The influence of Tellurium an Folic Acid Adminitration on Coping Behavioural Parameters in Maturing Rats: Transgenerational effects

Autores
Ratti, Silvia Gabriela; Sacchi, Osvaldo Jorge; Alvarez, Edgardo O
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
A previous study of our laboratory have shown that Tellurium (Te), a metalloid with low concentrations in soil and water in the earth, is able to modify important behavioural parameters related to cognitive functions when administered orally in maturing rats. Exposition of chronic non-toxic doses of Te affected spontaneous lateralized exploration, social interaction behaviour, and survival responses in the treated rats. Te effects were blocked by the simultaneous administration of folic acid, a well-known methyl group donor in the cell, suggesting an epigenetic mode of action of Te. Te behavioural effects on the second generation (F1 ) still were found in the next third generation (F2 ). In order to evaluate if these transgenerational behavioural alterations in F2 were depending on DNA methylating mechanisms, as observed in the F1 generation, F1 rats were mated at 90 days of age. Two groups of animals in the F2 offspring were formed; one treated with and the other not treated with folic acid. Results showed that the untreated folic acid F2 maturing rats, conserved the same pattern of behavioural alterations than its parents (F1 ), in spite that they were not exposed to Te. Those F2 animals treated with folic acid, instead recovered the normal behavioural responses in the three tests performed to evaluate coping behaviour. Results suggest that the molecular mechanism of Te is dependent on DNA methylating reactions, which is one of the molecular processes of epigenetic modulation in mammals
Fil: Ratti, Silvia Gabriela. Universidad Nacional de Cuyo; Argentina
Fil: Sacchi, Osvaldo Jorge. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Alvarez, Edgardo O. Universidad Nacional de Cuyo; Argentina
Materia
Tellurium
Lateralized behaviours
Epigenetic changes
Folic acid
Transgenerational effects
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/121297
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/121297
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling The influence of Tellurium an Folic Acid Adminitration on Coping Behavioural Parameters in Maturing Rats: Transgenerational effectsRatti, Silvia GabrielaSacchi, Osvaldo JorgeAlvarez, Edgardo OTelluriumLateralized behavioursEpigenetic changesFolic acidTransgenerational effectshttps://purl.org/becyt/ford/3.5https://purl.org/becyt/ford/3A previous study of our laboratory have shown that Tellurium (Te), a metalloid with low concentrations in soil and water in the earth, is able to modify important behavioural parameters related to cognitive functions when administered orally in maturing rats. Exposition of chronic non-toxic doses of Te affected spontaneous lateralized exploration, social interaction behaviour, and survival responses in the treated rats. Te effects were blocked by the simultaneous administration of folic acid, a well-known methyl group donor in the cell, suggesting an epigenetic mode of action of Te. Te behavioural effects on the second generation (F1 ) still were found in the next third generation (F2 ). In order to evaluate if these transgenerational behavioural alterations in F2 were depending on DNA methylating mechanisms, as observed in the F1 generation, F1 rats were mated at 90 days of age. Two groups of animals in the F2 offspring were formed; one treated with and the other not treated with folic acid. Results showed that the untreated folic acid F2 maturing rats, conserved the same pattern of behavioural alterations than its parents (F1 ), in spite that they were not exposed to Te. Those F2 animals treated with folic acid, instead recovered the normal behavioural responses in the three tests performed to evaluate coping behaviour. Results suggest that the molecular mechanism of Te is dependent on DNA methylating reactions, which is one of the molecular processes of epigenetic modulation in mammalsFil: Ratti, Silvia Gabriela. Universidad Nacional de Cuyo; ArgentinaFil: Sacchi, Osvaldo Jorge. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; ArgentinaFil: Alvarez, Edgardo O. Universidad Nacional de Cuyo; ArgentinaAustin Publishing Group2019-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/121297Ratti, Silvia Gabriela; Sacchi, Osvaldo Jorge; Alvarez, Edgardo O; The influence of Tellurium an Folic Acid Adminitration on Coping Behavioural Parameters in Maturing Rats: Transgenerational effects; Austin Publishing Group; Austin Anthropology; 3; 2; 11-2019; 223-2342324-2426CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://austinpublishinggroup.com/austin-anthropology/fulltext/anthropology-v3-id1009.phpinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:04:28Zoai:ri.conicet.gov.ar:11336/121297instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:04:29.079CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv The influence of Tellurium an Folic Acid Adminitration on Coping Behavioural Parameters in Maturing Rats: Transgenerational effects
title The influence of Tellurium an Folic Acid Adminitration on Coping Behavioural Parameters in Maturing Rats: Transgenerational effects
spellingShingle The influence of Tellurium an Folic Acid Adminitration on Coping Behavioural Parameters in Maturing Rats: Transgenerational effects
Ratti, Silvia Gabriela
Tellurium
Lateralized behaviours
Epigenetic changes
Folic acid
Transgenerational effects
