Association of Per3 length polymorphism with bipolar I disorder and schizophrenia
- Autores
- Karthikeyan, Ramanujam; Marimuthu, Ganapathy; Ramasubramanian, Chellamuthu; Arunachal, Gautham; BaHammam, Ahmed S.; Spence, David Warren; Cardinali, Daniel Pedro; Brown, Gregory M.; Pandi Perumal, Seithikurippu R.
- Año de publicación
- 2014
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- BACKGROUND: Sleep-wake disturbances have frequently been reported in bipolar disorder and schizophrenia, and are considered to be caused by an underlying circadian rhythm disorder. The study presented here was designed to investigate the existence of Per3 polymorphism in bipolar disorder type I (BD-I) and schizophrenic patients in South India. METHODS: Blood samples were collected from 311 BD-I patients, 293 schizophrenia patients, and 346 age- and sex-matched normal controls. Per3 genotyping was performed on DNA by polymerase chain reaction using specific primers. RESULTS: An increased prevalence of five repeat homozygotes was seen in BD-I patients as compared with healthy controls (odds ratio =1.72 [95% confidence interval: 1.08-2.76, P=0.02]). In BD-I patients, the frequency of the five repeat allele was higher (allele frequency =0.41), and that of the four repeat allele lower (allele frequency =0.36) (χ (2)=4.634; P<0.03) than in the control group. No significant association was observed in the allele frequencies of four and five repeat alleles in schizophrenia patients when compared with controls. CONCLUSION: The occurrence of the five repeat allele of Per3 may be a risk factor for BD-I onset in this ethnic group.
Fil: Karthikeyan, Ramanujam. Madurai Kamaraj University; India
Fil: Marimuthu, Ganapathy. Madurai Kamaraj University; India
Fil: Ramasubramanian, Chellamuthu. M. S. Chellamuthu Trust & Research Foundation; India
Fil: Arunachal, Gautham. M. S. Chellamuthu Trust & Research Foundation; India
Fil: BaHammam, Ahmed S.. King Saud University; India
Fil: Spence, David Warren.
Fil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Facultad de Ciencias Médicas. Departamento de Docencia e Investigación; Argentina. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina
Fil: Brown, Gregory M.. University of Toronto; Canadá
Fil: Pandi Perumal, Seithikurippu R.. University of New York; Estados Unidos - Materia
-
PER3 POLYMORPHISM
BIPOLAR DISORDER
CIRCADIAN RHYTHMS
CLOCK GENES
SCHIZOPHRENIA - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/16098
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Association of Per3 length polymorphism with bipolar I disorder and schizophreniaKarthikeyan, RamanujamMarimuthu, GanapathyRamasubramanian, ChellamuthuArunachal, GauthamBaHammam, Ahmed S.Spence, David WarrenCardinali, Daniel PedroBrown, Gregory M.Pandi Perumal, Seithikurippu R.PER3 POLYMORPHISMBIPOLAR DISORDERCIRCADIAN RHYTHMSCLOCK GENESSCHIZOPHRENIAhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3BACKGROUND: Sleep-wake disturbances have frequently been reported in bipolar disorder and schizophrenia, and are considered to be caused by an underlying circadian rhythm disorder. The study presented here was designed to investigate the existence of Per3 polymorphism in bipolar disorder type I (BD-I) and schizophrenic patients in South India. METHODS: Blood samples were collected from 311 BD-I patients, 293 schizophrenia patients, and 346 age- and sex-matched normal controls. Per3 genotyping was performed on DNA by polymerase chain reaction using specific primers. RESULTS: An increased prevalence of five repeat homozygotes was seen in BD-I patients as compared with healthy controls (odds ratio =1.72 [95% confidence interval: 1.08-2.76, P=0.02]). In BD-I patients, the frequency of the five repeat allele was higher (allele frequency =0.41), and that of the four repeat allele lower (allele frequency =0.36) (χ (2)=4.634; P<0.03) than in the control group. No significant association was observed in the allele frequencies of four and five repeat alleles in schizophrenia patients when compared with controls. CONCLUSION: The occurrence of the five repeat allele of Per3 may be a risk factor for BD-I onset in this ethnic group.Fil: Karthikeyan, Ramanujam. Madurai Kamaraj University; IndiaFil: Marimuthu, Ganapathy. Madurai Kamaraj University; IndiaFil: Ramasubramanian, Chellamuthu. M. S. Chellamuthu Trust & Research Foundation; IndiaFil: Arunachal, Gautham. M. S. Chellamuthu Trust & Research Foundation; IndiaFil: BaHammam, Ahmed S.. King Saud University; IndiaFil: Spence, David Warren.Fil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Facultad de Ciencias Médicas. Departamento de Docencia e Investigación; Argentina. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; ArgentinaFil: Brown, Gregory M.. University of Toronto; CanadáFil: Pandi Perumal, Seithikurippu R.. University of New York; Estados UnidosDove Press2014-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/16098Karthikeyan, Ramanujam; Marimuthu, Ganapathy; Ramasubramanian, Chellamuthu; Arunachal, Gautham; BaHammam, Ahmed S.; et al.; Association of Per3 length polymorphism with bipolar I disorder and schizophrenia; Dove Press; Neuropsychiatric Disease and Treatment; 10; 12-2014; 2025-23301176-6328enginfo:eu-repo/semantics/altIdentifier/doi/10.2147/NDT.S73765info:eu-repo/semantics/altIdentifier/url/https://www.dovepress.com/association-of-per3-length-polymorphism-withnbspbipolar-i-disorder-and-peer-reviewed-article-NDTinfo:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4267513/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:44:59Zoai:ri.conicet.gov.ar:11336/16098instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:44:59.798CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Association of Per3 length polymorphism with bipolar I disorder and schizophrenia |
title |
Association of Per3 length polymorphism with bipolar I disorder and schizophrenia |
spellingShingle |
Association of Per3 length polymorphism with bipolar I disorder and schizophrenia Karthikeyan, Ramanujam PER3 POLYMORPHISM BIPOLAR DISORDER CIRCADIAN RHYTHMS CLOCK GENES SCHIZOPHRENIA |
title_short |
Association of Per3 length polymorphism with bipolar I disorder and schizophrenia |
title_full |
Association of Per3 length polymorphism with bipolar I disorder and schizophrenia |
title_fullStr |
Association of Per3 length polymorphism with bipolar I disorder and schizophrenia |
title_full_unstemmed |
Association of Per3 length polymorphism with bipolar I disorder and schizophrenia |
title_sort |
Association of Per3 length polymorphism with bipolar I disorder and schizophrenia |
dc.creator.none.fl_str_mv |
Karthikeyan, Ramanujam Marimuthu, Ganapathy Ramasubramanian, Chellamuthu Arunachal, Gautham BaHammam, Ahmed S. Spence, David Warren Cardinali, Daniel Pedro Brown, Gregory M. Pandi Perumal, Seithikurippu R. |
author |
Karthikeyan, Ramanujam |
author_facet |
Karthikeyan, Ramanujam Marimuthu, Ganapathy Ramasubramanian, Chellamuthu Arunachal, Gautham BaHammam, Ahmed S. Spence, David Warren Cardinali, Daniel Pedro Brown, Gregory M. Pandi Perumal, Seithikurippu R. |
author_role |
author |
author2 |
Marimuthu, Ganapathy Ramasubramanian, Chellamuthu Arunachal, Gautham BaHammam, Ahmed S. Spence, David Warren Cardinali, Daniel Pedro Brown, Gregory M. Pandi Perumal, Seithikurippu R. |
author2_role |
author author author author author author author author |
dc.subject.none.fl_str_mv |
PER3 POLYMORPHISM BIPOLAR DISORDER CIRCADIAN RHYTHMS CLOCK GENES SCHIZOPHRENIA |
topic |
PER3 POLYMORPHISM BIPOLAR DISORDER CIRCADIAN RHYTHMS CLOCK GENES SCHIZOPHRENIA |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
