The Altered Behavioural Responses Displayed by Litter Rats After Chronic Administration of Non-Toxic Concentrations of ZnTe to Parent Rats Are Reversed by Simultaneous Folic Acid T...

Autores
Ratti, Silvia Gabriela; Alvarez Toro, Edgardo Orozimbo
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Trace elements are an omnipresent group of chemical elements that are present practically in all types of environments sustaining life. Since its principal characteristic is the very low concentration in ground and water, it was thought that its importance to metabolic processes to the living cell was minimal. However, in the past 15 years knowledge has been accumulated regarding that these chemical elements have important influences on the cell dynamic homeostatic mechanisms. Previous evidence from our laboratory has shown that chronic administration of ZnTe to pregnancy, delivery and subsequent juvenile stages in rats affected several of its behavioural parameters related to motivated, lateralized exploration, social and defensive behaviour. In the third part of this study, the possible effect of folic acid (FolA) on the Te-induced behavioural changes was studied. Three experimental groups were formed, Control, animals treated with tap water; ZnTe, animals treated with the trace elements, and ZnTe+FolA, animals treated with the combination of ZnTe and FolA, in the same way that of the previous experiments. Results show the folic acid treatment did not counteract the increase of motor activity observed in those animals treated with ZnTe. However, in the exploration induced by novelty measured in the Double Lateral Hole-board Labyrinth, the corridor behavioural activity displayed by animals under the combination of FolA and ZnTe was similar to control and significantly different from the ZnTe-treated group. The left exploration bias naturally present in control, and blocked in the ZnTe-treated animals, was restored to control values in the FolA+ZnTe treated animals. A similar observation was found with the percentage of animals with left-bias exploration, where those rats treated with the combination of FolA and ZnTe reached similar values to control and significantly greater than the ZnTe-treated rats which were statistically lower than control. Social behaviour, inhibited by ZnTe was restored to normal in the FolA treated animals. A similar observation was found in the defensive behaviour test. Results are compatible with the idea that FolA, which is known as a methyl donor reagent, can restore the behavioural effects of ZnTe, giving support to previous results suggesting that trace elements could act by molecular mechanisms involving epigenetical modulation of DNA.
Fil: Ratti, Silvia Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas; Argentina
Fil: Alvarez Toro, Edgardo Orozimbo. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Materia
Defensive Behaviour
Lateralization
Trace Elements
Folic Acid
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/40275
Acceder
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repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling The Altered Behavioural Responses Displayed by Litter Rats After Chronic Administration of Non-Toxic Concentrations of ZnTe to Parent Rats Are Reversed by Simultaneous Folic Acid TreatmentRatti, Silvia GabrielaAlvarez Toro, Edgardo OrozimboDefensive BehaviourLateralizationTrace ElementsFolic Acidhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Trace elements are an omnipresent group of chemical elements that are present practically in all types of environments sustaining life. Since its principal characteristic is the very low concentration in ground and water, it was thought that its importance to metabolic processes to the living cell was minimal. However, in the past 15 years knowledge has been accumulated regarding that these chemical elements have important influences on the cell dynamic homeostatic mechanisms. Previous evidence from our laboratory has shown that chronic administration of ZnTe to pregnancy, delivery and subsequent juvenile stages in rats affected several of its behavioural parameters related to motivated, lateralized exploration, social and defensive behaviour. In the third part of this study, the possible effect of folic acid (FolA) on the Te-induced behavioural changes was studied. Three experimental groups were formed, Control, animals treated with tap water; ZnTe, animals treated with the trace elements, and ZnTe+FolA, animals treated with the combination of ZnTe and FolA, in the same way that of the previous experiments. Results show the folic acid treatment did not counteract the increase of motor activity observed in those animals treated with ZnTe. However, in the exploration induced by novelty measured in the Double Lateral Hole-board Labyrinth, the corridor behavioural activity displayed by animals under the combination of FolA and ZnTe was similar to control and significantly different from the ZnTe-treated group. The left exploration bias naturally present in control, and blocked in the ZnTe-treated animals, was restored to control values in the FolA+ZnTe treated animals. A similar observation was found with the percentage of animals with left-bias exploration, where those rats treated with the combination of FolA and ZnTe reached similar values to control and significantly greater than the ZnTe-treated rats which were statistically lower than control. Social behaviour, inhibited by ZnTe was restored to normal in the FolA treated animals. A similar observation was found in the defensive behaviour test. Results are compatible with the idea that FolA, which is known as a methyl donor reagent, can restore the behavioural effects of ZnTe, giving support to previous results suggesting that trace elements could act by molecular mechanisms involving epigenetical modulation of DNA.Fil: Ratti, Silvia Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas; ArgentinaFil: Alvarez Toro, Edgardo Orozimbo. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; ArgentinaAmerican Scientific Publishers2015-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/40275Ratti, Silvia Gabriela; Alvarez Toro, Edgardo Orozimbo; The Altered Behavioural Responses Displayed by Litter Rats After Chronic Administration of Non-Toxic Concentrations of ZnTe to Parent Rats Are Reversed by Simultaneous Folic Acid Treatment; American Scientific Publishers; American Journal of Neuroprotection and Neuroregeneration; 7; 1; 10-2015; 56-641947-29511947-296XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1166/ajnn.2015.1101info:eu-repo/semantics/altIdentifier/url/http://www.ingentaconnect.com/content/asp/ajnn/2015/00000007/00000001/art00012info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:24:56Zoai:ri.conicet.gov.ar:11336/40275instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:24:56.413CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv The Altered Behavioural Responses Displayed by Litter Rats After Chronic Administration of Non-Toxic Concentrations of ZnTe to Parent Rats Are Reversed by Simultaneous Folic Acid Treatment
title The Altered Behavioural Responses Displayed by Litter Rats After Chronic Administration of Non-Toxic Concentrations of ZnTe to Parent Rats Are Reversed by Simultaneous Folic Acid Treatment
spellingShingle The Altered Behavioural Responses Displayed by Litter Rats After Chronic Administration of Non-Toxic Concentrations of ZnTe to Parent Rats Are Reversed by Simultaneous Folic Acid Treatment
Ratti, Silvia Gabriela
Defensive Behaviour
Lateralization
Trace Elements
Folic Acid
title_short The Altered Behavioural Responses Displayed by Litter Rats After Chronic Administration of Non-Toxic Concentrations of ZnTe to Parent Rats Are Reversed by Simultaneous Folic Acid Treatment
title_full The Altered Behavioural Responses Displayed by Litter Rats After Chronic Administration of Non-Toxic Concentrations of ZnTe to Parent Rats Are Reversed by Simultaneous Folic Acid Treatment
title_fullStr The Altered Behavioural Responses Displayed by Litter Rats After Chronic Administration of Non-Toxic Concentrations of ZnTe to Parent Rats Are Reversed by Simultaneous Folic Acid Treatment
title_full_unstemmed The Altered Behavioural Responses Displayed by Litter Rats After Chronic Administration of Non-Toxic Concentrations of ZnTe to Parent Rats Are Reversed by Simultaneous Folic Acid Treatment
title_sort The Altered Behavioural Responses Displayed by Litter Rats After Chronic Administration of Non-Toxic Concentrations of ZnTe to Parent Rats Are Reversed by Simultaneous Folic Acid Treatment
dc.creator.none.fl_str_mv Ratti, Silvia Gabriela
Alvarez Toro, Edgardo Orozimbo
author Ratti, Silvia Gabriela
author_facet Ratti, Silvia Gabriela
Alvarez Toro, Edgardo Orozimbo
author_role author
author2 Alvarez Toro, Edgardo Orozimbo
author2_role author
dc.subject.none.fl_str_mv Defensive Behaviour
Lateralization
Trace Elements
Folic Acid
topic Defensive Behaviour
Lateralization
Trace Elements
Folic Acid
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Trace elements are an omnipresent group of chemical elements that are present practically in all types of environments sustaining life. Since its principal characteristic is the very low concentration in ground and water, it was thought that its importance to metabolic processes to the living cell was minimal. However, in the past 15 years knowledge has been accumulated regarding that these chemical elements have important influences on the cell dynamic homeostatic mechanisms. Previous evidence from our laboratory has shown that chronic administration of ZnTe to pregnancy, delivery and subsequent juvenile stages in rats affected several of its behavioural parameters related to motivated, lateralized exploration, social and defensive behaviour. In the third part of this study, the possible effect of folic acid (FolA) on the Te-induced behavioural changes was studied. Three experimental groups were formed, Control, animals treated with tap water; ZnTe, animals treated with the trace elements, and ZnTe+FolA, animals treated with the combination of ZnTe and FolA, in the same way that of the previous experiments. Results show the folic acid treatment did not counteract the increase of motor activity observed in those animals treated with ZnTe. However, in the exploration induced by novelty measured in the Double Lateral Hole-board Labyrinth, the corridor behavioural activity displayed by animals under the combination of FolA and ZnTe was similar to control and significantly different from the ZnTe-treated group. The left exploration bias naturally present in control, and blocked in the ZnTe-treated animals, was restored to control values in the FolA+ZnTe treated animals. A similar observation was found with the percentage of animals with left-bias exploration, where those rats treated with the combination of FolA and ZnTe reached similar values to control and significantly greater than the ZnTe-treated rats which were statistically lower than control. Social behaviour, inhibited by ZnTe was restored to normal in the FolA treated animals. A similar observation was found in the defensive behaviour test. Results are compatible with the idea that FolA, which is known as a methyl donor reagent, can restore the behavioural effects of ZnTe, giving support to previous results suggesting that trace elements could act by molecular mechanisms involving epigenetical modulation of DNA.
