Hyperendemic clone of KPC producing Klebsiella pneumoniae ST 258 in Buenos Aires hospitals

Autores
Cejas, Daniela; Fernández Canigia, Liliana; Nastro, Marcela; Rodríguez, Cynthia; Tanco, Ana; Rodríguez, Hernan; Vay, Carlos Alberto; Maldonado, Ivana; Famiglietti, Angela María Rosa; Giovanakis, Marta; Magariños, Francisco; Berardinelli, Elena; Neira, Liliana; Mollerach, Marta Eugenia; Gutkind, Gabriel Osvaldo; Radice, Marcela Alejandra
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Since KPC-type carbapenemases were first reported in Klebsiella pneumoniae in 2001 in the USA , they have become a frequent resistant marker encountered also in other Enterobacteriaceae and Pseudomonads from the Americas, Europe, Asia and Middle East. Their wide spread across multiple continents and species has been associated with a mobile genetic element, Tn4401. More recently, the molecular epidemiology of KPC producing K. pneumoniae isolates has revealed the successful dissemination of a single sequence type 258 clone. Although in Argentina KPC-2 producing K. pneumonia were first detected in 2006 a substantial increase was observed in 2010, in Buenos Aires To characterize this occurrence, single, non-repetitive K. pneumonia isolates obtained from 57 patients from May 2009 through april 2010 in six hospitals in Buenos Aires were included. Antimicrobial susceptibility tests were conducted by disk diffusion according to CLSI recommendations. An enhancement in the inhibition zone of the carbapenem containing disks adjacent to the one containing the inhibitor was considered a positive screening for KPC. All the isolates displayed The presence of blaKPC was confirmed by PCR amplification As the XbaI PFGE patterns generated were indistinguishable , multilocus sequence typing (MLST) with seven housekeeping genes was performed on selected isolates representing the different hospitals, corresponding to ST258 The spread of KPC-producing clones constitutes a serious infection control concern. Prevention of their dissemination requires prompt, accurate and proactive laboratory detection systems followedby strong reinforcement of contact isolation precautions and hygiene measures. The outbreak was able to be easily controlled only at hospital 1 where the suspicious index case was detected and informed from the preliminary antibiotic tests, performed as mentioned previously. Control measurements were applied on these preliminary data, even before genetic confirmation.
Fil: Cejas, Daniela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Microbiología; Argentina
Fil: Fernández Canigia, Liliana. Hospital Aleman; Argentina
Fil: Nastro, Marcela. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Microbiología; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Rodríguez, Cynthia. Hospital Español de Buenos Aires;
Fil: Tanco, Ana. Hospital Español de Buenos Aires;
Fil: Rodríguez, Hernan. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Microbiología; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Vay, Carlos Alberto. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Microbiología; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Maldonado, Ivana. Hospital Aleman; Argentina
Fil: Famiglietti, Angela María Rosa. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Microbiología; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Giovanakis, Marta. Hospital Británico de Buenos Aires; Argentina
Fil: Magariños, Francisco. Sanatorio de la Providencia; Argentina
Fil: Berardinelli, Elena. Sanatorio de la Providencia; Argentina
Fil: Neira, Liliana. Policlínico Osplad; Argentina
Fil: Mollerach, Marta Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Microbiología; Argentina
Fil: Gutkind, Gabriel Osvaldo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Microbiología; Argentina
Fil: Radice, Marcela Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Microbiología; Argentina
Materia
KPC
KLEBSIELLA PNEUMONIAE
CARBAPENEMASE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/271746
Acceder
