First report of in vitro resistance of Psoroptes ovis to ivermectin in Argentina

Autores
Soler, Paula; Germano, Monica Daniela; Larroza, Marcela Patricia
Año de publicación
2022
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Sheep scab, or psoroptic mange, a disease caused by the mite Psoroptes ovis, is commonly treated with ivermectin (IVM) and other macrocyclic lactones. In Argentina, in vivo trials have shown a decrease in IVM effectiveness to treat both sheep and bovine scab. In this work, we used an in vitro technique to establish the efficacy of IVM and two other macrocyclic lactones, doramectin (DRM) and moxidectin (MXD), against P. ovis in sheep. Mites were exposed to plates with culture medium and either ethanol or each of the acaricides, and mite mortality at a diagnostic concentration of IVM was assessed. Total survival in one of the strains studied demonstrated the presence of resistance, associated with control failures previously described by the authors. These resistant mites also presented larger LC50 values for both DRM and MXD than expected. Since, in in vivo trials, we had also previously observed a decrease in DRM effectiveness, cross-resistance may exist between DRM and IVM. We propose the use of in vitro tests to evaluate the efficacy of acaricides, considering their practicality, low cost and proven usefulness in detecting resistance in cases of low effectiveness against sheep scab
Estación Experimental Agropecuaria Bariloche
Fil: Soler, Paula. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche. Area de Produccion Animal. Grupo de Sanidad Animal; Argentina
Fil: Germano, Monica Daniela. Instituto Nacional de Tecnologia Agropecuaria (INTA). Estacion Experimental Agropecuaria Bariloche; Argentina
Fil: Germano, Monica Daniela. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Instituto de Investigaciones Forestales y Agropecuarias Bariloche; Argentina
Fil: Larroza, Marcela Patricia. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche. Area de Produccion Animal. Grupo de Sanidad Animal; Argentina
Fuente
Experimental Parasitology 235 : Art. 108229 (Abril 2022)
Materia
Sanidad Animal
Sarna
Sarna Psoróptica
Enfermedades Parasitarias
Ivermectina
Animal Health
Mange
Psoroptic Mange
Parasitoses
Ivermectin
Nivel de accesibilidad
acceso restringido
Condiciones de uso
Repositorio
INTA Digital (INTA)
Institución
Instituto Nacional de Tecnología Agropecuaria
OAI Identificador
oai:localhost:20.500.12123/11410
Acceder
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oai_identifier_str oai:localhost:20.500.12123/11410
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spelling First report of in vitro resistance of Psoroptes ovis to ivermectin in ArgentinaSoler, PaulaGermano, Monica DanielaLarroza, Marcela PatriciaSanidad AnimalSarnaSarna PsorópticaEnfermedades ParasitariasIvermectinaAnimal HealthMangePsoroptic MangeParasitosesIvermectinSheep scab, or psoroptic mange, a disease caused by the mite Psoroptes ovis, is commonly treated with ivermectin (IVM) and other macrocyclic lactones. In Argentina, in vivo trials have shown a decrease in IVM effectiveness to treat both sheep and bovine scab. In this work, we used an in vitro technique to establish the efficacy of IVM and two other macrocyclic lactones, doramectin (DRM) and moxidectin (MXD), against P. ovis in sheep. Mites were exposed to plates with culture medium and either ethanol or each of the acaricides, and mite mortality at a diagnostic concentration of IVM was assessed. Total survival in one of the strains studied demonstrated the presence of resistance, associated with control failures previously described by the authors. These resistant mites also presented larger LC50 values for both DRM and MXD than expected. Since, in in vivo trials, we had also previously observed a decrease in DRM effectiveness, cross-resistance may exist between DRM and IVM. We propose the use of in vitro tests to evaluate the efficacy of acaricides, considering their practicality, low cost and proven usefulness in detecting resistance in cases of low effectiveness against sheep scabEstación Experimental Agropecuaria BarilocheFil: Soler, Paula. