Should we listen to our clock to prevent type 2 diabetes mellitus?

Autores
Karthikeyan, Ramanujam; Marimuthu, Ganapathy; Spence, David Warren; Pandi Perumal, Seithikurippu R.; BaHammam, Ahmed S.; Brown, Gregory M.; Cardinali, Daniel Pedro
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The circadian clock drives a number of metabolic processes including energy intake, storage and utilization coupled with the sleep/wake cycles. Globally, the increasing prevalence of type 2 diabetes (T2DM) has become a significant international public health concern. In view of the heavy societal burden caused by diabetes, and further, to reduce its growing incidence, it is clearly essential to understand the causes of this disease and to devise more effective strategies for its treatment. Although many factors cause T2DM, this article centers on the role of circadian regulation of metabolism. The correlation between the increased occurrence of T2DM and the ubiquity of modern social pressures such as 24/7 lifestyles as well as nocturnal lighting conditions point strongly to the hypothesis that malfunctioning of circadian controls may be involved in the etiology of the illness. Nocturnal light exposure, unusual timing of food, irregular sleep/wake schedules and traveling between different time zones are some of the factors responsible for improper entrainment of the clock. Recent reports have proposed that strengthening of circadian clock functioning and proper timing of food intake could stabilize glucose homeostasis. This strategy thus represents a chronotherapeutic option for non-pharmaceutical intervention in treating T2DM patients.
Fil: Karthikeyan, Ramanujam. Madurai Kamaraj University. School of Biological Sciences. Department of Animal Behaviour; India
Fil: Marimuthu, Ganapathy. Madurai Kamaraj University. School of Biological Sciences. Department of Animal Behaviour; India
Fil: Spence, David Warren.
Fil: Pandi Perumal, Seithikurippu R.. University of New York; Estados Unidos
Fil: BaHammam, Ahmed S.. King Saud University; Arabia Saudita
Fil: Brown, Gregory M.. University of Toronto; Canadá
Fil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Facultad de Ciencias Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
Circadian Rhythms
Clock Genes
Melatonin
Metabolism
Type 2 Diabetes Mellitus
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/15740
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Should we listen to our clock to prevent type 2 diabetes mellitus?Karthikeyan, RamanujamMarimuthu, GanapathySpence, David WarrenPandi Perumal, Seithikurippu R.BaHammam, Ahmed S.Brown, Gregory M.Cardinali, Daniel PedroCircadian RhythmsClock GenesMelatoninMetabolismType 2 Diabetes Mellitushttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3The circadian clock drives a number of metabolic processes including energy intake, storage and utilization coupled with the sleep/wake cycles. Globally, the increasing prevalence of type 2 diabetes (T2DM) has become a significant international public health concern. In view of the heavy societal burden caused by diabetes, and further, to reduce its growing incidence, it is clearly essential to understand the causes of this disease and to devise more effective strategies for its treatment. Although many factors cause T2DM, this article centers on the role of circadian regulation of metabolism. The correlation between the increased occurrence of T2DM and the ubiquity of modern social pressures such as 24/7 lifestyles as well as nocturnal lighting conditions point strongly to the hypothesis that malfunctioning of circadian controls may be involved in the etiology of the illness. Nocturnal light exposure, unusual timing of food, irregular sleep/wake schedules and traveling between different time zones are some of the factors responsible for improper entrainment of the clock. Recent reports have proposed that strengthening of circadian clock functioning and proper timing of food intake could stabilize glucose homeostasis. This strategy thus represents a chronotherapeutic option for non-pharmaceutical intervention in treating T2DM patients.Fil: Karthikeyan, Ramanujam. Madurai Kamaraj University. School of Biological Sciences. Department of Animal Behaviour; IndiaFil: Marimuthu, Ganapathy. Madurai Kamaraj University. School of Biological Sciences. Department of Animal Behaviour; IndiaFil: Spence, David Warren.Fil: Pandi Perumal, Seithikurippu R.. University of New York; Estados UnidosFil: BaHammam, Ahmed S.. King Saud University; Arabia SauditaFil: Brown, Gregory M.. University of Toronto; CanadáFil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Facultad de Ciencias Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaElsevier Ireland2014-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/15740Karthikeyan, Ramanujam; Marimuthu, Ganapathy; Spence, David Warren; Pandi Perumal, Seithikurippu R.; BaHammam, Ahmed S.; et al.; Should we listen to our clock to prevent type 2 diabetes mellitus?; Elsevier Ireland; Diabetes Research and Clinical Practice; 106; 2; 11-2014; 182-1900168-8227enginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.diabres.2014.07.029info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0168822714003313info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:01:02Zoai:ri.conicet.gov.ar:11336/15740instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:01:02.327CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Should we listen to our clock to prevent type 2 diabetes mellitus?
title Should we listen to our clock to prevent type 2 diabetes mellitus?
spellingShingle Should we listen to our clock to prevent type 2 diabetes mellitus?
