Failure of long-acting ivermectin formulation to control Psoroptic mange infection in grazing beef cattle

Autores
Cantón, Candela; Muchiut, Sebastián Manuel; Dominguez, Maria Paula; Miró, María Victoria; Lanusse, Carlos Edmundo; Alvarez, Luis Ignacio; Lifschitz, Adrian Luis
Año de publicación
2021
Idioma
inglés
Tipo de recurso
documento de conferencia
Estado
versión publicada
Descripción
The current work assessed the relationship between pharmacokinetic behavior and clinical efficacy of the classic ivermectin (IVM) formulation (1%) and the long-acting ivermectin (IVM-LA) formulation (3.15%) to cattle. The study was carried out on a commercial beef cattle farm with a grazing system of meat produticon. Twenty (20) calves with active mange infection were allocated into 2 groups (n=10) and treated with a single subcutaneous injection of either IVM (1%) at 0.2 mg/kg or IVM-LA (3.15%) at 0.63 mg/kg. The animals were weighed on a calibrated weighing scale to determine the dose prior to treatment. Blood samples were collected from 8 animals of each group to measure IVM concentrations by HPLC. Skin scraping samples were collected from each animal and mites were counted at 14, 21 and 28 days post-treatment. IVM-LA administration increased the systemic drug exposure compared to the classic IVM formulation (p<0.05). However, both formulations failed to achieve a clinical mange cure. While the classic IVM formulation obtained an acaricide efficacy of 0%, IVM-LA achieved an efficacy of 25% at day 14 post-treatment. The IVM-LA treatment reached the higher acaricide efficacy (38%) at 21 days post-treatment. The non-cured animals remained with active mange 28 days post-treatment. No differences (p>0.05) in the Psoroptic ovis scores density were observed after both formulations of IVM. Considering the reduction in mite counts is reported to be a suitable parameter to monitor acaricide resistance, the results of the present trial have shown the presence of P. ovis populations with reduced susceptibility to IVM. However, additional studies are needed both to confirm the resistance status and to opmize the control of psoroptic mange in cattle in the new acaricide resistance scenario.
Fil: Cantón, Candela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Muchiut, Sebastián Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Dominguez, Maria Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Miró, María Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Lanusse, Carlos Edmundo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Alvarez, Luis Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Lifschitz, Adrian Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
28º Conference of the World Association for the Advancement of Veterinary Parasitology
Dublin
Irlanda
World Association for the Advancement of Veterinary Parasitology WAAVP
University College of Dublin
Materia
Psoroptic mange
Cattle
Ivermectin
Failure
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/156958
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Failure of long-acting ivermectin formulation to control Psoroptic mange infection in grazing beef cattleCantón, CandelaMuchiut, Sebastián ManuelDominguez, Maria PaulaMiró, María VictoriaLanusse, Carlos EdmundoAlvarez, Luis IgnacioLifschitz, Adrian LuisPsoroptic mangeCattleIvermectinFailurehttps://purl.org/becyt/ford/4.3https://purl.org/becyt/ford/4The current work assessed the relationship between pharmacokinetic behavior and clinical efficacy of the classic ivermectin (IVM) formulation (1%) and the long-acting ivermectin (IVM-LA) formulation (3.15%) to cattle. The study was carried out on a commercial beef cattle farm with a grazing system of meat produticon. Twenty (20) calves with active mange infection were allocated into 2 groups (n=10) and treated with a single subcutaneous injection of either IVM (1%) at 0.2 mg/kg or IVM-LA (3.15%) at 0.63 mg/kg. The animals were weighed on a calibrated weighing scale to determine the dose prior to treatment. Blood samples were collected from 8 animals of each group to measure IVM concentrations by HPLC. Skin scraping samples were collected from each animal and mites were counted at 14, 21 and 28 days post-treatment. IVM-LA administration increased the systemic drug exposure compared to the classic IVM formulation (p<0.05). However, both formulations failed to achieve a clinical mange cure. While the classic IVM formulation obtained an acaricide efficacy of 0%, IVM-LA achieved an efficacy of 25% at day 14 post-treatment. The IVM-LA treatment reached the higher acaricide efficacy (38%) at 21 days post-treatment. The