An extra virgin olive oil‐enriched diet improves maternal, placental and cord blood parameters in GDM pregnancies

Autores
Gomez Ribot, Dalmiro Leonardo Antonio; Diaz, Esteban; Fazio, María Victoria; Gómez, Hebe Lorena; Fornes, Daiana; Macchi, Silvia Beatriz; Gresta, Carlos Alberto; Capobianco, Evangelina Lorena; Jawerbaum, Alicia Sandra
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Aims: To address the effect of a diet enriched in extra virgin olive oil (EVOO) on maternal metabolic parameters and placental proinflammatory markers in Gestational diabetes mellitus (GDM) patients. Methods: Pregnant women at 24-28 weeks of gestation were enrolled: 33 GDM patients which were randomly assigned or not to the EVOO-enriched group and 17 healthy controls. Metabolic parameters were determined. Peroxisome proliferator activated receptor (PPAR) γ and PPARα protein expression, expression of microRNA (miR)-130a and miR-518d (which respectively target these PPAR isoforms) and levels of proinflammatory markers were evaluated in term placentas. Matrix metalloproteinases (MMPs) activity was evaluated in term placentas and umbilical cord blood. Results: GDM patients that received the EVOO-enriched diet showed reduced pregnancy weight gain (GDM-EVOO:10.3 ± 0.9, GDM:14.2 ± 1.4, P =.03) and reduced triglyceridemia (GDM-EVOO:231 ± 14, GDM:292 ± 21, P =.02) compared to the non-EVOO-enriched GDM group. In GDM placentas, the EVOO-enriched diet did not regulate PPARγ protein expression or miR-130a expression, but prevented the reduced PPARα protein expression (P =.02 vs GDM) and the increased miR-518d expression (P =.009 vs GDM). Increased proinflammatory markers (interleukin-1β, tumour necrosis factor-α and nitric oxide overproduction) in GDM placentas were prevented by the EVOO-enriched diet (respectively P =.001, P =.001 and P =.01 vs GDM). MMPs overactivity was prevented in placenta and umbilical cord blood in the EVOO-enriched GDM group (MMP-9: respectively P =.01 and P =.001 vs GDM). Conclusions: A diet enriched in EVOO in GDM patients reduced maternal triglyceridemia and weight gain and has antiinflammatory properties in placenta and umbilical cord blood, possibly mediated by the regulation of PPAR pathways.
Fil: Gomez Ribot, Dalmiro Leonardo Antonio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina
Fil: Diaz, Esteban. Gobierno de la Ciudad Autónoma de Buenos Aires. Hospital General de Agudos Doctor Ignacio Pirovano; Argentina
Fil: Fazio, María Victoria. Gobierno de la Ciudad Autónoma de Buenos Aires. Hospital General de Agudos Doctor Ignacio Pirovano; Argentina
Fil: Gómez, Hebe Lorena. Gobierno de la Ciudad Autónoma de Buenos Aires. Hospital General de Agudos Doctor Ignacio Pirovano; Argentina
Fil: Fornes, Daiana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina
Fil: Macchi, Silvia Beatriz. Gobierno de la Ciudad Autónoma de Buenos Aires. Hospital General de Agudos Doctor Ignacio Pirovano; Argentina
Fil: Gresta, Carlos Alberto. Gobierno de la Ciudad Autónoma de Buenos Aires. Hospital General de Agudos Doctor Ignacio Pirovano; Argentina
Fil: Capobianco, Evangelina Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina
Fil: Jawerbaum, Alicia Sandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina
Materia
ANTI-INFLAMMATORY EFFECTS
DIETARY TREATMENT
FOETAL PROGRAMMING
MATERNAL DIABETES
MONOUNSATURATED FATTY ACIDS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/140474
Acceder
id CONICETDig_ee652164c084fbf32a459ce8683fd648
oai_identifier_str oai:ri.conicet.gov.ar:11336/140474
