Dexamethasone-21 phosphate loading and release from ph-sensitive copolymers of 2-hydroxyethyl methacrylate and 2-(diisopropylamino)ethyl methacrylate

Autores
Faccia, Paula Andrea; Pardini, Francisco Martín; Amalvy, Javier
Año de publicación
2015
Idioma
inglés
Tipo de recurso
documento de conferencia
Estado
versión publicada
Descripción
Smart polymerslike pH-sensitive systems can improve the pharmacological treatment ofdiseases. Topical application is perhaps the most typical treatment practice inophthalmic therapies, however it is inefficient and sometimes produces sideeffects. A possibility to improve drug residence time and bioavailability isthe use of a pH-sensitive hydrogel as a vehicle to control the drug delivery.In this work the behavior of copolymers containing 2-hydroxyethyl methacrylate(HEMA) with different proportions of 2-(diisopropylamino)ethyl methacrylate(DPA) and different amounts of cross-linker agent, ethylene glycoldimethacrylate (EGDMA) are evaluated as drugdelivery systems for ophthalmic therapies. Drug load and release studies atdifferent pH values were evaluated using dexamethasone-21 phosphate (DXP) as amodel drug. The interaction between the polymer matrix and the drug was studiedby IR spectroscopy (FTIR), and drug distribution and film morphology atdifferent pH values were studied by scanning electron microscopy (SEM). Theresults show that the loading of DXP increases with DPA content andcrosslinking degree. Also the incorporation of DXP into the matrix depends onthe medium pH and increase at basic pH. SEM images show important morphologicalchanges when varying the medium pH and it can be seen the presence of the DXPloading in the polymer matrix. FTIR spectra of copolymers show an interactionbetween the drug and the polymer matrix through the shifting of the carbonylstretching band. The release of DXP from copolymers of HEMA and DPA issensitive to small pH variations in the range of 7.00 and 7.80. Kineticsreleases shows case-II or anomalous diffusion behavior depending on theHEMA/DPA ratio. At medium ocular pH (7.40) the exponents values (n)obtained for the hydrogels containing 10 wt. % of DPA are close to 1.0,suggesting a case-II transport and for hydrogels containing 30 wt. % of DPA then values are between 0.5 and 1 indicating an anomalous behavior.
Fil: Faccia, Paula Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina
Fil: Pardini, Francisco Martín. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Investigaciones en Tecnología de Pinturas. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones en Tecnología de Pinturas; Argentina
Fil: Amalvy, Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Investigaciones en Tecnología de Pinturas. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones en Tecnología de Pinturas; Argentina
3° Reunión Internacional de Ciencias Farmacéuticas
Córdoba
Argentina
Universidad Nacional de Córdoba. Facultad de Ciencias Químicas
Materia
HIDROGELES pH RESPONSIVOS
LIBERACIÓNCONTROLADA
DEXAMETASONA-21 FOSFATO
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/234240
Acceder
id CONICETDig_e98bb3280fe190b88e008f427d190f13
oai_identifier_str oai:ri.conicet.gov.ar:11336/234240
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Dexamethasone-21 phosphate loading and release from ph-sensitive copolymers of 2-hydroxyethyl methacrylate and 2-(diisopropylamino)ethyl methacrylateFaccia, Paula AndreaPardini, Francisco MartínAmalvy, JavierHIDROGELES pH RESPONSIVOSLIBERACIÓNCONTROLADADEXAMETASONA-21 FOSFATOhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1Smart polymerslike pH-sensitive systems can improve the pharmacological treatment ofdiseases. Topical application is perhaps the most typical treatment practice inophthalmic therapies, however it is inefficient and sometimes produces sideeffects. A possibility to improve drug residence time and bioavailability isthe use of a pH-sensitive hydrogel as a vehicle to control the drug delivery.In this work the behavior of copolymers containing 2-hydroxyethyl methacrylate(HEMA) with different proportions of 2-(diisopropylamino)ethyl methacrylate(DPA) and different amounts of cross-linker agent, ethylene glycoldimethacrylate (EGDMA) are evaluated as drugdelivery systems for ophthalmic therapies. Drug load and release studies atdifferent pH values were evaluated using dexamethasone-21 phosphate (DXP) as amodel drug. The interaction between the polymer matrix and the drug was studiedby IR spectroscopy (FTIR), and drug distribution and film morphology atdifferent pH values were studied by scanning electron microscopy (SEM). Theresults show that the loading of DXP increases with DPA content andcrosslinking degree. Also the incorporation of DXP into the matrix depends onthe medium pH and increase at basic pH. SEM images show important morphologicalchanges when varying the medium pH and it can be seen the presence of the DXPloading in the polymer matrix. FTIR spectra of copolymers show an interactionbetween the drug and the polymer matrix through the shifting of the carbonylstretching band. The release of DXP from copolymers of HEMA and DPA issensitive to small pH variations in the range of 7.00 and 7.80. Kineticsreleases shows case-II or anomalous diffusion behavior depending on theHEMA/DPA ratio. At medium ocular pH (7.40) the exponents values (n)obtained for the hydrogels containing 10 wt. % of DPA are close to 1.0,suggesting a case-II transport and for hydrogels containing 30 wt. % of DPA then values are between 0.5 and 1 indicating an anomalous behavior.Fil: Faccia, Paula Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; ArgentinaFil: Pardini, Francisco Martín. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Investigaciones en Tecnología de Pinturas. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones en Tecnología de Pinturas; ArgentinaFil: Amalvy, Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Investigaciones en Tecnología de Pinturas. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones en Tecnología de Pinturas; Argentina3° Reunión Internacional de Ciencias FarmacéuticasCórdobaArgentinaUniversidad Nacional de Córdoba. Facultad de Ciencias QuímicasSociety of Pharmaceutical Sciences and Research2015info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectReuniónJournalhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/234240Dexamethasone-21 phosphate loading and release from ph-sensitive copolymers of 2-hydroxyethyl methacrylate and 2-(diisopropylamino)ethyl methacrylate; 3° Reunión Internacional de Ciencias Farmacéuticas; Córdoba; Argentina; 2014; 1-12320-5148CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://ijpsr.com/wp-content/uploads/2015/05/Proceedings-RICIFa2014-Cordoba-ARGENTINA.pdfInternacionalinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:43:10Zoai:ri.conicet.gov.ar:11336/234240instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:43:10.454CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Dexamethasone-21 phosphate loading and release from ph-sensitive copolymers of 2-hydroxyethyl methacrylate and 2-(diisopropylamino)ethyl methacrylate
title Dexamethasone-21 phosphate loading and release from ph-sensitive copolymers of 2-hydroxyethyl methacrylate and 2-(diisopropylamino)ethyl methacrylate
spellingShingle Dexamethasone-21 phosphate loading and release from ph-sensitive copolymers of 2-hydroxyethyl methacrylate and 2-(diisopropylamino)ethyl methacrylate
Faccia, Paula Andrea
HIDROGELES pH RESPONSIVOS
LIBERACIÓNCONTROLADA
DEXAMETASONA-21 FOSFATO
title_short Dexamethasone-21 phosphate loading and release from ph-sensitive copolymers of 2-hydroxyethyl methacrylate and 2-(diisopropylamino)ethyl methacrylate
title_full Dexamethasone-21 phosphate loading and release from ph-sensitive copolymers of 2-hydroxyethyl methacrylate and 2-(diisopropylamino)ethyl methacrylate
title_fullStr Dexamethasone-21 phosphate loading and release from ph-sensitive copolymers of 2-hydroxyethyl methacrylate and 2-(diisopropylamino)ethyl methacrylate
title_full_unstemmed Dexamethasone-21 phosphate loading and release from ph-sensitive copolymers of 2-hydroxyethyl methacrylate and 2-(diisopropylamino)ethyl methacrylate
title_sort Dexamethasone-21 phosphate loading and release from ph-sensitive copolymers of 2-hydroxyethyl methacrylate and 2-(diisopropylamino)ethyl methacrylate
dc.creator.none.fl_str_mv Faccia, Paula Andrea
Pardini, Francisco Martín
Amalvy, Javier
author Faccia, Paula Andrea
author_facet Faccia, Paula Andrea
Pardini, Francisco Martín
Amalvy, Javier
author_role author
author2 Pardini, Francisco Martín
Amalvy, Javier
author2_role author
author
dc.subject.none.fl_str_mv HIDROGELES pH RESPONSIVOS
LIBERACIÓNCONTROLADA
DEXAMETASONA-21 FOSFATO
topic HIDROGELES pH RESPONSIVOS
LIBERACIÓNCONTROLADA
DEXAMETASONA-21 FOSFATO
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Smart polymerslike pH-sensitive systems can improve the pharmacological treatment ofdiseases. Topical application is perhaps the most typical treatment practice inophthalmic therapies, however it is inefficient and sometimes produces sideeffects. A possibility to improve drug residence time and bioavailability isthe use of a pH-sensitive hydrogel as a vehicle to control the drug delivery.In this work the behavior of copolymers containing 2-hydroxyethyl methacrylate(HEMA) with different proportions of 2-(diisopropylamino)ethyl methacrylate(DPA) and different amounts of cross-linker agent, ethylene glycoldimethacrylate (EGDMA) are evaluated as drugdelivery systems for ophthalmic therapies. Drug load and release studies atdifferent pH values were evaluated using dexamethasone-21 phosphate (DXP) as amodel drug. The interaction between the polymer matrix and the drug was studiedby IR spectroscopy (FTIR), and drug distribution and film morphology atdifferent pH values were studied by scanning electron microscopy (SEM). Theresults show that the loading of DXP increases with DPA content andcrosslinking degree. Also the incorporation of DXP into the matrix depends onthe medium pH and increase at basic pH. SEM images show important morphologicalchanges when varying the medium pH and it can be seen the presence of the DXPloading in the polymer matrix. FTIR spectra of copolymers show an interactionbetween the drug and the polymer matrix through the shifting of the carbonylstretching band. The release of DXP from copolymers of HEMA and DPA issensitive to small pH variations in the range of 7.00 and 7.80. Kineticsreleases shows case-II or anomalous diffusion behavior depending on theHEMA/DPA ratio. At medium ocular pH (7.40) the exponents values (n)obtained for the hydrogels containing 10 wt. % of DPA are close to 1.0,suggesting a case-II transport and for hydrogels containing 30 wt. % of DPA then values are between 0.5 and 1 indicating an anomalous behavior.
