Anti HSV-1 activity of halistanol sulfate and halistanol sulfate C isolated from Brazilian marine sponge Petromica citrina (Demospongiae)

Autores
Guimarães, Tatiana Da Rosa; Quiroz, Carlos Guillermo; Rigotto, Caroline; De Oliveira, Simone Quintana; Rojo de Almeida, Maria Tereza; Bianco, Éverson Miguel; Moritz, Maria Izabel Goulart; Carraro, João Luís; Palermo, Jorge Alejandro; Cabrera, Gabriela Myriam; Schenkel, Eloir Paulo; Reginatto, Flávio Henrique; Oliveira Simões, Cláudia Maria
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The n-butanol fraction (BF) obtained from the crude extract of the marine sponge Petromica citrina, the halistanol-enriched fraction (TSH fraction), and the isolated compounds halistanol sulfate (1) and halistanol sulfate C (2), were evaluated for their inhibitory effects on the replication of the Herpes Simplex Virus type 1 (HSV-1, KOS strain) by the viral plaque number reduction assay. The TSH fraction was the most effective against HSV-1 replication (SI = 15.33), whereas compounds 1 (SI = 2.46) and 2 (SI = 1.95) were less active. The most active fraction and these compounds were also assayed to determine the viral multiplication step(s) upon which they act as well as their potential synergistic effects. The anti-HSV-1 activity detected was mediated by the inhibition of virus attachment and by the penetration into Vero cells, the virucidal effect on virus particles, and by the impairment in levels of ICP27 and gD proteins of HSV-1. In summary, these results suggest that the anti-HSV-1 activity of TSH fraction detected is possibly related to the synergic effects of compounds 1 and 2.
Fil: Guimarães, Tatiana Da Rosa. Universidade Federal de Santa Catarina; Brasil
Fil: Quiroz, Carlos Guillermo. Universidade Federal de Santa Catarina; Brasil
Fil: Rigotto, Caroline. Universidade Federal de Santa Catarina; Brasil
Fil: De Oliveira, Simone Quintana. Universidade Federal de Santa Catarina; Brasil
Fil: Rojo de Almeida, Maria Tereza. Universidade Federal de Santa Catarina; Brasil
Fil: Bianco, Éverson Miguel. Universidade Federal de Santa Catarina; Brasil
Fil: Moritz, Maria Izabel Goulart. Universidade Federal de Santa Catarina; Brasil
Fil: Carraro, João Luís. Universidade Federal do Rio de Janeiro; Brasil
Fil: Palermo, Jorge Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Unidad de Microanálisis y Métodos Físicos en Química Orgánica. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Unidad de Microanálisis y Métodos Físicos en Química Orgánica; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Orgánica; Argentina
Fil: Cabrera, Gabriela Myriam. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Unidad de Microanálisis y Métodos Físicos en Química Orgánica. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Unidad de Microanálisis y Métodos Físicos en Química Orgánica; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Orgánica; Argentina
Fil: Schenkel, Eloir Paulo. Universidade Federal de Santa Catarina; Brasil
Fil: Reginatto, Flávio Henrique. Universidade Federal de Santa Catarina; Brasil
Fil: Oliveira Simões, Cláudia Maria. Universidade Federal de Santa Catarina; Brasil
Materia
ANTIVIRAL ACTIVITY
HSV-1
MARINE SPONGE
PETROMICA CITRINA
SULFATE STEROLS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/84928
Acceder
id CONICETDig_57bf0d3429314a7bcf409c9fd866e504
oai_identifier_str oai:ri.conicet.gov.ar:11336/84928
