Dorsal raphe serotonin neurotransmission is required for the expression of nursing behavior and for pup survival

Autores
Muzerelle, Aude; Soiza Reilly, Mariano; Hainer, Cornelia; Ruet, Pierre Louis; Lesch, Klaus Peter; Bader, Michael; Alenina, Natalia; Scotto Lomassese, Sophie; Gaspar, Patricia
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Proper maternal care is an essential factor of reproductive success in mammals, involving a repertoire of behaviors oriented toward the feeding and care of the offspring. Among the neurotransmitters involved in the initiation of these behaviors, serotonin (5-HT) seems to play an important role. Here we compared pup-oriented maternal behaviors in mice with constitutive 5-HT depletion, the tryptophan hydroxylase 2-knock-out (Tph2-KO) and the Pet1-KO mice. We report that the only common pup-oriented defect in these 2 hyposerotoninergic models is a defective nursing in parturient mice and altered nursing-like (crouching) behavior in virgin mice, while pup retrieval defects are only present in Tph2-KO. Despite a normal mammary gland development and milk production, the defect in appropriate nursing is responsible for severe growth retardation and early lethality of pups born to hyposerotonergic dams. This nursing defect is due to acute rather constitutive 5-HT depletion, as it is reproduced by adult knockdown of Tph2 in the dorsal raphe nucleus in mothers with a prior normal maternal experience. We conclude that 5-HT innervation from the dorsal raphe is required for both the initiation and maintenance of a normal nursing behavior. Our findings may be related to observations of reduced maternal/infant interactions in human depression.
Fil: Muzerelle, Aude. Sorbonne University; Francia. Inserm; Francia
Fil: Soiza Reilly, Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina
Fil: Hainer, Cornelia. Max-Delbrück Center for Molecular Medecine; Alemania
Fil: Ruet, Pierre Louis. Inserm; Francia. Sorbonne University; Francia
Fil: Lesch, Klaus Peter. University Of Würzburg; Alemania. Universiteit Maastricht.; Países Bajos
Fil: Bader, Michael. Max-Delbrück Center for Molecular Medecine; Alemania
Fil: Alenina, Natalia. Max-Delbrück Center for Molecular Medecine; Alemania
Fil: Scotto Lomassese, Sophie. Inserm; Francia. Sorbonne University; Francia
Fil: Gaspar, Patricia. Sorbonne University; Francia. Inserm; Francia
Materia
SEROTONIN
DORSAL RAPHE
MATERNAL BEHAVIOR
PET-1
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/175288
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/175288
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Dorsal raphe serotonin neurotransmission is required for the expression of nursing behavior and for pup survivalMuzerelle, AudeSoiza Reilly, MarianoHainer, CorneliaRuet, Pierre LouisLesch, Klaus PeterBader, MichaelAlenina, NataliaScotto Lomassese, SophieGaspar, PatriciaSEROTONINDORSAL RAPHEMATERNAL BEHAVIORPET-1https://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Proper maternal care is an essential factor of reproductive success in mammals, involving a repertoire of behaviors oriented toward the feeding and care of the offspring. Among the neurotransmitters involved in the initiation of these behaviors, serotonin (5-HT) seems to play an important role. Here we compared pup-oriented maternal behaviors in mice with constitutive 5-HT depletion, the tryptophan hydroxylase 2-knock-out (Tph2-KO) and the Pet1-KO mice. We report that the only common pup-oriented defect in these 2 hyposerotoninergic models is a defective nursing in parturient mice and altered nursing-like (crouching) behavior in virgin mice, while pup retrieval defects are only present in Tph2-KO. Despite a normal mammary gland development and milk production, the defect in appropriate nursing is responsible for severe growth retardation and early lethality of pups born to hyposerotonergic dams. This nursing defect is due to acute rather constitutive 5-HT depletion, as it is reproduced by adult knockdown of Tph2 in the dorsal raphe nucleus in mothers with a prior normal maternal experience. We conclude that 5-HT innervation from the dorsal raphe is required for both the initiation and maintenance of a normal nursing behavior. Our findings may be related to observations of reduced maternal/infant interactions in human depression.Fil: Muzerelle, Aude. Sorbonne University; Francia. Inserm; FranciaFil: Soiza Reilly, Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; ArgentinaFil: