Multifocal epilepsy in children is associated with increased long-distance functional connectivity: An explorative EEG-fMRI study

Autores
Siniatchkin, Michael; Moehring, Jan; Kroeher, Bianca; Galka, Andreas; Ondarza, Gisela von; Moeller, Friederike; Wolff, Stephan; Tagliazucchi, Enzo Rodolfo; Steinmann, Elisabeth; Boor, Rainer; Stephani, Ulrich
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Objective: Multifocal epileptic activity is an unfavourable feature of a number of epileptic syndromes (Lennox-Gastaut syndrome, West syndrome, severe focal epilepsies) which suggests an overall vulnerability of the brain to pathological synchronization. However, the mechanisms of multifocal activity are insufficiently understood. This explorative study investigates whether pathological connectivity within brain areas of the default mode network as well as thalamus, brainstem and retrosplenial cortex may predispose individuals to multifocal epileptic activity. Methods: 33 children suffering from multifocal and monofocal (control group) epilepsies were investigated using EEG-fMRI recordings during sleep. The blood oxygenated level dependent (BOLD) signal of 15 regions of interest was extracted and temporally correlated (resting-state functional connectivity). Results: Patients with monofocal epilepsies were characterized by strong correlations between the corresponding interhemispheric homotopic regions. This pattern of correlations with pronounced short-distance and weak long-distance functional connectivity resembles the connectivity pattern described for healthy children. Patients with multifocal epileptic activity, however, demonstrated significantly stronger correlations between a large number of regions of the default mode network as well as thalamus and brainstem, with a significant increase in long-distance connectivity compared to children with monofocal epileptic activity. In the group of patients with multifocal epilepsies there were no differences in functional connectivity between patients with or without Lennox-Gastaut syndrome. Conclusion: This explorative study shows that multifocal activity is associated with generally increased long-distance functional connectivity in the brain. It can be suggested that this pronounced connectivity may represent either a risk to pathological over-synchronization or a consequence of the multifocal epileptic activity.
Fil: Siniatchkin, Michael. Christian-Albrechts-Universität zu Kiel; Alemania
Fil: Moehring, Jan. Christian-Albrechts-Universität zu Kiel; Alemania
Fil: Kroeher, Bianca. Christian-Albrechts-Universität zu Kiel; Alemania
Fil: Galka, Andreas. Christian-Albrechts-Universität zu Kiel; Alemania
Fil: Ondarza, Gisela von. Christian-Albrechts-Universität zu Kiel; Alemania
Fil: Moeller, Friederike. Christian-Albrechts-Universität zu Kiel; Alemania
Fil: Wolff, Stephan. Christian-Albrechts-Universität zu Kiel; Alemania
Fil: Tagliazucchi, Enzo Rodolfo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; Argentina. Christian-Albrechts-Universität zu Kiel; Alemania
Fil: Steinmann, Elisabeth. Christian-Albrechts-Universität zu Kiel; Alemania
Fil: Boor, Rainer. Christian-Albrechts-Universität zu Kiel; Alemania
Fil: Stephani, Ulrich. Christian-Albrechts-Universität zu Kiel; Alemania
Materia
CHILDREN
DEFAULT-MODE NETWORK
EEG-FMRI
FUNCTIONAL CONNECTIVITY
MULTIFOCAL EPILEPSY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/96785
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/96785
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Multifocal epilepsy in children is associated with increased long-distance functional connectivity: An explorative EEG-fMRI studySiniatchkin, MichaelMoehring, JanKroeher, BiancaGalka, AndreasOndarza, Gisela vonMoeller, FriederikeWolff, StephanTagliazucchi, Enzo RodolfoSteinmann, ElisabethBoor, RainerStephani, UlrichCHILDRENDEFAULT-MODE NETWORKEEG-FMRIFUNCTIONAL CONNECTIVITYMULTIFOCAL EPILEPSYhttps://purl.org/becyt/ford/1.3https://purl.org/becyt/ford/1Objective: Multifocal epileptic activity is an unfavourable feature of a number of epileptic syndromes (Lennox-Gastaut syndrome, West syndrome, severe focal epilepsies) which suggests an overall vulnerability of the brain to pathological synchronization. However, the mechanisms of multifocal activity are insufficiently understood. This explorative study investigates whether pathological connectivity within brain areas of the default mode network as well as thalamus, brainstem and retrosplenial cortex may predispose individuals to multifocal epileptic activity. Methods: 33 children suffering from multifocal and monofocal (control group) epilepsies were investigated using EEG-fMRI recordings during sleep. The blood oxygenated level dependent (BOLD) signal of 15 regions of interest was extracted and temporally correlated (resting-state functional connectivity). Results: Patients with monofocal epilepsies were characterized by strong correlations between the corresponding interhemispheric homotopic regions. This pattern of correlations with pronounced short-distance and weak long-distance functional connectivity resembles the connectivity pattern described for healthy children. Patients with multifocal epileptic activity, however, demonstrated significantly stronger correlations between a large number of regions of the default mode network as well as thalamus and brainstem, with a significant increase in long-distance connectivity compared to children with monofocal epileptic activity. In the group of patients with multifocal epilepsies there were no differences in functional connectivity between patients with or without Lennox-Gastaut syndrome. Conclusion: This explorative study shows that multifocal activity is associated with generally increased long-distance functional connectivity in the brain. It can be suggested that this pronounced connectivity may represent either a risk to pathological over-synchronization or a consequence of the multifocal