Fil: Ratti, Silvia Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas; Argentina
Fil: Alvarez Toro, Edgardo Orozimbo. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
description Trace elements are an omnipresent group of chemical elements that are present practically in all types of environments sustaining life. Since its principal characteristic is the very low concentration in ground and water, it was thought that its importance to metabolic processes to the living cell was minimal. However, in the past 15 years knowledge has been accumulated regarding that these chemical elements have important influences on the cell dynamic homeostatic mechanisms. Previous evidence from our laboratory has shown that chronic administration of ZnTe to pregnancy, delivery and subsequent juvenile stages in rats affected several of its behavioural parameters related to motivated, lateralized exploration, social and defensive behaviour. In the third part of this study, the possible effect of folic acid (FolA) on the Te-induced behavioural changes was studied. Three experimental groups were formed, Control, animals treated with tap water; ZnTe, animals treated with the trace elements, and ZnTe+FolA, animals treated with the combination of ZnTe and FolA, in the same way that of the previous experiments. Results show the folic acid treatment did not counteract the increase of motor activity observed in those animals treated with ZnTe. However, in the exploration induced by novelty measured in the Double Lateral Hole-board Labyrinth, the corridor behavioural activity displayed by animals under the combination of FolA and ZnTe was similar to control and significantly different from the ZnTe-treated group. The left exploration bias naturally present in control, and blocked in the ZnTe-treated animals, was restored to control values in the FolA+ZnTe treated animals. A similar observation was found with the percentage of animals with left-bias exploration, where those rats treated with the combination of FolA and ZnTe reached similar values to control and significantly greater than the ZnTe-treated rats which were statistically lower than control. Social behaviour, inhibited by ZnTe was restored to normal in the FolA treated animals. A similar observation was found in the defensive behaviour test. Results are compatible with the idea that FolA, which is known as a methyl donor reagent, can restore the behavioural effects of ZnTe, giving support to previous results suggesting that trace elements could act by molecular mechanisms involving epigenetical modulation of DNA.
publishDate 2015
dc.date.none.fl_str_mv 2015-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/40275
Ratti, Silvia Gabriela; Alvarez Toro, Edgardo Orozimbo; The Altered Behavioural Responses Displayed by Litter Rats After Chronic Administration of Non-Toxic Concentrations of ZnTe to Parent Rats Are Reversed by Simultaneous Folic Acid Treatment; American Scientific Publishers; American Journal of Neuroprotection and Neuroregeneration; 7; 1; 10-2015; 56-64
1947-2951
1947-296X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/40275
identifier_str_mv Ratti, Silvia Gabriela; Alvarez Toro, Edgardo Orozimbo; The Altered Behavioural Responses Displayed by Litter Rats After Chronic Administration of Non-Toxic Concentrations of ZnTe to Parent Rats Are Reversed by Simultaneous Folic Acid Treatment; American Scientific Publishers; American Journal of Neuroprotection and Neuroregeneration; 7; 1; 10-2015; 56-64
1947-2951
1947-296X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1166/ajnn.2015.1101
info:eu-repo/semantics/altIdentifier/url/http://www.ingentaconnect.com/content/asp/ajnn/2015/00000007/00000001/art00012
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Scientific Publishers
publisher.none.fl_str_mv American Scientific Publishers
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.891075

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