Karthikeyan, Ramanujam
Circadian Rhythms
Clock Genes
Melatonin
Metabolism
Type 2 Diabetes Mellitus
title_short Should we listen to our clock to prevent type 2 diabetes mellitus?
title_full Should we listen to our clock to prevent type 2 diabetes mellitus?
title_fullStr Should we listen to our clock to prevent type 2 diabetes mellitus?
title_full_unstemmed Should we listen to our clock to prevent type 2 diabetes mellitus?
title_sort Should we listen to our clock to prevent type 2 diabetes mellitus?
dc.creator.none.fl_str_mv Karthikeyan, Ramanujam
Marimuthu, Ganapathy
Spence, David Warren
Pandi Perumal, Seithikurippu R.
BaHammam, Ahmed S.
Brown, Gregory M.
Cardinali, Daniel Pedro
author Karthikeyan, Ramanujam
author_facet Karthikeyan, Ramanujam
Marimuthu, Ganapathy
Spence, David Warren
Pandi Perumal, Seithikurippu R.
BaHammam, Ahmed S.
Brown, Gregory M.
Cardinali, Daniel Pedro
author_role author
author2 Marimuthu, Ganapathy
Spence, David Warren
Pandi Perumal, Seithikurippu R.
BaHammam, Ahmed S.
Brown, Gregory M.
Cardinali, Daniel Pedro
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Circadian Rhythms
Clock Genes
Melatonin
Metabolism
Type 2 Diabetes Mellitus
topic Circadian Rhythms
Clock Genes
Melatonin
Metabolism
Type 2 Diabetes Mellitus
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The circadian clock drives a number of metabolic processes including energy intake, storage and utilization coupled with the sleep/wake cycles. Globally, the increasing prevalence of type 2 diabetes (T2DM) has become a significant international public health concern. In view of the heavy societal burden caused by diabetes, and further, to reduce its growing incidence, it is clearly essential to understand the causes of this disease and to devise more effective strategies for its treatment. Although many factors cause T2DM, this article centers on the role of circadian regulation of metabolism. The correlation between the increased occurrence of T2DM and the ubiquity of modern social pressures such as 24/7 lifestyles as well as nocturnal lighting conditions point strongly to the hypothesis that malfunctioning of circadian controls may be involved in the etiology of the illness. Nocturnal light exposure, unusual timing of food, irregular sleep/wake schedules and traveling between different time zones are some of the factors responsible for improper entrainment of the clock. Recent reports have proposed that strengthening of circadian clock functioning and proper timing of food intake could stabilize glucose homeostasis. This strategy thus represents a chronotherapeutic option for non-pharmaceutical intervention in treating T2DM patients.
Fil: Karthikeyan, Ramanujam. Madurai Kamaraj University. School of Biological Sciences. Department of Animal Behaviour; India
Fil: Marimuthu, Ganapathy. Madurai Kamaraj University. School of Biological Sciences. Department of Animal Behaviour; India
Fil: Spence, David Warren.
Fil: Pandi Perumal, Seithikurippu R.. University of New York; Estados Unidos
Fil: BaHammam, Ahmed S.. King Saud University; Arabia Saudita
Fil: Brown, Gregory M.. University of Toronto; Canadá
Fil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Facultad de Ciencias Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description The circadian clock drives a number of metabolic processes including energy intake, storage and utilization coupled with the sleep/wake cycles. Globally, the increasing prevalence of type 2 diabetes (T2DM) has become a significant international public health concern. In view of the heavy societal burden caused by diabetes, and further, to reduce its growing incidence, it is clearly essential to understand the causes of this disease and to devise more effective strategies for its treatment. Although many factors cause T2DM, this article centers on the role of circadian regulation of metabolism. The correlation between the increased occurrence of T2DM and the ubiquity of modern social pressures such as 24/7 lifestyles as well as nocturnal lighting conditions point strongly to the hypothesis that malfunctioning of circadian controls may be involved in the etiology of the illness. Nocturnal light exposure, unusual timing of food, irregular sleep/wake schedules and traveling between different time zones are some of the factors responsible for improper entrainment of the clock. Recent reports have proposed that strengthening of circadian clock functioning and proper timing of food intake could stabilize glucose homeostasis. This strategy thus represents a chronotherapeutic option for non-pharmaceutical intervention in treating T2DM patients.
publishDate 2014
dc.date.none.fl_str_mv 2014-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/15740
Karthikeyan, Ramanujam; Marimuthu, Ganapathy; Spence, David Warren; Pandi Perumal, Seithikurippu R.; BaHammam, Ahmed S.; et al.; Should we listen to our clock to prevent type 2 diabetes mellitus?; Elsevier Ireland; Diabetes Research and Clinical Practice; 106; 2; 11-2014; 182-190
0168-8227
url http://hdl.handle.net/11336/15740
identifier_str_mv Karthikeyan, Ramanujam; Marimuthu, Ganapathy; Spence, David Warren; Pandi Perumal, Seithikurippu R.; BaHammam, Ahmed S.; et al.; Should we listen to our clock to prevent type 2 diabetes mellitus?; Elsevier Ireland; Diabetes Research and Clinical Practice; 106; 2; 11-2014; 182-190
0168-8227
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.diabres.2014.07.029
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0168822714003313
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Ireland
publisher.none.fl_str_mv Elsevier Ireland
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842979921411964928
score 12.48226

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