Increased exposure to sodium during pregnancy and lactation changes basal and induced behavioral and neuroendocrine responses in adult male offspring
- Autores
- Silva, Marcia S.; Lúcio Oliveira, Fabiana; Mecawi, Andre Souza; Almeida, Lucas F.; Ruginsk, Silvia G.; Greenwood, Michael P.; Greenwood, Mingkwan; Vivas, Laura Marta; Elias, Lucila L. K.; Murphy, David; Antunes Rodrigues, José
- Año de publicación
- 2017
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Excessive sodium (Na+) intake in modern society has been associated with several chronic disorders such as hypertension. Several studies suggest that early life events can program physiological systems and lead to functional changes in adulthood. Therefore, we investigated behavioral and neuroendocrine responses under basal conditions and after 48 h of water deprivation in adult (60-day-old Wistar rats) male, Wistar rats originating from dams were offered only water or 0.15 mol/L NaCl during pregnancy and lactation. Early life salt exposure induced kidney damage, as shown by a higher number of ED-1 positive cells (macrophages/monocytes), increased daily urinary volume and Na+ excretion, blunted basal water intake and plasma oxytocin levels, and increased plasma corticosterone secretion. When challenged with water deprivation, animals exposed to 0.15 mol/L NaCl during early life showed impaired water intake, reduced salt preference ratio, and vasopressin (AVP) secretion. In summary, our data demonstrate that the perinatal exposure to excessive Na+ intake can induce kidney injury in adult offspring and significantly affect the key mechanisms regulating water balance, fluid intake, and AVP release in response to water deprivation. Collectively, these novel results highlight the impact of perinatal programming on the homeostatic mechanisms regulating fluid and electrolyte balance during exposure to an environmental stress (i.e. dehydration) in later life.
Fil: Silva, Marcia S.. Universidade de Sao Paulo; Brasil
Fil: Lúcio Oliveira, Fabiana. Universidade de Sao Paulo; Brasil
Fil: Mecawi, Andre Souza. University of Malaya; Malasia
Fil: Almeida, Lucas F.. Universidade de Sao Paulo; Brasil. Universidade Federal Rural do Rio de Janeiro; Brasil
Fil: Ruginsk, Silvia G.. Federal University of Alfenas; Brasil
Fil: Greenwood, Michael P.. University of Bristol; Reino Unido
Fil: Greenwood, Mingkwan. University of Bristol; Reino Unido
Fil: Vivas, Laura Marta. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; Argentina
Fil: Elias, Lucila L. K.. Universidade de Sao Paulo; Brasil
Fil: Murphy, David. Universidade de Sao Paulo; Brasil. Universidade Federal Rural do Rio de Janeiro; Brasil
Fil: Antunes Rodrigues, José. Universidade de Sao Paulo; Brasil - Materia
-
PERINATAL PROGRAMMING
SODIUM PREFERENCE RATIO
THIRST
VASOPRESSIN - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/64054
Ver los metadatos del registro completo
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CONICET Digital (CONICET) |
spelling |
Increased exposure to sodium during pregnancy and lactation changes basal and induced behavioral and neuroendocrine responses in adult male offspringSilva, Marcia S.Lúcio Oliveira, FabianaMecawi, Andre SouzaAlmeida, Lucas F.Ruginsk, Silvia G.Greenwood, Michael P.Greenwood, MingkwanVivas, Laura MartaElias, Lucila L. K.Murphy, DavidAntunes Rodrigues, JoséPERINATAL PROGRAMMINGSODIUM PREFERENCE RATIOTHIRSTVASOPRESSINhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Excessive sodium (Na+) intake in modern society has been associated with several chronic disorders such as hypertension. Several studies suggest that early life events can program physiological systems and lead to functional changes in adulthood. Therefore, we investigated behavioral and neuroendocrine responses under basal conditions and after 48 h of water deprivation in adult (60-day-old Wistar rats) male, Wistar rats originating from dams were offered only water or 0.15 mol/L NaCl during pregnancy and lactation. Early life salt exposure induced kidney damage, as shown by a higher number of ED-1 positive cells (macrophages/monocytes), increased daily urinary volume and Na+ excretion, blunted basal water intake and plasma oxytocin levels, and increased plasma corticosterone secretion. When challenged with water deprivation, animals exposed to 0.15 mol/L NaCl during early life showed impaired water intake, reduced salt preference ratio, and vasopressin (AVP) secretion. In summary, our data demonstrate that the perinatal exposure to excessive Na+ intake can induce kidney injury in adult offspring and significantly affect the key mechanisms regulating water balance, fluid intake, and AVP release in response