Immunobiotic feed developed with Lactobacillus delbrueckii subsp. delbrueckii TUA4408L and the soymilk by-product okara improves health and growth performance in pigs

Autores
Suda, Yoshihito; Sasaki, Nana; Kagawa, Kyoma; Elean, Mariano Daniel; Zhou, Binghui; Tomokiyo, Mikado; Islam, Md Aminul; Shahid Riaz Rajoka, Muhammad; Humayun Kober, A.K.M.; Shimazu, Tomoyuki; Egusa, Shintaro; Terashima, Yuji; Aso, Hisashi; Ikeda Ohtsubo, Wakako; Villena, Julio Cesar; Kitazawa, Haruki
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Lactobacillus delbrueckii subsp. delbrueckii TUA4408L is able to differentially modulate the innate immune response of porcine intestinal epithelial cells triggered by TLR4 activation. This strain also has a remarkable ability to grow on plant substrates. These two immunological and biotechnological characteristics prompted us to evaluate whether the soymilk by-product okara fermented with the TUA4408L strain can serve as an immunobiotic feed with the ability to beneficially modulate the intestinal immunity of piglets after weaning to improve their productivity. Our in vivo studies demonstrated that the administration of immunobiotic TUA4408L-fermented okara feed significantly increased piglet growth performance and meat quality. These positive effects were associated with the ability of the TUA4408L-fermented okara feed to beneficially modulate both intestinal microbiota and immunity in pigs. The immunobiotic feed improved the abundance of the beneficial bacteria Lactobacillus and Lactococcus in the gut of pigs, reduced blood markers of inflammation, and differentially regulated the expression of inflammatory and regulatory cytokines in the intestinal mucosa. These findings indicate that the immunobiotic TUA4408L-fermented okara feed could be an economical and environmentally friendly option to improve the growth performance and immune health of pigs.
Fil: Suda, Yoshihito. Miyagi University; Japón
Fil: Sasaki, Nana. Miyagi University; Japón
Fil: Kagawa, Kyoma. Miyagi University; Japón
Fil: Elean, Mariano Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
Fil: Zhou, Binghui. Tohoku University; Japón
Fil: Tomokiyo, Mikado. Tohoku University; Japón
Fil: Islam, Md Aminul. Tohoku University; Japón. Bangladesh Agricultural University; Bangladesh
Fil: Shahid Riaz Rajoka, Muhammad. Tohoku University; Japón
Fil: Humayun Kober, A.K.M.. Tohoku University; Japón. Chittagong Veterinary and Animal Sciences University; Bangladesh
Fil: Shimazu, Tomoyuki. Miyagi University; Japón
Fil: Egusa, Shintaro. No especifíca;
Fil: Terashima, Yuji. No especifíca;
Fil: Aso, Hisashi. Tohoku University; Japón
Fil: Ikeda Ohtsubo, Wakako. Tohoku University; Japón
Fil: Villena, Julio Cesar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
Fil: Kitazawa, Haruki. Tohoku University; Japón
Materia
IMMUNOBIOTICS
LACTOBACILLUS DELBRUECKII SUBSP. DELBRUECKII TUA4408L
OKARA
PIG IMMUNE HEALTH
PIG PERFORMANCE
PROBIOTICS FOR PIGS
SOYMILK BY-PRODUCT
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/153636
Acceder
id CONICETDig_faae9b21ac457f5f7c06228518feb206
oai_identifier_str oai:ri.conicet.gov.ar:11336/153636
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Immunobiotic feed developed with Lactobacillus delbrueckii subsp. delbrueckii TUA4408L and the soymilk by-product okara improves health and growth performance in pigsSuda, YoshihitoSasaki, NanaKagawa, KyomaElean, Mariano DanielZhou, BinghuiTomokiyo, MikadoIslam, Md AminulShahid Riaz Rajoka, MuhammadHumayun Kober, A.K.M.Shimazu, TomoyukiEgusa, ShintaroTerashima, YujiAso, HisashiIkeda Ohtsubo, WakakoVillena, Julio CesarKitazawa, HarukiIMMUNOBIOTICSLACTOBACILLUS DELBRUECKII SUBSP. DELBRUECKII TUA4408LOKARAPIG IMMUNE HEALTHPIG PERFORMANCEPROBIOTICS FOR