Incidence of the Nordihydroguaiaretic Acid Content on the In Vitro Antiviral Activity of Extracts Obtained from Larrea divaricata Cav. (Zygophyllaceae)

Autores
Konigheim, Brenda Salome; Aguilar, Juan Javier; Grasso, Sergio; Contigiani de Minio, Marta Silvia; Núñez Montoya, Susana Carolina
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The South American species Larrea divaricata Cav. (Zygophyllaceae) has been widely used in folk medicine against infectious diseases. In previous studies, we reported that several extracts obtained from the aerial parts of this species and the nordihydroguaiaretic acid (NDGA), its main lignan, inhibited Junin Virus (JUNV) in vitro. In this work, the objective was to assess whether NDGA is truly responsible for the antiviral activity produced by the extracts. Therefore, the presence and amount of NDGA in extracts were determined by HPLC. We established that NDGA in the extracts analyzed is required to inhibit JUNV and observed that some components of the bioactive extracts would increase the antiviral effect of NDGA. On the other hand, we estimated the selectivity index for NDGA against JUNV. Thus, NDGA and extracts containing this lignan exhibited potential therapeutic effects against the etiologic agent of the Argentine Hemorrhagic Fever, an endemo-epidemic illness in this country.
Fil: Konigheim, Brenda Salome. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia. Cátedra de Farmacognosia; Argentina
Fil: Aguilar, Juan Javier. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología “Dr. J. M. Vanella”; Argentina
Fil: Grasso, Sergio. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia. Cátedra de Farmacognosia; Argentina
Fil: Contigiani de Minio, Marta Silvia. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología “Dr. J. M. Vanella”; Argentina
Fil: Núñez Montoya, Susana Carolina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia. Cátedra de Farmacognosia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina
Materia
NORDIHYDROGUIARETIC ACID
ANTIVIRAL
LARREA DIVARICATA
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/272238
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/272238
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Incidence of the Nordihydroguaiaretic Acid Content on the In Vitro Antiviral Activity of Extracts Obtained from Larrea divaricata Cav. (Zygophyllaceae)Konigheim, Brenda SalomeAguilar, Juan JavierGrasso, SergioContigiani de Minio, Marta SilviaNúñez Montoya, Susana CarolinaNORDIHYDROGUIARETIC ACIDANTIVIRALLARREA DIVARICATAhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1https://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The South American species Larrea divaricata Cav. (Zygophyllaceae) has been widely used in folk medicine against infectious diseases. In previous studies, we reported that several extracts obtained from the aerial parts of this species and the nordihydroguaiaretic acid (NDGA), its main lignan, inhibited Junin Virus (JUNV) in vitro. In this work, the objective was to assess whether NDGA is truly responsible for the antiviral activity produced by the extracts. Therefore, the presence and amount of NDGA in extracts were determined by HPLC. We established that NDGA in the extracts analyzed is required to inhibit JUNV and observed that some components of the bioactive extracts would increase the antiviral effect of NDGA. On the other hand, we estimated the selectivity index for NDGA against JUNV. Thus, NDGA and extracts containing this lignan exhibited potential therapeutic effects against the etiologic agent of the Argentine Hemorrhagic Fever, an endemo-epidemic illness in this country.Fil: Konigheim, Brenda Salome. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia. Cátedra de Farmacognosia; ArgentinaFil: Aguilar, Juan Javier. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología “Dr. J. M. Vanella”; ArgentinaFil: Grasso, Sergio. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia. Cátedra de Farmacognosia; ArgentinaFil: Contigiani de Minio, Marta Silvia. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología “Dr. J. M. Vanella”; ArgentinaFil: Núñez Montoya, Susana Carolina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia. Cátedra de Farmacognosia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; ArgentinaColegio de Farmacéuticos de la Provincia de Buenos Aires2012-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/272238Konigheim, Brenda Salome; Aguilar, Juan Javier; Grasso, Sergio; Contigiani de Minio, Marta Silvia; Núñez Montoya, Susana Carolina; Incidence of the Nordihydroguaiaretic Acid Content on the In Vitro Antiviral Activity of Extracts Obtained from Larrea divaricata Cav. (Zygophyllaceae); Colegio de Farmacéuticos de la Provincia de Buenos Aires; Acta Farmacéutica Bonaerense; 31; 5; 9-2012; 659-6640326-23832362-3853CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.latamjpharm.org/previous_issue.php?vol=31&num=5info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:37:07Zoai:ri.conicet.gov.ar:11336/272238instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:37:07.665CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Incidence of the Nordihydroguaiaretic Acid Content on the In Vitro Antiviral Activity of Extracts Obtained from Larrea divaricata Cav. (Zygophyllaceae)
title Incidence of the Nordihydroguaiaretic Acid Content on the In Vitro Antiviral Activity of Extracts Obtained from Larrea divaricata Cav. (Zygophyllaceae)
spellingShingle Incidence of the Nordihydroguaiaretic Acid Content on the In Vitro Antiviral Activity of Extracts Obtained from Larrea divaricata Cav. (Zygophyllaceae)
