24-hour changes in ACTH, corticosterone, growth hormone, and leptin levels in young male rats subjected to calorie restriction

Autores
Chacón, Fernando; Esquifino, Ana I.; Perello, Mario; Cardinali, Daniel Pedro; Spinedi, Eduardo Julio; Alvarez, Maria P.
Año de publicación
2005
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Calorie restriction of young male rats increases plasma prolactin, decreases luteinizing hormone (LH) and testosterone, and disrupts their 24 h secretory pattern. To study whether this could be the consequence of stress, we examined the 24 h variations of plasma adrenocorticotropic hormone (ACTH) corticosterone, growth hormone (GH), leptin, and adrenal corticosterone. Rats were submitted to a calorie restriction equivalent to a 66% of usual intake for 4 weeks, starting on day 35 of life. Controls were kept in individual cages and allowed to eat a normal calorie regimen. Significantly lower ACTH levels were detected in calorie‐restricted rats. Plasma corticosterone levels during the light phase of the daily cycle were significantly higher in calorie‐restricted rats. Time‐of‐day variation in plasma ACTH and corticosterone levels attained significance in calorie‐restricted rats only, with a maximum toward the end of the resting phase. The daily pattern of adrenal gland corticosterone mirrored that of circulating corticosterone; however, calorie restriction reduced its levels. Plasma ACTH and corticosterone correlated significantly in controls only. Calorie restriction decreased plasma GH and leptin, and it distorted 24 h rhythmicity. In a second study, plasma ACTH and corticosterone levels were measured in group‐caged rats, isolated control rats, and calorie‐restricted rats during the light phase of the daily cycle. Plasma ACTH of calorie‐restricted rats was lower, and plasma corticosterone was higher, compared with isolated or group‐caged controls. The changes in the secretory pattern of hormones hereby reported may be part of the neuroendocrine and metabolic mechanisms evolved to maximize survival during periods of food shortage.
Fil: Chacón, Fernando. Universidad Complutense de Madrid; España
Fil: Esquifino, Ana I.. Universidad Complutense de Madrid; España
Fil: Perello, Mario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; Argentina
Fil: Cardinali, Daniel Pedro. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Fisiología, Biología Molecular y Celular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Spinedi, Eduardo Julio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; Argentina
Fil: Alvarez, Maria P.. Universidad Complutense de Madrid; España
Materia
ACTH
CALORIE RESTRICTION
CIRCADIAN RHYTHM
CORTICOSTERONE
FOOD ANTICIPATORY ACTIVITY
GROWTH HORMONE
LEPTIN
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/145423
Acceder
id CONICETDig_f67628040b11c3852982484a6784da76
oai_identifier_str oai:ri.conicet.gov.ar:11336/145423
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling 24-hour changes in ACTH, corticosterone, growth hormone, and leptin levels in young male rats subjected to calorie restrictionChacón, FernandoEsquifino, Ana I.Perello, MarioCardinali, Daniel PedroSpinedi, Eduardo JulioAlvarez, Maria P.ACTHCALORIE RESTRICTIONCIRCADIAN RHYTHMCORTICOSTERONEFOOD ANTICIPATORY ACTIVITYGROWTH HORMONELEPTINhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Calorie restriction of young male rats increases plasma prolactin, decreases luteinizing hormone (LH) and testosterone, and disrupts their 24 h secretory pattern. To study whether this could be the consequence of stress, we examined the 24 h variations of plasma adrenocorticotropic hormone (ACTH) corticosterone, growth hormone (GH), leptin, and adrenal corticosterone. Rats were submitted to a calorie restriction equivalent to a 66% of usual intake for 4 weeks, starting on day 35 of life. Controls were kept in individual cages and allowed to eat a normal calorie regimen. Significantly lower ACTH levels were detected in calorie‐restricted rats. Plasma corticosterone levels during