Bioevaluation of 32P patch designed for the treatment of skin diseases

Autores
Salgueiro, María Jimena; Duran, Hebe Alicia; Palmieri, Mónica Alejandra; Pirchio, Rosana; Medina, Vanina Araceli; Ughetti, Ricardo; Croci, Máximo; Nicolini, Jorge; Zubillaga, Marcela Beatriz
Año de publicación
2008
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Objective: The objective of this study was to design and evaluate a 32P patch for the treatment of skin diseases. Materials and Methods: The patch was prepared from chromic phosphate 32P and silicone. Bioelimination and biodistribution in healthy and treated animals, and the therapeutic efficacy of two treatment schemes (single dose and fractionated dose) in an animal model of skin cancer were studied. Results: Based on the bioelimination and biodistribution studies, no leakage of 32P from the patch was observed. The treated tumors reduced their mean diameter compared to controls. The single-dose therapeutic scheme showed a higher number of complete and partial remissions compared to the fractionated scheme. These results were confirmed by histopathological analysis of the samples. Conclusion: The 32P patch was designed and produced according to specifications for the treatment of superficial lesions of the skin. Although the 32P patch is an open source, it behaves like a sealed one for use in brachytherapy treatments.
Fil: Salgueiro, María Jimena. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Duran, Hebe Alicia. Comisión Nacional de Energía Atómica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Palmieri, Mónica Alejandra. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Biodiversidad y Biología Experimental; Argentina
Fil: Pirchio, Rosana. Comisión Nacional de Energía Atómica; Argentina
Fil: Medina, Vanina Araceli. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Ughetti, Ricardo. No especifíca;
Fil: Croci, Máximo. No especifíca;
Fil: Nicolini, Jorge. No especifíca;
Fil: Zubillaga, Marcela Beatriz. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
32P
BRACHYTHERAPY
PATCH
SKIN CANCER
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/160640
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/160640
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Bioevaluation of 32P patch designed for the treatment of skin diseasesSalgueiro, María JimenaDuran, Hebe AliciaPalmieri, Mónica AlejandraPirchio, RosanaMedina, Vanina AraceliUghetti, RicardoCroci, MáximoNicolini, JorgeZubillaga, Marcela Beatriz32PBRACHYTHERAPYPATCHSKIN CANCERhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Objective: The objective of this study was to design and evaluate a 32P patch for the treatment of skin diseases. Materials and Methods: The patch was prepared from chromic phosphate 32P and silicone. Bioelimination and biodistribution in healthy and treated animals, and the therapeutic efficacy of two treatment schemes (single dose and fractionated dose) in an animal model of skin cancer were studied. Results: Based on the bioelimination and biodistribution studies, no leakage of 32P from the patch was observed. The treated tumors reduced their mean diameter compared to controls. The single-dose therapeutic scheme showed a higher number of complete and partial remissions compared to the fractionated scheme. These results were confirmed by histopathological analysis of the samples. Conclusion: The 32P patch was designed and produced according to specifications for the treatment of superficial lesions of the skin. Although the 32P patch is an open source, it behaves like a sealed one for use in brachytherapy treatments.Fil: Salgueiro, María Jimena. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; ArgentinaFil: Duran, Hebe Alicia. Comisión Nacional de Energía Atómica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Palmieri, Mónica Alejandra. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Biodiversidad y Biología Experimental; ArgentinaFil: Pirchio, Rosana. Comisión Nacional de Energía Atómica; ArgentinaFil: Medina, Vanina Araceli. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Ughetti, Ricardo. No especifíca;Fil: Croci, Máximo. No especifíca;Fil: Nicolini, Jorge. No especifíca;Fil: Zubillaga, Marcela Beatriz. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaElsevier Science Inc.2008-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/160640Salgueiro, María Jimena; Duran, Hebe Alicia; Palmieri, Mónica Alejandra; Pirchio, Rosana; Medina, Vanina Araceli; et al.; Bioevaluation of 32P patch designed for the treatment of skin diseases; Elsevier Science Inc.; Nuclear Medicine And Biology; 35; 2; 2-2008; 233-2370969-8051CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0969805107002211info:eu-repo/semantics/altIdentifier/doi/10.1016/j.nucmedbio.2007.08.004info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-12-23T13:54:11Zoai:ri.conicet.gov.ar:11336/160640instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-12-23 13:54:11.479CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Bioevaluation of 32P patch designed for the treatment of skin diseases
title Bioevaluation of 32P patch designed for the treatment of skin diseases