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling An extra virgin olive oil‐enriched diet improves maternal, placental and cord blood parameters in GDM pregnanciesGomez Ribot, Dalmiro Leonardo AntonioDiaz, EstebanFazio, María VictoriaGómez, Hebe LorenaFornes, DaianaMacchi, Silvia BeatrizGresta, Carlos AlbertoCapobianco, Evangelina LorenaJawerbaum, Alicia SandraANTI-INFLAMMATORY EFFECTSDIETARY TREATMENTFOETAL PROGRAMMINGMATERNAL DIABETESMONOUNSATURATED FATTY ACIDShttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Aims: To address the effect of a diet enriched in extra virgin olive oil (EVOO) on maternal metabolic parameters and placental proinflammatory markers in Gestational diabetes mellitus (GDM) patients. Methods: Pregnant women at 24-28 weeks of gestation were enrolled: 33 GDM patients which were randomly assigned or not to the EVOO-enriched group and 17 healthy controls. Metabolic parameters were determined. Peroxisome proliferator activated receptor (PPAR) γ and PPARα protein expression, expression of microRNA (miR)-130a and miR-518d (which respectively target these PPAR isoforms) and levels of proinflammatory markers were evaluated in term placentas. Matrix metalloproteinases (MMPs) activity was evaluated in term placentas and umbilical cord blood. Results: GDM patients that received the EVOO-enriched diet showed reduced pregnancy weight gain (GDM-EVOO:10.3 ± 0.9, GDM:14.2 ± 1.4, P =.03) and reduced triglyceridemia (GDM-EVOO:231 ± 14, GDM:292 ± 21, P =.02) compared to the non-EVOO-enriched GDM group. In GDM placentas, the EVOO-enriched diet did not regulate PPARγ protein expression or miR-130a expression, but prevented the reduced PPARα protein expression (P =.02 vs GDM) and the increased miR-518d expression (P =.009 vs GDM). Increased proinflammatory markers (interleukin-1β, tumour necrosis factor-α and nitric oxide overproduction) in GDM placentas were prevented by the EVOO-enriched diet (respectively P =.001, P =.001 and P =.01 vs GDM). MMPs overactivity was prevented in placenta and umbilical cord blood in the EVOO-enriched GDM group (MMP-9: respectively P =.01 and P =.001 vs GDM). Conclusions: A diet enriched in EVOO in GDM patients reduced maternal triglyceridemia and weight gain and has antiinflammatory properties in placenta and umbilical cord blood, possibly mediated by the regulation of PPAR pathways.Fil: Gomez Ribot, Dalmiro Leonardo Antonio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; ArgentinaFil: Diaz, Esteban. Gobierno de la Ciudad Autónoma de Buenos Aires. Hospital General de Agudos Doctor Ignacio Pirovano; ArgentinaFil: Fazio, María Victoria. Gobierno de la Ciudad Autónoma de Buenos Aires. Hospital General de Agudos Doctor Ignacio Pirovano; ArgentinaFil: Gómez, Hebe Lorena. Gobierno de la Ciudad Autónoma de Buenos Aires. Hospital General de Agudos Doctor Ignacio Pirovano; ArgentinaFil: Fornes, Daiana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; ArgentinaFil: Macchi, Silvia Beatriz. Gobierno de la Ciudad Autónoma de Buenos Aires. Hospital General de Agudos Doctor Ignacio Pirovano; ArgentinaFil: Gresta, Carlos Alberto. Gobierno de la Ciudad Autónoma de Buenos Aires. Hospital General de Agudos Doctor Ignacio Pirovano; ArgentinaFil: Capobianco, Evangelina Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; ArgentinaFil: Jawerbaum, Alicia Sandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; ArgentinaJohn Wiley & Sons Ltd2020-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/140474Gomez Ribot, Dalmiro Leonardo Antonio; Diaz, Esteban; Fazio, María Victoria; Gómez, Hebe Lorena; Fornes, Daiana; et al.; An extra virgin olive oil‐enriched diet improves maternal, placental and cord blood parameters in GDM pregnancies; John Wiley & Sons Ltd; Diabetes/metabolism Research and Reviews; 36; 8; 5-2020; 1-301520-7552CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/dmrr.3349info:eu-repo/semantics/altIdentifier/doi/10.1002/dmrr.3349info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:02:53Zoai:ri.conicet.gov.ar:11336/140474instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:02:54.282CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv An extra virgin olive oil‐enriched diet improves maternal, placental and cord blood parameters in GDM pregnancies