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Anti HSV-1 activity of halistanol sulfate and halistanol sulfate C isolated from Brazilian marine sponge Petromica citrina (Demospongiae)Guimarães, Tatiana Da RosaQuiroz, Carlos GuillermoRigotto, CarolineDe Oliveira, Simone QuintanaRojo de Almeida, Maria TerezaBianco, Éverson MiguelMoritz, Maria Izabel GoulartCarraro, João LuísPalermo, Jorge AlejandroCabrera, Gabriela MyriamSchenkel, Eloir PauloReginatto, Flávio HenriqueOliveira Simões, Cláudia MariaANTIVIRAL ACTIVITYHSV-1MARINE SPONGEPETROMICA CITRINASULFATE STEROLShttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1The n-butanol fraction (BF) obtained from the crude extract of the marine sponge Petromica citrina, the halistanol-enriched fraction (TSH fraction), and the isolated compounds halistanol sulfate (1) and halistanol sulfate C (2), were evaluated for their inhibitory effects on the replication of the Herpes Simplex Virus type 1 (HSV-1, KOS strain) by the viral plaque number reduction assay. The TSH fraction was the most effective against HSV-1 replication (SI = 15.33), whereas compounds 1 (SI = 2.46) and 2 (SI = 1.95) were less active. The most active fraction and these compounds were also assayed to determine the viral multiplication step(s) upon which they act as well as their potential synergistic effects. The anti-HSV-1 activity detected was mediated by the inhibition of virus attachment and by the penetration into Vero cells, the virucidal effect on virus particles, and by the impairment in levels of ICP27 and gD proteins of HSV-1. In summary, these results suggest that the anti-HSV-1 activity of TSH fraction detected is possibly related to the synergic effects of compounds 1 and 2.Fil: Guimarães, Tatiana Da Rosa. Universidade Federal de Santa Catarina; BrasilFil: Quiroz, Carlos Guillermo. Universidade Federal de Santa Catarina; BrasilFil: Rigotto, Caroline. Universidade Federal de Santa Catarina; BrasilFil: De Oliveira, Simone Quintana. Universidade Federal de Santa Catarina; BrasilFil: Rojo de Almeida, Maria Tereza. Universidade Federal de Santa Catarina; BrasilFil: Bianco, Éverson Miguel. Universidade Federal de Santa Catarina; BrasilFil: Moritz, Maria Izabel Goulart. Universidade Federal de Santa Catarina; BrasilFil: Carraro, João Luís. Universidade Federal do Rio de Janeiro; BrasilFil: Palermo, Jorge Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Unidad de Microanálisis y Métodos Físicos en Química Orgánica. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Unidad de Microanálisis y Métodos Físicos en Química Orgánica; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Orgánica; ArgentinaFil: Cabrera, Gabriela Myriam. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Unidad de Microanálisis y Métodos Físicos en Química Orgánica. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Unidad de Microanálisis y Métodos Físicos en Química Orgánica; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Orgánica; ArgentinaFil: Schenkel, Eloir Paulo. Universidade Federal de Santa Catarina; BrasilFil: Reginatto, Flávio Henrique. Universidade Federal de Santa Catarina; BrasilFil: Oliveira Simões, Cláudia Maria. Universidade Federal de Santa Catarina; BrasilMolecular Diversity Preservation International2013-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/84928Guimarães, Tatiana Da Rosa; Quiroz, Carlos Guillermo; Rigotto, Caroline; De Oliveira, Simone Quintana; Rojo de Almeida, Maria Tereza; et al.; Anti HSV-1 activity of halistanol sulfate and halistanol sulfate C isolated from Brazilian marine sponge Petromica citrina (Demospongiae); Molecular Diversity Preservation International; Marine Drugs; 11; 11; 11-2013; 4176-41921660-3397CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.3390/md11114176info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/1660-3397/11/11/4176info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:16:42Zoai:ri.conicet.gov.ar:11336/84928instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:16:43.11CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Anti HSV-1 activity of halistanol sulfate and halistanol sulfate C isolated from Brazilian marine sponge Petromica citrina (Demospongiae)
