Green synthesis of privileged benzimidazole scaffolds using active deep eutectic solvent

Autores: Gioia, Maria Luisa Di; Cassano, Roberta; Costanzo, Paola; Herrera Cano, Natividad Carolina; Maiuolo, Loredana; Nardi, Monica; Nicoletta, Fiore Pasquale; Oliverio, Manuela; Procopio, Antonio
Año de publicación: 2019
Idioma: inglés
Tipo de recurso: artículo
Estado: versión publicada
Descripción: The exploitation and use of alternative synthetic methods, in the face of classical procedures that do not conform to the ethics of green chemistry, represent an ever-present problem in the pharmaceutical industry. The procedures for the synthesis of benzimidazoles have become a focus in synthetic organic chemistry, as they are building blocks of strong interest for the development of compounds with pharmacological activity. Various benzimidazole derivatives exhibit important activities such as antimicrobial, antiviral, anti-inflammatory, and analgesic activities, and some of the already synthesized compounds have found very strong applications in medicine praxis. Here we report a selective and sustainable method for the synthesis of 1,2-disubstituted or 2-substituted benzimidazoles, starting from o-phenylenediamine in the presence of different aldehydes. The use of deep eutectic solvent (DES), both as reaction medium and reagent without any external solvent, provides advantages in terms of yields as well as in the work up procedure of the reaction.
Fil: Gioia, Maria Luisa Di. Università della Calabria; Italia
Fil: Cassano, Roberta. Università della Calabria; Italia
Fil: Costanzo, Paola. Magna Græcia University. Department of Health Sciences; Italia
Fil: Herrera Cano, Natividad Carolina. Universidad Nacional de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Ciencia y Tecnología de Alimentos Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Ciencia y Tecnología de Alimentos Córdoba; Argentina
Fil: Maiuolo, Loredana. Università della Calabria; Italia
Fil: Nardi, Monica. Magna Græcia University. Department of Health Sciences; Italia
Fil: Nicoletta, Fiore Pasquale. Università della Calabria; Italia
Fil: Oliverio, Manuela. Magna Græcia University. Department of Health Sciences; Italia
Fil: Procopio, Antonio. Magna Græcia University. Department of Health Sciences; Italia
Materia: AROMATIC AMINES
BENZIMIDAZOLES
DEEP EUTECTIC SOLVENTS
GREEN CHEMISTRY
HETEROCYCLIC MOIETY
Nivel de accesibilidad: acceso abierto
Condiciones de uso: https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
Institución: Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador: oai:ri.conicet.gov.ar:11336/125715

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spelling	Green synthesis of privileged benzimidazole scaffolds using active deep eutectic solventGioia, Maria Luisa DiCassano, RobertaCostanzo, PaolaHerrera Cano, Natividad CarolinaMaiuolo, LoredanaNardi, MonicaNicoletta, Fiore PasqualeOliverio, ManuelaProcopio, AntonioAROMATIC AMINESBENZIMIDAZOLESDEEP EUTECTIC SOLVENTSGREEN CHEMISTRYHETEROCYCLIC MOIETYhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1The exploitation and use of alternative synthetic methods, in the face of classical procedures that do not conform to the ethics of green chemistry, represent an ever-present problem in the pharmaceutical industry. The procedures for the synthesis of benzimidazoles have become a focus in synthetic organic chemistry, as they are building blocks of strong interest for the development of compounds with pharmacological activity. Various benzimidazole derivatives exhibit important activities such as antimicrobial, antiviral, anti-inflammatory, and analgesic activities, and some of the already synthesized compounds have found very strong applications in medicine praxis. Here we report a selective and sustainable method for the synthesis of 1,2-disubstituted or 2-substituted benzimidazoles, starting from o-phenylenediamine in the presence of different aldehydes. The use of deep eutectic solvent (DES), both as reaction medium and reagent without any external solvent, provides advantages in terms of yields as well as in the work up procedure of the reaction.Fil: Gioia, Maria Luisa Di. Università della