A Brainstem Locomotor Circuit Drives the Activity of Speed Cells in the Medial Entorhinal Cortex

Autores
Carvalho, Miguel Murteira; Tanke, Nouk; Kropff, Emilio; Witter, Menno P.; Moser, May Britt; Moser, Edvard I.
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Locomotion activates an array of sensory inputs that may help build the self-position map of the medial entorhinal cortex (MEC). In this map, speed-coding neurons are thought to dynamically update representations of the animal’s position. A possible origin for the entorhinal speed signal is the mesencephalic locomotor region (MLR), which is critically involved in the activation of locomotor programs. Here, we describe, in rats, a circuit connecting the pedunculopontine tegmental nucleus (PPN) of the MLR to the MEC via the horizontal limb of the diagonal band of Broca (HDB). At each level of this pathway, locomotion speed is linearly encoded in neuronal firing rates. Optogenetic activation of PPN cells drives locomotion and modulates activity of speed-modulated neurons in HDB and MEC. Our results provide evidence for a pathway by which brainstem speed signals can reach cortical structures implicated in navigation and higher-order dynamic representations of space.
Fil: Carvalho, Miguel Murteira. Norwegian University of Science and Technology; Noruega
Fil: Tanke, Nouk. Norwegian University of Science and Technology; Noruega. Radboud University Medical Centre; Países Bajos
Fil: Kropff, Emilio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Fil: Witter, Menno P.. Norwegian University of Science and Technology; Noruega
Fil: Moser, May Britt. Norwegian University of Science and Technology; Noruega
Fil: Moser, Edvard I.. Norwegian University of Science and Technology; Noruega
Materia
DIAGONAL BAND OF BROCA
MEDIAL ENTORHINAL CORTEX
MESENCEPHALIC LOCOMOTOR REGION
PEDUNCULOPONTINE TEGMENTAL NUCLEUS
SPEED CELLS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/139209
Acceder
id CONICETDig_f57348c6d7fd49c5cbc8677e2756203f
oai_identifier_str oai:ri.conicet.gov.ar:11336/139209
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling A Brainstem Locomotor Circuit Drives the Activity of Speed Cells in the Medial Entorhinal CortexCarvalho, Miguel MurteiraTanke, NoukKropff, EmilioWitter, Menno P.Moser, May BrittMoser, Edvard I.DIAGONAL BAND OF BROCAMEDIAL ENTORHINAL CORTEXMESENCEPHALIC LOCOMOTOR REGIONPEDUNCULOPONTINE TEGMENTAL NUCLEUSSPEED CELLShttps://purl.org/becyt/ford/3.5https://purl.org/becyt/ford/3Locomotion activates an array of sensory inputs that may help build the self-position map of the medial entorhinal cortex (MEC). In this map, speed-coding neurons are thought to dynamically update representations of the animal’s position. A possible origin for the entorhinal speed signal is the mesencephalic locomotor region (MLR), which is critically involved in the activation of locomotor programs. Here, we describe, in rats, a circuit connecting the pedunculopontine tegmental nucleus (PPN) of the MLR to the MEC via the horizontal limb of the diagonal band of Broca (HDB). At each level of this pathway, locomotion speed is linearly encoded in neuronal firing rates. Optogenetic activation of PPN cells drives locomotion and modulates activity of speed-modulated neurons in HDB and MEC. Our results provide evidence for a pathway by which brainstem speed signals can reach cortical structures implicated in navigation and higher-order dynamic representations of space.Fil: Carvalho, Miguel Murteira. Norwegian University of Science and Technology; NoruegaFil: Tanke, Nouk. Norwegian University of Science and Technology; Noruega. Radboud University Medical Centre; Países BajosFil: Kropff, Emilio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; ArgentinaFil: Witter, Menno P.. Norwegian University of Science and Technology; NoruegaFil: Moser, May Britt. Norwegian University of Science and Technology; NoruegaFil: Moser, Edvard I.. Norwegian University of Science and Technology; NoruegaElsevier Science2020-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/139209Carvalho, Miguel Murteira; Tanke, Nouk; Kropff, Emilio; Witter, Menno P.; Moser, May Britt; et al.; A Brainstem Locomotor Circuit Drives the Activity of Speed Cells in the Medial Entorhinal Cortex; Elsevier Science; Cell Reports; 32; 10; 9-2020; 1-382211-1247CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.celrep.2020.108123info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S2211124720311128info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:33:03Zoai:ri.conicet.gov.ar:11336/139209instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:33:03.516CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv A Brainstem Locomotor Circuit Drives the Activity of Speed Cells in the Medial Entorhinal Cortex
title A Brainstem Locomotor Circuit Drives the Activity of Speed Cells in the Medial Entorhinal Cortex
spellingShingle A Brainstem Locomotor Circuit Drives the Activity of Speed Cells in the Medial Entorhinal Cortex
Carvalho, Miguel Murteira
DIAGONAL BAND OF BROCA
MEDIAL ENTORHINAL CORTEX
MESENCEPHALIC LOCOMOTOR REGION
PEDUNCULOPONTINE TEGMENTAL NUCLEUS
SPEED CELLS
title_short A Brainstem Locomotor Circuit Drives the Activity of Speed Cells in the Medial Entorhinal Cortex
title_full A Brainstem Locomotor Circuit Drives the Activity of Speed Cells in the Medial Entorhinal Cortex
title_fullStr A Brainstem Locomotor Circuit Drives the Activity of Speed Cells in the Medial Entorhinal Cortex
title_full_unstemmed A Brainstem Locomotor Circuit Drives the Activity of Speed Cells in the Medial Entorhinal Cortex
title_sort A Brainstem Locomotor Circuit Drives the Activity of Speed Cells in the Medial Entorhinal Cortex
dc.creator.none.fl_str_mv Carvalho, Miguel Murteira
Tanke, Nouk
Kropff, Emilio
Witter, Menno P.