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spelling Hyperendemic clone of KPC producing Klebsiella pneumoniae ST 258 in Buenos Aires hospitalsCejas, DanielaFernández Canigia, LilianaNastro, MarcelaRodríguez, CynthiaTanco, AnaRodríguez, HernanVay, Carlos AlbertoMaldonado, IvanaFamiglietti, Angela María RosaGiovanakis, MartaMagariños, FranciscoBerardinelli, ElenaNeira, LilianaMollerach, Marta EugeniaGutkind, Gabriel OsvaldoRadice, Marcela AlejandraKPCKLEBSIELLA PNEUMONIAECARBAPENEMASEhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Since KPC-type carbapenemases were first reported in Klebsiella pneumoniae in 2001 in the USA , they have become a frequent resistant marker encountered also in other Enterobacteriaceae and Pseudomonads from the Americas, Europe, Asia and Middle East. Their wide spread across multiple continents and species has been associated with a mobile genetic element, Tn4401. More recently, the molecular epidemiology of KPC producing K. pneumoniae isolates has revealed the successful dissemination of a single sequence type 258 clone. Although in Argentina KPC-2 producing K. pneumonia were first detected in 2006 a substantial increase was observed in 2010, in Buenos Aires To characterize this occurrence, single, non-repetitive K. pneumonia isolates obtained from 57 patients from May 2009 through april 2010 in six hospitals in Buenos Aires were included. Antimicrobial susceptibility tests were conducted by disk diffusion according to CLSI recommendations. An enhancement in the inhibition zone of the carbapenem containing disks adjacent to the one containing the inhibitor was considered a positive screening for KPC. All the isolates displayed The presence of blaKPC was confirmed by PCR amplification As the XbaI PFGE patterns generated were indistinguishable , multilocus sequence typing (MLST) with seven housekeeping genes was performed on selected isolates representing the different hospitals, corresponding to ST258 The spread of KPC-producing clones constitutes a serious infection control concern. Prevention of their dissemination requires prompt, accurate and proactive laboratory detection systems followedby strong reinforcement of contact isolation precautions and hygiene measures. The outbreak was able to be easily controlled only at hospital 1 where the suspicious index case was detected and informed from the preliminary antibiotic tests, performed as mentioned previously. Control measurements were applied on these preliminary data, even before genetic confirmation.Fil: Cejas, Daniela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Microbiología; ArgentinaFil: Fernández Canigia, Liliana. Hospital Aleman; ArgentinaFil: Nastro, Marcela. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Microbiología; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; ArgentinaFil: Rodríguez, Cynthia. Hospital Español de Buenos Aires;Fil: Tanco, Ana. Hospital Español de Buenos Aires;Fil: Rodríguez, Hernan. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Microbiología; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; ArgentinaFil: Vay, Carlos Alberto. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Microbiología; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; ArgentinaFil: Maldonado, Ivana. Hospital Aleman; ArgentinaFil: Famiglietti, Angela María Rosa. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Microbiología; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; ArgentinaFil: Giovanakis, Marta. Hospital Británico de Buenos Aires; ArgentinaFil: Magariños, Francisco. Sanatorio de la Providencia; ArgentinaFil: Berardinelli, Elena. Sanatorio de la Providencia; ArgentinaFil: Neira, Liliana. Policlínico Osplad; ArgentinaFil: Mollerach, Marta Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Microbiología; ArgentinaFil: Gutkind, Gabriel Osvaldo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Microbiología; ArgentinaFil: Radice, Marcela Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Microbiología; ArgentinaElsevier Science2012-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/271746Cejas, Daniela; Fernández Canigia, Liliana; Nastro, Marcela; Rodríguez, Cynthia; Tanco, Ana; et al.; Hyperendemic clone of KPC producing Klebsiella pneumoniae ST 258 in Buenos Aires hospitals; Elsevier Science; Infection, Genetics and Evolution; 12; 3; 4-2012; 499-5011567-1348CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S1567134811003479info:eu-repo/semantics/altIdentifier/doi/10.1016/j.meegid.2011.09.018info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:41:08Zoai:ri.conicet.gov.ar:11336/271746instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:41:09.151CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Hyperendemic clone of KPC producing Klebsiella pneumoniae ST 258 in Buenos Aires hospitals
