies and 5.68% (95% CI 4.23–7.32%) from 58 studies for non-high-risk and high-risk populations, respectively. Cumulative incidence for the high-risk population was 2.05 cases per 100 persons/year. Few published studies were rated as “good” in the risk of bias assessments. Variations in the methodology of the sources and limited information found in the countries’ surveillance systems hinder the comparison of data. Conclusion: The burden of gonorrhoea in LAC is not negligible. Our results provide public health and clinical decision support to assess potential interventions to prevent gonorrhoea. Trial Registration: The protocol is registered on PROSPERO (CRD42021253342). The study was funded by GlaxoSmithKline Biologicals SA (GSK study identifier VEO-000025).
Fil: Bardach, Ariel Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina
Fil: Alconada, Tomás. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Palermo, Carolina. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Rojas Roque, Carlos. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Sandoval, María Macarena. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Gomez, Jorge. Gsk; Argentina
Fil: Pinto, Thatiana. Glaxosmithkline Plc.; Panamá
Fil: Ciapponi, Agustín. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina
Materia
CARIBBEAN
ECONOMICS
EPIDEMIOLOGY
GONORRHOEA
LATIN AMERICA
SYSTEMATIC REVIEW
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/228813
Acceder
id CONICETDig_fa7492237f204be0d55be2c52693b310
oai_identifier_str oai:ri.conicet.gov.ar:11336/228813
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Burden of Disease of Gonorrhoea in Latin America: Systematic Review and Meta-analysisBardach, Ariel EstebanAlconada, TomásPalermo, CarolinaRojas Roque, CarlosSandoval, María MacarenaGomez, JorgePinto, ThatianaCiapponi, AgustínCARIBBEANECONOMICSEPIDEMIOLOGYGONORRHOEALATIN AMERICASYSTEMATIC REVIEWhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Introduction: Neisseria gonorrhoeae causes gonorrhoea, a globally neglected but increasing disease. This systematic review and meta-analysis reviewed the epidemiology and economic burden of gonorrhoea in Latin America and the Caribbean (LAC). Methods: We searched PubMed, EMBase, Cochrane Library, EconLIT, CINAHL, CRD, LILACS, Global Health, Global Dissertations and Theses, SciELO, Web of Science databases, countries’ ministries of health, and the IHME’s Global Burden of Disease databases. Studies published in the last 10 years (20 years for economic studies) were included if conducted in any LAC country, without language restrictions. The main outcome measures were incidence/prevalence, proportion of co-infections, case fatality rates, specific mortality/hospitalisation rates, direct/indirect costs, and impact of gonorrhoea on quality of life. To assess evidence quality, we used a checklist developed by the US National Heart, Lung, and Blood Institute for observational studies and trial control arms, the Cochrane Effective Practice Organization of Care Group tool for randomised controlled trials, and the CICERO checklist for economic studies. Results: We identified 1290 articles; 115 included epidemiological studies and one included an economic study. Ministry of health data from Argentina, Brazil, Chile, Colombia, Mexico, and Uruguay were identified. Gonorrhoea prevalence was 1.46% (95% confidence interval [CI] 1.00–2.00%) from 48 studies and 5.68% (95% CI 4.23–7.32%) from 58 studies for non-high-risk and high-risk populations, respectively. Cumulative incidence for the high-risk population was 2.05 cases per 100 persons/year. Few published studies were rated as “good” in the risk of bias assessments. Variations in the methodology of the sources and limited information found in the countries’ surveillance systems hinder the comparison of data. Conclusion: The burden of gonorrhoea in LAC is not negligible. Our results provide public health and clinical decision support to assess potential interventions to prevent gonorrhoea. Trial Registration: The protocol is registered on PROSPERO (CRD42021253342). The study was funded by GlaxoSmithKline Biologicals SA (GSK study identifier VEO-000025).Fil: Bardach, Ariel Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; ArgentinaFil: Alconada, Tomás. Instituto de Efectividad Clínica y Sanitaria; ArgentinaFil: Palermo, Carolina. Instituto de Efectividad Clínica y Sanitaria; ArgentinaFil: Rojas Roque, Carlos. Instituto de Efectividad Clínica y Sanitaria; ArgentinaFil: Sandoval, María Macarena. Instituto de Efectividad Clínica y Sanitaria; ArgentinaFil: Gomez, Jorge. Gsk; ArgentinaFil: Pinto, Thatiana. Glaxosmithkline Plc.; PanamáFil: Ciapponi, Agustín. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; ArgentinaSpringer2023-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/228813Bardach, Ariel Esteban; Alconada, Tomás; Palermo, Carolina; Rojas Roque, Carlos; Sandoval, María Macarena; et al.; Burden of Disease of Gonorrhoea in Latin America: Systematic Review and Meta-analysis; Springer; Infectious Diseases and Therapy; 12; 6; 6-2023; 1505-15252193-82292193-6382CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1007/s40121-023-00814-0info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007/s40121-023-00814-0info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:40:44Zoai:ri.conicet.gov.ar:11336/228813instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:40:44.627CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Burden of Disease of Gonorrhoea in Latin America: Systematic Review and Meta-analysis
title Burden of Disease of Gonorrhoea in Latin America: Systematic Review and Meta-analysis
spellingShingle Burden of Disease of Gonorrhoea in Latin America: Systematic Review and Meta-analysis
Bardach, Ariel Esteban
CARIBBEAN
ECONOMICS
EPIDEMIOLOGY
GONORRHOEA
LATIN AMERICA
SYSTEMATIC REVIEW
title_short Burden of Disease of Gonorrhoea in Latin America: Systematic Review and Meta-analysis
title_full Burden of Disease of Gonorrhoea in Latin America: Systematic Review and Meta-analysis
title_fullStr Burden of Disease of Gonorrhoea in Latin America: Systematic Review and Meta-analysis
title_full_unstemmed Burden of Disease of Gonorrhoea in Latin America: Systematic Review and Meta-analysis
title_sort Burden of Disease of Gonorrhoea in Latin America: Systematic Review and Meta-analysis
dc.creator.none.fl_str_mv Bardach, Ariel Esteban
Alconada, Tomás
Palermo, Carolina
Rojas Roque, Carlos
Sandoval, María Macarena
Gomez, Jorge
Pinto, Thatiana
Ciapponi, Agustín
author Bardach, Ariel Esteban
author_facet Bardach, Ariel Esteban
Alconada, Tomás
Palermo, Carolina
Rojas Roque, Carlos
Sandoval, María Macarena
Gomez, Jorge
Pinto, Thatiana
Ciapponi, Agustín
author_role author
author2 Alconada, Tomás
Palermo, Carolina
Rojas Roque, Carlos
Sandoval, María Macarena
Gomez, Jorge
Pinto, Thatiana
Ciapponi, Agustín
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv CARIBBEAN
ECONOMICS
EPIDEMIOLOGY
GONORRHOEA
LATIN AMERICA
SYSTEMATIC REVIEW
topic CARIBBEAN
ECONOMICS
EPIDEMIOLOGY
GONORRHOEA
LATIN AMERICA
SYSTEMATIC REVIEW
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Introduction: Neisseria gonorrhoeae causes gonorrhoea, a globally neglected but increasing disease. This systematic review and meta-analysis reviewed the epidemiology and economic burden of gonorrhoea in Latin America and the Caribbean (LAC). Methods: We searched PubMed, EMBase, Cochrane Library, EconLIT, CINAHL, CRD, LILACS, Global Health, Global Dissertations and Theses, SciELO, Web of Science databases, countries’ ministries of health, and the IHME’s Global Burden of Disease databases. Studies published in the last 10 years (20 years for economic studies) were included if conducted in any LAC country, without language restrictions. The main outcome measures were incidence/prevalence, proportion of co-infections, case fatality rates, specific mortality/hospitalisation rates, direct/indirect costs, and impact of gonorrhoea on quality of life. To assess evidence quality, we used a checklist developed by the US National Heart, Lung, and Blood Institute for observational studies and trial control arms, the Cochrane Effective Practice Organization of Care Group tool for randomised controlled trials, and the CICERO checklist for economic studies. Results: We identified 1290 articles; 115 included epidemiological studies and one included an economic study. Ministry of health data from Argentina, Brazil, Chile, Colombia, Mexico, and Uruguay were identified. Gonorrhoea prevalence was 1.46% (95% confidence interval [CI] 1.00–2.00%) from 48 studies and 5.68% (95% CI 4.23–7.32%) from 58 studies for non-high-risk and high-risk populations, respectively. Cumulative incidence for the high-risk population was 2.05 cases per 100 persons/year. Few published studies were rated as “good” in the risk of bias assessments. Variations in the methodology of the sources and limited information found in the countries’ surveillance systems hinder the comparison of data. Conclusion: The burden of gonorrhoea in LAC is not negligible. Our results provide public health and clinical decision support to assess potential interventions to prevent gonorrhoea. Trial Registration: The protocol is registered on PROSPERO (CRD42021253342). The study was funded by GlaxoSmithKline Biologicals SA (GSK study identifier VEO-000025).
