Frequency of theta rhythm is controlled by acceleration, but not speed, in running rats

Autores
Kropff, Emilio; Carmichael, James E.; Moser, Edvard I.; Moser, May Britt
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The theta rhythm organizes neural activity across hippocampus and entorhinal cortex. A role for theta oscillations in spatial navigation is supported by half a century of research reporting that theta frequency encodes running speed linearly so that displacement can be estimated through theta frequency integration. We show that this relationship is an artifact caused by the fact that the speed of freely moving animals could not be systematically disentangled from acceleration. Using an experimental procedure that clamps running speed at pre-set values, we find that the theta frequency of local field potentials and spike activity is linearly related to positive acceleration, but not negative acceleration or speed. The modulation by positive-only acceleration makes rhythmic activity at theta frequency unfit as a code to compute displacement or any other kinematic variable. Temporally precise variations in theta frequency may instead serve as a mechanism for speeding up entorhinal-hippocampal computations during accelerated movement.
Fil: Kropff, Emilio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina. Norwegian University of Science and Technology; Noruega
Fil: Carmichael, James E.. Norwegian University of Science and Technology; Noruega
Fil: Moser, Edvard I.. Norwegian University of Science and Technology; Noruega
Fil: Moser, May Britt. Norwegian University of Science and Technology; Noruega
Materia
ACCELERATION
BORDER CELLS
ENTORHINAL CORTEX
GRID CELLS
HEAD DIRECTION CELLS
HIPPOCAMPUS
SPACE
SPEED
SPEED CELLS
THETA RHYTHM
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/139177
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/139177
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Frequency of theta rhythm is controlled by acceleration, but not speed, in running ratsKropff, EmilioCarmichael, James E.Moser, Edvard I.Moser, May BrittACCELERATIONBORDER CELLSENTORHINAL CORTEXGRID CELLSHEAD DIRECTION CELLSHIPPOCAMPUSSPACESPEEDSPEED CELLSTHETA RHYTHMhttps://purl.org/becyt/ford/3.5https://purl.org/becyt/ford/3The theta rhythm organizes neural activity across hippocampus and entorhinal cortex. A role for theta oscillations in spatial navigation is supported by half a century of research reporting that theta frequency encodes running speed linearly so that displacement can be estimated through theta frequency integration. We show that this relationship is an artifact caused by the fact that the speed of freely moving animals could not be systematically disentangled from acceleration. Using an experimental procedure that clamps running speed at pre-set values, we find that the theta frequency of local field potentials and spike activity is linearly related to positive acceleration, but not negative acceleration or speed. The modulation by positive-only acceleration makes rhythmic activity at theta frequency unfit as a code to compute displacement or any other kinematic variable. Temporally precise variations in theta frequency may instead serve as a mechanism for speeding up entorhinal-hippocampal computations during accelerated movement.Fil: Kropff, Emilio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina. Norwegian University of Science and Technology; NoruegaFil: Carmichael, James E.. Norwegian University of Science and Technology; NoruegaFil: Moser, Edvard I.. Norwegian University of Science and Technology; NoruegaFil: Moser, May Britt. Norwegian University of Science and Technology; NoruegaCell Press2021-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/139177Kropff, Emilio; Carmichael, James E.; Moser, Edvard I.; Moser, May Britt; Frequency of theta rhythm is controlled by acceleration, but not speed, in running rats; Cell Press; Neuron; 109; 6; 3-2021; 1029-1039.e80896-62731097-4199CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.cell.com/neuron/fulltext/S0896-6273(21)00039-8info:eu-repo/semantics/altIdentifier/doi/10.1016/j.neuron.2021.01.017info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:50:37Zoai:ri.conicet.gov.ar:11336/139177instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:50:38.177CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Frequency of theta rhythm is controlled by acceleration, but not speed, in running rats
title Frequency of theta rhythm is controlled by acceleration, but not speed, in running rats
spellingShingle Frequency of theta rhythm is controlled by acceleration, but not speed, in running rats
Kropff, Emilio
ACCELERATION
BORDER CELLS
ENTORHINAL CORTEX
GRID CELLS
HEAD DIRECTION CELLS
HIPPOCAMPUS
SPACE
SPEED
SPEED CELLS
THETA RHYTHM
title_short Frequency of theta rhythm is controlled by acceleration, but not speed, in running rats
title_full Frequency of theta rhythm is controlled by acceleration, but not speed, in running rats
title_fullStr Frequency of theta rhythm is controlled by acceleration, but not speed, in running rats
title_full_unstemmed Frequency of theta rhythm is controlled by acceleration, but not speed, in running rats
title_sort Frequency of theta rhythm is controlled by acceleration, but not speed, in running rats
dc.creator.none.fl_str_mv Kropff, Emilio
Carmichael, James E.