title Hyperendemic clone of KPC producing Klebsiella pneumoniae ST 258 in Buenos Aires hospitals
spellingShingle Hyperendemic clone of KPC producing Klebsiella pneumoniae ST 258 in Buenos Aires hospitals
Cejas, Daniela
KPC
KLEBSIELLA PNEUMONIAE
CARBAPENEMASE
title_short Hyperendemic clone of KPC producing Klebsiella pneumoniae ST 258 in Buenos Aires hospitals
title_full Hyperendemic clone of KPC producing Klebsiella pneumoniae ST 258 in Buenos Aires hospitals
title_fullStr Hyperendemic clone of KPC producing Klebsiella pneumoniae ST 258 in Buenos Aires hospitals
title_full_unstemmed Hyperendemic clone of KPC producing Klebsiella pneumoniae ST 258 in Buenos Aires hospitals
title_sort Hyperendemic clone of KPC producing Klebsiella pneumoniae ST 258 in Buenos Aires hospitals
dc.creator.none.fl_str_mv Cejas, Daniela
Fernández Canigia, Liliana
Nastro, Marcela
Rodríguez, Cynthia
Tanco, Ana
Rodríguez, Hernan
Vay, Carlos Alberto
Maldonado, Ivana
Famiglietti, Angela María Rosa
Giovanakis, Marta
Magariños, Francisco
Berardinelli, Elena
Neira, Liliana
Mollerach, Marta Eugenia
Gutkind, Gabriel Osvaldo
Radice, Marcela Alejandra
author Cejas, Daniela
author_facet Cejas, Daniela
Fernández Canigia, Liliana
Nastro, Marcela
Rodríguez, Cynthia
Tanco, Ana
Rodríguez, Hernan
Vay, Carlos Alberto
Maldonado, Ivana
Famiglietti, Angela María Rosa
Giovanakis, Marta
Magariños, Francisco
Berardinelli, Elena
Neira, Liliana
Mollerach, Marta Eugenia
Gutkind, Gabriel Osvaldo
Radice, Marcela Alejandra
author_role author
author2 Fernández Canigia, Liliana
Nastro, Marcela
Rodríguez, Cynthia
Tanco, Ana
Rodríguez, Hernan
Vay, Carlos Alberto
Maldonado, Ivana
Famiglietti, Angela María Rosa
Giovanakis, Marta
Magariños, Francisco
Berardinelli, Elena
Neira, Liliana
Mollerach, Marta Eugenia
Gutkind, Gabriel Osvaldo
Radice, Marcela Alejandra
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv KPC
KLEBSIELLA PNEUMONIAE
CARBAPENEMASE
topic KPC
KLEBSIELLA PNEUMONIAE
CARBAPENEMASE
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Since KPC-type carbapenemases were first reported in Klebsiella pneumoniae in 2001 in the USA , they have become a frequent resistant marker encountered also in other Enterobacteriaceae and Pseudomonads from the Americas, Europe, Asia and Middle East. Their wide spread across multiple continents and species has been associated with a mobile genetic element, Tn4401. More recently, the molecular epidemiology of KPC producing K. pneumoniae isolates has revealed the successful dissemination of a single sequence type 258 clone. Although in Argentina KPC-2 producing K. pneumonia were first detected in 2006 a substantial increase was observed in 2010, in Buenos Aires To characterize this occurrence, single, non-repetitive K. pneumonia isolates obtained from 57 patients from May 2009 through april 2010 in six hospitals in Buenos Aires were included. Antimicrobial susceptibility tests were conducted by disk diffusion according to CLSI recommendations. An enhancement in the inhibition zone of the carbapenem containing disks adjacent to the one containing the inhibitor was considered a positive screening for KPC. All the isolates displayed The presence of blaKPC was confirmed by PCR amplification As the XbaI PFGE patterns generated were indistinguishable , multilocus sequence typing (MLST) with seven housekeeping genes was performed on selected isolates representing the different hospitals, corresponding to ST258 The spread of KPC-producing clones constitutes a serious infection control concern. Prevention of their dissemination requires prompt, accurate and proactive laboratory detection systems followedby strong reinforcement of contact isolation precautions and hygiene measures. The outbreak was able to be easily controlled only at hospital 1 where the suspicious index case was detected and informed from the preliminary antibiotic tests, performed as mentioned previously. Control measurements were applied on these preliminary data, even before genetic confirmation.
