Synthesis, characterization and swelling behavior of new pH-sensitive hydrogels derived from copolymers of 2-hydroxyethyl methacrylate and 2-(diisopropylamino) ethylmethacrylate
- Autores
- Faccia, Paula; Amalvy, Javier
- Año de publicación
- 2012
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- The aim of this work was to synthesize and to characterize new pH-sensitive hydrogels that can be used in the controlled release of drugs, useful for dermal treatments or ophthalmology’s therapies. Copolymers containing 2-hydroxyethyl methacrylate (HEMA) with different amounts of 2-(diisopropylamino)ethyl methacrylate (DPA) (10 and 30 wt %) and different amounts of cross- linker agent, ethylene glycol dimethacrylate (EGDMA) (1 and 3 wt %) were prepared by bulk photo-polymerization. The copolymers were fully characterized by using Fourier-transform infrared (FTIR) spectra, differential scanning calorimetry, thermogravimetric anal- ysis, UV–visible spectroscopy, and measuring water content and dynamic swelling degree. The results show that modifications in the amount of DPA and/or crosslinker in the hydrogel produce variations in the thermal properties. When adding of DPA, we observed an increase in the thermal stability and decomposition temperature, as well as a change in the mechanism of decomposition. Also a decrease in the glass transition temperature was observed with regard to the value for pure pHEMA, by the addition of DPA. The water content of the hydrogels depends on the DPA content and it is inversely proportional to both the pH value and the crosslinking degree. Pure poly-HEMA films did not show important changes over the pH range studied in this work. The dynamic swelling curves show the overshooting effect associated with the incorporation of DPA, the pH of the solution, and the crosslinking density. On the other hand, no important variations in the optical properties were observed. The synthesized hydrogels are useful as a drug delivery pH-sensitive matrix.
Fil: Faccia, Paula. UNLP (Universidad Nacional de La Plata). INIFTA (Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas). CONICET; Argentina
Fil: Amalvy, Javier. UNLP (Universidad Nacional de La Plata). INIFTA (Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas). CONICET. CIDEPINT (Centro de Investigación y Desarrollo en Tecnología de Pinturas) CONICET/CICPBA. UTN (Universidad Tecnológica Nacional). CITEMA (Centro de Investigación y Desarrollo en Ciencia y Tecnología de Materiales); Argentina
Peer Reviewed - Materia
- stimuli-sensitive polymers; hydrophilic polymers; drug delivery systems
- Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- http://creativecommons.org/licenses/by-nc-nd/4.0/
- Repositorio
- Institución
- Universidad Tecnológica Nacional
- OAI Identificador
- oai:ria.utn.edu.ar:20.500.12272/3421
Ver los metadatos del registro completo
id |
RIAUTN_720380b57153fe526d268d6a796046b2 |
---|---|
oai_identifier_str |
oai:ria.utn.edu.ar:20.500.12272/3421 |
network_acronym_str |
RIAUTN |
repository_id_str |
a |
network_name_str |
Repositorio Institucional Abierto (UTN) |
spelling |
Synthesis, characterization and swelling behavior of new pH-sensitive hydrogels derived from copolymers of 2-hydroxyethyl methacrylate and 2-(diisopropylamino) ethylmethacrylateFaccia, PaulaAmalvy, Javierstimuli-sensitive polymers; hydrophilic polymers; drug delivery systemsThe aim of this work was to synthesize and to characterize new pH-sensitive hydrogels that can be used in the controlled release of drugs, useful for dermal treatments or ophthalmology’s therapies. Copolymers containing 2-hydroxyethyl methacrylate (HEMA) with different amounts of 2-(diisopropylamino)ethyl methacrylate (DPA) (10 and 30 wt %) and different amounts of cross- linker agent, ethylene glycol dimethacrylate (EGDMA) (1 and 3 wt %) were prepared by bulk photo-polymerization. The copolymers were fully characterized by using Fourier-transform infrared (FTIR) spectra, differential scanning calorimetry, thermogravimetric anal- ysis, UV–visible spectroscopy, and measuring water content and dynamic swelling degree. The results show that modifications in the amount of DPA and/or crosslinker in the hydrogel produce variations in the thermal properties. When adding of DPA, we observed an increase in the thermal stability and decomposition temperature, as well as a change in the mechanism of decomposition. Also a decrease in the glass transition temperature was observed with regard to the value for pure pHEMA, by the addition of DPA. The water content of the hydrogels depends on the DPA content and it is inversely proportional to both the pH value and the crosslinking degree. Pure poly-HEMA films did not show important changes over the pH range studied in this work. The dynamic swelling curves show the overshooting effect associated with the incorporation of DPA, the pH of the solution, and the crosslinking density. On the other hand, no important variations in the optical properties were observed. The synthesized hydrogels are useful as a drug delivery pH-sensitive matrix.Fil: Faccia, Paula. UNLP (Universidad Nacional de La Plata). INIFTA (Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas). CONICET; Argentina