to water deprivation. Collectively, these novel results highlight the impact of perinatal programming on the homeostatic mechanisms regulating fluid and electrolyte balance during exposure to an environmental stress (i.e. dehydration) in later life.Fil: Silva, Marcia S.. Universidade de Sao Paulo; BrasilFil: Lúcio Oliveira, Fabiana. Universidade de Sao Paulo; BrasilFil: Mecawi, Andre Souza. University of Malaya; MalasiaFil: Almeida, Lucas F.. Universidade de Sao Paulo; Brasil. Universidade Federal Rural do Rio de Janeiro; BrasilFil: Ruginsk, Silvia G.. Federal University of Alfenas; BrasilFil: Greenwood, Michael P.. University of Bristol; Reino UnidoFil: Greenwood, Mingkwan. University of Bristol; Reino UnidoFil: Vivas, Laura Marta. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; ArgentinaFil: Elias, Lucila L. K.. Universidade de Sao Paulo; BrasilFil: Murphy, David. Universidade de Sao Paulo; Brasil. Universidade Federal Rural do Rio de Janeiro; BrasilFil: Antunes Rodrigues, José. Universidade de Sao Paulo; BrasilAmerican Physiological Society2017-03-29info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/64054Silva, Marcia S.; Lúcio Oliveira, Fabiana; Mecawi, Andre Souza; Almeida, Lucas F.; Ruginsk, Silvia G.; et al.; Increased exposure to sodium during pregnancy and lactation changes basal and induced behavioral and neuroendocrine responses in adult male offspring; American Physiological Society; Physiological Reports; 5; 6; 29-3-2017; 1-132051-817XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.14814/phy2.13210info:eu-repo/semantics/altIdentifier/url/https://physoc.onlinelibrary.wiley.com/doi/full/10.14814/phy2.13210info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:39:14Zoai:ri.conicet.gov.ar:11336/64054instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:39:14.315CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Increased exposure to sodium during pregnancy and lactation changes basal and induced behavioral and neuroendocrine responses in adult male offspring |
title |
Increased exposure to sodium during pregnancy and lactation changes basal and induced behavioral and neuroendocrine responses in adult male offspring |
spellingShingle |
Increased exposure to sodium during pregnancy and lactation changes basal and induced behavioral and neuroendocrine responses in adult male offspring Silva, Marcia S. PERINATAL PROGRAMMING SODIUM PREFERENCE RATIO THIRST VASOPRESSIN |
title_short |
Increased exposure to sodium during pregnancy and lactation changes basal and induced behavioral and neuroendocrine responses in adult male offspring |
title_full |
Increased exposure to sodium during pregnancy and lactation changes basal and induced behavioral and neuroendocrine responses in adult male offspring |
title_fullStr |
Increased exposure to sodium during pregnancy and lactation changes basal and induced behavioral and neuroendocrine responses in adult male offspring |
title_full_unstemmed |
Increased exposure to sodium during pregnancy and lactation changes basal and induced behavioral and neuroendocrine responses in adult male offspring |
title_sort |
Increased exposure to sodium during pregnancy and lactation changes basal and induced behavioral and neuroendocrine responses in adult male offspring |
dc.creator.none.fl_str_mv |
Silva, Marcia S. Lúcio Oliveira, Fabiana Mecawi, Andre Souza Almeida, Lucas F. Ruginsk, Silvia G. Greenwood, Michael P. Greenwood, Mingkwan Vivas, Laura Marta Elias, Lucila L. K. Murphy, David Antunes Rodrigues, José |
author |
Silva, Marcia S. |
author_facet |
Silva, Marcia S. Lúcio Oliveira, Fabiana Mecawi, Andre Souza Almeida, Lucas F. Ruginsk, Silvia G. Greenwood, Michael P. Greenwood, Mingkwan Vivas, Laura Marta Elias, Lucila L. K. Murphy, David Antunes Rodrigues, José |
author_role |
author |
author2 |
Lúcio Oliveira, Fabiana Mecawi, Andre Souza Almeida, Lucas F. Ruginsk, Silvia G. Greenwood, Michael P. Greenwood, Mingkwan Vivas, Laura Marta Elias, Lucila L. K. Murphy, David Antunes Rodrigues, José |
author2_role |
author author author author author author author author author author |
dc.subject.none.fl_str_mv |
PERINATAL PROGRAMMING SODIUM PREFERENCE RATIO THIRST VASOPRESSIN |
topic |