epileptic activity.Fil: Siniatchkin, Michael. Christian-Albrechts-Universität zu Kiel; AlemaniaFil: Moehring, Jan. Christian-Albrechts-Universität zu Kiel; AlemaniaFil: Kroeher, Bianca. Christian-Albrechts-Universität zu Kiel; AlemaniaFil: Galka, Andreas. Christian-Albrechts-Universität zu Kiel; AlemaniaFil: Ondarza, Gisela von. Christian-Albrechts-Universität zu Kiel; AlemaniaFil: Moeller, Friederike. Christian-Albrechts-Universität zu Kiel; AlemaniaFil: Wolff, Stephan. Christian-Albrechts-Universität zu Kiel; AlemaniaFil: Tagliazucchi, Enzo Rodolfo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; Argentina. Christian-Albrechts-Universität zu Kiel; AlemaniaFil: Steinmann, Elisabeth. Christian-Albrechts-Universität zu Kiel; AlemaniaFil: Boor, Rainer. Christian-Albrechts-Universität zu Kiel; AlemaniaFil: Stephani, Ulrich. Christian-Albrechts-Universität zu Kiel; AlemaniaElsevier2018-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/96785Siniatchkin, Michael; Moehring, Jan; Kroeher, Bianca; Galka, Andreas; Ondarza, Gisela von; et al.; Multifocal epilepsy in children is associated with increased long-distance functional connectivity: An explorative EEG-fMRI study; Elsevier; European Journal Of Paediatric Neurology; 22; 6; 11-2018; 1054-10651090-3798CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.ejpn.2018.07.001info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1090379817301812info:eu-repo/semantics/altIdentifier/url/https://www.ejpn-journal.com/article/S1090-3798(17)30181-2/pdfinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:32:35Zoai:ri.conicet.gov.ar:11336/96785instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:32:35.551CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Multifocal epilepsy in children is associated with increased long-distance functional connectivity: An explorative EEG-fMRI study
title Multifocal epilepsy in children is associated with increased long-distance functional connectivity: An explorative EEG-fMRI study
spellingShingle Multifocal epilepsy in children is associated with increased long-distance functional connectivity: An explorative EEG-fMRI study
Siniatchkin, Michael
CHILDREN
DEFAULT-MODE NETWORK
EEG-FMRI
FUNCTIONAL CONNECTIVITY
MULTIFOCAL EPILEPSY
title_short Multifocal epilepsy in children is associated with increased long-distance functional connectivity: An explorative EEG-fMRI study
title_full Multifocal epilepsy in children is associated with increased long-distance functional connectivity: An explorative EEG-fMRI study
title_fullStr Multifocal epilepsy in children is associated with increased long-distance functional connectivity: An explorative EEG-fMRI study
title_full_unstemmed Multifocal epilepsy in children is associated with increased long-distance functional connectivity: An explorative EEG-fMRI study
title_sort Multifocal epilepsy in children is associated with increased long-distance functional connectivity: An explorative EEG-fMRI study
dc.creator.none.fl_str_mv Siniatchkin, Michael
Moehring, Jan
Kroeher, Bianca
Galka, Andreas
Ondarza, Gisela von
Moeller, Friederike
Wolff, Stephan
Tagliazucchi, Enzo Rodolfo
Steinmann, Elisabeth
Boor, Rainer
Stephani, Ulrich
author Siniatchkin, Michael
author_facet Siniatchkin, Michael
Moehring, Jan
Kroeher, Bianca
Galka, Andreas
Ondarza, Gisela von
Moeller, Friederike
Wolff, Stephan
Tagliazucchi, Enzo Rodolfo
Steinmann, Elisabeth
Boor, Rainer
Stephani, Ulrich
author_role author
author2 Moehring, Jan
Kroeher, Bianca
Galka, Andreas
Ondarza, Gisela von
Moeller, Friederike
Wolff, Stephan
Tagliazucchi, Enzo Rodolfo
Steinmann, Elisabeth
Boor, Rainer
Stephani, Ulrich
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv CHILDREN
DEFAULT-MODE NETWORK
EEG-FMRI
FUNCTIONAL CONNECTIVITY
MULTIFOCAL EPILEPSY
topic CHILDREN
DEFAULT-MODE NETWORK
EEG-FMRI
FUNCTIONAL CONNECTIVITY
MULTIFOCAL EPILEPSY
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.3
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Objective: Multifocal epileptic activity is an unfavourable feature of a number of epileptic syndromes (Lennox-Gastaut syndrome, West syndrome, severe focal epilepsies) which suggests an overall vulnerability of the brain to pathological synchronization. However, the mechanisms of multifocal activity are insufficiently understood. This explorative study investigates whether pathological connectivity within brain areas of the default mode network as well as thalamus, brainstem and retrosplenial cortex may predispose individuals to multifocal epileptic activity. Methods: 33 children suffering from multifocal and monofocal (control group) epilepsies were investigated using EEG-fMRI recordings during sleep. The blood oxygenated level dependent (BOLD) signal of 15 regions of interest was extracted and temporally correlated (resting-state functional connectivity). Results: Patients with monofocal epilepsies were characterized by strong correlations between the corresponding interhemispheric homotopic regions. This pattern of correlations with pronounced short-distance and weak long-distance functional connectivity resembles the connectivity pattern described for healthy children. Patients with multifocal epileptic activity, however, demonstrated significantly stronger correlations between a large number of regions of the default mode network as well as thalamus and brainstem, with a significant increase in long-distance connectivity compared to children with monofocal epileptic activity. In the group of patients with multifocal epilepsies there were no differences in functional connectivity between patients with or without Lennox-Gastaut syndrome. Conclusion: This explorative study shows that multifocal activity is associated with generally increased long-distance functional connectivity in the brain. It can be suggested that this pronounced connectivity may represent either a risk to pathological over-synchronization or a consequence of the multifocal epileptic activity.
