Sedative and cardiovascular effects of Aloysia citriodora Palau, on mice and rats

Autores
Ragone, María Inés; Sella, Mariana; Pastore, Agustín; Consolini, Alicia Elvira
Año de publicación
2010
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Aloysia citriodora Palau, Verbenaceae (“cedrón”) is widely used as infusion or decoction in South America to treat indigestion, tachycardia and anxiety. We previously demonstrated its antispasmodic effect on rat duodenum. Now, its aqueous extract (AEC) from 1 to 10 mg/kg was sedative in mice on the open-field, effect which was potentiated by diazepam and sensitive to flumazenil. In normotensive rats, 1 to 30 mg AEC/kg induced a transitory hypotension, insensitive to atropine and L-NAME. Regarding an effect on α-adrenergic receptors, AEC non-competitively blocked the phenylephrine contraction on vas deferens. In isolated rat hearts, AEC induced negative inotropism, as well as vitexin, the main component. Then, the benzodiazepine-like sedation, negative inotropism and antispasmodic effect preclinically justify its popular use for abdominal cramps and as coadjuvant for anxiety and angor.
Fil: Ragone, María Inés. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Cátedra de Farmacología; Argentina
Fil: Sella, Mariana. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Cátedra de Farmacología; Argentina
Fil: Pastore, Agustín. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Cátedra de Farmacología; Argentina
Fil: Consolini, Alicia Elvira. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Cátedra de Farmacología; Argentina
Materia
ALOYSIA CITRIODORA
CARDIAC INOTROPISM
HYPOTENSIVE
OPEN-FIELD
SEDATIVE
VITEXIN
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/197948
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Sedative and cardiovascular effects of Aloysia citriodora Palau, on mice and ratsRagone, María InésSella, MarianaPastore, AgustínConsolini, Alicia ElviraALOYSIA CITRIODORACARDIAC INOTROPISMHYPOTENSIVEOPEN-FIELDSEDATIVEVITEXINhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Aloysia citriodora Palau, Verbenaceae (“cedrón”) is widely used as infusion or decoction in South America to treat indigestion, tachycardia and anxiety. We previously demonstrated its antispasmodic effect on rat duodenum. Now, its aqueous extract (AEC) from 1 to 10 mg/kg was sedative in mice on the open-field, effect which was potentiated by diazepam and sensitive to flumazenil. In normotensive rats, 1 to 30 mg AEC/kg induced a transitory hypotension, insensitive to atropine and L-NAME. Regarding an effect on α-adrenergic receptors, AEC non-competitively blocked the phenylephrine contraction on vas deferens. In isolated rat hearts, AEC induced negative inotropism, as well as vitexin, the main component. Then, the benzodiazepine-like sedation, negative inotropism and antispasmodic effect preclinically justify its popular use for abdominal cramps and as coadjuvant for anxiety and angor.Fil: Ragone, María Inés. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Cátedra de Farmacología; ArgentinaFil: Sella, Mariana. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Cátedra de Farmacología; ArgentinaFil: Pastore, Agustín. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Cátedra de Farmacología; ArgentinaFil: Consolini, Alicia Elvira. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Cátedra de Farmacología; ArgentinaColegio de Farmacéuticos de Provincia de Buenos Aires2010-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/197948Ragone, María Inés; Sella, Mariana; Pastore, Agustín; Consolini, Alicia Elvira; Sedative and cardiovascular effects of Aloysia citriodora Palau, on mice and rats; Colegio de Farmacéuticos de Provincia de Buenos Aires; Latin American Journal of Pharmacy; 29; 1; 1-2010; 79-860326-23832362-3853CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.latamjpharm.org/trabajos/29/1/LAJOP_29_1_1_11_A6K2OA3P16.pdfinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:32:13Zoai:ri.conicet.gov.ar:11336/197948instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:32:13.734CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Sedative and cardiovascular effects of Aloysia citriodora Palau, on mice and rats
title Sedative and cardiovascular effects of Aloysia citriodora Palau, on mice and rats
spellingShingle Sedative and cardiovascular effects of Aloysia citriodora Palau, on mice and rats
Ragone, María Inés
ALOYSIA CITRIODORA
CARDIAC INOTROPISM
HYPOTENSIVE
OPEN-FIELD
SEDATIVE
VITEXIN