Calabria; ItaliaFil: Cassano, Roberta. Università della Calabria; ItaliaFil: Costanzo, Paola. Magna Græcia University. Department of Health Sciences; ItaliaFil: Herrera Cano, Natividad Carolina. Universidad Nacional de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Ciencia y Tecnología de Alimentos Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Ciencia y Tecnología de Alimentos Córdoba; ArgentinaFil: Maiuolo, Loredana. Università della Calabria; ItaliaFil: Nardi, Monica. Magna Græcia University. Department of Health Sciences; ItaliaFil: Nicoletta, Fiore Pasquale. Università della Calabria; ItaliaFil: Oliverio, Manuela. Magna Græcia University. Department of Health Sciences; ItaliaFil: Procopio, Antonio. Magna Græcia University. Department of Health Sciences; ItaliaMolecular Diversity Preservation International2019-08-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/125715Gioia, Maria Luisa Di; Cassano, Roberta; Costanzo, Paola; Herrera Cano, Natividad Carolina; Maiuolo, Loredana; et al.; Green synthesis of privileged benzimidazole scaffolds using active deep eutectic solvent; Molecular Diversity Preservation International; Molecules; 24; 16; 2-8-2019; 28851420-3049CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.3390/molecules24162885info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/1420-3049/24/16/2885info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:46:23Zoai:ri.conicet.gov.ar:11336/125715instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:46:23.985CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv	Green synthesis of privileged benzimidazole scaffolds using active deep eutectic solvent
title	Green synthesis of privileged benzimidazole scaffolds using active deep eutectic solvent
spellingShingle	Green synthesis of privileged benzimidazole scaffolds using active deep eutectic solvent Gioia, Maria Luisa Di AROMATIC AMINES BENZIMIDAZOLES DEEP EUTECTIC SOLVENTS GREEN CHEMISTRY HETEROCYCLIC MOIETY
title_short	Green synthesis of privileged benzimidazole scaffolds using active deep eutectic solvent
title_full	Green synthesis of privileged benzimidazole scaffolds using active deep eutectic solvent
title_fullStr	Green synthesis of privileged benzimidazole scaffolds using active deep eutectic solvent
title_full_unstemmed	Green synthesis of privileged benzimidazole scaffolds using active deep eutectic solvent
title_sort	Green synthesis of privileged benzimidazole scaffolds using active deep eutectic solvent
dc.creator.none.fl_str_mv	Gioia, Maria Luisa Di Cassano, Roberta Costanzo, Paola Herrera Cano, Natividad Carolina Maiuolo, Loredana Nardi, Monica Nicoletta, Fiore Pasquale Oliverio, Manuela Procopio, Antonio
author	Gioia, Maria Luisa Di
author_facet	Gioia, Maria Luisa Di Cassano, Roberta Costanzo, Paola Herrera Cano, Natividad Carolina Maiuolo, Loredana Nardi, Monica Nicoletta, Fiore Pasquale Oliverio, Manuela Procopio, Antonio
author_role	author
author2	Cassano, Roberta Costanzo, Paola Herrera Cano, Natividad Carolina Maiuolo, Loredana Nardi, Monica Nicoletta, Fiore Pasquale Oliverio, Manuela Procopio, Antonio
author2_role	author author author author author author author author
dc.subject.none.fl_str_mv	AROMATIC AMINES BENZIMIDAZOLES DEEP EUTECTIC SOLVENTS GREEN CHEMISTRY HETEROCYCLIC MOIETY
topic	AROMATIC AMINES BENZIMIDAZOLES DEEP EUTECTIC SOLVENTS GREEN CHEMISTRY HETEROCYCLIC MOIETY
purl_subject.fl_str_mv	https://purl.org/becyt/ford/1.4 https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv	The exploitation and use of alternative synthetic methods, in the face of classical procedures that do not conform to the ethics of green chemistry, represent an ever-present problem in the pharmaceutical industry. The procedures for the synthesis of benzimidazoles have become a focus in synthetic organic chemistry, as they are building blocks of strong interest for the development of compounds with pharmacological activity. Various benzimidazole derivatives exhibit important activities such as antimicrobial, antiviral, anti-inflammatory, and analgesic activities, and some of the already synthesized compounds have found very strong applications in medicine praxis. Here we report a