Comparison of dipsogenic responses of adult rat offspring as a function of different perinatal programming models

Autores
Dadam, Florencia Maria; Amigone, Jorge Luis; Vivas, Laura Marta; Macchione, Ana Fabiola
Año de publicación
2022
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The perinatal environment interacts with the genotype of the developing organism resulting in a unique phenotype through a developmental or perinatal programming phenomenon. However, it remains unclear how this phenomenon differentially affects particular targets expressing specific drinking responses depending on the perinatal conditions. The main goal of the present study was to compare the dipsogenic responses induced by different thirst models as a function of two perinatal manipulation models, defined by the maternal free access to hypertonic sodium solution and a partial aortic ligation (PAL-W/Na) or a sham-ligation (Sham-W/Na). The programmed adult offspring of both perinatal manipulated models responded similarly when was challenged by overnight water dehydration or after a sodium depletion showing a reduced water intake in comparison to the non-programmed animals. However, when animals were evaluated after a body sodium overload, only adult Sham-W/Na offspring showed drinking differences compared to PAL and control offspring. By analyzing the central neurobiological substrates involved, a significant increase in the number of Fos + cells was found after sodium depletion in the subfornical organ of both programmed groups and an increase in the number of Fos + cells in the dorsal raphe nucleus was only observed in adult depleted PAL-W/Na. Our results suggest that perinatal programming is a phenomenon that differentially affects particular targets which induce specific dipsogenic responses depending on matching between perinatal programming conditions and the osmotic challenge in the latter environment. Probably, each programmed-drinking phenotype has a particular set point to elicit specific repertoires of mechanisms to reestablish fluid balance.
Fil: Dadam, Florencia Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
Fil: Amigone, Jorge Luis. Hospital Privado Universitario de Córdoba; Argentina
Fil: Vivas, Laura Marta. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
Fil: Macchione, Ana Fabiola. Universidad Nacional de Córdoba. Instituto de Investigaciones Psicológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Psicológicas; Argentina
Materia
ABSOLUTE DEHYDRATION
CHRONIC OVER-ACTIVATION OF RAS
DORSAL RAPHE NUCLEUS
HYPOVOLEMIC THIRST
PARTIAL AORTIC LIGATION
PRE/POSTNATAL IMPRINTING
RELATIVE DEHYDRATION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/211690
Acceder
id CONICETDig_e7306bbc4fac5b12ec75bef64390c222
oai_identifier_str oai:ri.conicet.gov.ar:11336/211690
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Comparison of dipsogenic responses of adult rat offspring as a function of different perinatal programming modelsDadam, Florencia MariaAmigone, Jorge LuisVivas, Laura MartaMacchione, Ana FabiolaABSOLUTE DEHYDRATIONCHRONIC OVER-ACTIVATION OF RASDORSAL RAPHE NUCLEUSHYPOVOLEMIC THIRSTPARTIAL AORTIC LIGATIONPRE/POSTNATAL IMPRINTINGRELATIVE DEHYDRATIONhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3The perinatal environment interacts with the genotype of the developing organism resulting in a unique phenotype through a developmental or perinatal programming phenomenon. However, it remains unclear how this phenomenon differentially affects particular targets expressing specific drinking responses depending on the perinatal conditions. The main goal of the present study was to compare the dipsogenic responses induced by different thirst models as a function of two perinatal manipulation models, defined by the maternal free access to hypertonic sodium solution and a partial aortic ligation (PAL-W/Na) or a sham-ligation (Sham-W/Na). The programmed adult offspring of both perinatal manipulated models responded similarly when was challenged by overnight water dehydration or after a sodium depletion showing a reduced water intake in comparison to the non-programmed animals. However, when animals were evaluated after a body sodium overload, only adult Sham-W/Na offspring showed drinking differences compared to PAL and control offspring. By analyzing the central neurobiological substrates involved, a significant increase in