Methylation status regulates lipoprotein lipase expression in chronic lymphocytic leukemia

Autores
Abreu, Cecilia; Moreno, Pilar; Palacios, Florencia; Borge, Mercedes; Morande, Pablo Elías; Landoni, Ana Inés; Gabus, Raul; Dighiero, Guillermo; Giordano, Mirta Nilda; Gamberale, Romina; Oppezzo, Pablo
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Among different prognostic factors in chronic lymphocytic leukemia (CLL), we previously demonstrated that lipoprotein lipase (LPL) is associated with an unmutated immunoglobulin profile and clinical poor outcome. Despite the usefulness of LPL for CLL prognosis, its functional role and the molecular mechanism regulating its expression are still open questions. Interaction of CLL B-cells with the tissue microenvironment favors disease progression by promoting malignant B-cell growth. Since tissue methylation can be altered by environmental factors, we investigated the methylation status of the LPL gene and the possibility that overexpression could be associated with microenvironment signals. Our results show that a demethylated state of the LPL gene is responsible for its anomalous expression in unmutated CLL cases and that this expression is dependent on microenvironment signals. Overall, this work proposes that an epigenetic mechanism, triggered by the microenvironment, regulates LPL expression in CLL disease.
Fil: Abreu, Cecilia. Instituto Pasteur de Montevideo; Uruguay
Fil: Moreno, Pilar. Instituto Pasteur de Montevideo; Uruguay
Fil: Palacios, Florencia. Instituto Pasteur de Montevideo; Uruguay
Fil: Borge, Mercedes. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Morande, Pablo Elías. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Landoni, Ana Inés. Hospital Maciel; Uruguay
Fil: Gabus, Raul. Hospital Maciel; Uruguay
Fil: Dighiero, Guillermo. Hospital Maciel; Uruguay
Fil: Giordano, Mirta Nilda. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Gamberale, Romina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Oppezzo, Pablo. Universidad de la República; Uruguay
Materia
Lipoprotein Lipase
Leukemia
Methylation
Microenvironment
Prognostic Factors
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/20863
Acceder
id CONICETDig_ec06de1c39ca50697d115f75f5967c06
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Methylation status regulates lipoprotein lipase expression in chronic lymphocytic leukemiaAbreu, CeciliaMoreno, PilarPalacios, FlorenciaBorge, MercedesMorande, Pablo ElíasLandoni, Ana InésGabus, RaulDighiero, GuillermoGiordano, Mirta NildaGamberale, RominaOppezzo, PabloLipoprotein LipaseLeukemiaMethylationMicroenvironmentPrognostic Factorshttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Among different prognostic factors in chronic lymphocytic leukemia (CLL), we previously demonstrated that lipoprotein lipase (LPL) is associated with an unmutated immunoglobulin profile and clinical poor outcome. Despite the usefulness of LPL for CLL prognosis, its functional role and the molecular mechanism regulating its expression are still open questions. Interaction of CLL B-cells with the tissue microenvironment favors disease progression by promoting malignant B-cell growth. Since tissue methylation can be altered by environmental factors, we investigated the methylation status of the LPL gene and the possibility that overexpression could be associated with microenvironment signals. Our results show that a demethylated state of the LPL gene is responsible for its anomalous expression in unmutated CLL cases and that this expression is dependent on microenvironment signals. Overall, this work proposes that an epigenetic mechanism, triggered by the microenvironment, regulates LPL expression in CLL disease.Fil: Abreu, Cecilia. Instituto Pasteur de Montevideo; UruguayFil: Moreno, Pilar. Instituto Pasteur de Montevideo; UruguayFil: Palacios, Florencia. Instituto Pasteur de Montevideo; UruguayFil: Borge, Mercedes. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: Morande, Pablo Elías. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: Landoni, Ana Inés. Hospital Maciel; UruguayFil: Gabus, Raul. Hospital Maciel; UruguayFil: Dighiero, Guillermo. Hospital Maciel; UruguayFil: Giordano, Mirta Nilda. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: Gamberale, Romina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: Oppezzo, Pablo. Universidad de la República; UruguayTaylor & Francis2013-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/20863Abreu, Cecilia; Moreno, Pilar; Palacios, Florencia; Borge, Mercedes; Morande, Pablo Elías; et al.; Methylation status regulates lipoprotein lipase expression in chronic lymphocytic leukemia; Taylor & Francis; Leukemia and Lymphoma; 54; 8; 8-2013; 1844-18481042-8194CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.3109/10428194.2013.796057info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/full/10.3109/10428194.2013.796057info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:48:28Zoai:ri.conicet.gov.ar:11336/20863instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:48:28.505CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Methylation status regulates lipoprotein lipase expression in chronic lymphocytic leukemia
title Methylation status regulates lipoprotein lipase expression in chronic lymphocytic leukemia
spellingShingle Methylation status regulates lipoprotein lipase expression in chronic lymphocytic leukemia