Fil: Faccia, Paula Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina
Fil: Pardini, Francisco Martín. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Investigaciones en Tecnología de Pinturas. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones en Tecnología de Pinturas; Argentina
Fil: Amalvy, Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas; Argentina. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Investigaciones en Tecnología de Pinturas. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones en Tecnología de Pinturas; Argentina
3° Reunión Internacional de Ciencias Farmacéuticas
Córdoba
Argentina
Universidad Nacional de Córdoba. Facultad de Ciencias Químicas
description Smart polymerslike pH-sensitive systems can improve the pharmacological treatment ofdiseases. Topical application is perhaps the most typical treatment practice inophthalmic therapies, however it is inefficient and sometimes produces sideeffects. A possibility to improve drug residence time and bioavailability isthe use of a pH-sensitive hydrogel as a vehicle to control the drug delivery.In this work the behavior of copolymers containing 2-hydroxyethyl methacrylate(HEMA) with different proportions of 2-(diisopropylamino)ethyl methacrylate(DPA) and different amounts of cross-linker agent, ethylene glycoldimethacrylate (EGDMA) are evaluated as drugdelivery systems for ophthalmic therapies. Drug load and release studies atdifferent pH values were evaluated using dexamethasone-21 phosphate (DXP) as amodel drug. The interaction between the polymer matrix and the drug was studiedby IR spectroscopy (FTIR), and drug distribution and film morphology atdifferent pH values were studied by scanning electron microscopy (SEM). Theresults show that the loading of DXP increases with DPA content andcrosslinking degree. Also the incorporation of DXP into the matrix depends onthe medium pH and increase at basic pH. SEM images show important morphologicalchanges when varying the medium pH and it can be seen the presence of the DXPloading in the polymer matrix. FTIR spectra of copolymers show an interactionbetween the drug and the polymer matrix through the shifting of the carbonylstretching band. The release of DXP from copolymers of HEMA and DPA issensitive to small pH variations in the range of 7.00 and 7.80. Kineticsreleases shows case-II or anomalous diffusion behavior depending on theHEMA/DPA ratio. At medium ocular pH (7.40) the exponents values (n)obtained for the hydrogels containing 10 wt. % of DPA are close to 1.0,suggesting a case-II transport and for hydrogels containing 30 wt. % of DPA then values are between 0.5 and 1 indicating an anomalous behavior.
publishDate 2015
dc.date.none.fl_str_mv 2015
dc.type.none.fl_str_mv info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/conferenceObject
Reunión
Journal
http://purl.org/coar/resource_type/c_5794
info:ar-repo/semantics/documentoDeConferencia
status_str publishedVersion
format conferenceObject
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/234240
Dexamethasone-21 phosphate loading and release from ph-sensitive copolymers of 2-hydroxyethyl methacrylate and 2-(diisopropylamino)ethyl methacrylate; 3° Reunión Internacional de Ciencias Farmacéuticas; Córdoba; Argentina; 2014; 1-1
2320-5148
CONICET Digital
CONICET
url http://hdl.handle.net/11336/234240
identifier_str_mv Dexamethasone-21 phosphate loading and release from ph-sensitive copolymers of 2-hydroxyethyl methacrylate and 2-(diisopropylamino)ethyl methacrylate; 3° Reunión Internacional de Ciencias Farmacéuticas; Córdoba; Argentina; 2014; 1-1
2320-5148
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://ijpsr.com/wp-content/uploads/2015/05/Proceedings-RICIFa2014-Cordoba-ARGENTINA.pdf
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.coverage.none.fl_str_mv Internacional
dc.publisher.none.fl_str_mv Society of Pharmaceutical Sciences and Research
publisher.none.fl_str_mv Society of Pharmaceutical Sciences and Research
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846082936102715392
score 13.22299

Publicaciones similares