Association of Per3 length polymorphism with bipolar I disorder and schizophrenia

Autores
Karthikeyan, Ramanujam; Marimuthu, Ganapathy; Ramasubramanian, Chellamuthu; Arunachal, Gautham; BaHammam, Ahmed S.; Spence, David Warren; Cardinali, Daniel Pedro; Brown, Gregory M.; Pandi Perumal, Seithikurippu R.
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
BACKGROUND: Sleep-wake disturbances have frequently been reported in bipolar disorder and schizophrenia, and are considered to be caused by an underlying circadian rhythm disorder. The study presented here was designed to investigate the existence of Per3 polymorphism in bipolar disorder type I (BD-I) and schizophrenic patients in South India. METHODS: Blood samples were collected from 311 BD-I patients, 293 schizophrenia patients, and 346 age- and sex-matched normal controls. Per3 genotyping was performed on DNA by polymerase chain reaction using specific primers. RESULTS: An increased prevalence of five repeat homozygotes was seen in BD-I patients as compared with healthy controls (odds ratio =1.72 [95% confidence interval: 1.08-2.76, P=0.02]). In BD-I patients, the frequency of the five repeat allele was higher (allele frequency =0.41), and that of the four repeat allele lower (allele frequency =0.36) (χ (2)=4.634; P<0.03) than in the control group. No significant association was observed in the allele frequencies of four and five repeat alleles in schizophrenia patients when compared with controls. CONCLUSION: The occurrence of the five repeat allele of Per3 may be a risk factor for BD-I onset in this ethnic group.
Fil: Karthikeyan, Ramanujam. Madurai Kamaraj University; India
Fil: Marimuthu, Ganapathy. Madurai Kamaraj University; India
Fil: Ramasubramanian, Chellamuthu. M. S. Chellamuthu Trust & Research Foundation; India
Fil: Arunachal, Gautham. M. S. Chellamuthu Trust & Research Foundation; India
Fil: BaHammam, Ahmed S.. King Saud University; India
Fil: Spence, David Warren.
Fil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Facultad de Ciencias Médicas. Departamento de Docencia e Investigación; Argentina. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina
Fil: Brown, Gregory M.. University of Toronto; Canadá
Fil: Pandi Perumal, Seithikurippu R.. University of New York; Estados Unidos
Materia
PER3 POLYMORPHISM
BIPOLAR DISORDER
CIRCADIAN RHYTHMS
CLOCK GENES
SCHIZOPHRENIA
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/16098
Acceder
id CONICETDig_2f39edcc6c0a31b5fb5cce751317c3e5
oai_identifier_str oai:ri.conicet.gov.ar:11336/16098
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Association of Per3 length polymorphism with bipolar I disorder and schizophreniaKarthikeyan, RamanujamMarimuthu, GanapathyRamasubramanian, ChellamuthuArunachal, GauthamBaHammam, Ahmed S.Spence, David WarrenCardinali, Daniel PedroBrown, Gregory M.Pandi Perumal, Seithikurippu R.PER3 POLYMORPHISMBIPOLAR DISORDERCIRCADIAN RHYTHMSCLOCK GENESSCHIZOPHRENIAhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3BACKGROUND: Sleep-wake disturbances have frequently been reported in bipolar disorder and schizophrenia, and are considered to be caused by an underlying circadian rhythm disorder. The study presented here was designed to investigate the existence of Per3 polymorphism in bipolar disorder type I (BD-I) and schizophrenic patients in South India. METHODS: Blood samples were collected from 311 BD-I patients, 293 schizophrenia patients, and 346 age- and sex-matched normal controls. Per3 genotyping was performed on DNA by polymerase chain reaction using specific primers. RESULTS: An increased prevalence of five repeat homozygotes was seen in BD-I patients as compared