the number of Fos + cells was found after sodium depletion in the subfornical organ of both programmed groups and an increase in the number of Fos + cells in the dorsal raphe nucleus was only observed in adult depleted PAL-W/Na. Our results suggest that perinatal programming is a phenomenon that differentially affects particular targets which induce specific dipsogenic responses depending on matching between perinatal programming conditions and the osmotic challenge in the latter environment. Probably, each programmed-drinking phenotype has a particular set point to elicit specific repertoires of mechanisms to reestablish fluid balance.Fil: Dadam, Florencia Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; ArgentinaFil: Amigone, Jorge Luis. Hospital Privado Universitario de Córdoba; ArgentinaFil: Vivas, Laura Marta. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; ArgentinaFil: Macchione, Ana Fabiola. Universidad Nacional de Córdoba. Instituto de Investigaciones Psicológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Psicológicas; ArgentinaPergamon-Elsevier Science Ltd2022-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/211690Dadam, Florencia Maria; Amigone, Jorge Luis; Vivas, Laura Marta; Macchione, Ana Fabiola; Comparison of dipsogenic responses of adult rat offspring as a function of different perinatal programming models; Pergamon-Elsevier Science Ltd; Brain Research Bulletin; 188; 10-2022; 77-910361-9230CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.brainresbull.2022.07.015info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0361923022001794info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2026-04-28T12:26:53Zoai:ri.conicet.gov.ar:11336/211690instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982026-04-28 12:26:54.189CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Comparison of dipsogenic responses of adult rat offspring as a function of different perinatal programming models
title Comparison of dipsogenic responses of adult rat offspring as a function of different perinatal programming models
spellingShingle Comparison of dipsogenic responses of adult rat offspring as a function of different perinatal programming models
Dadam, Florencia Maria
ABSOLUTE DEHYDRATION
CHRONIC OVER-ACTIVATION OF RAS
DORSAL RAPHE NUCLEUS
HYPOVOLEMIC THIRST
PARTIAL AORTIC LIGATION
PRE/POSTNATAL IMPRINTING
RELATIVE DEHYDRATION
title_short Comparison of dipsogenic responses of adult rat offspring as a function of different perinatal programming models
title_full Comparison of dipsogenic responses of adult rat offspring as a function of different perinatal programming models
title_fullStr Comparison of dipsogenic responses of adult rat offspring as a function of different perinatal programming models
title_full_unstemmed Comparison of dipsogenic responses of adult rat offspring as a function of different perinatal programming models
title_sort Comparison of dipsogenic responses of adult rat offspring as a function of different perinatal programming models
dc.creator.none.fl_str_mv Dadam, Florencia Maria
Amigone, Jorge Luis
Vivas, Laura Marta
Macchione, Ana Fabiola
author Dadam, Florencia Maria
author_facet Dadam, Florencia Maria
Amigone, Jorge Luis
Vivas, Laura Marta
Macchione, Ana Fabiola
author_role author
author2 Amigone, Jorge Luis
Vivas, Laura Marta
Macchione, Ana Fabiola
author2_role author
author
author
dc.subject.none.fl_str_mv ABSOLUTE DEHYDRATION
CHRONIC OVER-ACTIVATION OF RAS
DORSAL RAPHE NUCLEUS
HYPOVOLEMIC THIRST
PARTIAL AORTIC LIGATION
PRE/POSTNATAL IMPRINTING
RELATIVE DEHYDRATION
topic ABSOLUTE DEHYDRATION
CHRONIC OVER-ACTIVATION OF RAS
DORSAL RAPHE NUCLEUS
HYPOVOLEMIC THIRST
PARTIAL AORTIC LIGATION
PRE/POSTNATAL IMPRINTING
RELATIVE DEHYDRATION