title Anti HSV-1 activity of halistanol sulfate and halistanol sulfate C isolated from Brazilian marine sponge Petromica citrina (Demospongiae)
spellingShingle Anti HSV-1 activity of halistanol sulfate and halistanol sulfate C isolated from Brazilian marine sponge Petromica citrina (Demospongiae)
Guimarães, Tatiana Da Rosa
ANTIVIRAL ACTIVITY
HSV-1
MARINE SPONGE
PETROMICA CITRINA
SULFATE STEROLS
title_short Anti HSV-1 activity of halistanol sulfate and halistanol sulfate C isolated from Brazilian marine sponge Petromica citrina (Demospongiae)
title_full Anti HSV-1 activity of halistanol sulfate and halistanol sulfate C isolated from Brazilian marine sponge Petromica citrina (Demospongiae)
title_fullStr Anti HSV-1 activity of halistanol sulfate and halistanol sulfate C isolated from Brazilian marine sponge Petromica citrina (Demospongiae)
title_full_unstemmed Anti HSV-1 activity of halistanol sulfate and halistanol sulfate C isolated from Brazilian marine sponge Petromica citrina (Demospongiae)
title_sort Anti HSV-1 activity of halistanol sulfate and halistanol sulfate C isolated from Brazilian marine sponge Petromica citrina (Demospongiae)
dc.creator.none.fl_str_mv Guimarães, Tatiana Da Rosa
Quiroz, Carlos Guillermo
Rigotto, Caroline
De Oliveira, Simone Quintana
Rojo de Almeida, Maria Tereza
Bianco, Éverson Miguel
Moritz, Maria Izabel Goulart
Carraro, João Luís
Palermo, Jorge Alejandro
Cabrera, Gabriela Myriam
Schenkel, Eloir Paulo
Reginatto, Flávio Henrique
Oliveira Simões, Cláudia Maria
author Guimarães, Tatiana Da Rosa
author_facet Guimarães, Tatiana Da Rosa
Quiroz, Carlos Guillermo
Rigotto, Caroline
De Oliveira, Simone Quintana
Rojo de Almeida, Maria Tereza
Bianco, Éverson Miguel
Moritz, Maria Izabel Goulart
Carraro, João Luís
Palermo, Jorge Alejandro
Cabrera, Gabriela Myriam
Schenkel, Eloir Paulo
Reginatto, Flávio Henrique
Oliveira Simões, Cláudia Maria
author_role author
author2 Quiroz, Carlos Guillermo
Rigotto, Caroline
De Oliveira, Simone Quintana
Rojo de Almeida, Maria Tereza
Bianco, Éverson Miguel
Moritz, Maria Izabel Goulart
Carraro, João Luís
Palermo, Jorge Alejandro
Cabrera, Gabriela Myriam
Schenkel, Eloir Paulo
Reginatto, Flávio Henrique
Oliveira Simões, Cláudia Maria
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv ANTIVIRAL ACTIVITY
HSV-1
MARINE SPONGE
PETROMICA CITRINA
SULFATE STEROLS
topic ANTIVIRAL ACTIVITY
HSV-1
MARINE SPONGE
PETROMICA CITRINA
SULFATE STEROLS
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The n-butanol fraction (BF) obtained from the crude extract of the marine sponge Petromica citrina, the halistanol-enriched fraction (TSH fraction), and the isolated compounds halistanol sulfate (1) and halistanol sulfate C (2), were evaluated for their inhibitory effects on the replication of the Herpes Simplex Virus type 1 (HSV-1, KOS strain) by the viral plaque number reduction assay. The TSH fraction was the most effective against HSV-1 replication (SI = 15.33), whereas compounds 1 (SI = 2.46) and 2 (SI = 1.95) were less active. The most active fraction and these compounds were also assayed to determine the viral multiplication step(s) upon which they act as well as their potential synergistic effects. The anti-HSV-1 activity detected was mediated by the inhibition of virus attachment and by the penetration into Vero cells, the virucidal effect on virus particles, and by the impairment in levels of ICP27 and gD proteins of HSV-1. In summary, these results suggest that the anti-HSV-1 activity of TSH fraction detected is possibly related to the synergic effects of compounds 1 and 2.