with healthy controls (odds ratio =1.72 [95% confidence interval: 1.08-2.76, P=0.02]). In BD-I patients, the frequency of the five repeat allele was higher (allele frequency =0.41), and that of the four repeat allele lower (allele frequency =0.36) (χ (2)=4.634; P<0.03) than in the control group. No significant association was observed in the allele frequencies of four and five repeat alleles in schizophrenia patients when compared with controls. CONCLUSION: The occurrence of the five repeat allele of Per3 may be a risk factor for BD-I onset in this ethnic group.Fil: Karthikeyan, Ramanujam. Madurai Kamaraj University; IndiaFil: Marimuthu, Ganapathy. Madurai Kamaraj University; IndiaFil: Ramasubramanian, Chellamuthu. M. S. Chellamuthu Trust & Research Foundation; IndiaFil: Arunachal, Gautham. M. S. Chellamuthu Trust & Research Foundation; IndiaFil: BaHammam, Ahmed S.. King Saud University; IndiaFil: Spence, David Warren.Fil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Facultad de Ciencias Médicas. Departamento de Docencia e Investigación; Argentina. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; ArgentinaFil: Brown, Gregory M.. University of Toronto; CanadáFil: Pandi Perumal, Seithikurippu R.. University of New York; Estados UnidosDove Press2014-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/16098Karthikeyan, Ramanujam; Marimuthu, Ganapathy; Ramasubramanian, Chellamuthu; Arunachal, Gautham; BaHammam, Ahmed S.; et al.; Association of Per3 length polymorphism with bipolar I disorder and schizophrenia; Dove Press; Neuropsychiatric Disease and Treatment; 10; 12-2014; 2025-23301176-6328enginfo:eu-repo/semantics/altIdentifier/doi/10.2147/NDT.S73765info:eu-repo/semantics/altIdentifier/url/https://www.dovepress.com/association-of-per3-length-polymorphism-withnbspbipolar-i-disorder-and-peer-reviewed-article-NDTinfo:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4267513/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:35:15Zoai:ri.conicet.gov.ar:11336/16098instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:35:15.33CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Association of Per3 length polymorphism with bipolar I disorder and schizophrenia
title Association of Per3 length polymorphism with bipolar I disorder and schizophrenia
spellingShingle Association of Per3 length polymorphism with bipolar I disorder and schizophrenia
Karthikeyan, Ramanujam
PER3 POLYMORPHISM
BIPOLAR DISORDER
CIRCADIAN RHYTHMS
CLOCK GENES
SCHIZOPHRENIA
title_short Association of Per3 length polymorphism with bipolar I disorder and schizophrenia
title_full Association of Per3 length polymorphism with bipolar I disorder and schizophrenia
title_fullStr Association of Per3 length polymorphism with bipolar I disorder and schizophrenia
title_full_unstemmed Association of Per3 length polymorphism with bipolar I disorder and schizophrenia
title_sort Association of Per3 length polymorphism with bipolar I disorder and schizophrenia
dc.creator.none.fl_str_mv Karthikeyan, Ramanujam
Marimuthu, Ganapathy
Ramasubramanian, Chellamuthu
Arunachal, Gautham
BaHammam, Ahmed S.
Spence, David Warren
Cardinali, Daniel Pedro
Brown, Gregory M.
Pandi Perumal, Seithikurippu R.
author Karthikeyan, Ramanujam
author_facet Karthikeyan, Ramanujam
Marimuthu, Ganapathy
Ramasubramanian, Chellamuthu
Arunachal, Gautham
BaHammam, Ahmed S.
Spence, David Warren
Cardinali, Daniel Pedro
Brown, Gregory M.
Pandi Perumal, Seithikurippu R.
author_role author
author2 Marimuthu, Ganapathy
Ramasubramanian, Chellamuthu
Arunachal, Gautham
BaHammam, Ahmed S.
Spence, David Warren
Cardinali, Daniel Pedro
Brown, Gregory M.
Pandi Perumal, Seithikurippu R.