the light phase of the daily cycle were significantly higher in calorie‐restricted rats. Time‐of‐day variation in plasma ACTH and corticosterone levels attained significance in calorie‐restricted rats only, with a maximum toward the end of the resting phase. The daily pattern of adrenal gland corticosterone mirrored that of circulating corticosterone; however, calorie restriction reduced its levels. Plasma ACTH and corticosterone correlated significantly in controls only. Calorie restriction decreased plasma GH and leptin, and it distorted 24 h rhythmicity. In a second study, plasma ACTH and corticosterone levels were measured in group‐caged rats, isolated control rats, and calorie‐restricted rats during the light phase of the daily cycle. Plasma ACTH of calorie‐restricted rats was lower, and plasma corticosterone was higher, compared with isolated or group‐caged controls. The changes in the secretory pattern of hormones hereby reported may be part of the neuroendocrine and metabolic mechanisms evolved to maximize survival during periods of food shortage.Fil: Chacón, Fernando. Universidad Complutense de Madrid; EspañaFil: Esquifino, Ana I.. Universidad Complutense de Madrid; EspañaFil: Perello, Mario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; ArgentinaFil: Cardinali, Daniel Pedro. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Fisiología, Biología Molecular y Celular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Spinedi, Eduardo Julio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; ArgentinaFil: Alvarez, Maria P.. Universidad Complutense de Madrid; EspañaTaylor & Francis2005-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/145423Chacón, Fernando; Esquifino, Ana I.; Perello, Mario; Cardinali, Daniel Pedro; Spinedi, Eduardo Julio; et al.; 24-hour changes in ACTH, corticosterone, growth hormone, and leptin levels in young male rats subjected to calorie restriction; Taylor & Francis; Chronobiology International; 22; 2; 12-2005; 253-2650742-05281525-6073CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/abs/10.1081/cbi-200053522?journalCode=icbi20info:eu-repo/semantics/altIdentifier/doi/10.1081/CBI-200053522info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:49:59Zoai:ri.conicet.gov.ar:11336/145423instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:50:00.132CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv 24-hour changes in ACTH, corticosterone, growth hormone, and leptin levels in young male rats subjected to calorie restriction
title 24-hour changes in ACTH, corticosterone, growth hormone, and leptin levels in young male rats subjected to calorie restriction
spellingShingle 24-hour changes in ACTH, corticosterone, growth hormone, and leptin levels in young male rats subjected to calorie restriction
Chacón, Fernando
ACTH
CALORIE RESTRICTION
CIRCADIAN RHYTHM
CORTICOSTERONE
FOOD ANTICIPATORY ACTIVITY
GROWTH HORMONE
LEPTIN
title_short 24-hour changes in ACTH, corticosterone, growth hormone, and leptin levels in young male rats subjected to calorie restriction
title_full 24-hour changes in ACTH, corticosterone, growth hormone, and leptin levels in young male rats subjected to calorie restriction
title_fullStr 24-hour changes in ACTH, corticosterone, growth hormone, and leptin levels in young male rats subjected to calorie restriction
title_full_unstemmed 24-hour changes in ACTH, corticosterone, growth hormone, and leptin levels in young male rats subjected to calorie restriction
title_sort 24-hour changes in ACTH, corticosterone, growth hormone, and leptin levels in young male rats subjected to calorie restriction
dc.creator.none.fl_str_mv Chacón, Fernando
Esquifino, Ana I.
Perello, Mario
Cardinali, Daniel Pedro
Spinedi, Eduardo Julio
Alvarez, Maria P.
author Chacón, Fernando
author_facet Chacón, Fernando
Esquifino, Ana I.
Perello, Mario
Cardinali, Daniel Pedro
Spinedi, Eduardo Julio
Alvarez, Maria P.
author_role author
author2 Esquifino, Ana I.
Perello, Mario
Cardinali, Daniel Pedro
Spinedi, Eduardo Julio
Alvarez, Maria P.