Hainer, Cornelia. Max-Delbrück Center for Molecular Medecine; AlemaniaFil: Ruet, Pierre Louis. Inserm; Francia. Sorbonne University; FranciaFil: Lesch, Klaus Peter. University Of Würzburg; Alemania. Universiteit Maastricht.; Países BajosFil: Bader, Michael. Max-Delbrück Center for Molecular Medecine; AlemaniaFil: Alenina, Natalia. Max-Delbrück Center for Molecular Medecine; AlemaniaFil: Scotto Lomassese, Sophie. Inserm; Francia. Sorbonne University; FranciaFil: Gaspar, Patricia. Sorbonne University; Francia. Inserm; FranciaNature2021-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/175288Muzerelle, Aude; Soiza Reilly, Mariano; Hainer, Cornelia; Ruet, Pierre Louis; Lesch, Klaus Peter; et al.; Dorsal raphe serotonin neurotransmission is required for the expression of nursing behavior and for pup survival; Nature; Scientific Reports; 11; 1; 12-2021; 1-142045-2322CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.nature.com/articles/s41598-021-84368-6info:eu-repo/semantics/altIdentifier/doi/10.1038/s41598-021-84368-6info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:35:02Zoai:ri.conicet.gov.ar:11336/175288instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:35:02.968CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Dorsal raphe serotonin neurotransmission is required for the expression of nursing behavior and for pup survival
title Dorsal raphe serotonin neurotransmission is required for the expression of nursing behavior and for pup survival
spellingShingle Dorsal raphe serotonin neurotransmission is required for the expression of nursing behavior and for pup survival
Muzerelle, Aude
SEROTONIN
DORSAL RAPHE
MATERNAL BEHAVIOR
PET-1
title_short Dorsal raphe serotonin neurotransmission is required for the expression of nursing behavior and for pup survival
title_full Dorsal raphe serotonin neurotransmission is required for the expression of nursing behavior and for pup survival
title_fullStr Dorsal raphe serotonin neurotransmission is required for the expression of nursing behavior and for pup survival
title_full_unstemmed Dorsal raphe serotonin neurotransmission is required for the expression of nursing behavior and for pup survival
title_sort Dorsal raphe serotonin neurotransmission is required for the expression of nursing behavior and for pup survival
dc.creator.none.fl_str_mv Muzerelle, Aude
Soiza Reilly, Mariano
Hainer, Cornelia
Ruet, Pierre Louis
Lesch, Klaus Peter
Bader, Michael
Alenina, Natalia
Scotto Lomassese, Sophie
Gaspar, Patricia
author Muzerelle, Aude
author_facet Muzerelle, Aude
Soiza Reilly, Mariano
Hainer, Cornelia
Ruet, Pierre Louis
Lesch, Klaus Peter
Bader, Michael
Alenina, Natalia
Scotto Lomassese, Sophie
Gaspar, Patricia
author_role author
author2 Soiza Reilly, Mariano
Hainer, Cornelia
Ruet, Pierre Louis
Lesch, Klaus Peter
Bader, Michael
Alenina, Natalia
Scotto Lomassese, Sophie
Gaspar, Patricia
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv SEROTONIN
DORSAL RAPHE
MATERNAL BEHAVIOR
PET-1
topic SEROTONIN
DORSAL RAPHE
MATERNAL BEHAVIOR
PET-1
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Proper maternal care is an essential factor of reproductive success in mammals, involving a repertoire of behaviors oriented toward the feeding and care of the offspring. Among the neurotransmitters involved in the initiation of these behaviors, serotonin (5-HT) seems to play an important role. Here we compared pup-oriented maternal behaviors in mice with constitutive 5-HT depletion, the tryptophan hydroxylase 2-knock-out (Tph2-KO) and the Pet1-KO mice. We report that the only common pup-oriented defect in these 2 hyposerotoninergic models is a defective nursing in parturient mice and altered nursing-like (crouching) behavior in virgin mice, while pup retrieval defects are only present in Tph2-KO. Despite a normal mammary gland development and milk production, the defect in appropriate nursing is responsible for severe growth retardation and early lethality of pups born to hyposerotonergic dams. This nursing defect is due to acute rather constitutive 5-HT depletion, as it is reproduced by adult knockdown of Tph2 in the dorsal raphe nucleus in mothers with a prior normal maternal experience. We conclude that 5-HT innervation from the dorsal raphe is required for both the initiation and maintenance of a normal nursing behavior. Our findings may be related to observations of reduced maternal/infant interactions in human depression.