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv PER3 POLYMORPHISM
BIPOLAR DISORDER
CIRCADIAN RHYTHMS
CLOCK GENES
SCHIZOPHRENIA
topic PER3 POLYMORPHISM
BIPOLAR DISORDER
CIRCADIAN RHYTHMS
CLOCK GENES
SCHIZOPHRENIA
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv BACKGROUND: Sleep-wake disturbances have frequently been reported in bipolar disorder and schizophrenia, and are considered to be caused by an underlying circadian rhythm disorder. The study presented here was designed to investigate the existence of Per3 polymorphism in bipolar disorder type I (BD-I) and schizophrenic patients in South India. METHODS: Blood samples were collected from 311 BD-I patients, 293 schizophrenia patients, and 346 age- and sex-matched normal controls. Per3 genotyping was performed on DNA by polymerase chain reaction using specific primers. RESULTS: An increased prevalence of five repeat homozygotes was seen in BD-I patients as compared with healthy controls (odds ratio =1.72 [95% confidence interval: 1.08-2.76, P=0.02]). In BD-I patients, the frequency of the five repeat allele was higher (allele frequency =0.41), and that of the four repeat allele lower (allele frequency =0.36) (χ (2)=4.634; P<0.03) than in the control group. No significant association was observed in the allele frequencies of four and five repeat alleles in schizophrenia patients when compared with controls. CONCLUSION: The occurrence of the five repeat allele of Per3 may be a risk factor for BD-I onset in this ethnic group.
Fil: Karthikeyan, Ramanujam. Madurai Kamaraj University; India
Fil: Marimuthu, Ganapathy. Madurai Kamaraj University; India
Fil: Ramasubramanian, Chellamuthu. M. S. Chellamuthu Trust & Research Foundation; India
Fil: Arunachal, Gautham. M. S. Chellamuthu Trust & Research Foundation; India
Fil: BaHammam, Ahmed S.. King Saud University; India
Fil: Spence, David Warren.
Fil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Facultad de Ciencias Médicas. Departamento de Docencia e Investigación; Argentina. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina
Fil: Brown, Gregory M.. University of Toronto; Canadá
Fil: Pandi Perumal, Seithikurippu R.. University of New York; Estados Unidos
description BACKGROUND: Sleep-wake disturbances have frequently been reported in bipolar disorder and schizophrenia, and are considered to be caused by an underlying circadian rhythm disorder. The study presented here was designed to investigate the existence of Per3 polymorphism in bipolar disorder type I (BD-I) and schizophrenic patients in South India. METHODS: Blood samples were collected from 311 BD-I patients, 293 schizophrenia patients, and 346 age- and sex-matched normal controls. Per3 genotyping was performed on DNA by polymerase chain reaction using specific primers. RESULTS: An increased prevalence of five repeat homozygotes was seen in BD-I patients as compared with healthy controls (odds ratio =1.72 [95% confidence interval: 1.08-2.76, P=0.02]). In BD-I patients, the frequency of the five repeat allele was higher (allele frequency =0.41), and that of the four repeat allele lower (allele frequency =0.36) (χ (2)=4.634; P<0.03) than in the control group. No significant association was observed in the allele frequencies of four and five repeat alleles in schizophrenia patients when compared with controls. CONCLUSION: The occurrence of the five repeat allele of Per3 may be a risk factor for BD-I onset in this ethnic group.
publishDate 2014
dc.date.none.fl_str_mv 2014-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/16098
Karthikeyan, Ramanujam; Marimuthu, Ganapathy; Ramasubramanian, Chellamuthu; Arunachal, Gautham; BaHammam, Ahmed S.; et al.; Association of Per3 length polymorphism with bipolar I disorder and schizophrenia; Dove Press; Neuropsychiatric Disease and Treatment; 10; 12-2014; 2025-2330
1176-6328
url http://hdl.handle.net/11336/16098
identifier_str_mv Karthikeyan, Ramanujam; Marimuthu, Ganapathy; Ramasubramanian, Chellamuthu; Arunachal, Gautham; BaHammam, Ahmed S.; et al.; Association of Per3 length polymorphism with bipolar I disorder and schizophrenia; Dove Press; Neuropsychiatric Disease and Treatment; 10; 12-2014; 2025-2330
1176-6328
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.2147/NDT.S73765
info:eu-repo/semantics/altIdentifier/url/https://www.dovepress.com/association-of-per3-length-polymorphism-withnbspbipolar-i-disorder-and-peer-reviewed-article-NDT
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4267513/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Dove Press
publisher.none.fl_str_mv Dove Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.069144

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