The influence of Tellurium an Folic Acid Adminitration on Coping Behavioural Parameters in Maturing Rats: Transgenerational effects
- Autores
- Ratti, Silvia Gabriela; Sacchi, Osvaldo Jorge; Alvarez, Edgardo O
- Año de publicación
- 2019
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- A previous study of our laboratory have shown that Tellurium (Te), a metalloid with low concentrations in soil and water in the earth, is able to modify important behavioural parameters related to cognitive functions when administered orally in maturing rats. Exposition of chronic non-toxic doses of Te affected spontaneous lateralized exploration, social interaction behaviour, and survival responses in the treated rats. Te effects were blocked by the simultaneous administration of folic acid, a well-known methyl group donor in the cell, suggesting an epigenetic mode of action of Te. Te behavioural effects on the second generation (F1 ) still were found in the next third generation (F2 ). In order to evaluate if these transgenerational behavioural alterations in F2 were depending on DNA methylating mechanisms, as observed in the F1 generation, F1 rats were mated at 90 days of age. Two groups of animals in the F2 offspring were formed; one treated with and the other not treated with folic acid. Results showed that the untreated folic acid F2 maturing rats, conserved the same pattern of behavioural alterations than its parents (F1 ), in spite that they were not exposed to Te. Those F2 animals treated with folic acid, instead recovered the normal behavioural responses in the three tests performed to evaluate coping behaviour. Results suggest that the molecular mechanism of Te is dependent on DNA methylating reactions, which is one of the molecular processes of epigenetic modulation in mammals
Fil: Ratti, Silvia Gabriela. Universidad Nacional de Cuyo; Argentina
Fil: Sacchi, Osvaldo Jorge. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Alvarez, Edgardo O. Universidad Nacional de Cuyo; Argentina - Materia
-
Tellurium
Lateralized behaviours
Epigenetic changes
Folic acid
Transgenerational effects - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/121297
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The influence of Tellurium an Folic Acid Adminitration on Coping Behavioural Parameters in Maturing Rats: Transgenerational effectsRatti, Silvia GabrielaSacchi, Osvaldo JorgeAlvarez, Edgardo OTelluriumLateralized behavioursEpigenetic changesFolic acidTransgenerational effectshttps://purl.org/becyt/ford/3.5https://purl.org/becyt/ford/3A previous study of our laboratory have shown that Tellurium (Te), a metalloid with low concentrations in soil and water in the earth, is able to modify important behavioural parameters related to cognitive functions when administered orally in maturing rats. Exposition of chronic non-toxic doses of Te affected spontaneous lateralized exploration, social interaction behaviour, and survival responses in the treated rats. Te effects were blocked by the simultaneous administration of folic acid, a well-known methyl group donor in the cell, suggesting an epigenetic mode of action of Te. Te behavioural effects on the second generation (F1 ) still were found in the next third generation (F2 ). In order to evaluate if these transgenerational behavioural alterations in F2 were depending on DNA methylating mechanisms, as observed in the F1 generation, F1 rats were mated at 90 days of age. Two groups of animals in the F2 offspring were formed; one treated with and the other not treated with folic acid. Results showed that the untreated folic acid F2 maturing rats, conserved the same pattern of behavioural alterations than its parents (F1 ), in spite that they were not exposed to Te. Those F2 animals treated with folic acid, instead recovered the normal behavioural responses in the three tests performed to evaluate coping behaviour. Results suggest that the molecular mechanism of Te is dependent on DNA methylating reactions, which is one of the molecular processes of epigenetic modulation in mammalsFil: Ratti, Silvia Gabriela. Universidad Nacional de Cuyo; ArgentinaFil: Sacchi, Osvaldo Jorge. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; ArgentinaFil: Alvarez, Edgardo O. Universidad Nacional de Cuyo; ArgentinaAustin Publishing Group2019-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/121297Ratti, Silvia Gabriela; Sacchi, Osvaldo Jorge; Alvarez, Edgardo O; The influence of Tellurium an Folic Acid Adminitration on Coping Behavioural Parameters in Maturing Rats: Transgenerational effects; Austin Publishing Group; Austin Anthropology; 3; 2; 11-2019; 223-2342324-2426CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://austinpublishinggroup.com/austin-anthropology/fulltext/anthropology-v3-id1009.phpinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:36:24Zoai:ri.conicet.gov.ar:11336/121297instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:36:24.458CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
The influence of Tellurium an Folic Acid Adminitration on Coping Behavioural Parameters in Maturing Rats: Transgenerational effects |
title |
The influence of Tellurium an Folic Acid Adminitration on Coping Behavioural Parameters in Maturing Rats: Transgenerational effects |
spellingShingle |
The influence of Tellurium an Folic Acid Adminitration on Coping Behavioural Parameters in Maturing Rats: Transgenerational effects Ratti, Silvia Gabriela Tellurium Lateralized behaviours Epigenetic changes Folic acid Transgenerational effects |
title_short |
The influence of Tellurium an Folic Acid Adminitration on Coping Behavioural Parameters in Maturing Rats: Transgenerational effects |
