Methicillin-resistant Staphylococcus aureus ST30-SCCmec IVc clone as the major cause of community-acquired invasive infections in Argentina

Autores
Fernandez, Silvina; Fernandez, Silvina; de Vedia, Luis Alberto; de Vedia, Luis Alberto; Lopez Furst, M, J.; Lopez Furst, M, J.; Gardella, Noella Mariel; Gardella, Noella Mariel; Di Gregorio, Sabrina Noelia; Di Gregorio, Sabrina Noelia; Ganaha, M. C.; Ganaha, M. C.; Prieto, S.; Prieto, S.; Carbone, E.; Carbone, E.; Lista, N.; Lista, N.; Rotrying, F.; Rotrying, F.; Stryjewski, M. D.; Stryjewski, M. D.; Mollerach, Marta Eugenia; Mollerach, Marta Eugenia
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) infections have become a major concern worldwide. We conducted a prospective multicenter study of invasive CA-MRSA to evaluate clinical features and genotype of strains causing invasive infections in Argentina. A total of 55 patients with invasive CA-MRSA infections were included. Most patients (60%) had bloodstream infections, 42% required admission to intensive care unit and 16% died. No CA-MRSA isolates were multiresistant (resistant ≥ 3 classes of antibiotics). All isolates carried Panton-Valentine leukocidin (PVL) genes and staphylococcal cassette chromosome (SCCmec) type IV. The majority CA-MRSA strains belonged to ST30 and had identical PFGE patterns, qualifying as a clonal dissemination of a highly transmissible strain. In patients with invasive infections this clone genotyped as pulsed-field gel electrophoresis type C- ST30, SCCmec type IVc-spa type 019, PVL positive has become predominant and replaced the previously described CA-MRSA clone (PFGE type A, ST5, SCCmec type IV, spa type 311).
Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) infections have become a major concern worldwide. We conducted a prospective multicenter study of invasive CA-MRSA to evaluate clinical features and genotype of strains causing invasive infections in Argentina. A total of 55 patients with invasive CA-MRSA infections were included. Most patients (60%) had bloodstream infections, 42% required admission to intensive care unit and 16% died. No CA-MRSA isolates were multiresistant (resistant ≥ 3 classes of antibiotics). All isolates carried Panton-Valentine leukocidin (PVL) genes and staphylococcal cassette chromosome (SCCmec) type IV. The majority CA-MRSA strains belonged to ST30 and had identical PFGE patterns, qualifying as a clonal dissemination of a highly transmissible strain. In patients with invasive infections this clone genotyped as pulsed-field gel electrophoresis type C- ST30, SCCmec type IVc-spa type 019, PVL positive has become predominant and replaced the previously described CA-MRSA clone (PFGE type A, ST5, SCCmec type IV, spa type 311).
Fil: Fernandez, Silvina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología; Argentina
Fil: Fernandez, Silvina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología; Argentina
Fil: de Vedia, Luis Alberto. Gobierno de la Ciudad de Buenos Aires. Hospital de Infecciosas F. J. Muñiz; Argentina
Fil: de Vedia, Luis Alberto. Gobierno de la Ciudad de Buenos Aires. Hospital de Infecciosas F. J. Muñiz; Argentina
Fil: Lopez Furst, M, J.. Sanatorio Mendez; Argentina
Fil: Lopez Furst, M, J.. Sanatorio Mendez; Argentina
Fil: Gardella, Noella Mariel. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología; Argentina
Fil: Gardella, Noella Mariel. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología; Argentina
Fil: Di Gregorio, Sabrina Noelia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología; Argentina
Fil: Di Gregorio, Sabrina Noelia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología; Argentina
Fil: Ganaha, M. C.. Hospital Vicente López y Planes; Argentina
Fil: Ganaha, M. C.. Hospital Vicente López y Planes; Argentina
Fil: Prieto, S.. Hospital Nuestra Señora de Luján; Argentina
Fil: Prieto, S.. Hospital Nuestra Señora de Luján; Argentina
Fil: Carbone, E.. Hospital Aeronáutico; Argentina
Fil: Carbone, E.. Hospital Aeronáutico; Argentina
Fil: Lista, N.. Gobierno de la Ciudad de Buenos Aires. Hospital de Infecciosas F. J. Muñiz; Argentina
Fil: Lista, N.. Gobierno de la Ciudad de Buenos Aires. Hospital de Infecciosas F. J. Muñiz; Argentina
Fil: Rotrying, F.. Universidad Abierta Interamericana. Hospital Escuela; Argentina
Fil: Rotrying, F.. Universidad Abierta Interamericana. Hospital Escuela; Argentina
Fil: Stryjewski, M. D.. Centro de Educaciones Médicas e Investigación Clínica;
