Cross‐Talk between CD31 and the Signaling Lymphocytic Activation Molecule–Associated Protein during Interferon‐γ Production against Mycobacterium tuberculosis

Autores
Quiroga, María Florencia; Jurado, Javier Oscar; Martínez, Gustavo Javier; Pasquinelli, Virginia; Musella, Rosa María; Abbate, Pablo Eduardo; Issekutz, Andrew C.; Bracco, María Marta; Malbrán, Alejandro; Sieling, Peter Allan; Chuluyan, Hector Eduardo; García, Verónica Edith
Año de publicación
2007
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Effective host defense against tuberculosis requires Th1 cytokine responses. We studied the regulation of interferon (IFN)-γ production during tuberculosis by investigating the role of CD31, a receptor that attenuates T cell receptor signals. After antigen stimulation, CD3+CD31+ blood lymphocytes decreased in healthy donors and in tuberculosis patients with robust Th1 responses to Mycobacterium tuberculosis and IFN-γ was secreted only by CD31- T cells. In contrast, in patients with weak Th1 cytokine responses to M. tuberculosis, the level of CD3+CD31+ lymphocytes was increased and IFN-γ production was low. Furthermore, the inverse relationship between CD31 expression and IFN-γ production was in contrast to signaling lymphocytic activation molecule (SLAM) expression, an IFN-γ inducer in tuberculosis. Interestingly, CD31 bound to SLAM-associated protein (SAP), an IFN-γ inhibitor in tuberculosis, and when CD31 and SAP were coexpressed in lymphocytes, their association inhibited the IFN-γ response to M. tuberculosis. Thus, CD31, when binding to SAP, interferes with Th1 responses, suggesting that CD31 has a key regulatory role in the signaling pathway(s) leading to the IFN-γ response to M. tuberculosis.
Fil: Quiroga, María Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Jurado, Javier Oscar. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Martínez, Gustavo Javier. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Pasquinelli, Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Musella, Rosa María. Gobierno de la Ciudad de Buenos Aires. Hospital de Infecciosas "Dr. Francisco Javier Muñiz"; Argentina
Fil: Abbate, Pablo Eduardo. Gobierno de la Ciudad de Buenos Aires. Hospital de Infecciosas "Dr. Francisco Javier Muñiz"; Argentina
Fil: Issekutz, Andrew C.. Dalhousie University Halifax; Canadá
Fil: Bracco, María Marta. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex"; Argentina
Fil: Malbrán, Alejandro. Hospital Británico de Buenos Aires. Servicio de Alergia e Inmunología Clínica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Sieling, Peter Allan. University of California at Los Angeles; Estados Unidos
Fil: Chuluyan, Hector Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: García, Verónica Edith. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Materia
Cytokines
Signal Transduction
Antigens
Tuberculosis
Molecule
Donors
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/20325
Acceder
id CONICETDig_ea1b3749d5a28e30621c5df889f85475
oai_identifier_str oai:ri.conicet.gov.ar:11336/20325
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Cross‐Talk between CD31 and the Signaling Lymphocytic Activation Molecule–Associated Protein during Interferon‐γ Production against Mycobacterium tuberculosisQuiroga, María FlorenciaJurado, Javier OscarMartínez, Gustavo JavierPasquinelli, VirginiaMusella, Rosa MaríaAbbate, Pablo EduardoIssekutz, Andrew C.Bracco, María MartaMalbrán, AlejandroSieling, Peter AllanChuluyan, Hector EduardoGarcía, Verónica EdithCytokinesSignal TransductionAntigensTuberculosisMoleculeDonorshttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Effective host defense against tuberculosis requires Th1 cytokine responses. We studied the regulation of interferon (IFN)-γ production during tuberculosis by investigating the role of CD31, a receptor that attenuates T cell receptor signals. After antigen stimulation, CD3+CD31+ blood lymphocytes decreased in healthy donors and in tuberculosis patients with robust Th1 responses to Mycobacterium tuberculosis and IFN-γ was secreted only by CD31- T cells. In contrast, in patients with weak Th1 cytokine responses to M. tuberculosis, the level of CD3+CD31+ lymphocytes was increased and IFN-γ production was low. Furthermore, the inverse relationship between CD31 expression and IFN-γ production was in contrast to signaling lymphocytic activation molecule (SLAM) expression, an IFN-γ inducer in tuberculosis. Interestingly, CD31 bound to SLAM-associated protein (SAP), an IFN-γ inhibitor in tuberculosis, and when CD31 and SAP were coexpressed in lymphocytes, their association inhibited the IFN-γ response to M. tuberculosis. Thus, CD31, when binding to SAP, interferes with Th1 responses, suggesting that CD31 has a key regulatory role in the signaling pathway(s) leading to the IFN-γ response to M. tuberculosis.Fil: Quiroga, María Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; ArgentinaFil: Jurado, Javier Oscar. