Effect of aging on 24-hour pattern of stress hormones and leptin in rats

Autores
Cano, Pilar; Cardinali, Daniel Pedro; Spinedi, Eduardo Julio; Esquifino, Ana I.
Año de publicación
2008
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
This work analyzes the 24-hour changes of hypothalamic–pituitary–adrenal (HPA) axis activity and leptin release in aged rats. Three- and 22-month-old male Wistar rats were killed at 6 time intervals during a 24- hour cycle (n= 8–10 rats/group). Aging augmented plasma ACTH while it decreased plasma and adrenal gland corticosterone levels. Plasma and adrenal corticosterone levels attained high levels during all the scotophase, concomitantly with the maxima in ACTH levels, whereas in aged rats only a brief plasma corticosterone peak at the early scotophase and no time of day variations of adrenal corticosterone were observed. Aging augmented circulating leptin, with a significant interaction “age × time” in the factorial ANOVA, i.e. only in young rats time of day changes were significant, with the lowest values of leptin at the middle of the light period and higher values at night. When plasma leptin was expressed on body weight basis, the age-related differences became not significant but the daily pattern of plasma leptin found in young rats persisted. Plasma and adrenal corticosterone levels correlated significantly with plasma ACTH only in young rats. Likewise, plasma leptin correlated with plasma corticosterone only in young rats. These changes can be attributed to a disrupting effect of aging on the homeostatic mechanisms modulating HPA activity and leptin release.
Fil: Cano, Pilar. Universidad Complutense de Madrid; España
Fil: Cardinali, Daniel Pedro. Universidad Complutense de Madrid. Facultad de Medicina. Departamento de Fisiología; España. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Spinedi, Eduardo Julio. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas; Argentina
Fil: Esquifino, Ana I.. Universidad Complutense de Madrid; España
Materia
CRONOBIOLOGIA
ESTRES
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/105486
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/105486
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Effect of aging on 24-hour pattern of stress hormones and leptin in ratsCano, PilarCardinali, Daniel PedroSpinedi, Eduardo JulioEsquifino, Ana I.CRONOBIOLOGIAESTREShttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3This work analyzes the 24-hour changes of hypothalamic–pituitary–adrenal (HPA) axis activity and leptin release in aged rats. Three- and 22-month-old male Wistar rats were killed at 6 time intervals during a 24- hour cycle (n= 8–10 rats/group). Aging augmented plasma ACTH while it decreased plasma and adrenal gland corticosterone levels. Plasma and adrenal corticosterone levels attained high levels during all the scotophase, concomitantly with the maxima in ACTH levels, whereas in aged rats only a brief plasma corticosterone peak at the early scotophase and no time of day variations of adrenal corticosterone were observed. Aging augmented circulating leptin, with a significant interaction “age × time” in the factorial ANOVA, i.e. only in young rats time of day changes were significant, with the lowest values of leptin at the middle of the light period and higher values at night. When plasma leptin was expressed on body weight basis, the age-related differences became not significant but the daily pattern of plasma leptin found in young rats persisted. Plasma and adrenal corticosterone levels correlated significantly with plasma ACTH only in young rats. Likewise, plasma leptin correlated with plasma corticosterone only in young rats. These changes can be attributed to a disrupting effect of aging on the homeostatic mechanisms modulating HPA activity and leptin release.Fil: Cano, Pilar. Universidad Complutense de Madrid; EspañaFil: Cardinali, Daniel Pedro. Universidad Complutense de Madrid. Facultad de Medicina. Departamento de Fisiología; España. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Spinedi, Eduardo Julio. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas; ArgentinaFil: Esquifino, Ana I.. Universidad Complutense de Madrid; EspañaPergamon-Elsevier Science Ltd2008-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/105486Cano, Pilar; Cardinali, Daniel Pedro; Spinedi, Eduardo Julio; Esquifino, Ana I.; Effect of aging on 24-hour pattern of stress hormones and leptin in rats; Pergamon-Elsevier Science Ltd; Life Sciences; 83; 3-4; 7-2008; 142-1480024-3205CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.lfs.2008.06.001info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0024320508002348info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:06:02Zoai:ri.conicet.gov.ar:11336/105486instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:06:02.692CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Effect of aging on 24-hour pattern of stress hormones and leptin in rats
title Effect of aging on 24-hour pattern of stress hormones and leptin in rats
spellingShingle Effect of aging on 24-hour pattern of stress hormones and leptin in rats
Cano, Pilar
CRONOBIOLOGIA
ESTRES
title_short Effect of aging on 24-hour pattern of stress hormones and leptin in rats
title_full Effect of aging on 24-hour pattern of stress hormones and leptin in rats
title_fullStr Effect of aging on 24-hour pattern of stress hormones and leptin in rats
title_full_unstemmed Effect of aging on 24-hour pattern of stress hormones and leptin in rats
title_sort Effect of aging on 24-hour pattern of stress hormones and leptin in rats
dc.creator.none.fl_str_mv Cano, Pilar
Cardinali, Daniel Pedro
Spinedi, Eduardo Julio
Esquifino, Ana I.
