Development of new hydroactive dressings based on chitosan membranes: Characterization and in vivo behavior

Autores
de Queiroz, Alvaro Antonio Alençar; Gomes Ferraz, Humberto; Abraham, Gustavo Abel; Fernández, María del Mar; López Bravo, Antonio; San Román, Julio
Año de publicación
2003
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Different poly(vinyl alcohol) (PVA)/chitosan lactate (ChL)‐blended hydrogels containing nitrofurazone as a local anti‐infective drug were prepared by the phase‐inversion technique. The swelling degree, surface free energy, mechanical properties, and nitrofurazone release of these membranes were determined. Blood compatibility of these systems was evaluated by the open‐static platelet adhesion test with whole human blood. The results showed that water absorption into the PVA/ChL membranes slowed down, governed by the rate at which the dressing interacted with the physiological fluid. Swelling degree values up to 200% were observed. The rate of release of nitrofurazone seemed to depend on the ChL percentage on the blend as well as the pH of the solution. The surface free energy values were in the range of 20–30 dynes/cm, which was appropriate for a favorable interaction with blood. From the Young's module curve, it could be seen that elastic hydrogels were obtained with increment of ChL in the PVA/ChL blends. Values of platelet adhesion and whole blood clotting times for the PVA/ChL blends as well as the increase of ChL, which appears to reduce the fibrinogen adsorption on the PVA/ChL membranes, demonstrated that the blood compatibility of PVP/ChL blends is superior to that separated polymers. The results of in vivo experiments in rats were in very good agreement with these observations, suggesting that PVA/ChL may serve as a new type of potential wound‐dressing material.
Fil: de Queiroz, Alvaro Antonio Alençar. Universidade Federal de Itajuba; Brasil
Fil: Gomes Ferraz, Humberto. Universidade de Sao Paulo; Brasil
Fil: Abraham, Gustavo Abel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina. Instituto en Ciencia y Tecnología de Polímeros; España. Consejo Superior de Investigaciones Científicas; España
Fil: Fernández, María del Mar. Instituto en Ciencia y Tecnología de Polímeros; España. Consejo Superior de Investigaciones Científicas; España
Fil: López Bravo, Antonio. Hospital Provincial de Ávila; España
Fil: San Román, Julio. Hospital Provincial de Ávila; España
Materia
Poly(Vinyl Alcohol)
Chitosan Lactate
Hydrogel
Blood Compatibility
Wound Healing
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/77664
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/77664
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Development of new hydroactive dressings based on chitosan membranes: Characterization and in vivo behaviorde Queiroz, Alvaro Antonio AlençarGomes Ferraz, HumbertoAbraham, Gustavo AbelFernández, María del MarLópez Bravo, AntonioSan Román, JulioPoly(Vinyl Alcohol)Chitosan LactateHydrogelBlood CompatibilityWound Healinghttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1Different poly(vinyl alcohol) (PVA)/chitosan lactate (ChL)‐blended hydrogels containing nitrofurazone as a local anti‐infective drug were prepared by the phase‐inversion technique. The swelling degree, surface free energy, mechanical properties, and nitrofurazone release of these membranes were determined. Blood compatibility of these systems was evaluated by the open‐static platelet adhesion test with whole human blood. The results showed that water absorption into the PVA/ChL membranes slowed down, governed by the rate at which the dressing interacted with the physiological fluid. Swelling degree values up to 200% were observed. The rate of release of nitrofurazone seemed to depend on the ChL percentage on the blend as well as the pH of the solution. The surface free energy values were in the range of 20–30 dynes/cm, which was appropriate for a favorable interaction with blood. From the Young's module curve, it could be seen that elastic hydrogels were obtained with increment of ChL in the PVA/ChL blends. Values of platelet adhesion and whole blood clotting times for the PVA/ChL blends as well as the increase of ChL, which appears to reduce the fibrinogen adsorption on the PVA/ChL membranes, demonstrated that the blood compatibility of PVP/ChL blends is superior to that separated polymers. The results of in vivo experiments in rats were in very good agreement with these observations, suggesting that PVA/ChL may serve as a new type of potential wound‐dressing material.Fil: de Queiroz, Alvaro Antonio Alençar. Universidade Federal de Itajuba; BrasilFil: Gomes