Polysaccharides from Gracilaria corticata: Sulfation, chemical characterization and anti-HSV activities

Autores
Chattopadhyay, Kausik; Ghosh, Tuhin; Pujol, Carlos Alberto; Carlucci, Maria Josefina; Damonte, Elsa Beatriz; Ray, Bimalendu
Año de publicación
2008
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
In this study, we have analyzed water-extracted polysaccharides of Gracilaria corticata. The water extract (WE), a galactan-containing sub-fraction (F3) and their hyper sulfated derivatives (WES1, WES2, F3S1 and F3S2) had anti-HSV activity with inhibitory concentration 50% (IC50) from 1.1 to 27.4 μg/ml. Sub-fraction F3, which has a molecular mass of 30 kDa, consists of a backbone of β-(1 → 3) and α-(1 → 4)-linked-galactopyranosyl residues. This linear galactan contained Gal2Xyl1, Gal2AnGal2, Gal4 and Me-Gal3AnGal2 as oligomeric building subunits. Sulfate group was located at C-4 of (1 → 3)-linked galactopyranosyl residues of the native galactan, and appeared to be very important for the anti-herpetic activity.
Fil: Chattopadhyay, Kausik. The University of Burdwan; India
Fil: Ghosh, Tuhin. The University of Burdwan; India
Fil: Pujol, Carlos Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica. Laboratorio de Virología; Argentina
Fil: Carlucci, Maria Josefina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica. Laboratorio de Virología; Argentina
Fil: Damonte, Elsa Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica. Laboratorio de Virología; Argentina
Fil: Ray, Bimalendu. The University of Burdwan; India
Materia
Anti-Hsv Activity
Galactan Sulfate
Gracilaria Corticata
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/83538
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Polysaccharides from Gracilaria corticata: Sulfation, chemical characterization and anti-HSV activitiesChattopadhyay, KausikGhosh, TuhinPujol, Carlos AlbertoCarlucci, Maria JosefinaDamonte, Elsa BeatrizRay, BimalenduAnti-Hsv ActivityGalactan SulfateGracilaria Corticatahttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1In this study, we have analyzed water-extracted polysaccharides of Gracilaria corticata. The water extract (WE), a galactan-containing sub-fraction (F3) and their hyper sulfated derivatives (WES1, WES2, F3S1 and F3S2) had anti-HSV activity with inhibitory concentration 50% (IC50) from 1.1 to 27.4 μg/ml. Sub-fraction F3, which has a molecular mass of 30 kDa, consists of a backbone of β-(1 → 3) and α-(1 → 4)-linked-galactopyranosyl residues. This linear galactan contained Gal2Xyl1, Gal2AnGal2, Gal4 and Me-Gal3AnGal2 as oligomeric building subunits. Sulfate group was located at C-4 of (1 → 3)-linked galactopyranosyl residues of the native galactan, and appeared to be very important for the anti-herpetic activity.Fil: Chattopadhyay, Kausik. The University of Burdwan; IndiaFil: Ghosh, Tuhin. The University of Burdwan; IndiaFil: Pujol, Carlos Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica. Laboratorio de Virología; ArgentinaFil: Carlucci, Maria Josefina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica. Laboratorio de Virología; ArgentinaFil: Damonte, Elsa Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica. Laboratorio de Virología; ArgentinaFil: Ray, Bimalendu. The University of Burdwan; IndiaElsevier Science2008-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/83538Chattopadhyay, Kausik; Ghosh, Tuhin; Pujol, Carlos Alberto; Carlucci, Maria Josefina; Damonte, Elsa Beatriz; et al.; Polysaccharides from Gracilaria corticata: Sulfation, chemical characterization and anti-HSV activities; Elsevier Science; International Journal of Biological Macromolecules; 43; 4; 11-2008; 346-3510141-8130CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S014181300800158Xinfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.ijbiomac.2008.07.009info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:41:35Zoai:ri.conicet.gov.ar:11336/83538instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:41:35.715CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Polysaccharides from Gracilaria corticata: Sulfation, chemical characterization and anti-HSV activities
title Polysaccharides from Gracilaria corticata: Sulfation, chemical characterization and anti-HSV activities
spellingShingle Polysaccharides from Gracilaria corticata: Sulfation, chemical characterization and anti-HSV activities
