Medial prefrontal cortex is a crucial node of a rapid learning system that retrieves recent and remote memories

Autores
González, María Carolina; Kramar, Cecilia Paula; Garagoli, Fernando; Rossato, Janine I.; Weisstaub, Noelia V.; Cammarota, Martin Pablo; Medina, Jorge Horacio
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The neocortex is thought to be a distributed learning system that gradually integrates semantic information into the initial mnemonic representation rapidly formed by the hippocampus after acquisition. Nevertheless, an emerging view suggests that some cortical regions, in particular the medial prefrontal cortex (mPFC), may also have a role during the initial steps of memory consolidation as well as in the recall of recent memories. Here, we show that mPFC plays a critical role during the first few hours of inhibitory avoidance memory consolidation and is necessary for the normal retrieval of both recent and remote memories, supporting the idea that involvement of neocortical areas in memory processing is not restricted to the late post-training consolidation phase.
Fil: González, María Carolina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencias; Argentina
Fil: Kramar, Cecilia Paula. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencias; Argentina
Fil: Garagoli, Fernando. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencias; Argentina
Fil: Rossato, Janine I.. Universidade Federal do Rio Grande do Norte; Brasil
Fil: Weisstaub, Noelia V.. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencias; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas; Argentina
Fil: Cammarota, Martin Pablo. Universidade Federal do Rio Grande do Norte; Brasil
Fil: Medina, Jorge Horacio. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencias; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas; Argentina
Materia
Inhibitory Avoidance
Memory Consolidation
Memory Retrieval
Hippocampus
Medial Prefrontal Cortex
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/6598
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Medial prefrontal cortex is a crucial node of a rapid learning system that retrieves recent and remote memoriesGonzález, María CarolinaKramar, Cecilia PaulaGaragoli, FernandoRossato, Janine I.Weisstaub, Noelia V.Cammarota, Martin PabloMedina, Jorge HoracioInhibitory AvoidanceMemory ConsolidationMemory RetrievalHippocampusMedial Prefrontal Cortexhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3The neocortex is thought to be a distributed learning system that gradually integrates semantic information into the initial mnemonic representation rapidly formed by the hippocampus after acquisition. Nevertheless, an emerging view suggests that some cortical regions, in particular the medial prefrontal cortex (mPFC), may also have a role during the initial steps of memory consolidation as well as in the recall of recent memories. Here, we show that mPFC plays a critical role during the first few hours of inhibitory avoidance memory consolidation and is necessary for the normal retrieval of both recent and remote memories, supporting the idea that involvement of neocortical areas in memory processing is not restricted to the late post-training consolidation phase.Fil: González, María Carolina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencias; ArgentinaFil: Kramar, Cecilia Paula. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencias; ArgentinaFil: Garagoli, Fernando. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencias; ArgentinaFil: Rossato, Janine I.. Universidade Federal do Rio Grande do Norte; BrasilFil: Weisstaub, Noelia V.. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencias; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas; ArgentinaFil: Cammarota, Martin Pablo. Universidade Federal do Rio Grande do Norte; BrasilFil: Medina, Jorge Horacio. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencias; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas; ArgentinaElsevier2013-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/zipapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/6598González, María Carolina; Kramar, Cecilia Paula; Garagoli, Fernando; Rossato, Janine I.; Weisstaub, Noelia V.; et al.; Medial prefrontal cortex is a crucial node of a rapid learning system that retrieves recent and remote memories; Elsevier; Neurobiology of Learning and Memory; 103; 4-2013; 19-251074-7427enginfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1074742713000531info:eu-repo/semantics/altIdentifier/doi/10.1016/j.nlm.2013.04.006info:eu-repo/semantics/altIdentifier/doi/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:56:51Zoai:ri.conicet.gov.ar:11336/6598instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:56:51.61CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Medial prefrontal cortex is a crucial node of a rapid learning system that retrieves recent and remote memories
title Medial prefrontal cortex is a crucial node of a rapid learning system that retrieves recent and remote memories
spellingShingle Medial prefrontal cortex is a crucial node of a rapid learning system that retrieves recent and remote memories
González, María Carolina
Inhibitory Avoidance
Memory Consolidation
Memory Retrieval
Hippocampus
Medial Prefrontal Cortex
title_short Medial prefrontal cortex is a crucial node of a rapid learning system that retrieves recent and remote memories
title_full Medial prefrontal cortex is a crucial node of a rapid learning system that retrieves recent and remote memories
title_fullStr Medial prefrontal cortex is a crucial node of a rapid learning system that retrieves recent and remote memories
title_full_unstemmed Medial prefrontal cortex is a crucial node of a rapid learning system that retrieves recent and remote memories
title_sort Medial prefrontal cortex is a crucial node of a rapid learning system that retrieves recent and remote memories
dc.creator.none.fl_str_mv González, María Carolina
Kramar, Cecilia Paula
Garagoli, Fernando
Rossato, Janine I.