Moser, Edvard I.
Moser, May Britt
author Kropff, Emilio
author_facet Kropff, Emilio
Carmichael, James E.
Moser, Edvard I.
Moser, May Britt
author_role author
author2 Carmichael, James E.
Moser, Edvard I.
Moser, May Britt
author2_role author
author
author
dc.subject.none.fl_str_mv ACCELERATION
BORDER CELLS
ENTORHINAL CORTEX
GRID CELLS
HEAD DIRECTION CELLS
HIPPOCAMPUS
SPACE
SPEED
SPEED CELLS
THETA RHYTHM
topic ACCELERATION
BORDER CELLS
ENTORHINAL CORTEX
GRID CELLS
HEAD DIRECTION CELLS
HIPPOCAMPUS
SPACE
SPEED
SPEED CELLS
THETA RHYTHM
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.5
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The theta rhythm organizes neural activity across hippocampus and entorhinal cortex. A role for theta oscillations in spatial navigation is supported by half a century of research reporting that theta frequency encodes running speed linearly so that displacement can be estimated through theta frequency integration. We show that this relationship is an artifact caused by the fact that the speed of freely moving animals could not be systematically disentangled from acceleration. Using an experimental procedure that clamps running speed at pre-set values, we find that the theta frequency of local field potentials and spike activity is linearly related to positive acceleration, but not negative acceleration or speed. The modulation by positive-only acceleration makes rhythmic activity at theta frequency unfit as a code to compute displacement or any other kinematic variable. Temporally precise variations in theta frequency may instead serve as a mechanism for speeding up entorhinal-hippocampal computations during accelerated movement.
Fil: Kropff, Emilio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina. Norwegian University of Science and Technology; Noruega
Fil: Carmichael, James E.. Norwegian University of Science and Technology; Noruega
Fil: Moser, Edvard I.. Norwegian University of Science and Technology; Noruega
Fil: Moser, May Britt. Norwegian University of Science and Technology; Noruega
description The theta rhythm organizes neural activity across hippocampus and entorhinal cortex. A role for theta oscillations in spatial navigation is supported by half a century of research reporting that theta frequency encodes running speed linearly so that displacement can be estimated through theta frequency integration. We show that this relationship is an artifact caused by the fact that the speed of freely moving animals could not be systematically disentangled from acceleration. Using an experimental procedure that clamps running speed at pre-set values, we find that the theta frequency of local field potentials and spike activity is linearly related to positive acceleration, but not negative acceleration or speed. The modulation by positive-only acceleration makes rhythmic activity at theta frequency unfit as a code to compute displacement or any other kinematic variable. Temporally precise variations in theta frequency may instead serve as a mechanism for speeding up entorhinal-hippocampal computations during accelerated movement.
publishDate 2021
dc.date.none.fl_str_mv 2021-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/139177
Kropff, Emilio; Carmichael, James E.; Moser, Edvard I.; Moser, May Britt; Frequency of theta rhythm is controlled by acceleration, but not speed, in running rats; Cell Press; Neuron; 109; 6; 3-2021; 1029-1039.e8
0896-6273
1097-4199
CONICET Digital
CONICET
url http://hdl.handle.net/11336/139177
identifier_str_mv Kropff, Emilio; Carmichael, James E.; Moser, Edvard I.; Moser, May Britt; Frequency of theta rhythm is controlled by acceleration, but not speed, in running rats; Cell Press; Neuron; 109; 6; 3-2021; 1029-1039.e8
0896-6273
1097-4199
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.cell.com/neuron/fulltext/S0896-6273(21)00039-8
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.neuron.2021.01.017
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Cell Press
publisher.none.fl_str_mv Cell Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844613560601149440
score 13.070432

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