PIGSSOYMILK BY-PRODUCThttps://purl.org/becyt/ford/4.4https://purl.org/becyt/ford/4Lactobacillus delbrueckii subsp. delbrueckii TUA4408L is able to differentially modulate the innate immune response of porcine intestinal epithelial cells triggered by TLR4 activation. This strain also has a remarkable ability to grow on plant substrates. These two immunological and biotechnological characteristics prompted us to evaluate whether the soymilk by-product okara fermented with the TUA4408L strain can serve as an immunobiotic feed with the ability to beneficially modulate the intestinal immunity of piglets after weaning to improve their productivity. Our in vivo studies demonstrated that the administration of immunobiotic TUA4408L-fermented okara feed significantly increased piglet growth performance and meat quality. These positive effects were associated with the ability of the TUA4408L-fermented okara feed to beneficially modulate both intestinal microbiota and immunity in pigs. The immunobiotic feed improved the abundance of the beneficial bacteria Lactobacillus and Lactococcus in the gut of pigs, reduced blood markers of inflammation, and differentially regulated the expression of inflammatory and regulatory cytokines in the intestinal mucosa. These findings indicate that the immunobiotic TUA4408L-fermented okara feed could be an economical and environmentally friendly option to improve the growth performance and immune health of pigs.Fil: Suda, Yoshihito. Miyagi University; JapónFil: Sasaki, Nana. Miyagi University; JapónFil: Kagawa, Kyoma. Miyagi University; JapónFil: Elean, Mariano Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; ArgentinaFil: Zhou, Binghui. Tohoku University; JapónFil: Tomokiyo, Mikado. Tohoku University; JapónFil: Islam, Md Aminul. Tohoku University; Japón. Bangladesh Agricultural University; BangladeshFil: Shahid Riaz Rajoka, Muhammad. Tohoku University; JapónFil: Humayun Kober, A.K.M.. Tohoku University; Japón. Chittagong Veterinary and Animal Sciences University; BangladeshFil: Shimazu, Tomoyuki. Miyagi University; JapónFil: Egusa, Shintaro. No especifíca;Fil: Terashima, Yuji. No especifíca;Fil: Aso, Hisashi. Tohoku University; JapónFil: Ikeda Ohtsubo, Wakako. Tohoku University; JapónFil: Villena, Julio Cesar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; ArgentinaFil: Kitazawa, Haruki. Tohoku University; JapónMDPI2021-04-23info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/153636Suda, Yoshihito; Sasaki, Nana; Kagawa, Kyoma; Elean, Mariano Daniel; Zhou, Binghui; et al.; Immunobiotic feed developed with Lactobacillus delbrueckii subsp. delbrueckii TUA4408L and the soymilk by-product okara improves health and growth performance in pigs; MDPI; Microorganisms; 9; 5; 23-4-2021; 1-192076-2607CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.3390/microorganisms9050921info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2076-2607/9/5/921info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-17T10:54:45Zoai:ri.conicet.gov.ar:11336/153636instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-17 10:54:45.896CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Immunobiotic feed developed with Lactobacillus delbrueckii subsp. delbrueckii TUA4408L and the soymilk by-product okara improves health and growth performance in pigs
title Immunobiotic feed developed with Lactobacillus delbrueckii subsp. delbrueckii TUA4408L and the soymilk by-product okara improves health and growth performance in pigs
spellingShingle Immunobiotic feed developed with Lactobacillus delbrueckii subsp. delbrueckii TUA4408L and the soymilk by-product okara improves health and growth performance in pigs
Suda, Yoshihito
IMMUNOBIOTICS
LACTOBACILLUS DELBRUECKII SUBSP. DELBRUECKII TUA4408L
