Increased exposure to sodium during pregnancy and lactation changes basal and induced behavioral and neuroendocrine responses in adult male offspring

Autores
Silva, Marcia S.; Lúcio Oliveira, Fabiana; Mecawi, Andre Souza; Almeida, Lucas F.; Ruginsk, Silvia G.; Greenwood, Michael P.; Greenwood, Mingkwan; Vivas, Laura Marta; Elias, Lucila L. K.; Murphy, David; Antunes Rodrigues, José
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Excessive sodium (Na+) intake in modern society has been associated with several chronic disorders such as hypertension. Several studies suggest that early life events can program physiological systems and lead to functional changes in adulthood. Therefore, we investigated behavioral and neuroendocrine responses under basal conditions and after 48 h of water deprivation in adult (60-day-old Wistar rats) male, Wistar rats originating from dams were offered only water or 0.15 mol/L NaCl during pregnancy and lactation. Early life salt exposure induced kidney damage, as shown by a higher number of ED-1 positive cells (macrophages/monocytes), increased daily urinary volume and Na+ excretion, blunted basal water intake and plasma oxytocin levels, and increased plasma corticosterone secretion. When challenged with water deprivation, animals exposed to 0.15 mol/L NaCl during early life showed impaired water intake, reduced salt preference ratio, and vasopressin (AVP) secretion. In summary, our data demonstrate that the perinatal exposure to excessive Na+ intake can induce kidney injury in adult offspring and significantly affect the key mechanisms regulating water balance, fluid intake, and AVP release in response to water deprivation. Collectively, these novel results highlight the impact of perinatal programming on the homeostatic mechanisms regulating fluid and electrolyte balance during exposure to an environmental stress (i.e. dehydration) in later life.
Fil: Silva, Marcia S.. Universidade de Sao Paulo; Brasil
Fil: Lúcio Oliveira, Fabiana. Universidade de Sao Paulo; Brasil
Fil: Mecawi, Andre Souza. University of Malaya; Malasia
Fil: Almeida, Lucas F.. Universidade de Sao Paulo; Brasil. Universidade Federal Rural do Rio de Janeiro; Brasil
Fil: Ruginsk, Silvia G.. Federal University of Alfenas; Brasil
Fil: Greenwood, Michael P.. University of Bristol; Reino Unido
Fil: Greenwood, Mingkwan. University of Bristol; Reino Unido
Fil: Vivas, Laura Marta. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; Argentina
Fil: Elias, Lucila L. K.. Universidade de Sao Paulo; Brasil
Fil: Murphy, David. Universidade de Sao Paulo; Brasil. Universidade Federal Rural do Rio de Janeiro; Brasil
Fil: Antunes Rodrigues, José. Universidade de Sao Paulo; Brasil
Materia
PERINATAL PROGRAMMING
SODIUM PREFERENCE RATIO
THIRST
VASOPRESSIN
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/64054
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/64054
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Increased exposure to sodium during pregnancy and lactation changes basal and induced behavioral and neuroendocrine responses in adult male offspringSilva, Marcia S.Lúcio Oliveira, FabianaMecawi, Andre SouzaAlmeida, Lucas F.Ruginsk, Silvia G.Greenwood, Michael P.Greenwood, MingkwanVivas, Laura MartaElias, Lucila L. K.Murphy, DavidAntunes Rodrigues, JoséPERINATAL PROGRAMMINGSODIUM PREFERENCE RATIOTHIRSTVASOPRESSINhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Excessive sodium (Na+) intake in modern society has been associated with several chronic disorders such as hypertension. Several studies suggest that early life events can program physiological systems and lead to functional changes in adulthood. Therefore, we investigated behavioral and neuroendocrine responses under basal conditions and after 48 h of water deprivation in adult (60-day-old Wistar rats) male, Wistar rats originating from dams were offered only water or 0.15 mol/L NaCl during pregnancy and lactation. Early life salt exposure induced kidney damage, as shown by a higher number of ED-1 positive cells (macrophages/monocytes), increased daily urinary volume and Na+ excretion, blunted basal water intake and plasma oxytocin levels, and increased plasma corticosterone secretion. When challenged with water deprivation, animals exposed to 0.15 mol/L