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; ArgentinaFil: Martínez, Gustavo Javier. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; ArgentinaFil: Pasquinelli, Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; ArgentinaFil: Musella, Rosa María. Gobierno de la Ciudad de Buenos Aires. Hospital de Infecciosas "Dr. Francisco Javier Muñiz"; ArgentinaFil: Abbate, Pablo Eduardo. Gobierno de la Ciudad de Buenos Aires. Hospital de Infecciosas "Dr. Francisco Javier Muñiz"; ArgentinaFil: Issekutz, Andrew C.. Dalhousie University Halifax; CanadáFil: Bracco, María Marta. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex"; ArgentinaFil: Malbrán, Alejandro. Hospital Británico de Buenos Aires. Servicio de Alergia e Inmunología Clínica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Sieling, Peter Allan. University of California at Los Angeles; Estados UnidosFil: Chuluyan, Hector Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; ArgentinaFil: García, Verónica Edith. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; ArgentinaOxford University Press2007-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/20325Quiroga, María Florencia; Jurado, Javier Oscar; Martínez, Gustavo Javier; Pasquinelli, Virginia; Musella, Rosa María; et al.; Cross‐Talk between CD31 and the Signaling Lymphocytic Activation Molecule–Associated Protein during Interferon‐γ Production against Mycobacterium tuberculosis; Oxford University Press; Journal Of Infectious Diseases; 196; 9; 11-2007; 1369-13780022-1899CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/jid/article-lookup/doi/10.1086/522522info:eu-repo/semantics/altIdentifier/doi/10.1086/522522info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:57:55Zoai:ri.conicet.gov.ar:11336/20325instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:57:55.433CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Cross‐Talk between CD31 and the Signaling Lymphocytic Activation Molecule–Associated Protein during Interferon‐γ Production against Mycobacterium tuberculosis
title Cross‐Talk between CD31 and the Signaling Lymphocytic Activation Molecule–Associated Protein during Interferon‐γ Production against Mycobacterium tuberculosis
spellingShingle Cross‐Talk between CD31 and the Signaling Lymphocytic Activation Molecule–Associated Protein during Interferon‐γ Production against Mycobacterium tuberculosis
Quiroga, María Florencia
Cytokines
Signal Transduction
Antigens
Tuberculosis
Molecule
Donors
title_short Cross‐Talk between CD31 and the Signaling Lymphocytic Activation Molecule–Associated Protein during Interferon‐γ Production against Mycobacterium tuberculosis
title_full Cross‐Talk between CD31 and the Signaling Lymphocytic Activation Molecule–Associated Protein during Interferon‐γ Production against Mycobacterium tuberculosis
title_fullStr Cross‐Talk between CD31 and the Signaling Lymphocytic Activation Molecule–Associated Protein during Interferon‐γ Production against Mycobacterium tuberculosis
title_full_unstemmed Cross‐Talk between CD31 and the Signaling Lymphocytic Activation Molecule–Associated Protein during Interferon‐γ Production against Mycobacterium tuberculosis
title_sort Cross‐Talk between CD31 and the Signaling Lymphocytic Activation Molecule–Associated Protein during Interferon‐γ Production against Mycobacterium tuberculosis
dc.creator.none.fl_str_mv Quiroga, María Florencia
Jurado, Javier Oscar
Martínez, Gustavo Javier
Pasquinelli, Virginia
Musella, Rosa María
Abbate, Pablo Eduardo
Issekutz, Andrew C.
Bracco, María Marta
Malbrán, Alejandro
Sieling, Peter Allan
Chuluyan, Hector Eduardo
García, Verónica Edith
author Quiroga, María Florencia
author_facet Quiroga, María Florencia
Jurado, Javier Oscar
Martínez, Gustavo Javier
Pasquinelli, Virginia
Musella, Rosa María
Abbate, Pablo Eduardo
Issekutz, Andrew C.
Bracco, María Marta
Malbrán, Alejandro
Sieling, Peter Allan
Chuluyan, Hector Eduardo
García, Verónica Edith
author_role author
author2 Jurado, Javier Oscar
Martínez, Gustavo Javier
Pasquinelli, Virginia
Musella, Rosa María
Abbate, Pablo Eduardo
Issekutz, Andrew C.