Abreu, Cecilia
Lipoprotein Lipase
Leukemia
Methylation
Microenvironment
Prognostic Factors
title_short Methylation status regulates lipoprotein lipase expression in chronic lymphocytic leukemia
title_full Methylation status regulates lipoprotein lipase expression in chronic lymphocytic leukemia
title_fullStr Methylation status regulates lipoprotein lipase expression in chronic lymphocytic leukemia
title_full_unstemmed Methylation status regulates lipoprotein lipase expression in chronic lymphocytic leukemia
title_sort Methylation status regulates lipoprotein lipase expression in chronic lymphocytic leukemia
dc.creator.none.fl_str_mv Abreu, Cecilia
Moreno, Pilar
Palacios, Florencia
Borge, Mercedes
Morande, Pablo Elías
Landoni, Ana Inés
Gabus, Raul
Dighiero, Guillermo
Giordano, Mirta Nilda
Gamberale, Romina
Oppezzo, Pablo
author Abreu, Cecilia
author_facet Abreu, Cecilia
Moreno, Pilar
Palacios, Florencia
Borge, Mercedes
Morande, Pablo Elías
Landoni, Ana Inés
Gabus, Raul
Dighiero, Guillermo
Giordano, Mirta Nilda
Gamberale, Romina
Oppezzo, Pablo
author_role author
author2 Moreno, Pilar
Palacios, Florencia
Borge, Mercedes
Morande, Pablo Elías
Landoni, Ana Inés
Gabus, Raul
Dighiero, Guillermo
Giordano, Mirta Nilda
Gamberale, Romina
Oppezzo, Pablo
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Lipoprotein Lipase
Leukemia
Methylation
Microenvironment
Prognostic Factors
topic Lipoprotein Lipase
Leukemia
Methylation
Microenvironment
Prognostic Factors
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Among different prognostic factors in chronic lymphocytic leukemia (CLL), we previously demonstrated that lipoprotein lipase (LPL) is associated with an unmutated immunoglobulin profile and clinical poor outcome. Despite the usefulness of LPL for CLL prognosis, its functional role and the molecular mechanism regulating its expression are still open questions. Interaction of CLL B-cells with the tissue microenvironment favors disease progression by promoting malignant B-cell growth. Since tissue methylation can be altered by environmental factors, we investigated the methylation status of the LPL gene and the possibility that overexpression could be associated with microenvironment signals. Our results show that a demethylated state of the LPL gene is responsible for its anomalous expression in unmutated CLL cases and that this expression is dependent on microenvironment signals. Overall, this work proposes that an epigenetic mechanism, triggered by the microenvironment, regulates LPL expression in CLL disease.
Fil: Abreu, Cecilia. Instituto Pasteur de Montevideo; Uruguay
Fil: Moreno, Pilar. Instituto Pasteur de Montevideo; Uruguay
Fil: Palacios, Florencia. Instituto Pasteur de Montevideo; Uruguay
Fil: Borge, Mercedes. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Morande, Pablo Elías. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Landoni, Ana Inés. Hospital Maciel; Uruguay
Fil: Gabus, Raul. Hospital Maciel; Uruguay
Fil: Dighiero, Guillermo. Hospital Maciel; Uruguay
Fil: Giordano, Mirta Nilda. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Gamberale, Romina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Oppezzo, Pablo. Universidad de la República; Uruguay
description Among different prognostic factors in chronic lymphocytic leukemia (CLL), we previously demonstrated that lipoprotein lipase (LPL) is associated with an unmutated immunoglobulin profile and clinical poor outcome. Despite the usefulness of LPL for CLL prognosis, its functional role and the molecular mechanism regulating its expression are still open questions. Interaction of CLL B-cells with the tissue microenvironment favors disease progression by promoting malignant B-cell growth. Since tissue methylation can be altered by environmental factors, we investigated the methylation status of the LPL gene and the possibility that overexpression could be associated with microenvironment signals. Our results show that a demethylated state of the LPL gene is responsible for its anomalous expression in unmutated CLL cases and that this expression is dependent on microenvironment signals. Overall, this work proposes that an epigenetic mechanism, triggered by the microenvironment, regulates LPL expression in CLL disease.
publishDate 2013
dc.date.none.fl_str_mv 2013-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/20863
Abreu, Cecilia; Moreno, Pilar; Palacios, Florencia; Borge, Mercedes; Morande, Pablo Elías; et al.; Methylation status regulates lipoprotein lipase expression in chronic lymphocytic leukemia; Taylor & Francis; Leukemia and Lymphoma; 54; 8; 8-2013; 1844-1848
1042-8194
CONICET Digital
CONICET
url http://hdl.handle.net/11336/20863
identifier_str_mv Abreu, Cecilia; Moreno, Pilar; Palacios, Florencia; Borge, Mercedes; Morande, Pablo Elías; et al.; Methylation status regulates lipoprotein lipase expression in chronic lymphocytic leukemia; Taylor & Francis; Leukemia and Lymphoma; 54; 8; 8-2013; 1844-1848
1042-8194
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.3109/10428194.2013.796057
info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/full/10.3109/10428194.2013.796057
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Taylor & Francis
publisher.none.fl_str_mv Taylor & Francis
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842268925576871936
score 13.13397

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