Weisstaub, Noelia V.
Cammarota, Martin Pablo
Medina, Jorge Horacio
author González, María Carolina
author_facet González, María Carolina
Kramar, Cecilia Paula
Garagoli, Fernando
Rossato, Janine I.
Weisstaub, Noelia V.
Cammarota, Martin Pablo
Medina, Jorge Horacio
author_role author
author2 Kramar, Cecilia Paula
Garagoli, Fernando
Rossato, Janine I.
Weisstaub, Noelia V.
Cammarota, Martin Pablo
Medina, Jorge Horacio
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Inhibitory Avoidance
Memory Consolidation
Memory Retrieval
Hippocampus
Medial Prefrontal Cortex
topic Inhibitory Avoidance
Memory Consolidation
Memory Retrieval
Hippocampus
Medial Prefrontal Cortex
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The neocortex is thought to be a distributed learning system that gradually integrates semantic information into the initial mnemonic representation rapidly formed by the hippocampus after acquisition. Nevertheless, an emerging view suggests that some cortical regions, in particular the medial prefrontal cortex (mPFC), may also have a role during the initial steps of memory consolidation as well as in the recall of recent memories. Here, we show that mPFC plays a critical role during the first few hours of inhibitory avoidance memory consolidation and is necessary for the normal retrieval of both recent and remote memories, supporting the idea that involvement of neocortical areas in memory processing is not restricted to the late post-training consolidation phase.
Fil: González, María Carolina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencias; Argentina
Fil: Kramar, Cecilia Paula. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencias; Argentina
Fil: Garagoli, Fernando. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencias; Argentina
Fil: Rossato, Janine I.. Universidade Federal do Rio Grande do Norte; Brasil
Fil: Weisstaub, Noelia V.. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencias; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas; Argentina
Fil: Cammarota, Martin Pablo. Universidade Federal do Rio Grande do Norte; Brasil
Fil: Medina, Jorge Horacio. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencias; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas; Argentina
description The neocortex is thought to be a distributed learning system that gradually integrates semantic information into the initial mnemonic representation rapidly formed by the hippocampus after acquisition. Nevertheless, an emerging view suggests that some cortical regions, in particular the medial prefrontal cortex (mPFC), may also have a role during the initial steps of memory consolidation as well as in the recall of recent memories. Here, we show that mPFC plays a critical role during the first few hours of inhibitory avoidance memory consolidation and is necessary for the normal retrieval of both recent and remote memories, supporting the idea that involvement of neocortical areas in memory processing is not restricted to the late post-training consolidation phase.
publishDate 2013
dc.date.none.fl_str_mv 2013-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/6598
González, María Carolina; Kramar, Cecilia Paula; Garagoli, Fernando; Rossato, Janine I.; Weisstaub, Noelia V.; et al.; Medial prefrontal cortex is a crucial node of a rapid learning system that retrieves recent and remote memories; Elsevier; Neurobiology of Learning and Memory; 103; 4-2013; 19-25
1074-7427
url http://hdl.handle.net/11336/6598
identifier_str_mv González, María Carolina; Kramar, Cecilia Paula; Garagoli, Fernando; Rossato, Janine I.; Weisstaub, Noelia V.; et al.; Medial prefrontal cortex is a crucial node of a rapid learning system that retrieves recent and remote memories; Elsevier; Neurobiology of Learning and Memory; 103; 4-2013; 19-25
1074-7427
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1074742713000531
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.nlm.2013.04.006
info:eu-repo/semantics/altIdentifier/doi/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/zip
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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