title An extra virgin olive oil‐enriched diet improves maternal, placental and cord blood parameters in GDM pregnancies
spellingShingle An extra virgin olive oil‐enriched diet improves maternal, placental and cord blood parameters in GDM pregnancies
Gomez Ribot, Dalmiro Leonardo Antonio
ANTI-INFLAMMATORY EFFECTS
DIETARY TREATMENT
FOETAL PROGRAMMING
MATERNAL DIABETES
MONOUNSATURATED FATTY ACIDS
title_short An extra virgin olive oil‐enriched diet improves maternal, placental and cord blood parameters in GDM pregnancies
title_full An extra virgin olive oil‐enriched diet improves maternal, placental and cord blood parameters in GDM pregnancies
title_fullStr An extra virgin olive oil‐enriched diet improves maternal, placental and cord blood parameters in GDM pregnancies
title_full_unstemmed An extra virgin olive oil‐enriched diet improves maternal, placental and cord blood parameters in GDM pregnancies
title_sort An extra virgin olive oil‐enriched diet improves maternal, placental and cord blood parameters in GDM pregnancies
dc.creator.none.fl_str_mv Gomez Ribot, Dalmiro Leonardo Antonio
Diaz, Esteban
Fazio, María Victoria
Gómez, Hebe Lorena
Fornes, Daiana
Macchi, Silvia Beatriz
Gresta, Carlos Alberto
Capobianco, Evangelina Lorena
Jawerbaum, Alicia Sandra
author Gomez Ribot, Dalmiro Leonardo Antonio
author_facet Gomez Ribot, Dalmiro Leonardo Antonio
Diaz, Esteban
Fazio, María Victoria
Gómez, Hebe Lorena
Fornes, Daiana
Macchi, Silvia Beatriz
Gresta, Carlos Alberto
Capobianco, Evangelina Lorena
Jawerbaum, Alicia Sandra
author_role author
author2 Diaz, Esteban
Fazio, María Victoria
Gómez, Hebe Lorena
Fornes, Daiana
Macchi, Silvia Beatriz
Gresta, Carlos Alberto
Capobianco, Evangelina Lorena
Jawerbaum, Alicia Sandra
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv ANTI-INFLAMMATORY EFFECTS
DIETARY TREATMENT
FOETAL PROGRAMMING
MATERNAL DIABETES
MONOUNSATURATED FATTY ACIDS
topic ANTI-INFLAMMATORY EFFECTS
DIETARY TREATMENT
FOETAL PROGRAMMING
MATERNAL DIABETES
MONOUNSATURATED FATTY ACIDS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Aims: To address the effect of a diet enriched in extra virgin olive oil (EVOO) on maternal metabolic parameters and placental proinflammatory markers in Gestational diabetes mellitus (GDM) patients. Methods: Pregnant women at 24-28 weeks of gestation were enrolled: 33 GDM patients which were randomly assigned or not to the EVOO-enriched group and 17 healthy controls. Metabolic parameters were determined. Peroxisome proliferator activated receptor (PPAR) γ and PPARα protein expression, expression of microRNA (miR)-130a and miR-518d (which respectively target these PPAR isoforms) and levels of proinflammatory markers were evaluated in term placentas. Matrix metalloproteinases (MMPs) activity was evaluated in term placentas and umbilical cord blood. Results: GDM patients that received the EVOO-enriched diet showed reduced pregnancy weight gain (GDM-EVOO:10.3 ± 0.9, GDM:14.2 ± 1.4, P =.03) and reduced triglyceridemia (GDM-EVOO:231 ± 14, GDM:292 ± 21, P =.02) compared to the non-EVOO-enriched GDM group. In GDM placentas, the EVOO-enriched diet did not regulate PPARγ protein expression or miR-130a expression, but prevented the reduced PPARα protein expression (P =.02 vs GDM) and the increased miR-518d expression (P =.009 vs GDM). Increased proinflammatory markers (interleukin-1β, tumour necrosis factor-α and nitric oxide overproduction) in GDM placentas were prevented by the EVOO-enriched diet (respectively P =.001, P =.001 and P =.01 vs GDM). MMPs overactivity was prevented in placenta and umbilical cord blood in the EVOO-enriched GDM group (MMP-9: respectively P =.01 and P =.001 vs GDM). Conclusions: A diet enriched in EVOO in GDM patients reduced maternal triglyceridemia and weight gain and has antiinflammatory properties in placenta and umbilical cord blood, possibly mediated by the regulation of PPAR pathways.