OKARA
PIG IMMUNE HEALTH
PIG PERFORMANCE
PROBIOTICS FOR PIGS
SOYMILK BY-PRODUCT
title_short Immunobiotic feed developed with Lactobacillus delbrueckii subsp. delbrueckii TUA4408L and the soymilk by-product okara improves health and growth performance in pigs
title_full Immunobiotic feed developed with Lactobacillus delbrueckii subsp. delbrueckii TUA4408L and the soymilk by-product okara improves health and growth performance in pigs
title_fullStr Immunobiotic feed developed with Lactobacillus delbrueckii subsp. delbrueckii TUA4408L and the soymilk by-product okara improves health and growth performance in pigs
title_full_unstemmed Immunobiotic feed developed with Lactobacillus delbrueckii subsp. delbrueckii TUA4408L and the soymilk by-product okara improves health and growth performance in pigs
title_sort Immunobiotic feed developed with Lactobacillus delbrueckii subsp. delbrueckii TUA4408L and the soymilk by-product okara improves health and growth performance in pigs
dc.creator.none.fl_str_mv Suda, Yoshihito
Sasaki, Nana
Kagawa, Kyoma
Elean, Mariano Daniel
Zhou, Binghui
Tomokiyo, Mikado
Islam, Md Aminul
Shahid Riaz Rajoka, Muhammad
Humayun Kober, A.K.M.
Shimazu, Tomoyuki
Egusa, Shintaro
Terashima, Yuji
Aso, Hisashi
Ikeda Ohtsubo, Wakako
Villena, Julio Cesar
Kitazawa, Haruki
author Suda, Yoshihito
author_facet Suda, Yoshihito
Sasaki, Nana
Kagawa, Kyoma
Elean, Mariano Daniel
Zhou, Binghui
Tomokiyo, Mikado
Islam, Md Aminul
Shahid Riaz Rajoka, Muhammad
Humayun Kober, A.K.M.
Shimazu, Tomoyuki
Egusa, Shintaro
Terashima, Yuji
Aso, Hisashi
Ikeda Ohtsubo, Wakako
Villena, Julio Cesar
Kitazawa, Haruki
author_role author
author2 Sasaki, Nana
Kagawa, Kyoma
Elean, Mariano Daniel
Zhou, Binghui
Tomokiyo, Mikado
Islam, Md Aminul
Shahid Riaz Rajoka, Muhammad
Humayun Kober, A.K.M.
Shimazu, Tomoyuki
Egusa, Shintaro
Terashima, Yuji
Aso, Hisashi
Ikeda Ohtsubo, Wakako
Villena, Julio Cesar
Kitazawa, Haruki
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv IMMUNOBIOTICS
LACTOBACILLUS DELBRUECKII SUBSP. DELBRUECKII TUA4408L
OKARA
PIG IMMUNE HEALTH
PIG PERFORMANCE
PROBIOTICS FOR PIGS
SOYMILK BY-PRODUCT
topic IMMUNOBIOTICS
LACTOBACILLUS DELBRUECKII SUBSP. DELBRUECKII TUA4408L
OKARA
PIG IMMUNE HEALTH
PIG PERFORMANCE
PROBIOTICS FOR PIGS
SOYMILK BY-PRODUCT
purl_subject.fl_str_mv https://purl.org/becyt/ford/4.4
https://purl.org/becyt/ford/4
dc.description.none.fl_txt_mv Lactobacillus delbrueckii subsp. delbrueckii TUA4408L is able to differentially modulate the innate immune response of porcine intestinal epithelial cells triggered by TLR4 activation. This strain also has a remarkable ability to grow on plant substrates. These two immunological and biotechnological characteristics prompted us to evaluate whether the soymilk by-product okara fermented with the TUA4408L strain can serve as an immunobiotic feed with the ability to beneficially modulate the intestinal immunity of piglets after weaning to improve their productivity. Our in vivo studies demonstrated that the administration of immunobiotic TUA4408L-fermented okara feed significantly increased piglet growth performance and meat quality. These positive effects were associated with the ability of the TUA4408L-fermented okara feed to beneficially modulate both intestinal microbiota and immunity in pigs. The immunobiotic feed improved the abundance of the beneficial bacteria Lactobacillus and Lactococcus in the gut of pigs, reduced blood markers of inflammation, and differentially regulated the expression of inflammatory and regulatory cytokines in the intestinal mucosa. These findings indicate that the immunobiotic TUA4408L-fermented okara feed could be an economical and environmentally friendly option to improve the growth performance and immune health of pigs.
