Design and bioevaluation of a 32P-patch for brachytherapy of skin diseases

Autores
Salgueiro, María Jimena; Duran, Hebe Alicia; Palmieri, M.; Pirchio, R.; Nicolini, J.; Ughetti, R.; Papparella, M. L.; Casale, G.; Zubillaga, Marcela Beatriz
Año de publicación
2008
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The purpose of this study was to design and evaluate a 32P patch for brachytherapy of skin diseases. We employed Phosphoric-32P-acid and Chromic 32P-phosphate in combination with natural rubber or silicone to produce the patches. Stability studies in vitro to evaluate the leakage of radioactivity, autoradiographic studies to evaluate homogeneity and shielding, as well as therapeutic efficacy in an animal model of skin cancer of the selected 32P patch were performed. The 32P-silicone-patch demonstrated its safety for external application. Tumor growth was arrest and complete regressions of tumors were seen in some other cases with 40Gy applied in a single-dose scheme. In conclusion, the 32P-silicone-patch is easy to prepare and use in the treatment of skin diseases.
Fil: Salgueiro, María Jimena. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Física. Laboratorio de Radioisótopos; Argentina
Fil: Duran, Hebe Alicia. Universidad Nacional de San Martín; Argentina. Comisión Nacional de Energía Atómica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Palmieri, M.. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Biodiversidad y Biología Experimental; Argentina
Fil: Pirchio, R.. Comisión Nacional de Energía Atómica; Argentina
Fil: Nicolini, J.. No especifíca;
Fil: Ughetti, R.. No especifíca;
Fil: Papparella, M. L.. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Patología; Argentina
Fil: Casale, G.. No especifíca;
Fil: Zubillaga, Marcela Beatriz. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Física. Laboratorio de Radioisótopos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
32P
BRACHYTHERAPY
SKIN CANCER
PATCH
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/244595
Acceder
id CONICETDig_fc79fc08dea38ee55c58784b1c858285
oai_identifier_str oai:ri.conicet.gov.ar:11336/244595
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Design and bioevaluation of a 32P-patch for brachytherapy of skin diseasesSalgueiro, María JimenaDuran, Hebe AliciaPalmieri, M.Pirchio, R.Nicolini, J.Ughetti, R.Papparella, M. L.Casale, G.Zubillaga, Marcela Beatriz32PBRACHYTHERAPYSKIN CANCERPATCHhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3The purpose of this study was to design and evaluate a 32P patch for brachytherapy of skin diseases. We employed Phosphoric-32P-acid and Chromic 32P-phosphate in combination with natural rubber or silicone to produce the patches. Stability studies in vitro to evaluate the leakage of radioactivity, autoradiographic studies to evaluate homogeneity and shielding, as well as therapeutic efficacy in an animal model of skin cancer of the selected 32P patch were performed. The 32P-silicone-patch demonstrated its safety for external application. Tumor growth was arrest and complete regressions of tumors were seen in some other cases with 40Gy applied in a single-dose scheme. In conclusion, the 32P-silicone-patch is easy to prepare and use in the treatment of skin diseases.Fil: Salgueiro, María Jimena. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Física. Laboratorio de Radioisótopos; ArgentinaFil: Duran, Hebe Alicia. Universidad Nacional de San Martín; Argentina. Comisión Nacional de Energía Atómica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Palmieri, M.. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Biodiversidad y Biología Experimental; ArgentinaFil: Pirchio, R.. Comisión Nacional de Energía Atómica; ArgentinaFil: Nicolini, J.. No especifíca;Fil: Ughetti, R.. No especifíca;Fil: Papparella, M. L.. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Patología; ArgentinaFil: Casale, G.. No especifíca;Fil: Zubillaga, Marcela Beatriz. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Física. Laboratorio de Radioisótopos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaPergamon-Elsevier Science Ltd2008-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/244595Salgueiro, María Jimena; Duran, Hebe Alicia; Palmieri, M.; Pirchio, R.; Nicolini, J.; et al.; Design and bioevaluation of a 32P-patch for brachytherapy of skin diseases; Pergamon-Elsevier Science Ltd; Applied Radiation and Isotopes; 66; 3; 3-2008; 303-3090969-8043CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0969804307002825info:eu-repo/semantics/altIdentifier/doi/10.1016/j.apradiso.2007.09.008info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-12-23T13:28:49Zoai:ri.conicet.gov.ar:11336/244595instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-12-23 13:28:49.761CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Design and bioevaluation of a 32P-patch for brachytherapy of skin diseases
title Design and bioevaluation of a 32P-patch for brachytherapy of skin diseases
spellingShingle Design and bioevaluation of a 32P-patch for brachytherapy of skin diseases
Salgueiro, María Jimena
32P
BRACHYTHERAPY
SKIN CANCER
PATCH
title_short Design and bioevaluation of a 32P-patch for brachytherapy of skin diseases
title_full Design and bioevaluation of a 32P-patch for brachytherapy of skin diseases
title_fullStr Design and bioevaluation of a 32P-patch for brachytherapy of skin diseases
title_full_unstemmed Design and bioevaluation of a 32P-patch for brachytherapy of skin diseases
title_sort Design and bioevaluation of a 32P-patch for brachytherapy of skin diseases
dc.creator.none.fl_str_mv Salgueiro, María Jimena
Duran, Hebe Alicia
Palmieri, M.