NaCl during early life showed impaired water intake, reduced salt preference ratio, and vasopressin (AVP) secretion. In summary, our data demonstrate that the perinatal exposure to excessive Na+ intake can induce kidney injury in adult offspring and significantly affect the key mechanisms regulating water balance, fluid intake, and AVP release in response to water deprivation. Collectively, these novel results highlight the impact of perinatal programming on the homeostatic mechanisms regulating fluid and electrolyte balance during exposure to an environmental stress (i.e. dehydration) in later life.Fil: Silva, Marcia S.. Universidade de Sao Paulo; BrasilFil: Lúcio Oliveira, Fabiana. Universidade de Sao Paulo; BrasilFil: Mecawi, Andre Souza. University of Malaya; MalasiaFil: Almeida, Lucas F.. Universidade de Sao Paulo; Brasil. Universidade Federal Rural do Rio de Janeiro; BrasilFil: Ruginsk, Silvia G.. Federal University of Alfenas; BrasilFil: Greenwood, Michael P.. University of Bristol; Reino UnidoFil: Greenwood, Mingkwan. University of Bristol; Reino UnidoFil: Vivas, Laura Marta. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; ArgentinaFil: Elias, Lucila L. K.. Universidade de Sao Paulo; BrasilFil: Murphy, David. Universidade de Sao Paulo; Brasil. Universidade Federal Rural do Rio de Janeiro; BrasilFil: Antunes Rodrigues, José. Universidade de Sao Paulo; BrasilAmerican Physiological Society2017-03-29info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/64054Silva, Marcia S.; Lúcio Oliveira, Fabiana; Mecawi, Andre Souza; Almeida, Lucas F.; Ruginsk, Silvia G.; et al.; Increased exposure to sodium during pregnancy and lactation changes basal and induced behavioral and neuroendocrine responses in adult male offspring; American Physiological Society; Physiological Reports; 5; 6; 29-3-2017; 1-132051-817XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.14814/phy2.13210info:eu-repo/semantics/altIdentifier/url/https://physoc.onlinelibrary.wiley.com/doi/full/10.14814/phy2.13210info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:28:34Zoai:ri.conicet.gov.ar:11336/64054instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:28:34.501CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Increased exposure to sodium during pregnancy and lactation changes basal and induced behavioral and neuroendocrine responses in adult male offspring
title Increased exposure to sodium during pregnancy and lactation changes basal and induced behavioral and neuroendocrine responses in adult male offspring
spellingShingle Increased exposure to sodium during pregnancy and lactation changes basal and induced behavioral and neuroendocrine responses in adult male offspring
Silva, Marcia S.
PERINATAL PROGRAMMING
SODIUM PREFERENCE RATIO
THIRST
VASOPRESSIN
title_short Increased exposure to sodium during pregnancy and lactation changes basal and induced behavioral and neuroendocrine responses in adult male offspring
title_full Increased exposure to sodium during pregnancy and lactation changes basal and induced behavioral and neuroendocrine responses in adult male offspring
title_fullStr Increased exposure to sodium during pregnancy and lactation changes basal and induced behavioral and neuroendocrine responses in adult male offspring
title_full_unstemmed Increased exposure to sodium during pregnancy and lactation changes basal and induced behavioral and neuroendocrine responses in adult male offspring
title_sort Increased exposure to sodium during pregnancy and lactation changes basal and induced behavioral and neuroendocrine responses in adult male offspring
dc.creator.none.fl_str_mv Silva, Marcia S.
Lúcio Oliveira, Fabiana
Mecawi, Andre Souza
Almeida, Lucas F.
Ruginsk, Silvia G.
Greenwood, Michael P.
Greenwood, Mingkwan
Vivas, Laura Marta
Elias, Lucila L. K.
Murphy, David
Antunes Rodrigues, José
author Silva, Marcia S.
author_facet Silva, Marcia S.
Lúcio Oliveira, Fabiana
Mecawi, Andre Souza
Almeida, Lucas F.
Ruginsk, Silvia G.
Greenwood, Michael P.
Greenwood, Mingkwan
Vivas, Laura Marta
Elias, Lucila L. K.
Murphy, David
Antunes Rodrigues, José
author_role author
author2 Lúcio Oliveira, Fabiana
Mecawi, Andre Souza
Almeida, Lucas F.
Ruginsk, Silvia G.
Greenwood, Michael P.
Greenwood, Mingkwan
Vivas, Laura Marta
Elias, Lucila L. K.