Fil: Cejas, Daniela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Microbiología; Argentina
Fil: Fernández Canigia, Liliana. Hospital Aleman; Argentina
Fil: Nastro, Marcela. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Microbiología; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Rodríguez, Cynthia. Hospital Español de Buenos Aires;
Fil: Tanco, Ana. Hospital Español de Buenos Aires;
Fil: Rodríguez, Hernan. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Microbiología; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Vay, Carlos Alberto. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Microbiología; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Maldonado, Ivana. Hospital Aleman; Argentina
Fil: Famiglietti, Angela María Rosa. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Microbiología; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Giovanakis, Marta. Hospital Británico de Buenos Aires; Argentina
Fil: Magariños, Francisco. Sanatorio de la Providencia; Argentina
Fil: Berardinelli, Elena. Sanatorio de la Providencia; Argentina
Fil: Neira, Liliana. Policlínico Osplad; Argentina
Fil: Mollerach, Marta Eugenia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Microbiología; Argentina
Fil: Gutkind, Gabriel Osvaldo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Microbiología; Argentina
Fil: Radice, Marcela Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Microbiología; Argentina
description Since KPC-type carbapenemases were first reported in Klebsiella pneumoniae in 2001 in the USA , they have become a frequent resistant marker encountered also in other Enterobacteriaceae and Pseudomonads from the Americas, Europe, Asia and Middle East. Their wide spread across multiple continents and species has been associated with a mobile genetic element, Tn4401. More recently, the molecular epidemiology of KPC producing K. pneumoniae isolates has revealed the successful dissemination of a single sequence type 258 clone. Although in Argentina KPC-2 producing K. pneumonia were first detected in 2006 a substantial increase was observed in 2010, in Buenos Aires To characterize this occurrence, single, non-repetitive K. pneumonia isolates obtained from 57 patients from May 2009 through april 2010 in six hospitals in Buenos Aires were included. Antimicrobial susceptibility tests were conducted by disk diffusion according to CLSI recommendations. An enhancement in the inhibition zone of the carbapenem containing disks adjacent to the one containing the inhibitor was considered a positive screening for KPC. All the isolates displayed The presence of blaKPC was confirmed by PCR amplification As the XbaI PFGE patterns generated were indistinguishable , multilocus sequence typing (MLST) with seven housekeeping genes was performed on selected isolates representing the different hospitals, corresponding to ST258 The spread of KPC-producing clones constitutes a serious infection control concern. Prevention of their dissemination requires prompt, accurate and proactive laboratory detection systems followedby strong reinforcement of contact isolation precautions and hygiene measures. The outbreak was able to be easily controlled only at hospital 1 where the suspicious index case was detected and informed from the preliminary antibiotic tests, performed as mentioned previously. Control measurements were applied on these preliminary data, even before genetic confirmation.
publishDate 2012
dc.date.none.fl_str_mv 2012-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/271746
Cejas, Daniela; Fernández Canigia, Liliana; Nastro, Marcela; Rodríguez, Cynthia; Tanco, Ana; et al.; Hyperendemic clone of KPC producing Klebsiella pneumoniae ST 258 in Buenos Aires hospitals; Elsevier Science; Infection, Genetics and Evolution; 12; 3; 4-2012; 499-501
1567-1348
CONICET Digital
CONICET
url http://hdl.handle.net/11336/271746
identifier_str_mv Cejas, Daniela; Fernández Canigia, Liliana; Nastro, Marcela; Rodríguez, Cynthia; Tanco, Ana; et al.; Hyperendemic clone of KPC producing Klebsiella pneumoniae ST 258 in Buenos Aires hospitals; Elsevier Science; Infection, Genetics and Evolution; 12; 3; 4-2012; 499-501
1567-1348
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
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info:eu-repo/semantics/altIdentifier/doi/10.1016/j.meegid.2011.09.018
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https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
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dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
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instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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