Ferraz, Humberto. Universidade de Sao Paulo; BrasilFil: Abraham, Gustavo Abel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina. Instituto en Ciencia y Tecnología de Polímeros; España. Consejo Superior de Investigaciones Científicas; EspañaFil: Fernández, María del Mar. Instituto en Ciencia y Tecnología de Polímeros; España. Consejo Superior de Investigaciones Científicas; EspañaFil: López Bravo, Antonio. Hospital Provincial de Ávila; EspañaFil: San Román, Julio. Hospital Provincial de Ávila; EspañaWiley-liss, Div John Wiley & Sons Inc2003-01-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/77664de Queiroz, Alvaro Antonio Alençar; Gomes Ferraz, Humberto; Abraham, Gustavo Abel; Fernández, María del Mar; López Bravo, Antonio; et al.; Development of new hydroactive dressings based on chitosan membranes: Characterization and in vivo behavior; Wiley-liss, Div John Wiley & Sons Inc; Journal of Biomedical Materials Research Part A; 64A; 1; 4-1-2003; 147-1541549-3296CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/jbm.a.10265info:eu-repo/semantics/altIdentifier/doi/10.1002/jbm.a.10265info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:48:40Zoai:ri.conicet.gov.ar:11336/77664instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:48:40.847CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Development of new hydroactive dressings based on chitosan membranes: Characterization and in vivo behavior
title Development of new hydroactive dressings based on chitosan membranes: Characterization and in vivo behavior
spellingShingle Development of new hydroactive dressings based on chitosan membranes: Characterization and in vivo behavior
de Queiroz, Alvaro Antonio Alençar
Poly(Vinyl Alcohol)
Chitosan Lactate
Hydrogel
Blood Compatibility
Wound Healing
title_short Development of new hydroactive dressings based on chitosan membranes: Characterization and in vivo behavior
title_full Development of new hydroactive dressings based on chitosan membranes: Characterization and in vivo behavior
title_fullStr Development of new hydroactive dressings based on chitosan membranes: Characterization and in vivo behavior
title_full_unstemmed Development of new hydroactive dressings based on chitosan membranes: Characterization and in vivo behavior
title_sort Development of new hydroactive dressings based on chitosan membranes: Characterization and in vivo behavior
dc.creator.none.fl_str_mv de Queiroz, Alvaro Antonio Alençar
Gomes Ferraz, Humberto
Abraham, Gustavo Abel
Fernández, María del Mar
López Bravo, Antonio
San Román, Julio
author de Queiroz, Alvaro Antonio Alençar
author_facet de Queiroz, Alvaro Antonio Alençar
Gomes Ferraz, Humberto
Abraham, Gustavo Abel
Fernández, María del Mar
López Bravo, Antonio
San Román, Julio
author_role author
author2 Gomes Ferraz, Humberto
Abraham, Gustavo Abel
Fernández, María del Mar
López Bravo, Antonio
San Román, Julio
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Poly(Vinyl Alcohol)
Chitosan Lactate
Hydrogel
Blood Compatibility
Wound Healing
topic Poly(Vinyl Alcohol)
Chitosan Lactate
Hydrogel
Blood Compatibility
Wound Healing
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Different poly(vinyl alcohol) (PVA)/chitosan lactate (ChL)‐blended hydrogels containing nitrofurazone as a local anti‐infective drug were prepared by the phase‐inversion technique. The swelling degree, surface free energy, mechanical properties, and nitrofurazone release of these membranes were determined. Blood compatibility of these systems was evaluated by the open‐static platelet adhesion test with whole human blood. The results showed that water absorption into the PVA/ChL membranes slowed down, governed by the rate at which the dressing interacted with the physiological fluid. Swelling degree values up to 200% were observed. The rate of release of nitrofurazone seemed to depend on the ChL percentage on the blend as well as the pH of the solution. The surface free energy values were in the range of 20–30 dynes/cm, which was appropriate for a favorable interaction with blood. From the Young's module curve, it could be seen that elastic hydrogels were obtained with increment of ChL in the PVA/ChL blends. Values of platelet adhesion and whole blood clotting times for the PVA/ChL blends as well as the increase of ChL, which appears to reduce the fibrinogen adsorption on the PVA/ChL membranes, demonstrated that the blood compatibility of PVP/ChL blends is superior to that separated polymers. The results of in vivo experiments in rats were in very good agreement with these observations, suggesting that PVA/ChL may serve as a new type of potential wound‐dressing material.