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv ACTH
CALORIE RESTRICTION
CIRCADIAN RHYTHM
CORTICOSTERONE
FOOD ANTICIPATORY ACTIVITY
GROWTH HORMONE
LEPTIN
topic ACTH
CALORIE RESTRICTION
CIRCADIAN RHYTHM
CORTICOSTERONE
FOOD ANTICIPATORY ACTIVITY
GROWTH HORMONE
LEPTIN
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Calorie restriction of young male rats increases plasma prolactin, decreases luteinizing hormone (LH) and testosterone, and disrupts their 24 h secretory pattern. To study whether this could be the consequence of stress, we examined the 24 h variations of plasma adrenocorticotropic hormone (ACTH) corticosterone, growth hormone (GH), leptin, and adrenal corticosterone. Rats were submitted to a calorie restriction equivalent to a 66% of usual intake for 4 weeks, starting on day 35 of life. Controls were kept in individual cages and allowed to eat a normal calorie regimen. Significantly lower ACTH levels were detected in calorie‐restricted rats. Plasma corticosterone levels during the light phase of the daily cycle were significantly higher in calorie‐restricted rats. Time‐of‐day variation in plasma ACTH and corticosterone levels attained significance in calorie‐restricted rats only, with a maximum toward the end of the resting phase. The daily pattern of adrenal gland corticosterone mirrored that of circulating corticosterone; however, calorie restriction reduced its levels. Plasma ACTH and corticosterone correlated significantly in controls only. Calorie restriction decreased plasma GH and leptin, and it distorted 24 h rhythmicity. In a second study, plasma ACTH and corticosterone levels were measured in group‐caged rats, isolated control rats, and calorie‐restricted rats during the light phase of the daily cycle. Plasma ACTH of calorie‐restricted rats was lower, and plasma corticosterone was higher, compared with isolated or group‐caged controls. The changes in the secretory pattern of hormones hereby reported may be part of the neuroendocrine and metabolic mechanisms evolved to maximize survival during periods of food shortage.
Fil: Chacón, Fernando. Universidad Complutense de Madrid; España
Fil: Esquifino, Ana I.. Universidad Complutense de Madrid; España
Fil: Perello, Mario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; Argentina
Fil: Cardinali, Daniel Pedro. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Fisiología, Biología Molecular y Celular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Spinedi, Eduardo Julio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; Argentina
Fil: Alvarez, Maria P.. Universidad Complutense de Madrid; España
description Calorie restriction of young male rats increases plasma prolactin, decreases luteinizing hormone (LH) and testosterone, and disrupts their 24 h secretory pattern. To study whether this could be the consequence of stress, we examined the 24 h variations of plasma adrenocorticotropic hormone (ACTH) corticosterone, growth hormone (GH), leptin, and adrenal corticosterone. Rats were submitted to a calorie restriction equivalent to a 66% of usual intake for 4 weeks, starting on day 35 of life. Controls were kept in individual cages and allowed to eat a normal calorie regimen. Significantly lower ACTH levels were detected in calorie‐restricted rats. Plasma corticosterone levels during the light phase of the daily cycle were significantly higher in calorie‐restricted rats. Time‐of‐day variation in plasma ACTH and corticosterone levels attained significance in calorie‐restricted rats only, with a maximum toward the end of the resting phase. The daily pattern of adrenal gland corticosterone mirrored that of circulating corticosterone; however, calorie restriction reduced its levels. Plasma ACTH and corticosterone correlated significantly in controls only. Calorie restriction decreased plasma GH and leptin, and it distorted 24 h rhythmicity. In a second study, plasma ACTH and corticosterone levels were measured in group‐caged rats, isolated control rats, and calorie‐restricted rats during the light phase of the daily cycle. Plasma ACTH of calorie‐restricted rats was lower, and plasma corticosterone was higher, compared with isolated or group‐caged controls. The changes in the secretory pattern of hormones hereby reported may be part of the neuroendocrine and metabolic mechanisms evolved to maximize survival during periods of food shortage.
publishDate 2005
dc.date.none.fl_str_mv 2005-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/145423
Chacón, Fernando; Esquifino, Ana I.; Perello, Mario; Cardinali, Daniel Pedro; Spinedi, Eduardo Julio; et al.; 24-hour changes in ACTH, corticosterone, growth hormone, and leptin levels in young male rats subjected to calorie restriction; Taylor & Francis; Chronobiology International; 22; 2; 12-2005; 253-265
0742-0528
1525-6073
CONICET Digital
CONICET
url http://hdl.handle.net/11336/145423
identifier_str_mv Chacón, Fernando; Esquifino, Ana I.; Perello, Mario; Cardinali, Daniel Pedro; Spinedi, Eduardo Julio; et al.; 24-hour changes in ACTH, corticosterone, growth hormone, and leptin levels in young male rats subjected to calorie restriction; Taylor & Francis; Chronobiology International; 22; 2; 12-2005; 253-265
0742-0528
1525-6073
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/abs/10.1081/cbi-200053522?journalCode=icbi20
info:eu-repo/semantics/altIdentifier/doi/10.1081/CBI-200053522
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Taylor & Francis
publisher.none.fl_str_mv Taylor & Francis
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269006254309376
score 13.13397

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