The protective role of the microenvironment in hairy cell leukemia treatment: Facts and perspectives

Autores
Gargiulo, Ernesto; Giordano, Mirta Nilda; Niemann, Carsten U.; Moussay, Etienne; Paggetti, Jérôme; Morande, Pablo Elías
Año de publicación
2023
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Hairy cell leukemia (HCL) is an incurable, rare lymphoproliferative hematological malignancy of mature B cAlthough first line therapy with purine analogues leads to positive results, almost half of HCL patients relapse after 5-10 years, and standard treatment may not be an option due to intolerance or refractoriness. Proliferation and survival of HCL cells is regulated by surrounding accessory cells and soluble signals present in the tumor microenvironment, which actively contributes to disease progression. In vitro studies show that different therapeutic approaches tested in HCL impact the tumor microenvironment, and that this milieu offers a protection affecting treatment efficacy. Herein we explore the effects of the tumor microenvironment to different approved and experimental therapeutic options for HCL. Dissecting the complex interactions between leukemia cells and their milieu will be essential to develop new targeted therapies for HCL patients.
Fil: Gargiulo, Ernesto. Luxembourg Institute Of Health; Luxemburgo. Chronic Lymphocytic Leukemia Laboratory; Dinamarca. PERSIMUNE; Dinamarca
Fil: Giordano, Mirta Nilda. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Niemann, Carsten U.. Chronic Lymphocytic Leukemia Laboratory; Dinamarca. Universidad de Copenhagen; Dinamarca
Fil: Moussay, Etienne. Luxembourg Institute Of Health; Luxemburgo
Fil: Paggetti, Jérôme. Luxembourg Institute Of Health; Luxemburgo
Fil: Morande, Pablo Elías. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina. Luxembourg Institute Of Health; Luxemburgo
Materia
HCL
LEUKEMIA MICROENVIRONMENT
MICROENVIRONMENT TARGETING
NOVEL THERAPIES
TREATMENT RESISTANCE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/227735
Acceder
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network_name_str CONICET Digital (CONICET)
spelling The protective role of the microenvironment in hairy cell leukemia treatment: Facts and perspectivesGargiulo, ErnestoGiordano, Mirta NildaNiemann, Carsten U.Moussay, EtiennePaggetti, JérômeMorande, Pablo ElíasHCLLEUKEMIA MICROENVIRONMENTMICROENVIRONMENT TARGETINGNOVEL THERAPIESTREATMENT RESISTANCEhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Hairy cell leukemia (HCL) is an incurable, rare lymphoproliferative hematological malignancy of mature B cAlthough first line therapy with purine analogues leads to positive results, almost half of HCL patients relapse after 5-10 years, and standard treatment may not be an option due to intolerance or refractoriness. Proliferation and survival of HCL cells is regulated by surrounding accessory cells and soluble signals present in the tumor microenvironment, which actively contributes to disease progression. In vitro studies show that different therapeutic approaches tested in HCL impact the tumor microenvironment, and that this milieu offers a protection affecting treatment efficacy. Herein we explore the effects of the tumor microenvironment to different approved and experimental therapeutic options for HCL. Dissecting the complex interactions between leukemia cells and their milieu will be essential to develop new targeted therapies for HCL patients.Fil: Gargiulo, Ernesto. Luxembourg Institute Of Health; Luxemburgo. Chronic Lymphocytic Leukemia Laboratory; Dinamarca. PERSIMUNE; DinamarcaFil: Giordano, Mirta Nilda. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: Niemann, Carsten U.. Chronic Lymphocytic Leukemia Laboratory; Dinamarca. Universidad de Copenhagen; DinamarcaFil: Moussay, Etienne. Luxembourg Institute Of Health; LuxemburgoFil: Paggetti, Jérôme. Luxembourg Institute Of Health; LuxemburgoFil: Morande, Pablo Elías. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina. Luxembourg Institute Of Health; LuxemburgoFrontiers Media2023-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/227735Gargiulo, Ernesto; Giordano, Mirta Nilda; Niemann, Carsten U.; Moussay, Etienne; Paggetti, Jérôme; et al.; The protective role of the microenvironment in hairy cell leukemia treatment: Facts and perspectives; Frontiers Media; Frontiers in Oncology; 13; 1122699; 3-2023; 1-102234-943XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2023.1122699/fullinfo:eu-repo/semantics/altIdentifier/doi/10.3389/fonc.2023.1122699info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:05:19Zoai:ri.conicet.gov.ar:11336/227735instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:05:20.178CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv The protective role of the microenvironment in hairy cell leukemia treatment: Facts and perspectives
title The protective role of the microenvironment in hairy cell leukemia treatment: Facts and perspectives
spellingShingle The protective role of the microenvironment in hairy cell leukemia treatment: Facts and perspectives
Gargiulo, Ernesto
HCL
LEUKEMIA MICROENVIRONMENT
MICROENVIRONMENT TARGETING
NOVEL THERAPIES
TREATMENT RESISTANCE
title_short The protective role of the microenvironment in hairy cell leukemia treatment: Facts and perspectives
title_full The protective role of the microenvironment in hairy cell leukemia treatment: Facts and perspectives
title_fullStr The protective role of the microenvironment in hairy cell leukemia treatment: Facts and perspectives
title_full_unstemmed The protective role of the microenvironment in hairy cell leukemia treatment: Facts and perspectives
title_sort The protective role of the microenvironment in hairy cell leukemia treatment: Facts and perspectives
dc.creator.none.fl_str_mv Gargiulo, Ernesto
Giordano, Mirta Nilda
Niemann, Carsten U.
