Speed cells in the medial entorhinal cortex

Autores
Kropff, Emilio; Carmichael, James E.; Moser, May Britt; Moser, Edvard I.
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Grid cells in the medial entorhinal cortex have spatial firing fields that repeat periodically in a hexagonal pattern. When animals move, activity is translated between grid cells in accordance with the animal's displacement in the environment. For this translation to occur, grid cells must have continuous access to information about instantaneous running speed. However, a powerful entorhinal speed signal has not been identified. Here we show that running speed is represented in the firing rate of a ubiquitous but functionally dedicated population of entorhinal neurons distinct from other cell populations of the local circuit, such as grid, head-direction and border cells. These 'speed cells' are characterized by a context-invariant positive, linear response to running speed, and share with grid cells a prospective bias of ∼50-80 ms. Our observations point to speed cells as a key component of the dynamic representation of self-location in the medial entorhinal cortex.
Fil: Kropff, Emilio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquimicas de Buenos Aires; Argentina. Fundación Instituto Leloir; Argentina. Kavli Institute For Systems Neuroscience; Noruega
Fil: Carmichael, James E.. Norwegian University of Science and Technology. Kavli Institute For Systems Neuroscience; Noruega
Fil: Moser, May Britt. Norwegian University of Science and Technology. Kavli Institute For Systems Neuroscience; Noruega
Fil: Moser, Edvard I.. Norwegian University of Science and Technology. Kavli Institute For Systems Neuroscience; Noruega
Materia
Entorhinal Cortex
Hippocampus
Grid Cells
Head Direction Cells
Speed
Velocity
Space
Theta Rhythm
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/10493
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Speed cells in the medial entorhinal cortexKropff, EmilioCarmichael, James E.Moser, May BrittMoser, Edvard I.Entorhinal CortexHippocampusGrid CellsHead Direction CellsSpeedVelocitySpaceTheta Rhythmhttps://purl.org/becyt/ford/3.5https://purl.org/becyt/ford/3https://purl.org/becyt/ford/3.5https://purl.org/becyt/ford/3Grid cells in the medial entorhinal cortex have spatial firing fields that repeat periodically in a hexagonal pattern. When animals move, activity is translated between grid cells in accordance with the animal's displacement in the environment. For this translation to occur, grid cells must have continuous access to information about instantaneous running speed. However, a powerful entorhinal speed signal has not been identified. Here we show that running speed is represented in the firing rate of a ubiquitous but functionally dedicated population of entorhinal neurons distinct from other cell populations of the local circuit, such as grid, head-direction and border cells. These 'speed cells' are characterized by a context-invariant positive, linear response to running speed, and share with grid cells a prospective bias of ∼50-80 ms. Our observations point to speed cells as a key component of the dynamic representation of self-location in the medial entorhinal cortex.Fil: Kropff, Emilio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquimicas de Buenos Aires; Argentina. Fundación Instituto Leloir; Argentina. Kavli Institute For Systems Neuroscience; NoruegaFil: Carmichael, James E.. Norwegian University of Science and Technology. Kavli Institute For Systems Neuroscience; NoruegaFil: Moser, May Britt. Norwegian University of Science and Technology. Kavli Institute For Systems Neuroscience; NoruegaFil: Moser, Edvard I.. Norwegian University of Science and Technology. Kavli Institute For Systems Neuroscience; NoruegaNature Publishing Group2015-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/10493Kropff, Emilio; Carmichael, James E.; Moser, May Britt; Moser, Edvard I.; Speed cells in the medial entorhinal cortex; Nature Publishing Group; Nature; 523; 7561; 7-2015; 419-4240028-0836enginfo:eu-repo/semantics/altIdentifier/url/http://www.nature.com/nature/journal/v523/n7561/full/nature14622.htmlinfo:eu-repo/semantics/altIdentifier/doi/10.1038/nature14622info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:03:11Zoai:ri.conicet.gov.ar:11336/10493instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:03:12.18CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Speed cells in the medial entorhinal cortex
title Speed cells in the medial entorhinal cortex
spellingShingle Speed cells in the medial entorhinal cortex
Kropff, Emilio
Entorhinal Cortex
Hippocampus
Grid Cells
Head Direction Cells
Speed
Velocity
Space
Theta Rhythm
title_short Speed cells in the medial entorhinal cortex
title_full Speed cells in the medial entorhinal cortex
title_fullStr Speed cells in the medial entorhinal cortex
title_full_unstemmed Speed cells in the medial entorhinal cortex
title_sort Speed cells in the medial entorhinal cortex
dc.creator.none.fl_str_mv Kropff, Emilio
Carmichael, James E.
