Per3 length polymorphism in patients with type 2 diabetes mellitus

Autores
Karthikeyan, Ramanujam; Marimuthu, Ganapathy; Sooriyakumar, Murugesan; BaHammam, Ahmed S.; Spence, David Warren; Pandi Perumal, Seithikurippu R.; Brown, Gregory M.; Cardinali, Daniel Pedro
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
BACKGROUND: A number of observations support the involvement of circadian clock genes in the regulation of metabolic processes. One of these circadian genes, Per3, exhibits a variable number tandem repeat length polymorphism, consisting of two alleles, namely four and five repeat alleles, in its exon 18. The objective of this study was to examine the existence of Per3 variants in patients with type 2 diabetes mellitus (T2DM) as compared to a non T2DM control group. METHODS: Intravenous blood samples were collected to obtain white blood cells from 302 T2DM patients and 330 non-diabetic, age- and sex-matched, individuals. Per3 genotyping was performed on DNA by polymerase chain reaction. RESULTS: Frequency of five repeat allele was higher, and that of four repeat allele lower, in T2DM patients as compared to non-diabetic controls (χ2=6.977, p=0.0082) CONCLUSIONS: The results indicate an association of Per3 five repeat allele with T2DM occurrence and suggest that individuals with five repeat allele may be at a greater risk for T2DM as compared to those carrying the four repeat allele.
Fil: Karthikeyan, Ramanujam. Madurai Kamaraj University. School of Biological Sciences. Department of Animal Behaviour and Physiology; India
Fil: Marimuthu, Ganapathy. Madurai Kamaraj University. School of Biological Sciences. Department of Animal Behaviour and Physiology; India
Fil: Sooriyakumar, Murugesan. Madurai Medical College. Department of Medicine; India
Fil: BaHammam, Ahmed S.. King Saud University. College of Medicine; Arabia Saudita
Fil: Spence, David Warren.
Fil: Pandi Perumal, Seithikurippu R.. Somnogen Canada; Canadá
Fil: Brown, Gregory M.. University of Toronto; Canadá
Fil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Facultad de Ciencias Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
CIRCADIAN RHYTHMS
CLOCK GENE
METABOLISM
PER3 POLYMORPHISM
TYPE 2 DIABETES MELLITUS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/15739
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/15739
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Per3 length polymorphism in patients with type 2 diabetes mellitusKarthikeyan, RamanujamMarimuthu, GanapathySooriyakumar, MurugesanBaHammam, Ahmed S.Spence, David WarrenPandi Perumal, Seithikurippu R.Brown, Gregory M.Cardinali, Daniel PedroCIRCADIAN RHYTHMSCLOCK GENEMETABOLISMPER3 POLYMORPHISMTYPE 2 DIABETES MELLITUShttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3BACKGROUND: A number of observations support the involvement of circadian clock genes in the regulation of metabolic processes. One of these circadian genes, Per3, exhibits a variable number tandem repeat length polymorphism, consisting of two alleles, namely four and five repeat alleles, in its exon 18. The objective of this study was to examine the existence of Per3 variants in patients with type 2 diabetes mellitus (T2DM) as compared to a non T2DM control group. METHODS: Intravenous blood samples were collected to obtain white blood cells from 302 T2DM patients and 330 non-diabetic, age- and sex-matched, individuals. Per3 genotyping was performed on DNA by polymerase chain reaction. RESULTS: Frequency of five repeat allele was higher, and that of four repeat allele lower, in T2DM patients as compared to non-diabetic controls (χ2=6.977, p=0.0082) CONCLUSIONS: The results indicate an association of Per3 five repeat allele with T2DM occurrence and suggest that individuals with five repeat allele may be at a greater risk for T2DM as compared to those carrying the four repeat allele.Fil: Karthikeyan, Ramanujam. Madurai Kamaraj University. School of Biological Sciences. Department of Animal Behaviour and Physiology; IndiaFil: Marimuthu, Ganapathy. Madurai Kamaraj University. School of Biological Sciences. Department of Animal Behaviour and Physiology; IndiaFil: Sooriyakumar, Murugesan. Madurai Medical College. Department of Medicine; IndiaFil: BaHammam, Ahmed S.. King Saud University. College of Medicine; Arabia SauditaFil: Spence, David Warren.Fil: Pandi Perumal, Seithikurippu R.. Somnogen Canada; CanadáFil: Brown, Gregory M.. University of Toronto; CanadáFil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Facultad de Ciencias Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaDe Gruyter2014-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/15739Karthikeyan, Ramanujam; Marimuthu, Ganapathy; Sooriyakumar, Murugesan; BaHammam, Ahmed S.; Spence, David Warren; et al.; Per3 length polymorphism in patients with type 2 diabetes mellitus; De Gruyter; Hormone Molecular Biology and Clinical Investigation; 18; 3; 6-2014; 145-1491868-1883enginfo:eu-repo/semantics/altIdentifier/doi/10.1515/hmbci-2013-0049info:eu-repo/semantics/altIdentifier/url/https://www.degruyter.com/view/j/hmbci.2014.18.issue-3/hmbci-2013-0049/hmbci-2013-0049.xmlinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:52:00Zoai:ri.conicet.gov.ar:11336/15739instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:52:00.814CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Per3 length polymorphism in patients with type 2 diabetes mellitus
title Per3 length polymorphism in patients with type 2 diabetes mellitus
spellingShingle Per3 length polymorphism in patients with type 2 diabetes mellitus
Karthikeyan, Ramanujam
CIRCADIAN RHYTHMS
CLOCK GENE
METABOLISM
PER3 POLYMORPHISM
TYPE 2 DIABETES MELLITUS
title_short Per3 length polymorphism in patients with type 2 diabetes mellitus
title_full Per3 length polymorphism in patients with type 2 diabetes mellitus
title_fullStr Per3 length polymorphism in patients with type 2 diabetes mellitus
title_full_unstemmed Per3 length polymorphism in patients with type 2 diabetes mellitus
title_sort Per3 length polymorphism in patients with type 2 diabetes mellitus
dc.creator.none.fl_str_mv Karthikeyan, Ramanujam
Marimuthu, Ganapathy
Sooriyakumar, Murugesan
BaHammam, Ahmed S.
