24-hour rhythms of splenic mitogenic responses, lymphocyte subset populations and interferon γ release after calorie restriction or social isolation of rats

Autores
Cano, Pilar; Cardinali, Daniel Pedro; Fernández, Pilar; Reyes Toso, Carlos Felipe
Año de publicación
2006
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
To assess the effect of calorie restriction equivalent to a 66% food restriction or social isolation on splenic immune responses, calorie-restricted five week-old male Wistar rats, pair fed controls individually caged and pair fed controls caged in groups, were studied for four weeks. Calorie restricted and isolated rats showed increased splenic concanavalin A response with peak activity during the activity span. Mean 24 h values of splenic lipopolysaccharide response decreased in isolated rats compared to grouped rats. The highest values of T cells occurred in calorie restricted rats and those of B cells in isolated rats. Mean values of splenic CD4+ and CD8+ cells augmented in isolated or calorie restricted groups. The highest in vitro interferon-gamma production occurred in the isolated group and the lowest in the grouped rats, the differences among groups being significant. Both experimental procedures generally disrupted 24-h rhythmicity of splenic immune parameters. Mean values of plasma corticosterone were higher in calorie restricted rats than in isolated rats and both differed significantly from grouped rats. The results indicate that either calorie restriction or social isolation augmented cell-mediated immunity in rat spleen.
Fil: Cano, Pilar. Universidad Complutense de Madrid; España
Fil: Cardinali, Daniel Pedro. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas. Cátedra de Fisiologia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Fernández, Pilar. Universidad Complutense de Madrid; España
Fil: Reyes Toso, Carlos Felipe. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas. Cátedra de Fisiologia; Argentina
Materia
Calorie restriction
isolation
stress
spleen
lymphocyte subsets
interferon-g
mitogenic response
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/248262
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling 24-hour rhythms of splenic mitogenic responses, lymphocyte subset populations and interferon γ release after calorie restriction or social isolation of ratsCano, PilarCardinali, Daniel PedroFernández, PilarReyes Toso, Carlos FelipeCalorie restrictionisolationstressspleenlymphocyte subsetsinterferon-gmitogenic responsehttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3To assess the effect of calorie restriction equivalent to a 66% food restriction or social isolation on splenic immune responses, calorie-restricted five week-old male Wistar rats, pair fed controls individually caged and pair fed controls caged in groups, were studied for four weeks. Calorie restricted and isolated rats showed increased splenic concanavalin A response with peak activity during the activity span. Mean 24 h values of splenic lipopolysaccharide response decreased in isolated rats compared to grouped rats. The highest values of T cells occurred in calorie restricted rats and those of B cells in isolated rats. Mean values of splenic CD4+ and CD8+ cells augmented in isolated or calorie restricted groups. The highest in vitro interferon-gamma production occurred in the isolated group and the lowest in the grouped rats, the differences among groups being significant. Both experimental procedures generally disrupted 24-h rhythmicity of splenic immune parameters. Mean values of plasma corticosterone were higher in calorie restricted rats than in isolated rats and both differed significantly from grouped rats. The results indicate that either calorie restriction or social isolation augmented cell-mediated immunity in rat spleen.Fil: Cano, Pilar. Universidad Complutense de Madrid; EspañaFil: Cardinali, Daniel Pedro. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas. Cátedra de Fisiologia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Fernández, Pilar. Universidad Complutense de Madrid; EspañaFil: Reyes Toso, Carlos Felipe. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas. Cátedra de Fisiologia; ArgentinaTaylor & Francis Ltd2006-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/248262Cano, Pilar; Cardinali, Daniel Pedro; Fernández, Pilar; Reyes Toso, Carlos Felipe; 24-hour rhythms of splenic mitogenic responses, lymphocyte subset populations and interferon γ release after calorie restriction or social isolation of rats; Taylor & Francis Ltd; Biological Rhythm Research; 37; 3; 6-2006; 255-2630929-1016CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/abs/10.1080/09291010600690851info:eu-repo/semantics/altIdentifier/doi/10.1080/09291010600690851info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:44:02Zoai:ri.conicet.gov.ar:11336/248262instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:44:02.96CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv 24-hour rhythms of splenic mitogenic responses, lymphocyte subset populations and interferon γ release after calorie restriction or social isolation of rats
title 24-hour rhythms of splenic mitogenic responses, lymphocyte subset populations and interferon γ release after calorie restriction or social isolation of rats
spellingShingle 24-hour rhythms of splenic mitogenic responses, lymphocyte subset populations and interferon γ release after calorie restriction or social isolation of rats
Cano, Pilar
Calorie restriction
isolation
stress
spleen
lymphocyte subsets
interferon-g
mitogenic response