non-cured animals remained with active mange 28 days post-treatment. No differences (p>0.05) in the Psoroptic ovis scores density were observed after both formulations of IVM. Considering the reduction in mite counts is reported to be a suitable parameter to monitor acaricide resistance, the results of the present trial have shown the presence of P. ovis populations with reduced susceptibility to IVM. However, additional studies are needed both to confirm the resistance status and to opmize the control of psoroptic mange in cattle in the new acaricide resistance scenario.Fil: Cantón, Candela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; ArgentinaFil: Muchiut, Sebastián Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; ArgentinaFil: Dominguez, Maria Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; ArgentinaFil: Miró, María Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; ArgentinaFil: Lanusse, Carlos Edmundo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; ArgentinaFil: Alvarez, Luis Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; ArgentinaFil: Lifschitz, Adrian Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina28º Conference of the World Association for the Advancement of Veterinary ParasitologyDublinIrlandaWorld Association for the Advancement of Veterinary Parasitology WAAVPUniversity College of DublinWorld Association for the Advancement of Veterinary Parasitology2021info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectConferenciaBookhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/156958Failure of long-acting ivermectin formulation to control Psoroptic mange infection in grazing beef cattle; 28º Conference of the World Association for the Advancement of Veterinary Parasitology; Dublin; Irlanda; 2021; 1-2CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.waavp2021.com/info:eu-repo/semantics/altIdentifier/url/http://www.waavp2021.com/wp-content/uploads/2021/08/WAAVP-2021-Abstract-book-22.07.21-FINAL.pdfInternacionalinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:08:26Zoai:ri.conicet.gov.ar:11336/156958instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:08:26.595CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Failure of long-acting ivermectin formulation to control Psoroptic mange infection in grazing beef cattle
title Failure of long-acting ivermectin formulation to control Psoroptic mange infection in grazing beef cattle
spellingShingle Failure of long-acting ivermectin formulation to control Psoroptic mange infection in grazing beef cattle
Cantón, Candela
Psoroptic mange
Cattle
Ivermectin
Failure
title_short Failure of long-acting ivermectin formulation to control Psoroptic mange infection in grazing beef cattle
title_full Failure of long-acting ivermectin formulation to control Psoroptic mange infection in grazing beef cattle
title_fullStr Failure of long-acting ivermectin formulation to control Psoroptic mange infection in grazing beef cattle
title_full_unstemmed Failure of long-acting ivermectin formulation to control Psoroptic mange infection in grazing beef cattle
title_sort Failure of long-acting ivermectin formulation to control Psoroptic mange infection in grazing beef cattle
dc.creator.none.fl_str_mv Cantón, Candela
Muchiut, Sebastián Manuel
Dominguez, Maria Paula
Miró, María Victoria
Lanusse, Carlos Edmundo
Alvarez, Luis Ignacio
Lifschitz, Adrian Luis
author Cantón, Candela
author_facet Cantón, Candela
Muchiut, Sebastián Manuel
Dominguez, Maria Paula
Miró, María Victoria
Lanusse, Carlos Edmundo
Alvarez, Luis Ignacio
Lifschitz, Adrian Luis
author_role author
author2 Muchiut, Sebastián Manuel
Dominguez, Maria Paula
Miró, María Victoria
Lanusse, Carlos Edmundo
Alvarez, Luis Ignacio
Lifschitz, Adrian Luis
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Psoroptic mange
Cattle
Ivermectin
Failure
topic Psoroptic mange
Cattle
Ivermectin
Failure
purl_subject.fl_str_mv https://purl.org/becyt/ford/4.3
https://purl.org/becyt/ford/4