Fil: Guimarães, Tatiana Da Rosa. Universidade Federal de Santa Catarina; Brasil
Fil: Quiroz, Carlos Guillermo. Universidade Federal de Santa Catarina; Brasil
Fil: Rigotto, Caroline. Universidade Federal de Santa Catarina; Brasil
Fil: De Oliveira, Simone Quintana. Universidade Federal de Santa Catarina; Brasil
Fil: Rojo de Almeida, Maria Tereza. Universidade Federal de Santa Catarina; Brasil
Fil: Bianco, Éverson Miguel. Universidade Federal de Santa Catarina; Brasil
Fil: Moritz, Maria Izabel Goulart. Universidade Federal de Santa Catarina; Brasil
Fil: Carraro, João Luís. Universidade Federal do Rio de Janeiro; Brasil
Fil: Palermo, Jorge Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Unidad de Microanálisis y Métodos Físicos en Química Orgánica. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Unidad de Microanálisis y Métodos Físicos en Química Orgánica; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Orgánica; Argentina
Fil: Cabrera, Gabriela Myriam. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Unidad de Microanálisis y Métodos Físicos en Química Orgánica. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Unidad de Microanálisis y Métodos Físicos en Química Orgánica; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Orgánica; Argentina
Fil: Schenkel, Eloir Paulo. Universidade Federal de Santa Catarina; Brasil
Fil: Reginatto, Flávio Henrique. Universidade Federal de Santa Catarina; Brasil
Fil: Oliveira Simões, Cláudia Maria. Universidade Federal de Santa Catarina; Brasil
description The n-butanol fraction (BF) obtained from the crude extract of the marine sponge Petromica citrina, the halistanol-enriched fraction (TSH fraction), and the isolated compounds halistanol sulfate (1) and halistanol sulfate C (2), were evaluated for their inhibitory effects on the replication of the Herpes Simplex Virus type 1 (HSV-1, KOS strain) by the viral plaque number reduction assay. The TSH fraction was the most effective against HSV-1 replication (SI = 15.33), whereas compounds 1 (SI = 2.46) and 2 (SI = 1.95) were less active. The most active fraction and these compounds were also assayed to determine the viral multiplication step(s) upon which they act as well as their potential synergistic effects. The anti-HSV-1 activity detected was mediated by the inhibition of virus attachment and by the penetration into Vero cells, the virucidal effect on virus particles, and by the impairment in levels of ICP27 and gD proteins of HSV-1. In summary, these results suggest that the anti-HSV-1 activity of TSH fraction detected is possibly related to the synergic effects of compounds 1 and 2.
publishDate 2013
dc.date.none.fl_str_mv 2013-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/84928
Guimarães, Tatiana Da Rosa; Quiroz, Carlos Guillermo; Rigotto, Caroline; De Oliveira, Simone Quintana; Rojo de Almeida, Maria Tereza; et al.; Anti HSV-1 activity of halistanol sulfate and halistanol sulfate C isolated from Brazilian marine sponge Petromica citrina (Demospongiae); Molecular Diversity Preservation International; Marine Drugs; 11; 11; 11-2013; 4176-4192
1660-3397
CONICET Digital
CONICET
url http://hdl.handle.net/11336/84928
identifier_str_mv Guimarães, Tatiana Da Rosa; Quiroz, Carlos Guillermo; Rigotto, Caroline; De Oliveira, Simone Quintana; Rojo de Almeida, Maria Tereza; et al.; Anti HSV-1 activity of halistanol sulfate and halistanol sulfate C isolated from Brazilian marine sponge Petromica citrina (Demospongiae); Molecular Diversity Preservation International; Marine Drugs; 11; 11; 11-2013; 4176-4192
1660-3397
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.3390/md11114176
info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/1660-3397/11/11/4176
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Molecular Diversity Preservation International
publisher.none.fl_str_mv Molecular Diversity Preservation International
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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