Chattopadhyay, Kausik
Anti-Hsv Activity
Galactan Sulfate
Gracilaria Corticata
title_short Polysaccharides from Gracilaria corticata: Sulfation, chemical characterization and anti-HSV activities
title_full Polysaccharides from Gracilaria corticata: Sulfation, chemical characterization and anti-HSV activities
title_fullStr Polysaccharides from Gracilaria corticata: Sulfation, chemical characterization and anti-HSV activities
title_full_unstemmed Polysaccharides from Gracilaria corticata: Sulfation, chemical characterization and anti-HSV activities
title_sort Polysaccharides from Gracilaria corticata: Sulfation, chemical characterization and anti-HSV activities
dc.creator.none.fl_str_mv Chattopadhyay, Kausik
Ghosh, Tuhin
Pujol, Carlos Alberto
Carlucci, Maria Josefina
Damonte, Elsa Beatriz
Ray, Bimalendu
author Chattopadhyay, Kausik
author_facet Chattopadhyay, Kausik
Ghosh, Tuhin
Pujol, Carlos Alberto
Carlucci, Maria Josefina
Damonte, Elsa Beatriz
Ray, Bimalendu
author_role author
author2 Ghosh, Tuhin
Pujol, Carlos Alberto
Carlucci, Maria Josefina
Damonte, Elsa Beatriz
Ray, Bimalendu
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Anti-Hsv Activity
Galactan Sulfate
Gracilaria Corticata
topic Anti-Hsv Activity
Galactan Sulfate
Gracilaria Corticata
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv In this study, we have analyzed water-extracted polysaccharides of Gracilaria corticata. The water extract (WE), a galactan-containing sub-fraction (F3) and their hyper sulfated derivatives (WES1, WES2, F3S1 and F3S2) had anti-HSV activity with inhibitory concentration 50% (IC50) from 1.1 to 27.4 μg/ml. Sub-fraction F3, which has a molecular mass of 30 kDa, consists of a backbone of β-(1 → 3) and α-(1 → 4)-linked-galactopyranosyl residues. This linear galactan contained Gal2Xyl1, Gal2AnGal2, Gal4 and Me-Gal3AnGal2 as oligomeric building subunits. Sulfate group was located at C-4 of (1 → 3)-linked galactopyranosyl residues of the native galactan, and appeared to be very important for the anti-herpetic activity.
Fil: Chattopadhyay, Kausik. The University of Burdwan; India
Fil: Ghosh, Tuhin. The University of Burdwan; India
Fil: Pujol, Carlos Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica. Laboratorio de Virología; Argentina
Fil: Carlucci, Maria Josefina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica. Laboratorio de Virología; Argentina
Fil: Damonte, Elsa Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica. Laboratorio de Virología; Argentina
Fil: Ray, Bimalendu. The University of Burdwan; India
description In this study, we have analyzed water-extracted polysaccharides of Gracilaria corticata. The water extract (WE), a galactan-containing sub-fraction (F3) and their hyper sulfated derivatives (WES1, WES2, F3S1 and F3S2) had anti-HSV activity with inhibitory concentration 50% (IC50) from 1.1 to 27.4 μg/ml. Sub-fraction F3, which has a molecular mass of 30 kDa, consists of a backbone of β-(1 → 3) and α-(1 → 4)-linked-galactopyranosyl residues. This linear galactan contained Gal2Xyl1, Gal2AnGal2, Gal4 and Me-Gal3AnGal2 as oligomeric building subunits. Sulfate group was located at C-4 of (1 → 3)-linked galactopyranosyl residues of the native galactan, and appeared to be very important for the anti-herpetic activity.
publishDate 2008
dc.date.none.fl_str_mv 2008-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/83538
Chattopadhyay, Kausik; Ghosh, Tuhin; Pujol, Carlos Alberto; Carlucci, Maria Josefina; Damonte, Elsa Beatriz; et al.; Polysaccharides from Gracilaria corticata: Sulfation, chemical characterization and anti-HSV activities; Elsevier Science; International Journal of Biological Macromolecules; 43; 4; 11-2008; 346-351
0141-8130
CONICET Digital
CONICET
url http://hdl.handle.net/11336/83538
identifier_str_mv Chattopadhyay, Kausik; Ghosh, Tuhin; Pujol, Carlos Alberto; Carlucci, Maria Josefina; Damonte, Elsa Beatriz; et al.; Polysaccharides from Gracilaria corticata: Sulfation, chemical characterization and anti-HSV activities; Elsevier Science; International Journal of Biological Macromolecules; 43; 4; 11-2008; 346-351
0141-8130
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S014181300800158X
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.ijbiomac.2008.07.009
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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