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche. Area de Produccion Animal. Grupo de Sanidad Animal; ArgentinaFil: Germano, Monica Daniela. Instituto Nacional de Tecnologia Agropecuaria (INTA). Estacion Experimental Agropecuaria Bariloche; ArgentinaFil: Germano, Monica Daniela. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Instituto de Investigaciones Forestales y Agropecuarias Bariloche; ArgentinaFil: Larroza, Marcela Patricia. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche. Area de Produccion Animal. Grupo de Sanidad Animal; ArgentinaElsevier2022-03-15T21:31:38Z2022-03-15T21:31:38Z2022-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfhttp://hdl.handle.net/20.500.12123/11410https://www.sciencedirect.com/science/article/abs/pii/S00144894220002360014-4894https://doi.org/10.1016/j.exppara.2022.108229Experimental Parasitology 235 : Art. 108229 (Abril 2022)reponame:INTA Digital (INTA)instname:Instituto Nacional de Tecnología Agropecuariaenginfo:eu-repograntAgreement/INTA/2019-PD-E5-I104-001/2019-PD-E5-I104-001/AR./Estudios sobre generación de resistencia a los antimicrobianos y desarrollo de alternativas profilácticas y terapéuticasinfo:eu-repograntAgreement/INTA/2019-PE-E1-I002-001/2019-PE-E1-I002-001/AR./Tecnologías sostenibles para la estabilización y mejora de la competitividad de las cadenas productivas de ovinos, caprinos y camélidos sudamericanos.info:eu-repo/semantics/restrictedAccess2025-09-04T09:49:17Zoai:localhost:20.500.12123/11410instacron:INTAInstitucionalhttp://repositorio.inta.gob.ar/Organismo científico-tecnológicoNo correspondehttp://repositorio.inta.gob.ar/oai/requesttripaldi.nicolas@inta.gob.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:l2025-09-04 09:49:17.906INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuariafalse
dc.title.none.fl_str_mv First report of in vitro resistance of Psoroptes ovis to ivermectin in Argentina
title First report of in vitro resistance of Psoroptes ovis to ivermectin in Argentina
spellingShingle First report of in vitro resistance of Psoroptes ovis to ivermectin in Argentina
Soler, Paula
Sanidad Animal
Sarna
Sarna Psoróptica
Enfermedades Parasitarias
Ivermectina
Animal Health
Mange
Psoroptic Mange
Parasitoses
Ivermectin
title_short First report of in vitro resistance of Psoroptes ovis to ivermectin in Argentina
title_full First report of in vitro resistance of Psoroptes ovis to ivermectin in Argentina
title_fullStr First report of in vitro resistance of Psoroptes ovis to ivermectin in Argentina
title_full_unstemmed First report of in vitro resistance of Psoroptes ovis to ivermectin in Argentina
title_sort First report of in vitro resistance of Psoroptes ovis to ivermectin in Argentina
dc.creator.none.fl_str_mv Soler, Paula
Germano, Monica Daniela
Larroza, Marcela Patricia
author Soler, Paula
author_facet Soler, Paula
Germano, Monica Daniela
Larroza, Marcela Patricia
author_role author
author2 Germano, Monica Daniela
Larroza, Marcela Patricia
author2_role author
author
dc.subject.none.fl_str_mv Sanidad Animal
Sarna
Sarna Psoróptica
Enfermedades Parasitarias
Ivermectina
Animal Health
Mange
Psoroptic Mange
Parasitoses
Ivermectin
topic Sanidad Animal
Sarna
Sarna Psoróptica
Enfermedades Parasitarias
Ivermectina
Animal Health
Mange
Psoroptic Mange
Parasitoses
Ivermectin
dc.description.none.fl_txt_mv Sheep scab, or psoroptic mange, a disease caused by the mite Psoroptes ovis, is commonly treated with ivermectin (IVM) and other macrocyclic lactones. In Argentina, in vivo trials have shown a decrease in IVM effectiveness to treat both sheep and bovine scab. In this work, we used an in vitro technique to establish the efficacy of IVM and two other macrocyclic lactones, doramectin (DRM) and moxidectin (MXD), against P. ovis in sheep. Mites were exposed to plates with culture medium and either ethanol or each of the acaricides, and mite mortality at a diagnostic concentration of IVM was assessed. Total survival in one of the strains studied demonstrated the presence of resistance, associated with control failures previously described by the authors. These resistant mites also presented larger LC50 values for both DRM and MXD than expected. Since, in in vivo trials, we had also previously observed a decrease in DRM effectiveness, cross-resistance may exist between DRM and IVM. We propose the use of in vitro tests to evaluate the efficacy of acaricides, considering their practicality, low cost and proven usefulness in detecting resistance in cases of low effectiveness against sheep scab