Fil: Stryjewski, M. D.. Centro de Educaciones Médicas e Investigación Clínica;
Fil: Mollerach, Marta Eugenia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología; Argentina
Fil: Mollerach, Marta Eugenia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología; Argentina
Materia
Methicillin-Resistance Community-Associated Staphylococcus Aureus
Methicillin-Resistance Community-Associated Staphylococcus Aureus
Mrsa Invasive Infection
Mrsa Invasive Infection
Molecular Epidemiology
Molecular Epidemiology
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/1712
Acceder
id CONICETDig_f4a864727554b6920625139a447a4fb8
oai_identifier_str oai:ri.conicet.gov.ar:11336/1712
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Methicillin-resistant Staphylococcus aureus ST30-SCCmec IVc clone as the major cause of community-acquired invasive infections in ArgentinaMethicillin-resistant Staphylococcus aureus ST30-SCCmec IVc clone as the major cause of community-acquired invasive infections in ArgentinaFernandez, SilvinaFernandez, Silvinade Vedia, Luis Albertode Vedia, Luis AlbertoLopez Furst, M, J.Lopez Furst, M, J.Gardella, Noella MarielGardella, Noella MarielDi Gregorio, Sabrina NoeliaDi Gregorio, Sabrina NoeliaGanaha, M. C.Ganaha, M. C.Prieto, S.Prieto, S.Carbone, E.Carbone, E.Lista, N.Lista, N.Rotrying, F.Rotrying, F.Stryjewski, M. D.Stryjewski, M. D.Mollerach, Marta EugeniaMollerach, Marta EugeniaMethicillin-Resistance Community-Associated Staphylococcus AureusMethicillin-Resistance Community-Associated Staphylococcus AureusMrsa Invasive InfectionMrsa Invasive InfectionMolecular EpidemiologyMolecular Epidemiologyhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3https://purl.org/becyt/ford/3https://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3https://purl.org/becyt/ford/3Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) infections have become a major concern worldwide. We conducted a prospective multicenter study of invasive CA-MRSA to evaluate clinical features and genotype of strains causing invasive infections in Argentina. A total of 55 patients with invasive CA-MRSA infections were included. Most patients (60%) had bloodstream infections, 42% required admission to intensive care unit and 16% died. No CA-MRSA isolates were multiresistant (resistant ≥ 3 classes of antibiotics). All isolates carried Panton-Valentine leukocidin (PVL) genes and staphylococcal cassette chromosome (SCCmec) type IV. The majority CA-MRSA strains belonged to ST30 and had identical PFGE patterns, qualifying as a clonal dissemination of a highly transmissible strain. In patients with invasive infections this clone genotyped as pulsed-field gel electrophoresis type C- ST30, SCCmec type IVc-spa type 019, PVL positive has become predominant and replaced the previously described CA-MRSA clone (PFGE type A, ST5, SCCmec type IV, spa type 311).Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) infections have become a major concern worldwide. We conducted a prospective multicenter study of invasive CA-MRSA to evaluate clinical features and genotype of strains causing invasive infections in Argentina. A total of 55 patients with invasive CA-MRSA infections were included. Most patients (60%) had bloodstream infections, 42% required admission to intensive care unit and 16% died. No CA-MRSA isolates were multiresistant (resistant ≥ 3 classes of antibiotics). All isolates carried Panton-Valentine leukocidin (PVL) genes and staphylococcal cassette chromosome (SCCmec) type IV. The majority CA-MRSA strains belonged to ST30 and had identical PFGE patterns, qualifying as a clonal dissemination of a highly transmissible strain. In patients with invasive infections this clone genotyped as pulsed-field gel electrophoresis type C- ST30, SCCmec type IVc-spa type 019, PVL positive has become predominant and replaced the previously described CA-MRSA clone (PFGE type A, ST5, SCCmec type IV, spa type 311).Fil: Fernandez, Silvina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología; ArgentinaFil: Fernandez, Silvina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología; ArgentinaFil: de Vedia, Luis Alberto. Gobierno de la Ciudad de Buenos Aires. Hospital de Infecciosas F. J. Muñiz; ArgentinaFil: de Vedia, Luis Alberto. Gobierno de la Ciudad de Buenos Aires. Hospital de Infecciosas F. J. Muñiz; ArgentinaFil: Lopez Furst, M, J.. Sanatorio Mendez; ArgentinaFil: Lopez Furst, M, J.. Sanatorio Mendez; ArgentinaFil: Gardella, Noella Mariel. