Emergence of ceftazidime/avibactam resistance in KPC-8–producing Klebsiella pneumoniae in South America

Autores
García, J.; Nastro, Marcela; Cejas, Daniela; Santana, G.; Mancino, M.B.; Hidalgo, M.; Maccallini, G.; Vay, C.; Radice, Marcela Alejandra; Dabos, L.; Famiglietti, Angela María Rosa; Rodríguez, H.
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Klebsiella pneumoniae is one of the so-called ESKAPE pathogens. These organisms are the main cause of nosocomial infections worldwide, causing life-threatening infections amongst critically ill and immunocompromised individuals. They are characterized by drug resistance mechanisms. Klebsiella pneumoniae carbapenemase (KPC)-producing isolates display resistance to multiple antimicrobial agents, usually including last-resort alternative options, leading to an urgent need to develop new drugs or combinations. In Argentina sequence type (ST) 258 harbouring bla KPC-2 emerged in 2010 and remained prevalent until the last few years, when the emergence of different STs such as ST25, ST11 and ST307 appeared likely to change the local epidemiology.
Fil: García, J.. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Nastro, Marcela. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Cejas, Daniela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquimica. Instituto de Investigaciones En Bacteriologia y Virologia Molecular; Argentina
Fil: Santana, G.. No especifíca;
Fil: Mancino, M.B.. No especifíca;
Fil: Hidalgo, M.. No especifíca;
Fil: Maccallini, G.. No especifíca;
Fil: Vay, C.. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Radice, Marcela Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquimica. Instituto de Investigaciones En Bacteriologia y Virologia Molecular; Argentina
Fil: Dabos, L.. Université Paris Sud; Francia
Fil: Famiglietti, Angela María Rosa. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Rodríguez, H.. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Materia
Klebsiella pneumoniae
KPC-8
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/142260
Acceder
id CONICETDig_21a3631ea25a25af067d689cebc9ea2a
oai_identifier_str oai:ri.conicet.gov.ar:11336/142260
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Emergence of ceftazidime/avibactam resistance in KPC-8–producing Klebsiella pneumoniae in South AmericaGarcía, J.Nastro, MarcelaCejas, DanielaSantana, G.Mancino, M.B.Hidalgo, M.Maccallini, G.Vay, C.Radice, Marcela AlejandraDabos, L.Famiglietti, Angela María RosaRodríguez, H.Klebsiella pneumoniaeKPC-8https://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Klebsiella pneumoniae is one of the so-called ESKAPE pathogens. These organisms are the main cause of nosocomial infections worldwide, causing life-threatening infections amongst critically ill and immunocompromised individuals. They are characterized by drug resistance mechanisms. Klebsiella pneumoniae carbapenemase (KPC)-producing isolates display resistance to multiple antimicrobial agents, usually including last-resort alternative options, leading to an urgent need to develop new drugs or combinations. In Argentina sequence type (ST) 258 harbouring bla KPC-2 emerged in 2010 and remained prevalent until the last few years, when the emergence of different STs such as ST25, ST11 and ST307 appeared likely to change the local epidemiology.Fil: García, J.. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; ArgentinaFil: Nastro, Marcela. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; ArgentinaFil: Cejas, Daniela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquimica. Instituto de Investigaciones En Bacteriologia y Virologia Molecular; ArgentinaFil: Santana, G.. No especifíca;Fil: Mancino, M.B.. No especifíca;Fil: Hidalgo, M.. No especifíca;Fil: Maccallini, G.. No especifíca;Fil: Vay, C.. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; ArgentinaFil: Radice, Marcela Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquimica. Instituto de Investigaciones En Bacteriologia y Virologia Molecular; ArgentinaFil: Dabos, L.. Université Paris Sud; FranciaFil: Famiglietti, Angela María Rosa. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; ArgentinaFil: Rodríguez, H.. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; ArgentinaWiley Blackwell Publishing, Inc2020-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/142260García, J.; Nastro, Marcela; Cejas, Daniela; Santana, G.; Mancino, M.B.; et al.; Emergence of ceftazidime/avibactam resistance in KPC-8–producing Klebsiella pneumoniae in South America; Wiley Blackwell Publishing, Inc; Clinical Microbiology And Infection; 26; 9; 9-2020; 1264-12651198-743XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S1198743X20301567info:eu-repo/semantics/altIdentifier/doi/10.1016/j.cmi.2020.03.013info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:17:11Zoai:ri.conicet.gov.ar:11336/142260instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:17:11.963CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Emergence of ceftazidime/avibactam resistance in KPC-8–producing Klebsiella pneumoniae in South America
title Emergence of ceftazidime/avibactam resistance in KPC-8–producing Klebsiella pneumoniae in South America
spellingShingle Emergence of ceftazidime/avibactam resistance in KPC-8–producing Klebsiella pneumoniae in South America
García, J.