Pirchio, R.
Nicolini, J.
Ughetti, R.
Papparella, M. L.
Casale, G.
Zubillaga, Marcela Beatriz
author Salgueiro, María Jimena
author_facet Salgueiro, María Jimena
Duran, Hebe Alicia
Palmieri, M.
Pirchio, R.
Nicolini, J.
Ughetti, R.
Papparella, M. L.
Casale, G.
Zubillaga, Marcela Beatriz
author_role author
author2 Duran, Hebe Alicia
Palmieri, M.
Pirchio, R.
Nicolini, J.
Ughetti, R.
Papparella, M. L.
Casale, G.
Zubillaga, Marcela Beatriz
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv 32P
BRACHYTHERAPY
SKIN CANCER
PATCH
topic 32P
BRACHYTHERAPY
SKIN CANCER
PATCH
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The purpose of this study was to design and evaluate a 32P patch for brachytherapy of skin diseases. We employed Phosphoric-32P-acid and Chromic 32P-phosphate in combination with natural rubber or silicone to produce the patches. Stability studies in vitro to evaluate the leakage of radioactivity, autoradiographic studies to evaluate homogeneity and shielding, as well as therapeutic efficacy in an animal model of skin cancer of the selected 32P patch were performed. The 32P-silicone-patch demonstrated its safety for external application. Tumor growth was arrest and complete regressions of tumors were seen in some other cases with 40Gy applied in a single-dose scheme. In conclusion, the 32P-silicone-patch is easy to prepare and use in the treatment of skin diseases.
Fil: Salgueiro, María Jimena. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Física. Laboratorio de Radioisótopos; Argentina
Fil: Duran, Hebe Alicia. Universidad Nacional de San Martín; Argentina. Comisión Nacional de Energía Atómica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Palmieri, M.. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Biodiversidad y Biología Experimental; Argentina
Fil: Pirchio, R.. Comisión Nacional de Energía Atómica; Argentina
Fil: Nicolini, J.. No especifíca;
Fil: Ughetti, R.. No especifíca;
Fil: Papparella, M. L.. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Patología; Argentina
Fil: Casale, G.. No especifíca;
Fil: Zubillaga, Marcela Beatriz. Universidad de Buenos Aires. Facultad de Ingeniería. Departamento de Física. Laboratorio de Radioisótopos; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description The purpose of this study was to design and evaluate a 32P patch for brachytherapy of skin diseases. We employed Phosphoric-32P-acid and Chromic 32P-phosphate in combination with natural rubber or silicone to produce the patches. Stability studies in vitro to evaluate the leakage of radioactivity, autoradiographic studies to evaluate homogeneity and shielding, as well as therapeutic efficacy in an animal model of skin cancer of the selected 32P patch were performed. The 32P-silicone-patch demonstrated its safety for external application. Tumor growth was arrest and complete regressions of tumors were seen in some other cases with 40Gy applied in a single-dose scheme. In conclusion, the 32P-silicone-patch is easy to prepare and use in the treatment of skin diseases.
publishDate 2008
dc.date.none.fl_str_mv 2008-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/244595
Salgueiro, María Jimena; Duran, Hebe Alicia; Palmieri, M.; Pirchio, R.; Nicolini, J.; et al.; Design and bioevaluation of a 32P-patch for brachytherapy of skin diseases; Pergamon-Elsevier Science Ltd; Applied Radiation and Isotopes; 66; 3; 3-2008; 303-309
0969-8043
CONICET Digital
CONICET
url http://hdl.handle.net/11336/244595
identifier_str_mv Salgueiro, María Jimena; Duran, Hebe Alicia; Palmieri, M.; Pirchio, R.; Nicolini, J.; et al.; Design and bioevaluation of a 32P-patch for brachytherapy of skin diseases; Pergamon-Elsevier Science Ltd; Applied Radiation and Isotopes; 66; 3; 3-2008; 303-309
0969-8043
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0969804307002825
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.apradiso.2007.09.008
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1852335175445250048
score 13.075124

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