Fil: Amalvy, Javier. UNLP (Universidad Nacional de La Plata). INIFTA (Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas). CONICET. CIDEPINT (Centro de Investigación y Desarrollo en Tecnología de Pinturas) CONICET/CICPBA. UTN (Universidad Tecnológica Nacional). CITEMA (Centro de Investigación y Desarrollo en Ciencia y Tecnología de Materiales); ArgentinaPeer Reviewed2019-02-09T21:56:31Z2019-02-09T21:56:31Z2012info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfJournal of Applied Polymer Sciencehttp://hdl.handle.net/20.500.12272/342110.1002/app.37576enginfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-nd/4.0/Wiley Periodicals, Inc.Atribución (Attribution): En cualquier explotación de la obra autorizada por la licencia será necesario reconocer la autoría (obligatoria en todos los casos). No comercial (Non Commercial): La explotación de la obra queda limitada a usos no comerciales. Sin obras derivadas (No Derivate Works): La autorización para explotar la obra no incluye la posibilidad de crear una obra derivada (traducciones, adaptaciones, etc.).Attribution-NonCommercial-NoDerivatives 4.0 Internacionalreponame:Repositorio Institucional Abierto (UTN)instname:Universidad Tecnológica Nacional2025-09-29T14:29:31Zoai:ria.utn.edu.ar:20.500.12272/3421instacron:UTNInstitucionalhttp://ria.utn.edu.ar/Universidad públicaNo correspondehttp://ria.utn.edu.ar/oaigestionria@rec.utn.edu.ar; fsuarez@rec.utn.edu.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:a2025-09-29 14:29:31.483Repositorio Institucional Abierto (UTN) - Universidad Tecnológica Nacionalfalse |
dc.title.none.fl_str_mv |
Synthesis, characterization and swelling behavior of new pH-sensitive hydrogels derived from copolymers of 2-hydroxyethyl methacrylate and 2-(diisopropylamino) ethylmethacrylate |
title |
Synthesis, characterization and swelling behavior of new pH-sensitive hydrogels derived from copolymers of 2-hydroxyethyl methacrylate and 2-(diisopropylamino) ethylmethacrylate |
spellingShingle |
Synthesis, characterization and swelling behavior of new pH-sensitive hydrogels derived from copolymers of 2-hydroxyethyl methacrylate and 2-(diisopropylamino) ethylmethacrylate Faccia, Paula stimuli-sensitive polymers; hydrophilic polymers; drug delivery systems |
title_short |
Synthesis, characterization and swelling behavior of new pH-sensitive hydrogels derived from copolymers of 2-hydroxyethyl methacrylate and 2-(diisopropylamino) ethylmethacrylate |
title_full |
Synthesis, characterization and swelling behavior of new pH-sensitive hydrogels derived from copolymers of 2-hydroxyethyl methacrylate and 2-(diisopropylamino) ethylmethacrylate |
title_fullStr |
Synthesis, characterization and swelling behavior of new pH-sensitive hydrogels derived from copolymers of 2-hydroxyethyl methacrylate and 2-(diisopropylamino) ethylmethacrylate |
title_full_unstemmed |
Synthesis, characterization and swelling behavior of new pH-sensitive hydrogels derived from copolymers of 2-hydroxyethyl methacrylate and 2-(diisopropylamino) ethylmethacrylate |
title_sort |
Synthesis, characterization and swelling behavior of new pH-sensitive hydrogels derived from copolymers of 2-hydroxyethyl methacrylate and 2-(diisopropylamino) ethylmethacrylate |
dc.creator.none.fl_str_mv |
Faccia, Paula Amalvy, Javier |
author |
Faccia, Paula |
author_facet |
Faccia, Paula Amalvy, Javier |
author_role |
author |
author2 |
Amalvy, Javier |
author2_role |
author |
dc.subject.none.fl_str_mv |
stimuli-sensitive polymers; hydrophilic polymers; drug delivery systems |
topic |
stimuli-sensitive polymers; hydrophilic polymers; drug delivery systems |
dc.description.none.fl_txt_mv |
The aim of this work was to synthesize and to characterize new pH-sensitive hydrogels that can be used in the controlled release of drugs, useful for dermal treatments or ophthalmology’s therapies. Copolymers containing 2-hydroxyethyl methacrylate (HEMA) with different amounts of 2-(diisopropylamino)ethyl methacrylate (DPA) (10 and 30 wt %) and different amounts of cross- linker agent, ethylene glycol dimethacrylate (EGDMA) (1 and 3 wt %) were prepared by bulk photo-polymerization. The copolymers were fully characterized by using Fourier-transform infrared (FTIR) spectra, differential scanning calorimetry, thermogravimetric anal- ysis, UV–visible spectroscopy, and measuring water content and dynamic swelling degree. The results show that modifications in the amount of DPA and/or crosslinker in the hydrogel produce variations in the thermal properties. When adding of DPA, we observed an increase in the thermal stability and decomposition temperature, as well as a change in the mechanism of decomposition. Also a decrease in the