Fil: Gomez Ribot, Dalmiro Leonardo Antonio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina
Fil: Diaz, Esteban. Gobierno de la Ciudad Autónoma de Buenos Aires. Hospital General de Agudos Doctor Ignacio Pirovano; Argentina
Fil: Fazio, María Victoria. Gobierno de la Ciudad Autónoma de Buenos Aires. Hospital General de Agudos Doctor Ignacio Pirovano; Argentina
Fil: Gómez, Hebe Lorena. Gobierno de la Ciudad Autónoma de Buenos Aires. Hospital General de Agudos Doctor Ignacio Pirovano; Argentina
Fil: Fornes, Daiana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina
Fil: Macchi, Silvia Beatriz. Gobierno de la Ciudad Autónoma de Buenos Aires. Hospital General de Agudos Doctor Ignacio Pirovano; Argentina
Fil: Gresta, Carlos Alberto. Gobierno de la Ciudad Autónoma de Buenos Aires. Hospital General de Agudos Doctor Ignacio Pirovano; Argentina
Fil: Capobianco, Evangelina Lorena. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina
Fil: Jawerbaum, Alicia Sandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina
description Aims: To address the effect of a diet enriched in extra virgin olive oil (EVOO) on maternal metabolic parameters and placental proinflammatory markers in Gestational diabetes mellitus (GDM) patients. Methods: Pregnant women at 24-28 weeks of gestation were enrolled: 33 GDM patients which were randomly assigned or not to the EVOO-enriched group and 17 healthy controls. Metabolic parameters were determined. Peroxisome proliferator activated receptor (PPAR) γ and PPARα protein expression, expression of microRNA (miR)-130a and miR-518d (which respectively target these PPAR isoforms) and levels of proinflammatory markers were evaluated in term placentas. Matrix metalloproteinases (MMPs) activity was evaluated in term placentas and umbilical cord blood. Results: GDM patients that received the EVOO-enriched diet showed reduced pregnancy weight gain (GDM-EVOO:10.3 ± 0.9, GDM:14.2 ± 1.4, P =.03) and reduced triglyceridemia (GDM-EVOO:231 ± 14, GDM:292 ± 21, P =.02) compared to the non-EVOO-enriched GDM group. In GDM placentas, the EVOO-enriched diet did not regulate PPARγ protein expression or miR-130a expression, but prevented the reduced PPARα protein expression (P =.02 vs GDM) and the increased miR-518d expression (P =.009 vs GDM). Increased proinflammatory markers (interleukin-1β, tumour necrosis factor-α and nitric oxide overproduction) in GDM placentas were prevented by the EVOO-enriched diet (respectively P =.001, P =.001 and P =.01 vs GDM). MMPs overactivity was prevented in placenta and umbilical cord blood in the EVOO-enriched GDM group (MMP-9: respectively P =.01 and P =.001 vs GDM). Conclusions: A diet enriched in EVOO in GDM patients reduced maternal triglyceridemia and weight gain and has antiinflammatory properties in placenta and umbilical cord blood, possibly mediated by the regulation of PPAR pathways.
publishDate 2020
dc.date.none.fl_str_mv 2020-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/140474
Gomez Ribot, Dalmiro Leonardo Antonio; Diaz, Esteban; Fazio, María Victoria; Gómez, Hebe Lorena; Fornes, Daiana; et al.; An extra virgin olive oil‐enriched diet improves maternal, placental and cord blood parameters in GDM pregnancies; John Wiley & Sons Ltd; Diabetes/metabolism Research and Reviews; 36; 8; 5-2020; 1-30
1520-7552
CONICET Digital
CONICET
url http://hdl.handle.net/11336/140474
identifier_str_mv Gomez Ribot, Dalmiro Leonardo Antonio; Diaz, Esteban; Fazio, María Victoria; Gómez, Hebe Lorena; Fornes, Daiana; et al.; An extra virgin olive oil‐enriched diet improves maternal, placental and cord blood parameters in GDM pregnancies; John Wiley & Sons Ltd; Diabetes/metabolism Research and Reviews; 36; 8; 5-2020; 1-30
1520-7552
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/dmrr.3349
info:eu-repo/semantics/altIdentifier/doi/10.1002/dmrr.3349
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv John Wiley & Sons Ltd
publisher.none.fl_str_mv John Wiley & Sons Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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