Bracco, María Marta
Malbrán, Alejandro
Sieling, Peter Allan
Chuluyan, Hector Eduardo
García, Verónica Edith
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Cytokines
Signal Transduction
Antigens
Tuberculosis
Molecule
Donors
topic Cytokines
Signal Transduction
Antigens
Tuberculosis
Molecule
Donors
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Effective host defense against tuberculosis requires Th1 cytokine responses. We studied the regulation of interferon (IFN)-γ production during tuberculosis by investigating the role of CD31, a receptor that attenuates T cell receptor signals. After antigen stimulation, CD3+CD31+ blood lymphocytes decreased in healthy donors and in tuberculosis patients with robust Th1 responses to Mycobacterium tuberculosis and IFN-γ was secreted only by CD31- T cells. In contrast, in patients with weak Th1 cytokine responses to M. tuberculosis, the level of CD3+CD31+ lymphocytes was increased and IFN-γ production was low. Furthermore, the inverse relationship between CD31 expression and IFN-γ production was in contrast to signaling lymphocytic activation molecule (SLAM) expression, an IFN-γ inducer in tuberculosis. Interestingly, CD31 bound to SLAM-associated protein (SAP), an IFN-γ inhibitor in tuberculosis, and when CD31 and SAP were coexpressed in lymphocytes, their association inhibited the IFN-γ response to M. tuberculosis. Thus, CD31, when binding to SAP, interferes with Th1 responses, suggesting that CD31 has a key regulatory role in the signaling pathway(s) leading to the IFN-γ response to M. tuberculosis.
Fil: Quiroga, María Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Jurado, Javier Oscar. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Martínez, Gustavo Javier. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Pasquinelli, Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Musella, Rosa María. Gobierno de la Ciudad de Buenos Aires. Hospital de Infecciosas "Dr. Francisco Javier Muñiz"; Argentina
Fil: Abbate, Pablo Eduardo. Gobierno de la Ciudad de Buenos Aires. Hospital de Infecciosas "Dr. Francisco Javier Muñiz"; Argentina
Fil: Issekutz, Andrew C.. Dalhousie University Halifax; Canadá
Fil: Bracco, María Marta. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex"; Argentina
Fil: Malbrán, Alejandro. Hospital Británico de Buenos Aires. Servicio de Alergia e Inmunología Clínica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Sieling, Peter Allan. University of California at Los Angeles; Estados Unidos
Fil: Chuluyan, Hector Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: García, Verónica Edith. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
description Effective host defense against tuberculosis requires Th1 cytokine responses. We studied the regulation of interferon (IFN)-γ production during tuberculosis by investigating the role of CD31, a receptor that attenuates T cell receptor signals. After antigen stimulation, CD3+CD31+ blood lymphocytes decreased in healthy donors and in tuberculosis patients with robust Th1 responses to Mycobacterium tuberculosis and IFN-γ was secreted only by CD31- T cells. In contrast, in patients with weak Th1 cytokine responses to M. tuberculosis, the level of CD3+CD31+ lymphocytes was increased and IFN-γ production was low. Furthermore, the inverse relationship between CD31 expression and IFN-γ production was in contrast to signaling lymphocytic activation molecule (SLAM) expression, an IFN-γ inducer in tuberculosis. Interestingly, CD31 bound to SLAM-associated protein (SAP), an IFN-γ inhibitor in tuberculosis, and when CD31 and SAP were coexpressed in lymphocytes, their association inhibited the IFN-γ response to M. tuberculosis. Thus, CD31, when binding to SAP, interferes with Th1 responses, suggesting that CD31 has a key regulatory role in the signaling pathway(s) leading to the IFN-γ response to M. tuberculosis.
publishDate 2007
dc.date.none.fl_str_mv 2007-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/20325
Quiroga, María Florencia; Jurado, Javier Oscar; Martínez, Gustavo Javier; Pasquinelli, Virginia; Musella, Rosa María; et al.; Cross‐Talk between CD31 and the Signaling Lymphocytic Activation Molecule–Associated Protein during Interferon‐γ Production against Mycobacterium tuberculosis; Oxford University Press; Journal Of Infectious Diseases; 196; 9; 11-2007; 1369-1378
0022-1899
CONICET Digital
CONICET
url http://hdl.handle.net/11336/20325
identifier_str_mv Quiroga, María Florencia; Jurado, Javier Oscar; Martínez, Gustavo Javier; Pasquinelli, Virginia; Musella, Rosa María; et al.; Cross‐Talk between CD31 and the Signaling Lymphocytic Activation Molecule–Associated Protein during Interferon‐γ Production against Mycobacterium tuberculosis; Oxford University Press; Journal Of Infectious Diseases; 196; 9; 11-2007; 1369-1378
0022-1899
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/jid/article-lookup/doi/10.1086/522522
info:eu-repo/semantics/altIdentifier/doi/10.1086/522522
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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