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología; ArgentinaFil: Gardella, Noella Mariel. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología; ArgentinaFil: Di Gregorio, Sabrina Noelia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología; ArgentinaFil: Di Gregorio, Sabrina Noelia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología; ArgentinaFil: Ganaha, M. C.. Hospital Vicente López y Planes; ArgentinaFil: Ganaha, M. C.. Hospital Vicente López y Planes; ArgentinaFil: Prieto, S.. Hospital Nuestra Señora de Luján; ArgentinaFil: Prieto, S.. Hospital Nuestra Señora de Luján; ArgentinaFil: Carbone, E.. Hospital Aeronáutico; ArgentinaFil: Carbone, E.. Hospital Aeronáutico; ArgentinaFil: Lista, N.. Gobierno de la Ciudad de Buenos Aires. Hospital de Infecciosas F. J. Muñiz; ArgentinaFil: Lista, N.. Gobierno de la Ciudad de Buenos Aires. Hospital de Infecciosas F. J. Muñiz; ArgentinaFil: Rotrying, F.. Universidad Abierta Interamericana. Hospital Escuela; ArgentinaFil: Rotrying, F.. Universidad Abierta Interamericana. Hospital Escuela; ArgentinaFil: Stryjewski, M. D.. Centro de Educaciones Médicas e Investigación Clínica;Fil: Stryjewski, M. D.. Centro de Educaciones Médicas e Investigación Clínica;Fil: Mollerach, Marta Eugenia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología; ArgentinaFil: Mollerach, Marta Eugenia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología; ArgentinaElsevierElsevier2013-01-202013-01-20info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/1712Fernandez, Silvina; de Vedia, Luis Alberto; Lopez Furst, M, J.; Gardella, Noella Mariel; Di Gregorio, Sabrina Noelia; et al.; Methicillin-resistant Staphylococcus aureus ST30-SCCmec IVc clone as the major cause of community-acquired invasive infections in Argentina; Elsevier; Infection, Genetics and Evolution; 14; 20-1-2013; 401-405Fernandez, Silvina; de Vedia, Luis Alberto; Lopez Furst, M, J.; Gardella, Noella Mariel; Di Gregorio, Sabrina Noelia; et al.; Methicillin-resistant Staphylococcus aureus ST30-SCCmec IVc clone as the major cause of community-acquired invasive infections in Argentina; Elsevier; Infection, Genetics and Evolution; 14; 20-1-2013; 401-4051567-13481567-1348engenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.meegid.2012.12.018info:eu-repo/semantics/altIdentifier/doi/10.1016/j.meegid.2012.12.018info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1567134813000038info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1567134813000038info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:22:14Zoai:ri.conicet.gov.ar:11336/1712instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:22:14.37CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Methicillin-resistant Staphylococcus aureus ST30-SCCmec IVc clone as the major cause of community-acquired invasive infections in Argentina
Methicillin-resistant Staphylococcus aureus ST30-SCCmec IVc clone as the major cause of community-acquired invasive infections in Argentina
title Methicillin-resistant Staphylococcus aureus ST30-SCCmec IVc clone as the major cause of community-acquired invasive infections in Argentina
spellingShingle Methicillin-resistant Staphylococcus aureus ST30-SCCmec IVc clone as the major cause of community-acquired invasive infections in Argentina
Fernandez, Silvina
Methicillin-Resistance Community-Associated Staphylococcus Aureus
Methicillin-Resistance Community-Associated Staphylococcus Aureus
Mrsa Invasive Infection
Mrsa Invasive Infection
Molecular Epidemiology
Molecular Epidemiology
title_short Methicillin-resistant Staphylococcus aureus ST30-SCCmec IVc clone as the major cause of community-acquired invasive infections in Argentina
title_full Methicillin-resistant Staphylococcus aureus ST30-SCCmec IVc clone as the major cause of community-acquired invasive infections in Argentina
title_fullStr Methicillin-resistant Staphylococcus aureus ST30-SCCmec IVc clone as the major cause of community-acquired invasive infections in Argentina
title_full_unstemmed Methicillin-resistant Staphylococcus aureus ST30-SCCmec IVc clone as the major cause of community-acquired invasive infections in Argentina
title_sort Methicillin-resistant Staphylococcus aureus ST30-SCCmec IVc clone as the major cause of community-acquired invasive infections in Argentina
dc.creator.none.fl_str_mv Fernandez, Silvina
Fernandez, Silvina
de Vedia, Luis Alberto
de Vedia, Luis Alberto
Lopez Furst, M, J.