Spence, David Warren
Pandi Perumal, Seithikurippu R.
Brown, Gregory M.
Cardinali, Daniel Pedro
author Karthikeyan, Ramanujam
author_facet Karthikeyan, Ramanujam
Marimuthu, Ganapathy
Sooriyakumar, Murugesan
BaHammam, Ahmed S.
Spence, David Warren
Pandi Perumal, Seithikurippu R.
Brown, Gregory M.
Cardinali, Daniel Pedro
author_role author
author2 Marimuthu, Ganapathy
Sooriyakumar, Murugesan
BaHammam, Ahmed S.
Spence, David Warren
Pandi Perumal, Seithikurippu R.
Brown, Gregory M.
Cardinali, Daniel Pedro
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv CIRCADIAN RHYTHMS
CLOCK GENE
METABOLISM
PER3 POLYMORPHISM
TYPE 2 DIABETES MELLITUS
topic CIRCADIAN RHYTHMS
CLOCK GENE
METABOLISM
PER3 POLYMORPHISM
TYPE 2 DIABETES MELLITUS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv BACKGROUND: A number of observations support the involvement of circadian clock genes in the regulation of metabolic processes. One of these circadian genes, Per3, exhibits a variable number tandem repeat length polymorphism, consisting of two alleles, namely four and five repeat alleles, in its exon 18. The objective of this study was to examine the existence of Per3 variants in patients with type 2 diabetes mellitus (T2DM) as compared to a non T2DM control group. METHODS: Intravenous blood samples were collected to obtain white blood cells from 302 T2DM patients and 330 non-diabetic, age- and sex-matched, individuals. Per3 genotyping was performed on DNA by polymerase chain reaction. RESULTS: Frequency of five repeat allele was higher, and that of four repeat allele lower, in T2DM patients as compared to non-diabetic controls (χ2=6.977, p=0.0082) CONCLUSIONS: The results indicate an association of Per3 five repeat allele with T2DM occurrence and suggest that individuals with five repeat allele may be at a greater risk for T2DM as compared to those carrying the four repeat allele.
Fil: Karthikeyan, Ramanujam. Madurai Kamaraj University. School of Biological Sciences. Department of Animal Behaviour and Physiology; India
Fil: Marimuthu, Ganapathy. Madurai Kamaraj University. School of Biological Sciences. Department of Animal Behaviour and Physiology; India
Fil: Sooriyakumar, Murugesan. Madurai Medical College. Department of Medicine; India
Fil: BaHammam, Ahmed S.. King Saud University. College of Medicine; Arabia Saudita
Fil: Spence, David Warren.
Fil: Pandi Perumal, Seithikurippu R.. Somnogen Canada; Canadá
Fil: Brown, Gregory M.. University of Toronto; Canadá
Fil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Facultad de Ciencias Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description BACKGROUND: A number of observations support the involvement of circadian clock genes in the regulation of metabolic processes. One of these circadian genes, Per3, exhibits a variable number tandem repeat length polymorphism, consisting of two alleles, namely four and five repeat alleles, in its exon 18. The objective of this study was to examine the existence of Per3 variants in patients with type 2 diabetes mellitus (T2DM) as compared to a non T2DM control group. METHODS: Intravenous blood samples were collected to obtain white blood cells from 302 T2DM patients and 330 non-diabetic, age- and sex-matched, individuals. Per3 genotyping was performed on DNA by polymerase chain reaction. RESULTS: Frequency of five repeat allele was higher, and that of four repeat allele lower, in T2DM patients as compared to non-diabetic controls (χ2=6.977, p=0.0082) CONCLUSIONS: The results indicate an association of Per3 five repeat allele with T2DM occurrence and suggest that individuals with five repeat allele may be at a greater risk for T2DM as compared to those carrying the four repeat allele.
publishDate 2014
dc.date.none.fl_str_mv 2014-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/15739
Karthikeyan, Ramanujam; Marimuthu, Ganapathy; Sooriyakumar, Murugesan; BaHammam, Ahmed S.; Spence, David Warren; et al.; Per3 length polymorphism in patients with type 2 diabetes mellitus; De Gruyter; Hormone Molecular Biology and Clinical Investigation; 18; 3; 6-2014; 145-149
1868-1883
url http://hdl.handle.net/11336/15739
identifier_str_mv Karthikeyan, Ramanujam; Marimuthu, Ganapathy; Sooriyakumar, Murugesan; BaHammam, Ahmed S.; Spence, David Warren; et al.; Per3 length polymorphism in patients with type 2 diabetes mellitus; De Gruyter; Hormone Molecular Biology and Clinical Investigation; 18; 3; 6-2014; 145-149
1868-1883
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1515/hmbci-2013-0049
info:eu-repo/semantics/altIdentifier/url/https://www.degruyter.com/view/j/hmbci.2014.18.issue-3/hmbci-2013-0049/hmbci-2013-0049.xml
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv De Gruyter
publisher.none.fl_str_mv De Gruyter
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269129687433216
score 13.13397

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