PERINATAL PROGRAMMING SODIUM PREFERENCE RATIO THIRST VASOPRESSIN |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Excessive sodium (Na+) intake in modern society has been associated with several chronic disorders such as hypertension. Several studies suggest that early life events can program physiological systems and lead to functional changes in adulthood. Therefore, we investigated behavioral and neuroendocrine responses under basal conditions and after 48 h of water deprivation in adult (60-day-old Wistar rats) male, Wistar rats originating from dams were offered only water or 0.15 mol/L NaCl during pregnancy and lactation. Early life salt exposure induced kidney damage, as shown by a higher number of ED-1 positive cells (macrophages/monocytes), increased daily urinary volume and Na+ excretion, blunted basal water intake and plasma oxytocin levels, and increased plasma corticosterone secretion. When challenged with water deprivation, animals exposed to 0.15 mol/L NaCl during early life showed impaired water intake, reduced salt preference ratio, and vasopressin (AVP) secretion. In summary, our data demonstrate that the perinatal exposure to excessive Na+ intake can induce kidney injury in adult offspring and significantly affect the key mechanisms regulating water balance, fluid intake, and AVP release in response to water deprivation. Collectively, these novel results highlight the impact of perinatal programming on the homeostatic mechanisms regulating fluid and electrolyte balance during exposure to an environmental stress (i.e. dehydration) in later life. Fil: Silva, Marcia S.. Universidade de Sao Paulo; Brasil Fil: Lúcio Oliveira, Fabiana. Universidade de Sao Paulo; Brasil Fil: Mecawi, Andre Souza. University of Malaya; Malasia Fil: Almeida, Lucas F.. Universidade de Sao Paulo; Brasil. Universidade Federal Rural do Rio de Janeiro; Brasil Fil: Ruginsk, Silvia G.. Federal University of Alfenas; Brasil Fil: Greenwood, Michael P.. University of Bristol; Reino Unido Fil: Greenwood, Mingkwan. University of Bristol; Reino Unido Fil: Vivas, Laura Marta. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; Argentina Fil: Elias, Lucila L. K.. Universidade de Sao Paulo; Brasil Fil: Murphy, David. Universidade de Sao Paulo; Brasil. Universidade Federal Rural do Rio de Janeiro; Brasil Fil: Antunes Rodrigues, José. Universidade de Sao Paulo; Brasil |
description |
Excessive sodium (Na+) intake in modern society has been associated with several chronic disorders such as hypertension. Several studies suggest that early life events can program physiological systems and lead to functional changes in adulthood. Therefore, we investigated behavioral and neuroendocrine responses under basal conditions and after 48 h of water deprivation in adult (60-day-old Wistar rats) male, Wistar rats originating from dams were offered only water or 0.15 mol/L NaCl during pregnancy and lactation. Early life salt exposure induced kidney damage, as shown by a higher number of ED-1 positive cells (macrophages/monocytes), increased daily urinary volume and Na+ excretion, blunted basal water intake and plasma oxytocin levels, and increased plasma corticosterone secretion. When challenged with water deprivation, animals exposed to 0.15 mol/L NaCl during early life showed impaired water intake, reduced salt preference ratio, and vasopressin (AVP) secretion. In summary, our data demonstrate that the perinatal exposure to excessive Na+ intake can induce kidney injury in adult offspring and significantly affect the key mechanisms regulating water balance, fluid intake, and AVP release in response to water deprivation. Collectively, these novel results highlight the impact of perinatal programming on the homeostatic mechanisms regulating fluid and electrolyte balance during exposure to an environmental stress (i.e. dehydration) in later life. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-03-29 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/64054 Silva, Marcia S.; Lúcio Oliveira, Fabiana; Mecawi, Andre Souza; Almeida, Lucas F.; Ruginsk, Silvia G.; et al.; Increased exposure to sodium during pregnancy and lactation changes basal and induced behavioral and neuroendocrine responses in adult male offspring; American Physiological Society; Physiological Reports; 5; 6; 29-3-2017; 1-13 2051-817X CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/64054 |
identifier_str_mv |
Silva, Marcia S.; Lúcio Oliveira, Fabiana; Mecawi, Andre Souza; Almeida, Lucas F.; Ruginsk, Silvia G.; et al.; Increased exposure to sodium during pregnancy and lactation changes basal and induced behavioral and neuroendocrine responses in adult male offspring; American Physiological Society; Physiological Reports; 5; 6; 29-3-2017; 1-13 2051-817X CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.14814/phy2.13210 info:eu-repo/semantics/altIdentifier/url/https://physoc.onlinelibrary.wiley.com/doi/full/10.14814/phy2.13210 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
American Physiological Society |
publisher.none.fl_str_mv |
American Physiological Society |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844613240858869760 |
score |
13.070432 |