selective and sustainable method for the synthesis of 1,2-disubstituted or 2-substituted benzimidazoles, starting from o-phenylenediamine in the presence of different aldehydes. The use of deep eutectic solvent (DES), both as reaction medium and reagent without any external solvent, provides advantages in terms of yields as well as in the work up procedure of the reaction. Fil: Gioia, Maria Luisa Di. Università della Calabria; Italia Fil: Cassano, Roberta. Università della Calabria; Italia Fil: Costanzo, Paola. Magna Græcia University. Department of Health Sciences; Italia Fil: Herrera Cano, Natividad Carolina. Universidad Nacional de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Ciencia y Tecnología de Alimentos Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Ciencia y Tecnología de Alimentos Córdoba; Argentina Fil: Maiuolo, Loredana. Università della Calabria; Italia Fil: Nardi, Monica. Magna Græcia University. Department of Health Sciences; Italia Fil: Nicoletta, Fiore Pasquale. Università della Calabria; Italia Fil: Oliverio, Manuela. Magna Græcia University. Department of Health Sciences; Italia Fil: Procopio, Antonio. Magna Græcia University. Department of Health Sciences; Italia
description	The exploitation and use of alternative synthetic methods, in the face of classical procedures that do not conform to the ethics of green chemistry, represent an ever-present problem in the pharmaceutical industry. The procedures for the synthesis of benzimidazoles have become a focus in synthetic organic chemistry, as they are building blocks of strong interest for the development of compounds with pharmacological activity. Various benzimidazole derivatives exhibit important activities such as antimicrobial, antiviral, anti-inflammatory, and analgesic activities, and some of the already synthesized compounds have found very strong applications in medicine praxis. Here we report a selective and sustainable method for the synthesis of 1,2-disubstituted or 2-substituted benzimidazoles, starting from o-phenylenediamine in the presence of different aldehydes. The use of deep eutectic solvent (DES), both as reaction medium and reagent without any external solvent, provides advantages in terms of yields as well as in the work up procedure of the reaction.
publishDate	2019
dc.date.none.fl_str_mv	2019-08-02
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	http://hdl.handle.net/11336/125715 Gioia, Maria Luisa Di; Cassano, Roberta; Costanzo, Paola; Herrera Cano, Natividad Carolina; Maiuolo, Loredana; et al.; Green synthesis of privileged benzimidazole scaffolds using active deep eutectic solvent; Molecular Diversity Preservation International; Molecules; 24; 16; 2-8-2019; 2885 1420-3049 CONICET Digital CONICET
url	http://hdl.handle.net/11336/125715
identifier_str_mv	Gioia, Maria Luisa Di; Cassano, Roberta; Costanzo, Paola; Herrera Cano, Natividad Carolina; Maiuolo, Loredana; et al.; Green synthesis of privileged benzimidazole scaffolds using active deep eutectic solvent; Molecular Diversity Preservation International; Molecules; 24; 16; 2-8-2019; 2885 1420-3049 CONICET Digital CONICET
dc.language.none.fl_str_mv	eng
language	eng
dc.relation.none.fl_str_mv	info:eu-repo/semantics/altIdentifier/doi/10.3390/molecules24162885 info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/1420-3049/24/16/2885
dc.rights.none.fl_str_mv	info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv	openAccess
rights_invalid_str_mv	https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv	application/pdf application/pdf
dc.publisher.none.fl_str_mv	Molecular Diversity Preservation International
publisher.none.fl_str_mv	Molecular Diversity Preservation International
dc.source.none.fl_str_mv	reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str	CONICET Digital (CONICET)
collection	CONICET Digital (CONICET)
instname_str	Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv	CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv	dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score	13.13397

Green synthesis of privileged benzimidazole scaffolds using active deep eutectic solvent

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