title_short The influence of Tellurium an Folic Acid Adminitration on Coping Behavioural Parameters in Maturing Rats: Transgenerational effects
title_full The influence of Tellurium an Folic Acid Adminitration on Coping Behavioural Parameters in Maturing Rats: Transgenerational effects
title_fullStr The influence of Tellurium an Folic Acid Adminitration on Coping Behavioural Parameters in Maturing Rats: Transgenerational effects
title_full_unstemmed The influence of Tellurium an Folic Acid Adminitration on Coping Behavioural Parameters in Maturing Rats: Transgenerational effects
title_sort The influence of Tellurium an Folic Acid Adminitration on Coping Behavioural Parameters in Maturing Rats: Transgenerational effects
dc.creator.none.fl_str_mv Ratti, Silvia Gabriela
Sacchi, Osvaldo Jorge
Alvarez, Edgardo O
author Ratti, Silvia Gabriela
author_facet Ratti, Silvia Gabriela
Sacchi, Osvaldo Jorge
Alvarez, Edgardo O
author_role author
author2 Sacchi, Osvaldo Jorge
Alvarez, Edgardo O
author2_role author
author
dc.subject.none.fl_str_mv Tellurium
Lateralized behaviours
Epigenetic changes
Folic acid
Transgenerational effects
topic Tellurium
Lateralized behaviours
Epigenetic changes
Folic acid
Transgenerational effects
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.5
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv A previous study of our laboratory have shown that Tellurium (Te), a metalloid with low concentrations in soil and water in the earth, is able to modify important behavioural parameters related to cognitive functions when administered orally in maturing rats. Exposition of chronic non-toxic doses of Te affected spontaneous lateralized exploration, social interaction behaviour, and survival responses in the treated rats. Te effects were blocked by the simultaneous administration of folic acid, a well-known methyl group donor in the cell, suggesting an epigenetic mode of action of Te. Te behavioural effects on the second generation (F1 ) still were found in the next third generation (F2 ). In order to evaluate if these transgenerational behavioural alterations in F2 were depending on DNA methylating mechanisms, as observed in the F1 generation, F1 rats were mated at 90 days of age. Two groups of animals in the F2 offspring were formed; one treated with and the other not treated with folic acid. Results showed that the untreated folic acid F2 maturing rats, conserved the same pattern of behavioural alterations than its parents (F1 ), in spite that they were not exposed to Te. Those F2 animals treated with folic acid, instead recovered the normal behavioural responses in the three tests performed to evaluate coping behaviour. Results suggest that the molecular mechanism of Te is dependent on DNA methylating reactions, which is one of the molecular processes of epigenetic modulation in mammals
Fil: Ratti, Silvia Gabriela. Universidad Nacional de Cuyo; Argentina
Fil: Sacchi, Osvaldo Jorge. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Alvarez, Edgardo O. Universidad Nacional de Cuyo; Argentina
description A previous study of our laboratory have shown that Tellurium (Te), a metalloid with low concentrations in soil and water in the earth, is able to modify important behavioural parameters related to cognitive functions when administered orally in maturing rats. Exposition of chronic non-toxic doses of Te affected spontaneous lateralized exploration, social interaction behaviour, and survival responses in the treated rats. Te effects were blocked by the simultaneous administration of folic acid, a well-known methyl group donor in the cell, suggesting an epigenetic mode of action of Te. Te behavioural effects on the second generation (F1 ) still were found in the next third generation (F2 ). In order to evaluate if these transgenerational behavioural alterations in F2 were depending on DNA methylating mechanisms, as observed in the F1 generation, F1 rats were mated at 90 days of age. Two groups of animals in the F2 offspring were formed; one treated with and the other not treated with folic acid. Results showed that the untreated folic acid F2 maturing rats, conserved the same pattern of behavioural alterations than its parents (F1 ), in spite that they were not exposed to Te. Those F2 animals treated with folic acid, instead recovered the normal behavioural responses in the three tests performed to evaluate coping behaviour. Results suggest that the molecular mechanism of Te is dependent on DNA methylating reactions, which is one of the molecular processes of epigenetic modulation in mammals
publishDate 2019
dc.date.none.fl_str_mv 2019-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/121297
Ratti, Silvia Gabriela; Sacchi, Osvaldo Jorge; Alvarez, Edgardo O; The influence of Tellurium an Folic Acid Adminitration on Coping Behavioural Parameters in Maturing Rats: Transgenerational effects; Austin Publishing Group; Austin Anthropology; 3; 2; 11-2019; 223-234
2324-2426
CONICET Digital
CONICET
url http://hdl.handle.net/11336/121297
identifier_str_mv Ratti, Silvia Gabriela; Sacchi, Osvaldo Jorge; Alvarez, Edgardo O; The influence of Tellurium an Folic Acid Adminitration on Coping Behavioural Parameters in Maturing Rats: Transgenerational effects; Austin Publishing Group; Austin Anthropology; 3; 2; 11-2019; 223-234
2324-2426
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://austinpublishinggroup.com/austin-anthropology/fulltext/anthropology-v3-id1009.php
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Austin Publishing Group
publisher.none.fl_str_mv Austin Publishing Group
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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