Fil: Suda, Yoshihito. Miyagi University; Japón
Fil: Sasaki, Nana. Miyagi University; Japón
Fil: Kagawa, Kyoma. Miyagi University; Japón
Fil: Elean, Mariano Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
Fil: Zhou, Binghui. Tohoku University; Japón
Fil: Tomokiyo, Mikado. Tohoku University; Japón
Fil: Islam, Md Aminul. Tohoku University; Japón. Bangladesh Agricultural University; Bangladesh
Fil: Shahid Riaz Rajoka, Muhammad. Tohoku University; Japón
Fil: Humayun Kober, A.K.M.. Tohoku University; Japón. Chittagong Veterinary and Animal Sciences University; Bangladesh
Fil: Shimazu, Tomoyuki. Miyagi University; Japón
Fil: Egusa, Shintaro. No especifíca;
Fil: Terashima, Yuji. No especifíca;
Fil: Aso, Hisashi. Tohoku University; Japón
Fil: Ikeda Ohtsubo, Wakako. Tohoku University; Japón
Fil: Villena, Julio Cesar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
Fil: Kitazawa, Haruki. Tohoku University; Japón
description Lactobacillus delbrueckii subsp. delbrueckii TUA4408L is able to differentially modulate the innate immune response of porcine intestinal epithelial cells triggered by TLR4 activation. This strain also has a remarkable ability to grow on plant substrates. These two immunological and biotechnological characteristics prompted us to evaluate whether the soymilk by-product okara fermented with the TUA4408L strain can serve as an immunobiotic feed with the ability to beneficially modulate the intestinal immunity of piglets after weaning to improve their productivity. Our in vivo studies demonstrated that the administration of immunobiotic TUA4408L-fermented okara feed significantly increased piglet growth performance and meat quality. These positive effects were associated with the ability of the TUA4408L-fermented okara feed to beneficially modulate both intestinal microbiota and immunity in pigs. The immunobiotic feed improved the abundance of the beneficial bacteria Lactobacillus and Lactococcus in the gut of pigs, reduced blood markers of inflammation, and differentially regulated the expression of inflammatory and regulatory cytokines in the intestinal mucosa. These findings indicate that the immunobiotic TUA4408L-fermented okara feed could be an economical and environmentally friendly option to improve the growth performance and immune health of pigs.
publishDate 2021
dc.date.none.fl_str_mv 2021-04-23
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/153636
Suda, Yoshihito; Sasaki, Nana; Kagawa, Kyoma; Elean, Mariano Daniel; Zhou, Binghui; et al.; Immunobiotic feed developed with Lactobacillus delbrueckii subsp. delbrueckii TUA4408L and the soymilk by-product okara improves health and growth performance in pigs; MDPI; Microorganisms; 9; 5; 23-4-2021; 1-19
2076-2607
CONICET Digital
CONICET
url http://hdl.handle.net/11336/153636
identifier_str_mv Suda, Yoshihito; Sasaki, Nana; Kagawa, Kyoma; Elean, Mariano Daniel; Zhou, Binghui; et al.; Immunobiotic feed developed with Lactobacillus delbrueckii subsp. delbrueckii TUA4408L and the soymilk by-product okara improves health and growth performance in pigs; MDPI; Microorganisms; 9; 5; 23-4-2021; 1-19
2076-2607
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.3390/microorganisms9050921
info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2076-2607/9/5/921
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.000565

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