BACKGROUND: Sleep-wake disturbances have frequently been reported in bipolar disorder and schizophrenia, and are considered to be caused by an underlying circadian rhythm disorder. The study presented here was designed to investigate the existence of Per3 polymorphism in bipolar disorder type I (BD-I) and schizophrenic patients in South India. METHODS: Blood samples were collected from 311 BD-I patients, 293 schizophrenia patients, and 346 age- and sex-matched normal controls. Per3 genotyping was performed on DNA by polymerase chain reaction using specific primers. RESULTS: An increased prevalence of five repeat homozygotes was seen in BD-I patients as compared with healthy controls (odds ratio =1.72 [95% confidence interval: 1.08-2.76, P=0.02]). In BD-I patients, the frequency of the five repeat allele was higher (allele frequency =0.41), and that of the four repeat allele lower (allele frequency =0.36) (χ (2)=4.634; P<0.03) than in the control group. No significant association was observed in the allele frequencies of four and five repeat alleles in schizophrenia patients when compared with controls. CONCLUSION: The occurrence of the five repeat allele of Per3 may be a risk factor for BD-I onset in this ethnic group. Fil: Karthikeyan, Ramanujam. Madurai Kamaraj University; India Fil: Marimuthu, Ganapathy. Madurai Kamaraj University; India Fil: Ramasubramanian, Chellamuthu. M. S. Chellamuthu Trust & Research Foundation; India Fil: Arunachal, Gautham. M. S. Chellamuthu Trust & Research Foundation; India Fil: BaHammam, Ahmed S.. King Saud University; India Fil: Spence, David Warren. Fil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Facultad de Ciencias Médicas. Departamento de Docencia e Investigación; Argentina. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina Fil: Brown, Gregory M.. University of Toronto; Canadá Fil: Pandi Perumal, Seithikurippu R.. University of New York; Estados Unidos |
description |
BACKGROUND: Sleep-wake disturbances have frequently been reported in bipolar disorder and schizophrenia, and are considered to be caused by an underlying circadian rhythm disorder. The study presented here was designed to investigate the existence of Per3 polymorphism in bipolar disorder type I (BD-I) and schizophrenic patients in South India. METHODS: Blood samples were collected from 311 BD-I patients, 293 schizophrenia patients, and 346 age- and sex-matched normal controls. Per3 genotyping was performed on DNA by polymerase chain reaction using specific primers. RESULTS: An increased prevalence of five repeat homozygotes was seen in BD-I patients as compared with healthy controls (odds ratio =1.72 [95% confidence interval: 1.08-2.76, P=0.02]). In BD-I patients, the frequency of the five repeat allele was higher (allele frequency =0.41), and that of the four repeat allele lower (allele frequency =0.36) (χ (2)=4.634; P<0.03) than in the control group. No significant association was observed in the allele frequencies of four and five repeat alleles in schizophrenia patients when compared with controls. CONCLUSION: The occurrence of the five repeat allele of Per3 may be a risk factor for BD-I onset in this ethnic group. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-12 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/16098 Karthikeyan, Ramanujam; Marimuthu, Ganapathy; Ramasubramanian, Chellamuthu; Arunachal, Gautham; BaHammam, Ahmed S.; et al.; Association of Per3 length polymorphism with bipolar I disorder and schizophrenia; Dove Press; Neuropsychiatric Disease and Treatment; 10; 12-2014; 2025-2330 1176-6328 |
url |
http://hdl.handle.net/11336/16098 |
identifier_str_mv |
Karthikeyan, Ramanujam; Marimuthu, Ganapathy; Ramasubramanian, Chellamuthu; Arunachal, Gautham; BaHammam, Ahmed S.; et al.; Association of Per3 length polymorphism with bipolar I disorder and schizophrenia; Dove Press; Neuropsychiatric Disease and Treatment; 10; 12-2014; 2025-2330 1176-6328 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.2147/NDT.S73765 info:eu-repo/semantics/altIdentifier/url/https://www.dovepress.com/association-of-per3-length-polymorphism-withnbspbipolar-i-disorder-and-peer-reviewed-article-NDT info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4267513/ |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Dove Press |
publisher.none.fl_str_mv |
Dove Press |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
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dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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13.13397 |