Lopez Furst, M, J.
Gardella, Noella Mariel
Gardella, Noella Mariel
Di Gregorio, Sabrina Noelia
Di Gregorio, Sabrina Noelia
Ganaha, M. C.
Ganaha, M. C.
Prieto, S.
Prieto, S.
Carbone, E.
Carbone, E.
Lista, N.
Lista, N.
Rotrying, F.
Rotrying, F.
Stryjewski, M. D.
Stryjewski, M. D.
Mollerach, Marta Eugenia
Mollerach, Marta Eugenia
author Fernandez, Silvina
author_facet Fernandez, Silvina
de Vedia, Luis Alberto
Lopez Furst, M, J.
Gardella, Noella Mariel
Di Gregorio, Sabrina Noelia
Ganaha, M. C.
Prieto, S.
Carbone, E.
Lista, N.
Rotrying, F.
Stryjewski, M. D.
Mollerach, Marta Eugenia
author_role author
author2 de Vedia, Luis Alberto
Lopez Furst, M, J.
Gardella, Noella Mariel
Di Gregorio, Sabrina Noelia
Ganaha, M. C.
Prieto, S.
Carbone, E.
Lista, N.
Rotrying, F.
Stryjewski, M. D.
Mollerach, Marta Eugenia
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Methicillin-Resistance Community-Associated Staphylococcus Aureus
Methicillin-Resistance Community-Associated Staphylococcus Aureus
Mrsa Invasive Infection
Mrsa Invasive Infection
Molecular Epidemiology
Molecular Epidemiology
topic Methicillin-Resistance Community-Associated Staphylococcus Aureus
Methicillin-Resistance Community-Associated Staphylococcus Aureus
Mrsa Invasive Infection
Mrsa Invasive Infection
Molecular Epidemiology
Molecular Epidemiology
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
https://purl.org/becyt/ford/3
https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) infections have become a major concern worldwide. We conducted a prospective multicenter study of invasive CA-MRSA to evaluate clinical features and genotype of strains causing invasive infections in Argentina. A total of 55 patients with invasive CA-MRSA infections were included. Most patients (60%) had bloodstream infections, 42% required admission to intensive care unit and 16% died. No CA-MRSA isolates were multiresistant (resistant ≥ 3 classes of antibiotics). All isolates carried Panton-Valentine leukocidin (PVL) genes and staphylococcal cassette chromosome (SCCmec) type IV. The majority CA-MRSA strains belonged to ST30 and had identical PFGE patterns, qualifying as a clonal dissemination of a highly transmissible strain. In patients with invasive infections this clone genotyped as pulsed-field gel electrophoresis type C- ST30, SCCmec type IVc-spa type 019, PVL positive has become predominant and replaced the previously described CA-MRSA clone (PFGE type A, ST5, SCCmec type IV, spa type 311).
Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) infections have become a major concern worldwide. We conducted a prospective multicenter study of invasive CA-MRSA to evaluate clinical features and genotype of strains causing invasive infections in Argentina. A total of 55 patients with invasive CA-MRSA infections were included. Most patients (60%) had bloodstream infections, 42% required admission to intensive care unit and 16% died. No CA-MRSA isolates were multiresistant (resistant ≥ 3 classes of antibiotics). All isolates carried Panton-Valentine leukocidin (PVL) genes and staphylococcal cassette chromosome (SCCmec) type IV. The majority CA-MRSA strains belonged to ST30 and had identical PFGE patterns, qualifying as a clonal dissemination of a highly transmissible strain. In patients with invasive infections this clone genotyped as pulsed-field gel electrophoresis type C- ST30, SCCmec type IVc-spa type 019, PVL positive has become predominant and replaced the previously described CA-MRSA clone (PFGE type A, ST5, SCCmec type IV, spa type 311).