Klebsiella pneumoniae
KPC-8
title_short Emergence of ceftazidime/avibactam resistance in KPC-8–producing Klebsiella pneumoniae in South America
title_full Emergence of ceftazidime/avibactam resistance in KPC-8–producing Klebsiella pneumoniae in South America
title_fullStr Emergence of ceftazidime/avibactam resistance in KPC-8–producing Klebsiella pneumoniae in South America
title_full_unstemmed Emergence of ceftazidime/avibactam resistance in KPC-8–producing Klebsiella pneumoniae in South America
title_sort Emergence of ceftazidime/avibactam resistance in KPC-8–producing Klebsiella pneumoniae in South America
dc.creator.none.fl_str_mv García, J.
Nastro, Marcela
Cejas, Daniela
Santana, G.
Mancino, M.B.
Hidalgo, M.
Maccallini, G.
Vay, C.
Radice, Marcela Alejandra
Dabos, L.
Famiglietti, Angela María Rosa
Rodríguez, H.
author García, J.
author_facet García, J.
Nastro, Marcela
Cejas, Daniela
Santana, G.
Mancino, M.B.
Hidalgo, M.
Maccallini, G.
Vay, C.
Radice, Marcela Alejandra
Dabos, L.
Famiglietti, Angela María Rosa
Rodríguez, H.
author_role author
author2 Nastro, Marcela
Cejas, Daniela
Santana, G.
Mancino, M.B.
Hidalgo, M.
Maccallini, G.
Vay, C.
Radice, Marcela Alejandra
Dabos, L.
Famiglietti, Angela María Rosa
Rodríguez, H.
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Klebsiella pneumoniae
KPC-8
topic Klebsiella pneumoniae
KPC-8
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Klebsiella pneumoniae is one of the so-called ESKAPE pathogens. These organisms are the main cause of nosocomial infections worldwide, causing life-threatening infections amongst critically ill and immunocompromised individuals. They are characterized by drug resistance mechanisms. Klebsiella pneumoniae carbapenemase (KPC)-producing isolates display resistance to multiple antimicrobial agents, usually including last-resort alternative options, leading to an urgent need to develop new drugs or combinations. In Argentina sequence type (ST) 258 harbouring bla KPC-2 emerged in 2010 and remained prevalent until the last few years, when the emergence of different STs such as ST25, ST11 and ST307 appeared likely to change the local epidemiology.
Fil: García, J.. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Nastro, Marcela. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Cejas, Daniela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquimica. Instituto de Investigaciones En Bacteriologia y Virologia Molecular; Argentina
Fil: Santana, G.. No especifíca;
Fil: Mancino, M.B.. No especifíca;
Fil: Hidalgo, M.. No especifíca;
Fil: Maccallini, G.. No especifíca;
Fil: Vay, C.. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Radice, Marcela Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquimica. Instituto de Investigaciones En Bacteriologia y Virologia Molecular; Argentina
Fil: Dabos, L.. Université Paris Sud; Francia
Fil: Famiglietti, Angela María Rosa. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Rodríguez, H.. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
description Klebsiella pneumoniae is one of the so-called ESKAPE pathogens. These organisms are the main cause of nosocomial infections worldwide, causing life-threatening infections amongst critically ill and immunocompromised individuals. They are characterized by drug resistance mechanisms. Klebsiella pneumoniae carbapenemase (KPC)-producing isolates display resistance to multiple antimicrobial agents, usually including last-resort alternative options, leading to an urgent need to develop new drugs or combinations. In Argentina sequence type (ST) 258 harbouring bla KPC-2 emerged in 2010 and remained prevalent until the last few years, when the emergence of different STs such as ST25, ST11 and ST307 appeared likely to change the local epidemiology.
publishDate 2020
dc.date.none.fl_str_mv 2020-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/142260
García, J.; Nastro, Marcela; Cejas, Daniela; Santana, G.; Mancino, M.B.; et al.; Emergence of ceftazidime/avibactam resistance in KPC-8–producing Klebsiella pneumoniae in South America; Wiley Blackwell Publishing, Inc; Clinical Microbiology And Infection; 26; 9; 9-2020; 1264-1265
1198-743X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/142260
identifier_str_mv García, J.; Nastro, Marcela; Cejas, Daniela; Santana, G.; Mancino, M.B.; et al.; Emergence of ceftazidime/avibactam resistance in KPC-8–producing Klebsiella pneumoniae in South America; Wiley Blackwell Publishing, Inc; Clinical Microbiology And Infection; 26; 9; 9-2020; 1264-1265
1198-743X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S1198743X20301567
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.cmi.2020.03.013
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842980940268175360
score 12.993085

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