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The perinatal environment interacts with the genotype of the developing organism resulting in a unique phenotype through a developmental or perinatal programming phenomenon. However, it remains unclear how this phenomenon differentially affects particular targets expressing specific drinking responses depending on the perinatal conditions. The main goal of the present study was to compare the dipsogenic responses induced by different thirst models as a function of two perinatal manipulation models, defined by the maternal free access to hypertonic sodium solution and a partial aortic ligation (PAL-W/Na) or a sham-ligation (Sham-W/Na). The programmed adult offspring of both perinatal manipulated models responded similarly when was challenged by overnight water dehydration or after a sodium depletion showing a reduced water intake in comparison to the non-programmed animals. However, when animals were evaluated after a body sodium overload, only adult Sham-W/Na offspring showed drinking differences compared to PAL and control offspring. By analyzing the central neurobiological substrates involved, a significant increase in the number of Fos + cells was found after sodium depletion in the subfornical organ of both programmed groups and an increase in the number of Fos + cells in the dorsal raphe nucleus was only observed in adult depleted PAL-W/Na. Our results suggest that perinatal programming is a phenomenon that differentially affects particular targets which induce specific dipsogenic responses depending on matching between perinatal programming conditions and the osmotic challenge in the latter environment. Probably, each programmed-drinking phenotype has a particular set point to elicit specific repertoires of mechanisms to reestablish fluid balance.
Fil: Dadam, Florencia Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
Fil: Amigone, Jorge Luis. Hospital Privado Universitario de Córdoba; Argentina
Fil: Vivas, Laura Marta. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
Fil: Macchione, Ana Fabiola. Universidad Nacional de Córdoba. Instituto de Investigaciones Psicológicas. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Psicológicas; Argentina
description The perinatal environment interacts with the genotype of the developing organism resulting in a unique phenotype through a developmental or perinatal programming phenomenon. However, it remains unclear how this phenomenon differentially affects particular targets expressing specific drinking responses depending on the perinatal conditions. The main goal of the present study was to compare the dipsogenic responses induced by different thirst models as a function of two perinatal manipulation models, defined by the maternal free access to hypertonic sodium solution and a partial aortic ligation (PAL-W/Na) or a sham-ligation (Sham-W/Na). The programmed adult offspring of both perinatal manipulated models responded similarly when was challenged by overnight water dehydration or after a sodium depletion showing a reduced water intake in comparison to the non-programmed animals. However, when animals were evaluated after a body sodium overload, only adult Sham-W/Na offspring showed drinking differences compared to PAL and control offspring. By analyzing the central neurobiological substrates involved, a significant increase in the number of Fos + cells was found after sodium depletion in the subfornical organ of both programmed groups and an increase in the number of Fos + cells in the dorsal raphe nucleus was only observed in adult depleted PAL-W/Na. Our results suggest that perinatal programming is a phenomenon that differentially affects particular targets which induce specific dipsogenic responses depending on matching between perinatal programming conditions and the osmotic challenge in the latter environment. Probably, each programmed-drinking phenotype has a particular set point to elicit specific repertoires of mechanisms to reestablish fluid balance.
publishDate 2022
dc.date.none.fl_str_mv 2022-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/211690
Dadam, Florencia Maria; Amigone, Jorge Luis; Vivas, Laura Marta; Macchione, Ana Fabiola; Comparison of dipsogenic responses of adult rat offspring as a function of different perinatal programming models; Pergamon-Elsevier Science Ltd; Brain Research Bulletin; 188; 10-2022; 77-91
0361-9230
CONICET Digital
CONICET
url http://hdl.handle.net/11336/211690
identifier_str_mv Dadam, Florencia Maria; Amigone, Jorge Luis; Vivas, Laura Marta; Macchione, Ana Fabiola; Comparison of dipsogenic responses of adult rat offspring as a function of different perinatal programming models; Pergamon-Elsevier Science Ltd; Brain Research Bulletin; 188; 10-2022; 77-91
0361-9230
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.brainresbull.2022.07.015
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0361923022001794
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.039539

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