Moser, May Britt
Moser, Edvard I.
author Carvalho, Miguel Murteira
author_facet Carvalho, Miguel Murteira
Tanke, Nouk
Kropff, Emilio
Witter, Menno P.
Moser, May Britt
Moser, Edvard I.
author_role author
author2 Tanke, Nouk
Kropff, Emilio
Witter, Menno P.
Moser, May Britt
Moser, Edvard I.
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv DIAGONAL BAND OF BROCA
MEDIAL ENTORHINAL CORTEX
MESENCEPHALIC LOCOMOTOR REGION
PEDUNCULOPONTINE TEGMENTAL NUCLEUS
SPEED CELLS
topic DIAGONAL BAND OF BROCA
MEDIAL ENTORHINAL CORTEX
MESENCEPHALIC LOCOMOTOR REGION
PEDUNCULOPONTINE TEGMENTAL NUCLEUS
SPEED CELLS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.5
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Locomotion activates an array of sensory inputs that may help build the self-position map of the medial entorhinal cortex (MEC). In this map, speed-coding neurons are thought to dynamically update representations of the animal’s position. A possible origin for the entorhinal speed signal is the mesencephalic locomotor region (MLR), which is critically involved in the activation of locomotor programs. Here, we describe, in rats, a circuit connecting the pedunculopontine tegmental nucleus (PPN) of the MLR to the MEC via the horizontal limb of the diagonal band of Broca (HDB). At each level of this pathway, locomotion speed is linearly encoded in neuronal firing rates. Optogenetic activation of PPN cells drives locomotion and modulates activity of speed-modulated neurons in HDB and MEC. Our results provide evidence for a pathway by which brainstem speed signals can reach cortical structures implicated in navigation and higher-order dynamic representations of space.
Fil: Carvalho, Miguel Murteira. Norwegian University of Science and Technology; Noruega
Fil: Tanke, Nouk. Norwegian University of Science and Technology; Noruega. Radboud University Medical Centre; Países Bajos
Fil: Kropff, Emilio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Fil: Witter, Menno P.. Norwegian University of Science and Technology; Noruega
Fil: Moser, May Britt. Norwegian University of Science and Technology; Noruega
Fil: Moser, Edvard I.. Norwegian University of Science and Technology; Noruega
description Locomotion activates an array of sensory inputs that may help build the self-position map of the medial entorhinal cortex (MEC). In this map, speed-coding neurons are thought to dynamically update representations of the animal’s position. A possible origin for the entorhinal speed signal is the mesencephalic locomotor region (MLR), which is critically involved in the activation of locomotor programs. Here, we describe, in rats, a circuit connecting the pedunculopontine tegmental nucleus (PPN) of the MLR to the MEC via the horizontal limb of the diagonal band of Broca (HDB). At each level of this pathway, locomotion speed is linearly encoded in neuronal firing rates. Optogenetic activation of PPN cells drives locomotion and modulates activity of speed-modulated neurons in HDB and MEC. Our results provide evidence for a pathway by which brainstem speed signals can reach cortical structures implicated in navigation and higher-order dynamic representations of space.
publishDate 2020
dc.date.none.fl_str_mv 2020-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/139209
Carvalho, Miguel Murteira; Tanke, Nouk; Kropff, Emilio; Witter, Menno P.; Moser, May Britt; et al.; A Brainstem Locomotor Circuit Drives the Activity of Speed Cells in the Medial Entorhinal Cortex; Elsevier Science; Cell Reports; 32; 10; 9-2020; 1-38
2211-1247
CONICET Digital
CONICET
url http://hdl.handle.net/11336/139209
identifier_str_mv Carvalho, Miguel Murteira; Tanke, Nouk; Kropff, Emilio; Witter, Menno P.; Moser, May Britt; et al.; A Brainstem Locomotor Circuit Drives the Activity of Speed Cells in the Medial Entorhinal Cortex; Elsevier Science; Cell Reports; 32; 10; 9-2020; 1-38
2211-1247
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.celrep.2020.108123
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S2211124720311128
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844614345528442880
score 13.070432

Publicaciones similares