Moussay, Etienne
Paggetti, Jérôme
Morande, Pablo Elías
author Gargiulo, Ernesto
author_facet Gargiulo, Ernesto
Giordano, Mirta Nilda
Niemann, Carsten U.
Moussay, Etienne
Paggetti, Jérôme
Morande, Pablo Elías
author_role author
author2 Giordano, Mirta Nilda
Niemann, Carsten U.
Moussay, Etienne
Paggetti, Jérôme
Morande, Pablo Elías
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv HCL
LEUKEMIA MICROENVIRONMENT
MICROENVIRONMENT TARGETING
NOVEL THERAPIES
TREATMENT RESISTANCE
topic HCL
LEUKEMIA MICROENVIRONMENT
MICROENVIRONMENT TARGETING
NOVEL THERAPIES
TREATMENT RESISTANCE
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Hairy cell leukemia (HCL) is an incurable, rare lymphoproliferative hematological malignancy of mature B cAlthough first line therapy with purine analogues leads to positive results, almost half of HCL patients relapse after 5-10 years, and standard treatment may not be an option due to intolerance or refractoriness. Proliferation and survival of HCL cells is regulated by surrounding accessory cells and soluble signals present in the tumor microenvironment, which actively contributes to disease progression. In vitro studies show that different therapeutic approaches tested in HCL impact the tumor microenvironment, and that this milieu offers a protection affecting treatment efficacy. Herein we explore the effects of the tumor microenvironment to different approved and experimental therapeutic options for HCL. Dissecting the complex interactions between leukemia cells and their milieu will be essential to develop new targeted therapies for HCL patients.
Fil: Gargiulo, Ernesto. Luxembourg Institute Of Health; Luxemburgo. Chronic Lymphocytic Leukemia Laboratory; Dinamarca. PERSIMUNE; Dinamarca
Fil: Giordano, Mirta Nilda. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Niemann, Carsten U.. Chronic Lymphocytic Leukemia Laboratory; Dinamarca. Universidad de Copenhagen; Dinamarca
Fil: Moussay, Etienne. Luxembourg Institute Of Health; Luxemburgo
Fil: Paggetti, Jérôme. Luxembourg Institute Of Health; Luxemburgo
Fil: Morande, Pablo Elías. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina. Luxembourg Institute Of Health; Luxemburgo
description Hairy cell leukemia (HCL) is an incurable, rare lymphoproliferative hematological malignancy of mature B cAlthough first line therapy with purine analogues leads to positive results, almost half of HCL patients relapse after 5-10 years, and standard treatment may not be an option due to intolerance or refractoriness. Proliferation and survival of HCL cells is regulated by surrounding accessory cells and soluble signals present in the tumor microenvironment, which actively contributes to disease progression. In vitro studies show that different therapeutic approaches tested in HCL impact the tumor microenvironment, and that this milieu offers a protection affecting treatment efficacy. Herein we explore the effects of the tumor microenvironment to different approved and experimental therapeutic options for HCL. Dissecting the complex interactions between leukemia cells and their milieu will be essential to develop new targeted therapies for HCL patients.
publishDate 2023
dc.date.none.fl_str_mv 2023-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/227735
Gargiulo, Ernesto; Giordano, Mirta Nilda; Niemann, Carsten U.; Moussay, Etienne; Paggetti, Jérôme; et al.; The protective role of the microenvironment in hairy cell leukemia treatment: Facts and perspectives; Frontiers Media; Frontiers in Oncology; 13; 1122699; 3-2023; 1-10
2234-943X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/227735
identifier_str_mv Gargiulo, Ernesto; Giordano, Mirta Nilda; Niemann, Carsten U.; Moussay, Etienne; Paggetti, Jérôme; et al.; The protective role of the microenvironment in hairy cell leukemia treatment: Facts and perspectives; Frontiers Media; Frontiers in Oncology; 13; 1122699; 3-2023; 1-10
2234-943X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2023.1122699/full
info:eu-repo/semantics/altIdentifier/doi/10.3389/fonc.2023.1122699
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.993085

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