author Cano, Pilar
author_facet Cano, Pilar
Cardinali, Daniel Pedro
Spinedi, Eduardo Julio
Esquifino, Ana I.
author_role author
author2 Cardinali, Daniel Pedro
Spinedi, Eduardo Julio
Esquifino, Ana I.
author2_role author
author
author
dc.subject.none.fl_str_mv CRONOBIOLOGIA
ESTRES
topic CRONOBIOLOGIA
ESTRES
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv This work analyzes the 24-hour changes of hypothalamic–pituitary–adrenal (HPA) axis activity and leptin release in aged rats. Three- and 22-month-old male Wistar rats were killed at 6 time intervals during a 24- hour cycle (n= 8–10 rats/group). Aging augmented plasma ACTH while it decreased plasma and adrenal gland corticosterone levels. Plasma and adrenal corticosterone levels attained high levels during all the scotophase, concomitantly with the maxima in ACTH levels, whereas in aged rats only a brief plasma corticosterone peak at the early scotophase and no time of day variations of adrenal corticosterone were observed. Aging augmented circulating leptin, with a significant interaction “age × time” in the factorial ANOVA, i.e. only in young rats time of day changes were significant, with the lowest values of leptin at the middle of the light period and higher values at night. When plasma leptin was expressed on body weight basis, the age-related differences became not significant but the daily pattern of plasma leptin found in young rats persisted. Plasma and adrenal corticosterone levels correlated significantly with plasma ACTH only in young rats. Likewise, plasma leptin correlated with plasma corticosterone only in young rats. These changes can be attributed to a disrupting effect of aging on the homeostatic mechanisms modulating HPA activity and leptin release.
Fil: Cano, Pilar. Universidad Complutense de Madrid; España
Fil: Cardinali, Daniel Pedro. Universidad Complutense de Madrid. Facultad de Medicina. Departamento de Fisiología; España. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Spinedi, Eduardo Julio. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas; Argentina
Fil: Esquifino, Ana I.. Universidad Complutense de Madrid; España
description This work analyzes the 24-hour changes of hypothalamic–pituitary–adrenal (HPA) axis activity and leptin release in aged rats. Three- and 22-month-old male Wistar rats were killed at 6 time intervals during a 24- hour cycle (n= 8–10 rats/group). Aging augmented plasma ACTH while it decreased plasma and adrenal gland corticosterone levels. Plasma and adrenal corticosterone levels attained high levels during all the scotophase, concomitantly with the maxima in ACTH levels, whereas in aged rats only a brief plasma corticosterone peak at the early scotophase and no time of day variations of adrenal corticosterone were observed. Aging augmented circulating leptin, with a significant interaction “age × time” in the factorial ANOVA, i.e. only in young rats time of day changes were significant, with the lowest values of leptin at the middle of the light period and higher values at night. When plasma leptin was expressed on body weight basis, the age-related differences became not significant but the daily pattern of plasma leptin found in young rats persisted. Plasma and adrenal corticosterone levels correlated significantly with plasma ACTH only in young rats. Likewise, plasma leptin correlated with plasma corticosterone only in young rats. These changes can be attributed to a disrupting effect of aging on the homeostatic mechanisms modulating HPA activity and leptin release.
publishDate 2008
dc.date.none.fl_str_mv 2008-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/105486
Cano, Pilar; Cardinali, Daniel Pedro; Spinedi, Eduardo Julio; Esquifino, Ana I.; Effect of aging on 24-hour pattern of stress hormones and leptin in rats; Pergamon-Elsevier Science Ltd; Life Sciences; 83; 3-4; 7-2008; 142-148
0024-3205
CONICET Digital
CONICET
url http://hdl.handle.net/11336/105486
identifier_str_mv Cano, Pilar; Cardinali, Daniel Pedro; Spinedi, Eduardo Julio; Esquifino, Ana I.; Effect of aging on 24-hour pattern of stress hormones and leptin in rats; Pergamon-Elsevier Science Ltd; Life Sciences; 83; 3-4; 7-2008; 142-148
0024-3205
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.lfs.2008.06.001
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0024320508002348
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269939540426752
score 13.13397

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