Moser, May Britt
Moser, Edvard I.
author Kropff, Emilio
author_facet Kropff, Emilio
Carmichael, James E.
Moser, May Britt
Moser, Edvard I.
author_role author
author2 Carmichael, James E.
Moser, May Britt
Moser, Edvard I.
author2_role author
author
author
dc.subject.none.fl_str_mv Entorhinal Cortex
Hippocampus
Grid Cells
Head Direction Cells
Speed
Velocity
Space
Theta Rhythm
topic Entorhinal Cortex
Hippocampus
Grid Cells
Head Direction Cells
Speed
Velocity
Space
Theta Rhythm
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.5
https://purl.org/becyt/ford/3
https://purl.org/becyt/ford/3.5
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Grid cells in the medial entorhinal cortex have spatial firing fields that repeat periodically in a hexagonal pattern. When animals move, activity is translated between grid cells in accordance with the animal's displacement in the environment. For this translation to occur, grid cells must have continuous access to information about instantaneous running speed. However, a powerful entorhinal speed signal has not been identified. Here we show that running speed is represented in the firing rate of a ubiquitous but functionally dedicated population of entorhinal neurons distinct from other cell populations of the local circuit, such as grid, head-direction and border cells. These 'speed cells' are characterized by a context-invariant positive, linear response to running speed, and share with grid cells a prospective bias of ∼50-80 ms. Our observations point to speed cells as a key component of the dynamic representation of self-location in the medial entorhinal cortex.
Fil: Kropff, Emilio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquimicas de Buenos Aires; Argentina. Fundación Instituto Leloir; Argentina. Kavli Institute For Systems Neuroscience; Noruega
Fil: Carmichael, James E.. Norwegian University of Science and Technology. Kavli Institute For Systems Neuroscience; Noruega
Fil: Moser, May Britt. Norwegian University of Science and Technology. Kavli Institute For Systems Neuroscience; Noruega
Fil: Moser, Edvard I.. Norwegian University of Science and Technology. Kavli Institute For Systems Neuroscience; Noruega
description Grid cells in the medial entorhinal cortex have spatial firing fields that repeat periodically in a hexagonal pattern. When animals move, activity is translated between grid cells in accordance with the animal's displacement in the environment. For this translation to occur, grid cells must have continuous access to information about instantaneous running speed. However, a powerful entorhinal speed signal has not been identified. Here we show that running speed is represented in the firing rate of a ubiquitous but functionally dedicated population of entorhinal neurons distinct from other cell populations of the local circuit, such as grid, head-direction and border cells. These 'speed cells' are characterized by a context-invariant positive, linear response to running speed, and share with grid cells a prospective bias of ∼50-80 ms. Our observations point to speed cells as a key component of the dynamic representation of self-location in the medial entorhinal cortex.
publishDate 2015
dc.date.none.fl_str_mv 2015-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/10493
Kropff, Emilio; Carmichael, James E.; Moser, May Britt; Moser, Edvard I.; Speed cells in the medial entorhinal cortex; Nature Publishing Group; Nature; 523; 7561; 7-2015; 419-424
0028-0836
url http://hdl.handle.net/11336/10493
identifier_str_mv Kropff, Emilio; Carmichael, James E.; Moser, May Britt; Moser, Edvard I.; Speed cells in the medial entorhinal cortex; Nature Publishing Group; Nature; 523; 7561; 7-2015; 419-424
0028-0836
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.nature.com/nature/journal/v523/n7561/full/nature14622.html
info:eu-repo/semantics/altIdentifier/doi/10.1038/nature14622
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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