Estación Experimental Agropecuaria Bariloche
Fil: Soler, Paula. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche. Area de Produccion Animal. Grupo de Sanidad Animal; Argentina
Fil: Germano, Monica Daniela. Instituto Nacional de Tecnologia Agropecuaria (INTA). Estacion Experimental Agropecuaria Bariloche; Argentina
Fil: Germano, Monica Daniela. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Instituto de Investigaciones Forestales y Agropecuarias Bariloche; Argentina
Fil: Larroza, Marcela Patricia. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche. Area de Produccion Animal. Grupo de Sanidad Animal; Argentina
description Sheep scab, or psoroptic mange, a disease caused by the mite Psoroptes ovis, is commonly treated with ivermectin (IVM) and other macrocyclic lactones. In Argentina, in vivo trials have shown a decrease in IVM effectiveness to treat both sheep and bovine scab. In this work, we used an in vitro technique to establish the efficacy of IVM and two other macrocyclic lactones, doramectin (DRM) and moxidectin (MXD), against P. ovis in sheep. Mites were exposed to plates with culture medium and either ethanol or each of the acaricides, and mite mortality at a diagnostic concentration of IVM was assessed. Total survival in one of the strains studied demonstrated the presence of resistance, associated with control failures previously described by the authors. These resistant mites also presented larger LC50 values for both DRM and MXD than expected. Since, in in vivo trials, we had also previously observed a decrease in DRM effectiveness, cross-resistance may exist between DRM and IVM. We propose the use of in vitro tests to evaluate the efficacy of acaricides, considering their practicality, low cost and proven usefulness in detecting resistance in cases of low effectiveness against sheep scab
publishDate 2022
dc.date.none.fl_str_mv 2022-03-15T21:31:38Z
2022-03-15T21:31:38Z
2022-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12123/11410
https://www.sciencedirect.com/science/article/abs/pii/S0014489422000236
0014-4894
https://doi.org/10.1016/j.exppara.2022.108229
url http://hdl.handle.net/20.500.12123/11410
https://www.sciencedirect.com/science/article/abs/pii/S0014489422000236
https://doi.org/10.1016/j.exppara.2022.108229
identifier_str_mv 0014-4894
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repograntAgreement/INTA/2019-PD-E5-I104-001/2019-PD-E5-I104-001/AR./Estudios sobre generación de resistencia a los antimicrobianos y desarrollo de alternativas profilácticas y terapéuticas
info:eu-repograntAgreement/INTA/2019-PE-E1-I002-001/2019-PE-E1-I002-001/AR./Tecnologías sostenibles para la estabilización y mejora de la competitividad de las cadenas productivas de ovinos, caprinos y camélidos sudamericanos.
dc.rights.none.fl_str_mv info:eu-repo/semantics/restrictedAccess
eu_rights_str_mv restrictedAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv Experimental Parasitology 235 : Art. 108229 (Abril 2022)
reponame:INTA Digital (INTA)
instname:Instituto Nacional de Tecnología Agropecuaria
reponame_str INTA Digital (INTA)
collection INTA Digital (INTA)
instname_str Instituto Nacional de Tecnología Agropecuaria
repository.name.fl_str_mv INTA Digital (INTA) - Instituto Nacional de Tecnología Agropecuaria
repository.mail.fl_str_mv tripaldi.nicolas@inta.gob.ar
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score 12.623145

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