glass transition temperature was observed with regard to the value for pure pHEMA, by the addition of DPA. The water content of the hydrogels depends on the DPA content and it is inversely proportional to both the pH value and the crosslinking degree. Pure poly-HEMA films did not show important changes over the pH range studied in this work. The dynamic swelling curves show the overshooting effect associated with the incorporation of DPA, the pH of the solution, and the crosslinking density. On the other hand, no important variations in the optical properties were observed. The synthesized hydrogels are useful as a drug delivery pH-sensitive matrix. Fil: Faccia, Paula. UNLP (Universidad Nacional de La Plata). INIFTA (Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas). CONICET; Argentina Fil: Amalvy, Javier. UNLP (Universidad Nacional de La Plata). INIFTA (Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas). CONICET. CIDEPINT (Centro de Investigación y Desarrollo en Tecnología de Pinturas) CONICET/CICPBA. UTN (Universidad Tecnológica Nacional). CITEMA (Centro de Investigación y Desarrollo en Ciencia y Tecnología de Materiales); Argentina Peer Reviewed |
description |
The aim of this work was to synthesize and to characterize new pH-sensitive hydrogels that can be used in the controlled release of drugs, useful for dermal treatments or ophthalmology’s therapies. Copolymers containing 2-hydroxyethyl methacrylate (HEMA) with different amounts of 2-(diisopropylamino)ethyl methacrylate (DPA) (10 and 30 wt %) and different amounts of cross- linker agent, ethylene glycol dimethacrylate (EGDMA) (1 and 3 wt %) were prepared by bulk photo-polymerization. The copolymers were fully characterized by using Fourier-transform infrared (FTIR) spectra, differential scanning calorimetry, thermogravimetric anal- ysis, UV–visible spectroscopy, and measuring water content and dynamic swelling degree. The results show that modifications in the amount of DPA and/or crosslinker in the hydrogel produce variations in the thermal properties. When adding of DPA, we observed an increase in the thermal stability and decomposition temperature, as well as a change in the mechanism of decomposition. Also a decrease in the glass transition temperature was observed with regard to the value for pure pHEMA, by the addition of DPA. The water content of the hydrogels depends on the DPA content and it is inversely proportional to both the pH value and the crosslinking degree. Pure poly-HEMA films did not show important changes over the pH range studied in this work. The dynamic swelling curves show the overshooting effect associated with the incorporation of DPA, the pH of the solution, and the crosslinking density. On the other hand, no important variations in the optical properties were observed. The synthesized hydrogels are useful as a drug delivery pH-sensitive matrix. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012 2019-02-09T21:56:31Z 2019-02-09T21:56:31Z |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
Journal of Applied Polymer Science http://hdl.handle.net/20.500.12272/3421 10.1002/app.37576 |
identifier_str_mv |
Journal of Applied Polymer Science 10.1002/app.37576 |
url |
http://hdl.handle.net/20.500.12272/3421 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-nd/4.0/ Wiley Periodicals, Inc. Atribución (Attribution): En cualquier explotación de la obra autorizada por la licencia será necesario reconocer la autoría (obligatoria en todos los casos). No comercial (Non Commercial): La explotación de la obra queda limitada a usos no comerciales. Sin obras derivadas (No Derivate Works): La autorización para explotar la obra no incluye la posibilidad de crear una obra derivada (traducciones, adaptaciones, etc.). Attribution-NonCommercial-NoDerivatives 4.0 Internacional |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
http://creativecommons.org/licenses/by-nc-nd/4.0/ Wiley Periodicals, Inc. Atribución (Attribution): En cualquier explotación de la obra autorizada por la licencia será necesario reconocer la autoría (obligatoria en todos los casos). No comercial (Non Commercial): La explotación de la obra queda limitada a usos no comerciales. Sin obras derivadas (No Derivate Works): La autorización para explotar la obra no incluye la posibilidad de crear una obra derivada (traducciones, adaptaciones, etc.). Attribution-NonCommercial-NoDerivatives 4.0 Internacional |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositorio Institucional Abierto (UTN) instname:Universidad Tecnológica Nacional |
reponame_str |
Repositorio Institucional Abierto (UTN) |
collection |
Repositorio Institucional Abierto (UTN) |
instname_str |
Universidad Tecnológica Nacional |
repository.name.fl_str_mv |
Repositorio Institucional Abierto (UTN) - Universidad Tecnológica Nacional |
repository.mail.fl_str_mv |
gestionria@rec.utn.edu.ar; fsuarez@rec.utn.edu.ar |
_version_ |
1844621787852177408 |
score |
12.559606 |