title_short Sedative and cardiovascular effects of Aloysia citriodora Palau, on mice and rats
title_full Sedative and cardiovascular effects of Aloysia citriodora Palau, on mice and rats
title_fullStr Sedative and cardiovascular effects of Aloysia citriodora Palau, on mice and rats
title_full_unstemmed Sedative and cardiovascular effects of Aloysia citriodora Palau, on mice and rats
title_sort Sedative and cardiovascular effects of Aloysia citriodora Palau, on mice and rats
dc.creator.none.fl_str_mv Ragone, María Inés
Sella, Mariana
Pastore, Agustín
Consolini, Alicia Elvira
author Ragone, María Inés
author_facet Ragone, María Inés
Sella, Mariana
Pastore, Agustín
Consolini, Alicia Elvira
author_role author
author2 Sella, Mariana
Pastore, Agustín
Consolini, Alicia Elvira
author2_role author
author
author
dc.subject.none.fl_str_mv ALOYSIA CITRIODORA
CARDIAC INOTROPISM
HYPOTENSIVE
OPEN-FIELD
SEDATIVE
VITEXIN
topic ALOYSIA CITRIODORA
CARDIAC INOTROPISM
HYPOTENSIVE
OPEN-FIELD
SEDATIVE
VITEXIN
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Aloysia citriodora Palau, Verbenaceae (“cedrón”) is widely used as infusion or decoction in South America to treat indigestion, tachycardia and anxiety. We previously demonstrated its antispasmodic effect on rat duodenum. Now, its aqueous extract (AEC) from 1 to 10 mg/kg was sedative in mice on the open-field, effect which was potentiated by diazepam and sensitive to flumazenil. In normotensive rats, 1 to 30 mg AEC/kg induced a transitory hypotension, insensitive to atropine and L-NAME. Regarding an effect on α-adrenergic receptors, AEC non-competitively blocked the phenylephrine contraction on vas deferens. In isolated rat hearts, AEC induced negative inotropism, as well as vitexin, the main component. Then, the benzodiazepine-like sedation, negative inotropism and antispasmodic effect preclinically justify its popular use for abdominal cramps and as coadjuvant for anxiety and angor.
Fil: Ragone, María Inés. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Cátedra de Farmacología; Argentina
Fil: Sella, Mariana. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Cátedra de Farmacología; Argentina
Fil: Pastore, Agustín. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Cátedra de Farmacología; Argentina
Fil: Consolini, Alicia Elvira. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Cátedra de Farmacología; Argentina
description Aloysia citriodora Palau, Verbenaceae (“cedrón”) is widely used as infusion or decoction in South America to treat indigestion, tachycardia and anxiety. We previously demonstrated its antispasmodic effect on rat duodenum. Now, its aqueous extract (AEC) from 1 to 10 mg/kg was sedative in mice on the open-field, effect which was potentiated by diazepam and sensitive to flumazenil. In normotensive rats, 1 to 30 mg AEC/kg induced a transitory hypotension, insensitive to atropine and L-NAME. Regarding an effect on α-adrenergic receptors, AEC non-competitively blocked the phenylephrine contraction on vas deferens. In isolated rat hearts, AEC induced negative inotropism, as well as vitexin, the main component. Then, the benzodiazepine-like sedation, negative inotropism and antispasmodic effect preclinically justify its popular use for abdominal cramps and as coadjuvant for anxiety and angor.
publishDate 2010
dc.date.none.fl_str_mv 2010-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/197948
Ragone, María Inés; Sella, Mariana; Pastore, Agustín; Consolini, Alicia Elvira; Sedative and cardiovascular effects of Aloysia citriodora Palau, on mice and rats; Colegio de Farmacéuticos de Provincia de Buenos Aires; Latin American Journal of Pharmacy; 29; 1; 1-2010; 79-86
0326-2383
2362-3853
CONICET Digital
CONICET
url http://hdl.handle.net/11336/197948
identifier_str_mv Ragone, María Inés; Sella, Mariana; Pastore, Agustín; Consolini, Alicia Elvira; Sedative and cardiovascular effects of Aloysia citriodora Palau, on mice and rats; Colegio de Farmacéuticos de Provincia de Buenos Aires; Latin American Journal of Pharmacy; 29; 1; 1-2010; 79-86
0326-2383
2362-3853
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.latamjpharm.org/trabajos/29/1/LAJOP_29_1_1_11_A6K2OA3P16.pdf
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Colegio de Farmacéuticos de Provincia de Buenos Aires
publisher.none.fl_str_mv Colegio de Farmacéuticos de Provincia de Buenos Aires
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844614334946213888
score 13.070432

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