spellingShingle Bioevaluation of 32P patch designed for the treatment of skin diseases
Salgueiro, María Jimena
32P
BRACHYTHERAPY
PATCH
SKIN CANCER
title_short Bioevaluation of 32P patch designed for the treatment of skin diseases
title_full Bioevaluation of 32P patch designed for the treatment of skin diseases
title_fullStr Bioevaluation of 32P patch designed for the treatment of skin diseases
title_full_unstemmed Bioevaluation of 32P patch designed for the treatment of skin diseases
title_sort Bioevaluation of 32P patch designed for the treatment of skin diseases
dc.creator.none.fl_str_mv Salgueiro, María Jimena
Duran, Hebe Alicia
Palmieri, Mónica Alejandra
Pirchio, Rosana
Medina, Vanina Araceli
Ughetti, Ricardo
Croci, Máximo
Nicolini, Jorge
Zubillaga, Marcela Beatriz
author Salgueiro, María Jimena
author_facet Salgueiro, María Jimena
Duran, Hebe Alicia
Palmieri, Mónica Alejandra
Pirchio, Rosana
Medina, Vanina Araceli
Ughetti, Ricardo
Croci, Máximo
Nicolini, Jorge
Zubillaga, Marcela Beatriz
author_role author
author2 Duran, Hebe Alicia
Palmieri, Mónica Alejandra
Pirchio, Rosana
Medina, Vanina Araceli
Ughetti, Ricardo
Croci, Máximo
Nicolini, Jorge
Zubillaga, Marcela Beatriz
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv 32P
BRACHYTHERAPY
PATCH
SKIN CANCER
topic 32P
BRACHYTHERAPY
PATCH
SKIN CANCER
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Objective: The objective of this study was to design and evaluate a 32P patch for the treatment of skin diseases. Materials and Methods: The patch was prepared from chromic phosphate 32P and silicone. Bioelimination and biodistribution in healthy and treated animals, and the therapeutic efficacy of two treatment schemes (single dose and fractionated dose) in an animal model of skin cancer were studied. Results: Based on the bioelimination and biodistribution studies, no leakage of 32P from the patch was observed. The treated tumors reduced their mean diameter compared to controls. The single-dose therapeutic scheme showed a higher number of complete and partial remissions compared to the fractionated scheme. These results were confirmed by histopathological analysis of the samples. Conclusion: The 32P patch was designed and produced according to specifications for the treatment of superficial lesions of the skin. Although the 32P patch is an open source, it behaves like a sealed one for use in brachytherapy treatments.
Fil: Salgueiro, María Jimena. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Duran, Hebe Alicia. Comisión Nacional de Energía Atómica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Palmieri, Mónica Alejandra. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Biodiversidad y Biología Experimental; Argentina
Fil: Pirchio, Rosana. Comisión Nacional de Energía Atómica; Argentina
Fil: Medina, Vanina Araceli. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Ughetti, Ricardo. No especifíca;
Fil: Croci, Máximo. No especifíca;
Fil: Nicolini, Jorge. No especifíca;
Fil: Zubillaga, Marcela Beatriz. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description Objective: The objective of this study was to design and evaluate a 32P patch for the treatment of skin diseases. Materials and Methods: The patch was prepared from chromic phosphate 32P and silicone. Bioelimination and biodistribution in healthy and treated animals, and the therapeutic efficacy of two treatment schemes (single dose and fractionated dose) in an animal model of skin cancer were studied. Results: Based on the bioelimination and biodistribution studies, no leakage of 32P from the patch was observed. The treated tumors reduced their mean diameter compared to controls. The single-dose therapeutic scheme showed a higher number of complete and partial remissions compared to the fractionated scheme. These results were confirmed by histopathological analysis of the samples. Conclusion: The 32P patch was designed and produced according to specifications for the treatment of superficial lesions of the skin. Although the 32P patch is an open source, it behaves like a sealed one for use in brachytherapy treatments.
publishDate 2008
dc.date.none.fl_str_mv 2008-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/160640
Salgueiro, María Jimena; Duran, Hebe Alicia; Palmieri, Mónica Alejandra; Pirchio, Rosana; Medina, Vanina Araceli; et al.; Bioevaluation of 32P patch designed for the treatment of skin diseases; Elsevier Science Inc.; Nuclear Medicine And Biology; 35; 2; 2-2008; 233-237
0969-8051
CONICET Digital
CONICET
url http://hdl.handle.net/11336/160640
identifier_str_mv Salgueiro, María Jimena; Duran, Hebe Alicia; Palmieri, Mónica Alejandra; Pirchio, Rosana; Medina, Vanina Araceli; et al.; Bioevaluation of 32P patch designed for the treatment of skin diseases; Elsevier Science Inc.; Nuclear Medicine And Biology; 35; 2; 2-2008; 233-237
0969-8051
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0969805107002211
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.nucmedbio.2007.08.004
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science Inc.
publisher.none.fl_str_mv Elsevier Science Inc.
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1852335438980710400
score 13.075124

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