Konigheim, Brenda Salome
NORDIHYDROGUIARETIC ACID
ANTIVIRAL
LARREA DIVARICATA
title_short Incidence of the Nordihydroguaiaretic Acid Content on the In Vitro Antiviral Activity of Extracts Obtained from Larrea divaricata Cav. (Zygophyllaceae)
title_full Incidence of the Nordihydroguaiaretic Acid Content on the In Vitro Antiviral Activity of Extracts Obtained from Larrea divaricata Cav. (Zygophyllaceae)
title_fullStr Incidence of the Nordihydroguaiaretic Acid Content on the In Vitro Antiviral Activity of Extracts Obtained from Larrea divaricata Cav. (Zygophyllaceae)
title_full_unstemmed Incidence of the Nordihydroguaiaretic Acid Content on the In Vitro Antiviral Activity of Extracts Obtained from Larrea divaricata Cav. (Zygophyllaceae)
title_sort Incidence of the Nordihydroguaiaretic Acid Content on the In Vitro Antiviral Activity of Extracts Obtained from Larrea divaricata Cav. (Zygophyllaceae)
dc.creator.none.fl_str_mv Konigheim, Brenda Salome
Aguilar, Juan Javier
Grasso, Sergio
Contigiani de Minio, Marta Silvia
Núñez Montoya, Susana Carolina
author Konigheim, Brenda Salome
author_facet Konigheim, Brenda Salome
Aguilar, Juan Javier
Grasso, Sergio
Contigiani de Minio, Marta Silvia
Núñez Montoya, Susana Carolina
author_role author
author2 Aguilar, Juan Javier
Grasso, Sergio
Contigiani de Minio, Marta Silvia
Núñez Montoya, Susana Carolina
author2_role author
author
author
author
dc.subject.none.fl_str_mv NORDIHYDROGUIARETIC ACID
ANTIVIRAL
LARREA DIVARICATA
topic NORDIHYDROGUIARETIC ACID
ANTIVIRAL
LARREA DIVARICATA
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The South American species Larrea divaricata Cav. (Zygophyllaceae) has been widely used in folk medicine against infectious diseases. In previous studies, we reported that several extracts obtained from the aerial parts of this species and the nordihydroguaiaretic acid (NDGA), its main lignan, inhibited Junin Virus (JUNV) in vitro. In this work, the objective was to assess whether NDGA is truly responsible for the antiviral activity produced by the extracts. Therefore, the presence and amount of NDGA in extracts were determined by HPLC. We established that NDGA in the extracts analyzed is required to inhibit JUNV and observed that some components of the bioactive extracts would increase the antiviral effect of NDGA. On the other hand, we estimated the selectivity index for NDGA against JUNV. Thus, NDGA and extracts containing this lignan exhibited potential therapeutic effects against the etiologic agent of the Argentine Hemorrhagic Fever, an endemo-epidemic illness in this country.
Fil: Konigheim, Brenda Salome. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia. Cátedra de Farmacognosia; Argentina
Fil: Aguilar, Juan Javier. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología “Dr. J. M. Vanella”; Argentina
Fil: Grasso, Sergio. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia. Cátedra de Farmacognosia; Argentina
Fil: Contigiani de Minio, Marta Silvia. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Virología “Dr. J. M. Vanella”; Argentina
Fil: Núñez Montoya, Susana Carolina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia. Cátedra de Farmacognosia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; Argentina
description The South American species Larrea divaricata Cav. (Zygophyllaceae) has been widely used in folk medicine against infectious diseases. In previous studies, we reported that several extracts obtained from the aerial parts of this species and the nordihydroguaiaretic acid (NDGA), its main lignan, inhibited Junin Virus (JUNV) in vitro. In this work, the objective was to assess whether NDGA is truly responsible for the antiviral activity produced by the extracts. Therefore, the presence and amount of NDGA in extracts were determined by HPLC. We established that NDGA in the extracts analyzed is required to inhibit JUNV and observed that some components of the bioactive extracts would increase the antiviral effect of NDGA. On the other hand, we estimated the selectivity index for NDGA against JUNV. Thus, NDGA and extracts containing this lignan exhibited potential therapeutic effects against the etiologic agent of the Argentine Hemorrhagic Fever, an endemo-epidemic illness in this country.
publishDate 2012
dc.date.none.fl_str_mv 2012-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/272238
Konigheim, Brenda Salome; Aguilar, Juan Javier; Grasso, Sergio; Contigiani de Minio, Marta Silvia; Núñez Montoya, Susana Carolina; Incidence of the Nordihydroguaiaretic Acid Content on the In Vitro Antiviral Activity of Extracts Obtained from Larrea divaricata Cav. (Zygophyllaceae); Colegio de Farmacéuticos de la Provincia de Buenos Aires; Acta Farmacéutica Bonaerense; 31; 5; 9-2012; 659-664
0326-2383
2362-3853
CONICET Digital
CONICET
url http://hdl.handle.net/11336/272238
identifier_str_mv Konigheim, Brenda Salome; Aguilar, Juan Javier; Grasso, Sergio; Contigiani de Minio, Marta Silvia; Núñez Montoya, Susana Carolina; Incidence of the Nordihydroguaiaretic Acid Content on the In Vitro Antiviral Activity of Extracts Obtained from Larrea divaricata Cav. (Zygophyllaceae); Colegio de Farmacéuticos de la Provincia de Buenos Aires; Acta Farmacéutica Bonaerense; 31; 5; 9-2012; 659-664
0326-2383
2362-3853
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.latamjpharm.org/previous_issue.php?vol=31&num=5
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Colegio de Farmacéuticos de la Provincia de Buenos Aires
publisher.none.fl_str_mv Colegio de Farmacéuticos de la Provincia de Buenos Aires
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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