Fil: Bardach, Ariel Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina
Fil: Alconada, Tomás. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Palermo, Carolina. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Rojas Roque, Carlos. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Sandoval, María Macarena. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Gomez, Jorge. Gsk; Argentina
Fil: Pinto, Thatiana. Glaxosmithkline Plc.; Panamá
Fil: Ciapponi, Agustín. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentina
description Introduction: Neisseria gonorrhoeae causes gonorrhoea, a globally neglected but increasing disease. This systematic review and meta-analysis reviewed the epidemiology and economic burden of gonorrhoea in Latin America and the Caribbean (LAC). Methods: We searched PubMed, EMBase, Cochrane Library, EconLIT, CINAHL, CRD, LILACS, Global Health, Global Dissertations and Theses, SciELO, Web of Science databases, countries’ ministries of health, and the IHME’s Global Burden of Disease databases. Studies published in the last 10 years (20 years for economic studies) were included if conducted in any LAC country, without language restrictions. The main outcome measures were incidence/prevalence, proportion of co-infections, case fatality rates, specific mortality/hospitalisation rates, direct/indirect costs, and impact of gonorrhoea on quality of life. To assess evidence quality, we used a checklist developed by the US National Heart, Lung, and Blood Institute for observational studies and trial control arms, the Cochrane Effective Practice Organization of Care Group tool for randomised controlled trials, and the CICERO checklist for economic studies. Results: We identified 1290 articles; 115 included epidemiological studies and one included an economic study. Ministry of health data from Argentina, Brazil, Chile, Colombia, Mexico, and Uruguay were identified. Gonorrhoea prevalence was 1.46% (95% confidence interval [CI] 1.00–2.00%) from 48 studies and 5.68% (95% CI 4.23–7.32%) from 58 studies for non-high-risk and high-risk populations, respectively. Cumulative incidence for the high-risk population was 2.05 cases per 100 persons/year. Few published studies were rated as “good” in the risk of bias assessments. Variations in the methodology of the sources and limited information found in the countries’ surveillance systems hinder the comparison of data. Conclusion: The burden of gonorrhoea in LAC is not negligible. Our results provide public health and clinical decision support to assess potential interventions to prevent gonorrhoea. Trial Registration: The protocol is registered on PROSPERO (CRD42021253342). The study was funded by GlaxoSmithKline Biologicals SA (GSK study identifier VEO-000025).
publishDate 2023
dc.date.none.fl_str_mv 2023-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/228813
Bardach, Ariel Esteban; Alconada, Tomás; Palermo, Carolina; Rojas Roque, Carlos; Sandoval, María Macarena; et al.; Burden of Disease of Gonorrhoea in Latin America: Systematic Review and Meta-analysis; Springer; Infectious Diseases and Therapy; 12; 6; 6-2023; 1505-1525
2193-8229
2193-6382
CONICET Digital
CONICET
url http://hdl.handle.net/11336/228813
identifier_str_mv Bardach, Ariel Esteban; Alconada, Tomás; Palermo, Carolina; Rojas Roque, Carlos; Sandoval, María Macarena; et al.; Burden of Disease of Gonorrhoea in Latin America: Systematic Review and Meta-analysis; Springer; Infectious Diseases and Therapy; 12; 6; 6-2023; 1505-1525
2193-8229
2193-6382
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
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info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007/s40121-023-00814-0
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
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eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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