title_full |
The influence of Tellurium an Folic Acid Adminitration on Coping Behavioural Parameters in Maturing Rats: Transgenerational effects |
title_fullStr |
The influence of Tellurium an Folic Acid Adminitration on Coping Behavioural Parameters in Maturing Rats: Transgenerational effects |
title_full_unstemmed |
The influence of Tellurium an Folic Acid Adminitration on Coping Behavioural Parameters in Maturing Rats: Transgenerational effects |
title_sort |
The influence of Tellurium an Folic Acid Adminitration on Coping Behavioural Parameters in Maturing Rats: Transgenerational effects |
dc.creator.none.fl_str_mv |
Ratti, Silvia Gabriela Sacchi, Osvaldo Jorge Alvarez, Edgardo O |
author |
Ratti, Silvia Gabriela |
author_facet |
Ratti, Silvia Gabriela Sacchi, Osvaldo Jorge Alvarez, Edgardo O |
author_role |
author |
author2 |
Sacchi, Osvaldo Jorge Alvarez, Edgardo O |
author2_role |
author author |
dc.subject.none.fl_str_mv |
Tellurium Lateralized behaviours Epigenetic changes Folic acid Transgenerational effects |
topic |
Tellurium Lateralized behaviours Epigenetic changes Folic acid Transgenerational effects |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.5 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
A previous study of our laboratory have shown that Tellurium (Te), a metalloid with low concentrations in soil and water in the earth, is able to modify important behavioural parameters related to cognitive functions when administered orally in maturing rats. Exposition of chronic non-toxic doses of Te affected spontaneous lateralized exploration, social interaction behaviour, and survival responses in the treated rats. Te effects were blocked by the simultaneous administration of folic acid, a well-known methyl group donor in the cell, suggesting an epigenetic mode of action of Te. Te behavioural effects on the second generation (F1 ) still were found in the next third generation (F2 ). In order to evaluate if these transgenerational behavioural alterations in F2 were depending on DNA methylating mechanisms, as observed in the F1 generation, F1 rats were mated at 90 days of age. Two groups of animals in the F2 offspring were formed; one treated with and the other not treated with folic acid. Results showed that the untreated folic acid F2 maturing rats, conserved the same pattern of behavioural alterations than its parents (F1 ), in spite that they were not exposed to Te. Those F2 animals treated with folic acid, instead recovered the normal behavioural responses in the three tests performed to evaluate coping behaviour. Results suggest that the molecular mechanism of Te is dependent on DNA methylating reactions, which is one of the molecular processes of epigenetic modulation in mammals Fil: Ratti, Silvia Gabriela. Universidad Nacional de Cuyo; Argentina Fil: Sacchi, Osvaldo Jorge. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina Fil: Alvarez, Edgardo O. Universidad Nacional de Cuyo; Argentina |
description |
A previous study of our laboratory have shown that Tellurium (Te), a metalloid with low concentrations in soil and water in the earth, is able to modify important behavioural parameters related to cognitive functions when administered orally in maturing rats. Exposition of chronic non-toxic doses of Te affected spontaneous lateralized exploration, social interaction behaviour, and survival responses in the treated rats. Te effects were blocked by the simultaneous administration of folic acid, a well-known methyl group donor in the cell, suggesting an epigenetic mode of action of Te. Te behavioural effects on the second generation (F1 ) still were found in the next third generation (F2 ). In order to evaluate if these transgenerational behavioural alterations in F2 were depending on DNA methylating mechanisms, as observed in the F1 generation, F1 rats were mated at 90 days of age. Two groups of animals in the F2 offspring were formed; one treated with and the other not treated with folic acid. Results showed that the untreated folic acid F2 maturing rats, conserved the same pattern of behavioural alterations than its parents (F1 ), in spite that they were not exposed to Te. Those F2 animals treated with folic acid, instead recovered the normal behavioural responses in the three tests performed to evaluate coping behaviour. Results suggest that the molecular mechanism of Te is dependent on DNA methylating reactions, which is one of the molecular processes of epigenetic modulation in mammals |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-11 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/121297 Ratti, Silvia Gabriela; Sacchi, Osvaldo Jorge; Alvarez, Edgardo O; The influence of Tellurium an Folic Acid Adminitration on Coping Behavioural Parameters in Maturing Rats: Transgenerational effects; Austin Publishing Group; Austin Anthropology; 3; 2; 11-2019; 223-234 2324-2426 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/121297 |
identifier_str_mv |
Ratti, Silvia Gabriela; Sacchi, Osvaldo Jorge; Alvarez, Edgardo O; The influence of Tellurium an Folic Acid Adminitration on Coping Behavioural Parameters in Maturing Rats: Transgenerational effects; Austin Publishing Group; Austin Anthropology; 3; 2; 11-2019; 223-234 2324-2426 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://austinpublishinggroup.com/austin-anthropology/fulltext/anthropology-v3-id1009.php |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Austin Publishing Group |
publisher.none.fl_str_mv |
Austin Publishing Group |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844613141026045952 |
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13.070432 |