Fil: Muzerelle, Aude. Sorbonne University; Francia. Inserm; Francia
Fil: Soiza Reilly, Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina
Fil: Hainer, Cornelia. Max-Delbrück Center for Molecular Medecine; Alemania
Fil: Ruet, Pierre Louis. Inserm; Francia. Sorbonne University; Francia
Fil: Lesch, Klaus Peter. University Of Würzburg; Alemania. Universiteit Maastricht.; Países Bajos
Fil: Bader, Michael. Max-Delbrück Center for Molecular Medecine; Alemania
Fil: Alenina, Natalia. Max-Delbrück Center for Molecular Medecine; Alemania
Fil: Scotto Lomassese, Sophie. Inserm; Francia. Sorbonne University; Francia
Fil: Gaspar, Patricia. Sorbonne University; Francia. Inserm; Francia
description Proper maternal care is an essential factor of reproductive success in mammals, involving a repertoire of behaviors oriented toward the feeding and care of the offspring. Among the neurotransmitters involved in the initiation of these behaviors, serotonin (5-HT) seems to play an important role. Here we compared pup-oriented maternal behaviors in mice with constitutive 5-HT depletion, the tryptophan hydroxylase 2-knock-out (Tph2-KO) and the Pet1-KO mice. We report that the only common pup-oriented defect in these 2 hyposerotoninergic models is a defective nursing in parturient mice and altered nursing-like (crouching) behavior in virgin mice, while pup retrieval defects are only present in Tph2-KO. Despite a normal mammary gland development and milk production, the defect in appropriate nursing is responsible for severe growth retardation and early lethality of pups born to hyposerotonergic dams. This nursing defect is due to acute rather constitutive 5-HT depletion, as it is reproduced by adult knockdown of Tph2 in the dorsal raphe nucleus in mothers with a prior normal maternal experience. We conclude that 5-HT innervation from the dorsal raphe is required for both the initiation and maintenance of a normal nursing behavior. Our findings may be related to observations of reduced maternal/infant interactions in human depression.
publishDate 2021
dc.date.none.fl_str_mv 2021-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/175288
Muzerelle, Aude; Soiza Reilly, Mariano; Hainer, Cornelia; Ruet, Pierre Louis; Lesch, Klaus Peter; et al.; Dorsal raphe serotonin neurotransmission is required for the expression of nursing behavior and for pup survival; Nature; Scientific Reports; 11; 1; 12-2021; 1-14
2045-2322
CONICET Digital
CONICET
url http://hdl.handle.net/11336/175288
identifier_str_mv Muzerelle, Aude; Soiza Reilly, Mariano; Hainer, Cornelia; Ruet, Pierre Louis; Lesch, Klaus Peter; et al.; Dorsal raphe serotonin neurotransmission is required for the expression of nursing behavior and for pup survival; Nature; Scientific Reports; 11; 1; 12-2021; 1-14
2045-2322
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.nature.com/articles/s41598-021-84368-6
info:eu-repo/semantics/altIdentifier/doi/10.1038/s41598-021-84368-6
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Nature
publisher.none.fl_str_mv Nature
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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