title_short 24-hour rhythms of splenic mitogenic responses, lymphocyte subset populations and interferon γ release after calorie restriction or social isolation of rats
title_full 24-hour rhythms of splenic mitogenic responses, lymphocyte subset populations and interferon γ release after calorie restriction or social isolation of rats
title_fullStr 24-hour rhythms of splenic mitogenic responses, lymphocyte subset populations and interferon γ release after calorie restriction or social isolation of rats
title_full_unstemmed 24-hour rhythms of splenic mitogenic responses, lymphocyte subset populations and interferon γ release after calorie restriction or social isolation of rats
title_sort 24-hour rhythms of splenic mitogenic responses, lymphocyte subset populations and interferon γ release after calorie restriction or social isolation of rats
dc.creator.none.fl_str_mv Cano, Pilar
Cardinali, Daniel Pedro
Fernández, Pilar
Reyes Toso, Carlos Felipe
author Cano, Pilar
author_facet Cano, Pilar
Cardinali, Daniel Pedro
Fernández, Pilar
Reyes Toso, Carlos Felipe
author_role author
author2 Cardinali, Daniel Pedro
Fernández, Pilar
Reyes Toso, Carlos Felipe
author2_role author
author
author
dc.subject.none.fl_str_mv Calorie restriction
isolation
stress
spleen
lymphocyte subsets
interferon-g
mitogenic response
topic Calorie restriction
isolation
stress
spleen
lymphocyte subsets
interferon-g
mitogenic response
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv To assess the effect of calorie restriction equivalent to a 66% food restriction or social isolation on splenic immune responses, calorie-restricted five week-old male Wistar rats, pair fed controls individually caged and pair fed controls caged in groups, were studied for four weeks. Calorie restricted and isolated rats showed increased splenic concanavalin A response with peak activity during the activity span. Mean 24 h values of splenic lipopolysaccharide response decreased in isolated rats compared to grouped rats. The highest values of T cells occurred in calorie restricted rats and those of B cells in isolated rats. Mean values of splenic CD4+ and CD8+ cells augmented in isolated or calorie restricted groups. The highest in vitro interferon-gamma production occurred in the isolated group and the lowest in the grouped rats, the differences among groups being significant. Both experimental procedures generally disrupted 24-h rhythmicity of splenic immune parameters. Mean values of plasma corticosterone were higher in calorie restricted rats than in isolated rats and both differed significantly from grouped rats. The results indicate that either calorie restriction or social isolation augmented cell-mediated immunity in rat spleen.
Fil: Cano, Pilar. Universidad Complutense de Madrid; España
Fil: Cardinali, Daniel Pedro. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas. Cátedra de Fisiologia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Fernández, Pilar. Universidad Complutense de Madrid; España
Fil: Reyes Toso, Carlos Felipe. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas. Cátedra de Fisiologia; Argentina
description To assess the effect of calorie restriction equivalent to a 66% food restriction or social isolation on splenic immune responses, calorie-restricted five week-old male Wistar rats, pair fed controls individually caged and pair fed controls caged in groups, were studied for four weeks. Calorie restricted and isolated rats showed increased splenic concanavalin A response with peak activity during the activity span. Mean 24 h values of splenic lipopolysaccharide response decreased in isolated rats compared to grouped rats. The highest values of T cells occurred in calorie restricted rats and those of B cells in isolated rats. Mean values of splenic CD4+ and CD8+ cells augmented in isolated or calorie restricted groups. The highest in vitro interferon-gamma production occurred in the isolated group and the lowest in the grouped rats, the differences among groups being significant. Both experimental procedures generally disrupted 24-h rhythmicity of splenic immune parameters. Mean values of plasma corticosterone were higher in calorie restricted rats than in isolated rats and both differed significantly from grouped rats. The results indicate that either calorie restriction or social isolation augmented cell-mediated immunity in rat spleen.
publishDate 2006
dc.date.none.fl_str_mv 2006-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/248262
Cano, Pilar; Cardinali, Daniel Pedro; Fernández, Pilar; Reyes Toso, Carlos Felipe; 24-hour rhythms of splenic mitogenic responses, lymphocyte subset populations and interferon γ release after calorie restriction or social isolation of rats; Taylor & Francis Ltd; Biological Rhythm Research; 37; 3; 6-2006; 255-263
0929-1016
CONICET Digital
CONICET
url http://hdl.handle.net/11336/248262
identifier_str_mv Cano, Pilar; Cardinali, Daniel Pedro; Fernández, Pilar; Reyes Toso, Carlos Felipe; 24-hour rhythms of splenic mitogenic responses, lymphocyte subset populations and interferon γ release after calorie restriction or social isolation of rats; Taylor & Francis Ltd; Biological Rhythm Research; 37; 3; 6-2006; 255-263
0929-1016
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/abs/10.1080/09291010600690851
info:eu-repo/semantics/altIdentifier/doi/10.1080/09291010600690851
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Taylor & Francis Ltd
publisher.none.fl_str_mv Taylor & Francis Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842268641046822912
score 13.13397

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