Increasing microenvironment complexity in HL

Autores
Chabay, Paola Andrea
Año de publicación
2023
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
cHL is unique among lymphoid malignancies, given that malignant HRSC comprise less than 1% of the total cell population. HRSC secrete chemokines and cytokines that drive the formation of a complex microenvironment of nontumor cells. This microenvironment consists of both innate as well as adaptive immune cells.2 The extensive but ineffective immune cell infiltrates found in cHL suggest that HRSC have developed mechanisms to escape immunosurveillance. Furthermore, HRSC depend on microenvironmental signals for survival and growth. Even though many cHL patients are cured with current treatment regimens, 20% to 30% fail to respond or experience a relapse after treatment. Moreover, especially in adolescents and young adults, treatment-related toxicity and long-term morbidity are persistent challenges requiring more basic research to identify new therapeutic targets, particularly within this unique microenvironment.3,4 Stewart et al provide evidence for the first time of the expression of immunoregulatory checkpoints and the secretion of chemokines from previously uncharacterized cells that contribute to the exhaustion of T cells and contribute to immune evasion in cHL.
Fil: Chabay, Paola Andrea. Gobierno de la Ciudad de Buenos Aires. Instituto Multidisciplinario de Investigaciones en Patologías Pediátricas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto Multidisciplinario de Investigaciones en Patologías Pediátricas; Argentina
Materia
Hodgkin lymphoma
microenvironment
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/227646
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Increasing microenvironment complexity in HLChabay, Paola AndreaHodgkin lymphomamicroenvironmenthttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3cHL is unique among lymphoid malignancies, given that malignant HRSC comprise less than 1% of the total cell population. HRSC secrete chemokines and cytokines that drive the formation of a complex microenvironment of nontumor cells. This microenvironment consists of both innate as well as adaptive immune cells.2 The extensive but ineffective immune cell infiltrates found in cHL suggest that HRSC have developed mechanisms to escape immunosurveillance. Furthermore, HRSC depend on microenvironmental signals for survival and growth. Even though many cHL patients are cured with current treatment regimens, 20% to 30% fail to respond or experience a relapse after treatment. Moreover, especially in adolescents and young adults, treatment-related toxicity and long-term morbidity are persistent challenges requiring more basic research to identify new therapeutic targets, particularly within this unique microenvironment.3,4 Stewart et al provide evidence for the first time of the expression of immunoregulatory checkpoints and the secretion of chemokines from previously uncharacterized cells that contribute to the exhaustion of T cells and contribute to immune evasion in cHL.Fil: Chabay, Paola Andrea. Gobierno de la Ciudad de Buenos Aires. Instituto Multidisciplinario de Investigaciones en Patologías Pediátricas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto Multidisciplinario de Investigaciones en Patologías Pediátricas; ArgentinaAmerican Society of Hematology2023-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/227646Chabay, Paola Andrea; Increasing microenvironment complexity in HL; American Society of Hematology; Blood; 141; 19; 5-2023; 2290-22910006-4971CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1182/blood.2023019661info:eu-repo/semantics/altIdentifier/url/https://ashpublications.org/blood/article/141/19/2290/495579/Increasing-microenvironment-complexity-in-HLinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:22:30Zoai:ri.conicet.gov.ar:11336/227646instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:22:30.973CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Increasing microenvironment complexity in HL
title Increasing microenvironment complexity in HL
spellingShingle Increasing microenvironment complexity in HL
Chabay, Paola Andrea
Hodgkin lymphoma
microenvironment
title_short Increasing microenvironment complexity in HL
title_full Increasing microenvironment complexity in HL
title_fullStr Increasing microenvironment complexity in HL
title_full_unstemmed Increasing microenvironment complexity in HL
title_sort Increasing microenvironment complexity in HL
dc.creator.none.fl_str_mv Chabay, Paola Andrea
author Chabay, Paola Andrea
author_facet Chabay, Paola Andrea
author_role author
dc.subject.none.fl_str_mv Hodgkin lymphoma
microenvironment
topic Hodgkin lymphoma
microenvironment
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv cHL is unique among lymphoid malignancies, given that malignant HRSC comprise less than 1% of the total cell population. HRSC secrete chemokines and cytokines that drive the formation of a complex microenvironment of nontumor cells. This microenvironment consists of both innate as well as adaptive immune cells.2 The extensive but ineffective immune cell infiltrates found in cHL suggest that HRSC have developed mechanisms to escape immunosurveillance. Furthermore, HRSC depend on microenvironmental signals for survival and growth. Even though many cHL patients are cured with current treatment regimens, 20% to 30% fail to respond or experience a relapse after treatment. Moreover, especially in adolescents and young adults, treatment-related toxicity and long-term morbidity are persistent challenges requiring more basic research to identify new therapeutic targets, particularly within this unique microenvironment.3,4 Stewart et al provide evidence for the first time of the expression of immunoregulatory checkpoints and the secretion of chemokines from previously uncharacterized cells that contribute to the exhaustion of T cells and contribute to immune evasion in cHL.
Fil: Chabay, Paola Andrea. Gobierno de la Ciudad de Buenos Aires. Instituto Multidisciplinario de Investigaciones en Patologías Pediátricas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto Multidisciplinario de Investigaciones en Patologías Pediátricas; Argentina
description cHL is unique among lymphoid malignancies, given that malignant HRSC comprise less than 1% of the total cell population. HRSC secrete chemokines and cytokines that drive the formation of a complex microenvironment of nontumor cells. This microenvironment consists of both innate as well as adaptive immune cells.2 The extensive but ineffective immune cell infiltrates found in cHL suggest that HRSC have developed mechanisms to escape immunosurveillance. Furthermore, HRSC depend on microenvironmental signals for survival and growth. Even though many cHL patients are cured with current treatment regimens, 20% to 30% fail to respond or experience a relapse after treatment. Moreover, especially in adolescents and young adults, treatment-related toxicity and long-term morbidity are persistent challenges requiring more basic research to identify new therapeutic targets, particularly within this unique microenvironment.3,4 Stewart et al provide evidence for the first time of the expression of immunoregulatory checkpoints and the secretion of chemokines from previously uncharacterized cells that contribute to the exhaustion of T cells and contribute to immune evasion in cHL.
publishDate 2023
dc.date.none.fl_str_mv 2023-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/227646
Chabay, Paola Andrea; Increasing microenvironment complexity in HL; American Society of Hematology; Blood; 141; 19; 5-2023; 2290-2291
0006-4971
CONICET Digital
CONICET
url http://hdl.handle.net/11336/227646
identifier_str_mv Chabay, Paola Andrea; Increasing microenvironment complexity in HL; American Society of Hematology; Blood; 141; 19; 5-2023; 2290-2291
0006-4971
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1182/blood.2023019661
info:eu-repo/semantics/altIdentifier/url/https://ashpublications.org/blood/article/141/19/2290/495579/Increasing-microenvironment-complexity-in-HL
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Society of Hematology
publisher.none.fl_str_mv American Society of Hematology
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844614216810496000
score 13.070432

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