dc.description.none.fl_txt_mv The current work assessed the relationship between pharmacokinetic behavior and clinical efficacy of the classic ivermectin (IVM) formulation (1%) and the long-acting ivermectin (IVM-LA) formulation (3.15%) to cattle. The study was carried out on a commercial beef cattle farm with a grazing system of meat produticon. Twenty (20) calves with active mange infection were allocated into 2 groups (n=10) and treated with a single subcutaneous injection of either IVM (1%) at 0.2 mg/kg or IVM-LA (3.15%) at 0.63 mg/kg. The animals were weighed on a calibrated weighing scale to determine the dose prior to treatment. Blood samples were collected from 8 animals of each group to measure IVM concentrations by HPLC. Skin scraping samples were collected from each animal and mites were counted at 14, 21 and 28 days post-treatment. IVM-LA administration increased the systemic drug exposure compared to the classic IVM formulation (p<0.05). However, both formulations failed to achieve a clinical mange cure. While the classic IVM formulation obtained an acaricide efficacy of 0%, IVM-LA achieved an efficacy of 25% at day 14 post-treatment. The IVM-LA treatment reached the higher acaricide efficacy (38%) at 21 days post-treatment. The non-cured animals remained with active mange 28 days post-treatment. No differences (p>0.05) in the Psoroptic ovis scores density were observed after both formulations of IVM. Considering the reduction in mite counts is reported to be a suitable parameter to monitor acaricide resistance, the results of the present trial have shown the presence of P. ovis populations with reduced susceptibility to IVM. However, additional studies are needed both to confirm the resistance status and to opmize the control of psoroptic mange in cattle in the new acaricide resistance scenario.
Fil: Cantón, Candela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Muchiut, Sebastián Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Dominguez, Maria Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Miró, María Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Lanusse, Carlos Edmundo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Alvarez, Luis Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Lifschitz, Adrian Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
28º Conference of the World Association for the Advancement of Veterinary Parasitology
Dublin
Irlanda
World Association for the Advancement of Veterinary Parasitology WAAVP
University College of Dublin
description The current work assessed the relationship between pharmacokinetic behavior and clinical efficacy of the classic ivermectin (IVM) formulation (1%) and the long-acting ivermectin (IVM-LA) formulation (3.15%) to cattle. The study was carried out on a commercial beef cattle farm with a grazing system of meat produticon. Twenty (20) calves with active mange infection were allocated into 2 groups (n=10) and treated with a single subcutaneous injection of either IVM (1%) at 0.2 mg/kg or IVM-LA (3.15%) at 0.63 mg/kg. The animals were weighed on a calibrated weighing scale to determine the dose prior to treatment. Blood samples were collected from 8 animals of each group to measure IVM concentrations by HPLC. Skin scraping samples were collected from each animal and mites were counted at 14, 21 and 28 days post-treatment. IVM-LA administration increased the systemic drug exposure compared to the classic IVM formulation (p<0.05). However, both formulations failed to achieve a clinical mange cure. While the classic IVM formulation obtained an acaricide efficacy of 0%, IVM-LA achieved an efficacy of 25% at day 14 post-treatment. The IVM-LA treatment reached the higher acaricide efficacy (38%) at 21 days post-treatment. The non-cured animals remained with active mange 28 days post-treatment. No differences (p>0.05) in the Psoroptic ovis scores density were observed after both formulations of IVM. Considering the reduction in mite counts is reported to be a suitable parameter to monitor acaricide resistance, the results of the present trial have shown the presence of P. ovis populations with reduced susceptibility to IVM. However, additional studies are needed both to confirm the resistance status and to opmize the control of psoroptic mange in cattle in the new acaricide resistance scenario.
publishDate 2021
dc.date.none.fl_str_mv 2021
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Failure of long-acting ivermectin formulation to control Psoroptic mange infection in grazing beef cattle; 28º Conference of the World Association for the Advancement of Veterinary Parasitology; Dublin; Irlanda; 2021; 1-2
CONICET Digital
CONICET
url http://hdl.handle.net/11336/156958
identifier_str_mv Failure of long-acting ivermectin formulation to control Psoroptic mange infection in grazing beef cattle; 28º Conference of the World Association for the Advancement of Veterinary Parasitology; Dublin; Irlanda; 2021; 1-2
CONICET Digital
CONICET
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dc.publisher.none.fl_str_mv World Association for the Advancement of Veterinary Parasitology
publisher.none.fl_str_mv World Association for the Advancement of Veterinary Parasitology
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