Murphy, David
Antunes Rodrigues, José
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv PERINATAL PROGRAMMING
SODIUM PREFERENCE RATIO
THIRST
VASOPRESSIN
topic PERINATAL PROGRAMMING
SODIUM PREFERENCE RATIO
THIRST
VASOPRESSIN
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Excessive sodium (Na+) intake in modern society has been associated with several chronic disorders such as hypertension. Several studies suggest that early life events can program physiological systems and lead to functional changes in adulthood. Therefore, we investigated behavioral and neuroendocrine responses under basal conditions and after 48 h of water deprivation in adult (60-day-old Wistar rats) male, Wistar rats originating from dams were offered only water or 0.15 mol/L NaCl during pregnancy and lactation. Early life salt exposure induced kidney damage, as shown by a higher number of ED-1 positive cells (macrophages/monocytes), increased daily urinary volume and Na+ excretion, blunted basal water intake and plasma oxytocin levels, and increased plasma corticosterone secretion. When challenged with water deprivation, animals exposed to 0.15 mol/L NaCl during early life showed impaired water intake, reduced salt preference ratio, and vasopressin (AVP) secretion. In summary, our data demonstrate that the perinatal exposure to excessive Na+ intake can induce kidney injury in adult offspring and significantly affect the key mechanisms regulating water balance, fluid intake, and AVP release in response to water deprivation. Collectively, these novel results highlight the impact of perinatal programming on the homeostatic mechanisms regulating fluid and electrolyte balance during exposure to an environmental stress (i.e. dehydration) in later life.
Fil: Silva, Marcia S.. Universidade de Sao Paulo; Brasil
Fil: Lúcio Oliveira, Fabiana. Universidade de Sao Paulo; Brasil
Fil: Mecawi, Andre Souza. University of Malaya; Malasia
Fil: Almeida, Lucas F.. Universidade de Sao Paulo; Brasil. Universidade Federal Rural do Rio de Janeiro; Brasil
Fil: Ruginsk, Silvia G.. Federal University of Alfenas; Brasil
Fil: Greenwood, Michael P.. University of Bristol; Reino Unido
Fil: Greenwood, Mingkwan. University of Bristol; Reino Unido
Fil: Vivas, Laura Marta. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; Argentina
Fil: Elias, Lucila L. K.. Universidade de Sao Paulo; Brasil
Fil: Murphy, David. Universidade de Sao Paulo; Brasil. Universidade Federal Rural do Rio de Janeiro; Brasil
Fil: Antunes Rodrigues, José. Universidade de Sao Paulo; Brasil
description Excessive sodium (Na+) intake in modern society has been associated with several chronic disorders such as hypertension. Several studies suggest that early life events can program physiological systems and lead to functional changes in adulthood. Therefore, we investigated behavioral and neuroendocrine responses under basal conditions and after 48 h of water deprivation in adult (60-day-old Wistar rats) male, Wistar rats originating from dams were offered only water or 0.15 mol/L NaCl during pregnancy and lactation. Early life salt exposure induced kidney damage, as shown by a higher number of ED-1 positive cells (macrophages/monocytes), increased daily urinary volume and Na+ excretion, blunted basal water intake and plasma oxytocin levels, and increased plasma corticosterone secretion. When challenged with water deprivation, animals exposed to 0.15 mol/L NaCl during early life showed impaired water intake, reduced salt preference ratio, and vasopressin (AVP) secretion. In summary, our data demonstrate that the perinatal exposure to excessive Na+ intake can induce kidney injury in adult offspring and significantly affect the key mechanisms regulating water balance, fluid intake, and AVP release in response to water deprivation. Collectively, these novel results highlight the impact of perinatal programming on the homeostatic mechanisms regulating fluid and electrolyte balance during exposure to an environmental stress (i.e. dehydration) in later life.
publishDate 2017
dc.date.none.fl_str_mv 2017-03-29
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/64054
Silva, Marcia S.; Lúcio Oliveira, Fabiana; Mecawi, Andre Souza; Almeida, Lucas F.; Ruginsk, Silvia G.; et al.; Increased exposure to sodium during pregnancy and lactation changes basal and induced behavioral and neuroendocrine responses in adult male offspring; American Physiological Society; Physiological Reports; 5; 6; 29-3-2017; 1-13
2051-817X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/64054
identifier_str_mv Silva, Marcia S.; Lúcio Oliveira, Fabiana; Mecawi, Andre Souza; Almeida, Lucas F.; Ruginsk, Silvia G.; et al.; Increased exposure to sodium during pregnancy and lactation changes basal and induced behavioral and neuroendocrine responses in adult male offspring; American Physiological Society; Physiological Reports; 5; 6; 29-3-2017; 1-13
2051-817X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.14814/phy2.13210
info:eu-repo/semantics/altIdentifier/url/https://physoc.onlinelibrary.wiley.com/doi/full/10.14814/phy2.13210
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Physiological Society
publisher.none.fl_str_mv American Physiological Society
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846082750238425088
score 13.22299

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