Fil: Siniatchkin, Michael. Christian-Albrechts-Universität zu Kiel; Alemania
Fil: Moehring, Jan. Christian-Albrechts-Universität zu Kiel; Alemania
Fil: Kroeher, Bianca. Christian-Albrechts-Universität zu Kiel; Alemania
Fil: Galka, Andreas. Christian-Albrechts-Universität zu Kiel; Alemania
Fil: Ondarza, Gisela von. Christian-Albrechts-Universität zu Kiel; Alemania
Fil: Moeller, Friederike. Christian-Albrechts-Universität zu Kiel; Alemania
Fil: Wolff, Stephan. Christian-Albrechts-Universität zu Kiel; Alemania
Fil: Tagliazucchi, Enzo Rodolfo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; Argentina. Christian-Albrechts-Universität zu Kiel; Alemania
Fil: Steinmann, Elisabeth. Christian-Albrechts-Universität zu Kiel; Alemania
Fil: Boor, Rainer. Christian-Albrechts-Universität zu Kiel; Alemania
Fil: Stephani, Ulrich. Christian-Albrechts-Universität zu Kiel; Alemania
description Objective: Multifocal epileptic activity is an unfavourable feature of a number of epileptic syndromes (Lennox-Gastaut syndrome, West syndrome, severe focal epilepsies) which suggests an overall vulnerability of the brain to pathological synchronization. However, the mechanisms of multifocal activity are insufficiently understood. This explorative study investigates whether pathological connectivity within brain areas of the default mode network as well as thalamus, brainstem and retrosplenial cortex may predispose individuals to multifocal epileptic activity. Methods: 33 children suffering from multifocal and monofocal (control group) epilepsies were investigated using EEG-fMRI recordings during sleep. The blood oxygenated level dependent (BOLD) signal of 15 regions of interest was extracted and temporally correlated (resting-state functional connectivity). Results: Patients with monofocal epilepsies were characterized by strong correlations between the corresponding interhemispheric homotopic regions. This pattern of correlations with pronounced short-distance and weak long-distance functional connectivity resembles the connectivity pattern described for healthy children. Patients with multifocal epileptic activity, however, demonstrated significantly stronger correlations between a large number of regions of the default mode network as well as thalamus and brainstem, with a significant increase in long-distance connectivity compared to children with monofocal epileptic activity. In the group of patients with multifocal epilepsies there were no differences in functional connectivity between patients with or without Lennox-Gastaut syndrome. Conclusion: This explorative study shows that multifocal activity is associated with generally increased long-distance functional connectivity in the brain. It can be suggested that this pronounced connectivity may represent either a risk to pathological over-synchronization or a consequence of the multifocal epileptic activity.
publishDate 2018
dc.date.none.fl_str_mv 2018-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/96785
Siniatchkin, Michael; Moehring, Jan; Kroeher, Bianca; Galka, Andreas; Ondarza, Gisela von; et al.; Multifocal epilepsy in children is associated with increased long-distance functional connectivity: An explorative EEG-fMRI study; Elsevier; European Journal Of Paediatric Neurology; 22; 6; 11-2018; 1054-1065
1090-3798
CONICET Digital
CONICET
url http://hdl.handle.net/11336/96785
identifier_str_mv Siniatchkin, Michael; Moehring, Jan; Kroeher, Bianca; Galka, Andreas; Ondarza, Gisela von; et al.; Multifocal epilepsy in children is associated with increased long-distance functional connectivity: An explorative EEG-fMRI study; Elsevier; European Journal Of Paediatric Neurology; 22; 6; 11-2018; 1054-1065
1090-3798
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.ejpn.2018.07.001
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1090379817301812
info:eu-repo/semantics/altIdentifier/url/https://www.ejpn-journal.com/article/S1090-3798(17)30181-2/pdf
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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