Fil: Fernandez, Silvina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología; Argentina
Fil: Fernandez, Silvina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Inmunología, Genética y Metabolismo; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología; Argentina
Fil: de Vedia, Luis Alberto. Gobierno de la Ciudad de Buenos Aires. Hospital de Infecciosas F. J. Muñiz; Argentina
Fil: de Vedia, Luis Alberto. Gobierno de la Ciudad de Buenos Aires. Hospital de Infecciosas F. J. Muñiz; Argentina
Fil: Lopez Furst, M, J.. Sanatorio Mendez; Argentina
Fil: Lopez Furst, M, J.. Sanatorio Mendez; Argentina
Fil: Gardella, Noella Mariel. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología; Argentina
Fil: Gardella, Noella Mariel. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología; Argentina
Fil: Di Gregorio, Sabrina Noelia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología; Argentina
Fil: Di Gregorio, Sabrina Noelia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología; Argentina
Fil: Ganaha, M. C.. Hospital Vicente López y Planes; Argentina
Fil: Ganaha, M. C.. Hospital Vicente López y Planes; Argentina
Fil: Prieto, S.. Hospital Nuestra Señora de Luján; Argentina
Fil: Prieto, S.. Hospital Nuestra Señora de Luján; Argentina
Fil: Carbone, E.. Hospital Aeronáutico; Argentina
Fil: Carbone, E.. Hospital Aeronáutico; Argentina
Fil: Lista, N.. Gobierno de la Ciudad de Buenos Aires. Hospital de Infecciosas F. J. Muñiz; Argentina
Fil: Lista, N.. Gobierno de la Ciudad de Buenos Aires. Hospital de Infecciosas F. J. Muñiz; Argentina
Fil: Rotrying, F.. Universidad Abierta Interamericana. Hospital Escuela; Argentina
Fil: Rotrying, F.. Universidad Abierta Interamericana. Hospital Escuela; Argentina
Fil: Stryjewski, M. D.. Centro de Educaciones Médicas e Investigación Clínica;
Fil: Stryjewski, M. D.. Centro de Educaciones Médicas e Investigación Clínica;
Fil: Mollerach, Marta Eugenia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología; Argentina
Fil: Mollerach, Marta Eugenia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología; Argentina
description Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) infections have become a major concern worldwide. We conducted a prospective multicenter study of invasive CA-MRSA to evaluate clinical features and genotype of strains causing invasive infections in Argentina. A total of 55 patients with invasive CA-MRSA infections were included. Most patients (60%) had bloodstream infections, 42% required admission to intensive care unit and 16% died. No CA-MRSA isolates were multiresistant (resistant ≥ 3 classes of antibiotics). All isolates carried Panton-Valentine leukocidin (PVL) genes and staphylococcal cassette chromosome (SCCmec) type IV. The majority CA-MRSA strains belonged to ST30 and had identical PFGE patterns, qualifying as a clonal dissemination of a highly transmissible strain. In patients with invasive infections this clone genotyped as pulsed-field gel electrophoresis type C- ST30, SCCmec type IVc-spa type 019, PVL positive has become predominant and replaced the previously described CA-MRSA clone (PFGE type A, ST5, SCCmec type IV, spa type 311).
publishDate 2013
dc.date.none.fl_str_mv 2013-01-20
2013-01-20
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/1712
Fernandez, Silvina; de Vedia, Luis Alberto; Lopez Furst, M, J.; Gardella, Noella Mariel; Di Gregorio, Sabrina Noelia; et al.; Methicillin-resistant Staphylococcus aureus ST30-SCCmec IVc clone as the major cause of community-acquired invasive infections in Argentina; Elsevier; Infection, Genetics and Evolution; 14; 20-1-2013; 401-405
Fernandez, Silvina; de Vedia, Luis Alberto; Lopez Furst, M, J.; Gardella, Noella Mariel; Di Gregorio, Sabrina Noelia; et al.; Methicillin-resistant Staphylococcus aureus ST30-SCCmec IVc clone as the major cause of community-acquired invasive infections in Argentina; Elsevier; Infection, Genetics and Evolution; 14; 20-1-2013; 401-405
1567-1348
1567-1348
url http://hdl.handle.net/11336/1712
identifier_str_mv Fernandez, Silvina; de Vedia, Luis Alberto; Lopez Furst, M, J.; Gardella, Noella Mariel; Di Gregorio, Sabrina Noelia; et al.; Methicillin-resistant Staphylococcus aureus ST30-SCCmec IVc clone as the major cause of community-acquired invasive infections in Argentina; Elsevier; Infection, Genetics and Evolution; 14; 20-1-2013; 401-405
1567-1348
dc.language.none.fl_str_mv eng
eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.meegid.2012.12.018
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.meegid.2012.12.018
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1567134813000038
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1567134813000038
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
Elsevier
publisher.none.fl_str_mv Elsevier
Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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