Fil: de Queiroz, Alvaro Antonio Alençar. Universidade Federal de Itajuba; Brasil
Fil: Gomes Ferraz, Humberto. Universidade de Sao Paulo; Brasil
Fil: Abraham, Gustavo Abel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina. Instituto en Ciencia y Tecnología de Polímeros; España. Consejo Superior de Investigaciones Científicas; España
Fil: Fernández, María del Mar. Instituto en Ciencia y Tecnología de Polímeros; España. Consejo Superior de Investigaciones Científicas; España
Fil: López Bravo, Antonio. Hospital Provincial de Ávila; España
Fil: San Román, Julio. Hospital Provincial de Ávila; España
description Different poly(vinyl alcohol) (PVA)/chitosan lactate (ChL)‐blended hydrogels containing nitrofurazone as a local anti‐infective drug were prepared by the phase‐inversion technique. The swelling degree, surface free energy, mechanical properties, and nitrofurazone release of these membranes were determined. Blood compatibility of these systems was evaluated by the open‐static platelet adhesion test with whole human blood. The results showed that water absorption into the PVA/ChL membranes slowed down, governed by the rate at which the dressing interacted with the physiological fluid. Swelling degree values up to 200% were observed. The rate of release of nitrofurazone seemed to depend on the ChL percentage on the blend as well as the pH of the solution. The surface free energy values were in the range of 20–30 dynes/cm, which was appropriate for a favorable interaction with blood. From the Young's module curve, it could be seen that elastic hydrogels were obtained with increment of ChL in the PVA/ChL blends. Values of platelet adhesion and whole blood clotting times for the PVA/ChL blends as well as the increase of ChL, which appears to reduce the fibrinogen adsorption on the PVA/ChL membranes, demonstrated that the blood compatibility of PVP/ChL blends is superior to that separated polymers. The results of in vivo experiments in rats were in very good agreement with these observations, suggesting that PVA/ChL may serve as a new type of potential wound‐dressing material.
publishDate 2003
dc.date.none.fl_str_mv 2003-01-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/77664
de Queiroz, Alvaro Antonio Alençar; Gomes Ferraz, Humberto; Abraham, Gustavo Abel; Fernández, María del Mar; López Bravo, Antonio; et al.; Development of new hydroactive dressings based on chitosan membranes: Characterization and in vivo behavior; Wiley-liss, Div John Wiley & Sons Inc; Journal of Biomedical Materials Research Part A; 64A; 1; 4-1-2003; 147-154
1549-3296
CONICET Digital
CONICET
url http://hdl.handle.net/11336/77664
identifier_str_mv de Queiroz, Alvaro Antonio Alençar; Gomes Ferraz, Humberto; Abraham, Gustavo Abel; Fernández, María del Mar; López Bravo, Antonio; et al.; Development of new hydroactive dressings based on chitosan membranes: Characterization and in vivo behavior; Wiley-liss, Div John Wiley & Sons Inc; Journal of Biomedical Materials Research Part A; 64A; 1; 4-1-2003; 147-154
1549-3296
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/jbm.a.10265
info:eu-repo/semantics/altIdentifier/doi/10.1002/jbm.a.10265
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley-liss, Div John Wiley & Sons Inc
publisher.none.fl_str_mv Wiley-liss, Div John Wiley & Sons Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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