First identification of Strongyloides stercoralis infection in a pet dog in Argentina, using integrated diagnostic approaches

Autores
Borrás, Pablo; Pérez, Matías Gastón; Repetto, Silvia; Barrera, Juan Pedro; Risso, Marikena Guadalupe; Montoya, Ana; Miró, Guadalupe; Fernandez, Federico; Telesca, Laura; Britton, Collette; Ruybal, Paula
Año de publicación
2023
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Background: Strongyloides stercoralis is a soil-transmitted intestinal nematode with a complex life cycle that primarily affects humans, non-human primates, dogs, and occasionally cats. This study presents, to the best of our knowledge, the first case of S. stercoralis infection and its genotyping in a domestic dog from Argentina. Methods: The patient was a female wired-haired Teckel dog exhibiting recurrent coughing. Coproparasitological analysis using the Baermann technique revealed the presence of rhabditiform larvae morphologically compatible with S. stercoralis. To confirm this finding, molecular diagnosis (18S ribosomal RNA) and analysis of the cox1 gene were performed. Results: We identified a haplotype (HP20) that has previously only been related to S. stercoralis infection in dogs, but was found in the present study to be highly related to the haplotype (HP16) of a zoonotic variant and divergent from those previously described from human patients in Argentina. Furthermore, unlike in human cases following treatment with ivermectin, the dog was negative after moxidectin treatment according to polymerase chain reaction of the sampled faeces. Conclusions: This case report shows the importance of further investigation into potential transmission events and prevalences of S. stercoralis in dogs and humans in South America. The results reported here should also encourage future work that examines different scenarios of infection with S. stercoralis in dogs and humans with the aim of integrating clinical management, diagnosis, treatment and follow-up strategies in the quest for new approaches for the treatment of this disease in animals and humans. The findings support the adoption of a One Health approach, which recognizes the interconnectedness between animal and human health, in addressing parasitic infections such as strongyloidiasis.
Fil: Borrás, Pablo. Universidad Maimónides; Argentina
Fil: Pérez, Matías Gastón. University of Glasgow; Reino Unido
Fil: Repetto, Silvia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médica; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología; Argentina
Fil: Barrera, Juan Pedro. Universidad Complutense de Madrid; España
Fil: Risso, Marikena Guadalupe. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médica; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología; Argentina
Fil: Montoya, Ana. Universidad Complutense de Madrid; España
Fil: Miró, Guadalupe. Universidad Complutense de Madrid; España
Fil: Fernandez, Federico. Laboratorio Innolab; Argentina
Fil: Telesca, Laura. Veterinario de Practica Privada; Argentina
Fil: Britton, Collette. University of Glasgow; Reino Unido
Fil: Ruybal, Paula. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médica; Argentina
Materia
DOMESTIC DOG
MOXIDECTIN
ONE HEALTH
PARASITE BIODIVERSITY
STRONGYLOIDES STERCORALIS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/227730
Acceder
id CONICETDig_e40f36fecb4957c48916cd065cfb091b
oai_identifier_str oai:ri.conicet.gov.ar:11336/227730
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling First identification of Strongyloides stercoralis infection in a pet dog in Argentina, using integrated diagnostic approachesBorrás, PabloPérez, Matías GastónRepetto, SilviaBarrera, Juan PedroRisso, Marikena GuadalupeMontoya, AnaMiró, GuadalupeFernandez, FedericoTelesca, LauraBritton, ColletteRuybal, PaulaDOMESTIC DOGMOXIDECTINONE HEALTHPARASITE BIODIVERSITYSTRONGYLOIDES STERCORALIShttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Background: Strongyloides stercoralis is a soil-transmitted intestinal nematode with a complex life cycle that primarily affects humans, non-human primates, dogs, and occasionally cats. This study presents, to the best of our knowledge, the first case of S. stercoralis infection and its genotyping in a domestic dog from Argentina. Methods: The patient was a female wired-haired Teckel dog exhibiting recurrent coughing. Coproparasitological analysis using the Baermann technique revealed the presence of rhabditiform larvae morphologically compatible with S. stercoralis. To confirm this finding, molecular diagnosis (18S ribosomal RNA) and analysis of the cox1 gene were performed. Results: We identified a haplotype (HP20) that has previously only been related to S. stercoralis infection in dogs, but was found in the present study to be highly related to the haplotype (HP16) of a zoonotic variant and divergent from those previously described from human patients in Argentina. Furthermore, unlike in human cases following treatment with ivermectin, the dog was negative after moxidectin treatment according to polymerase chain reaction of the sampled faeces. Conclusions: This case report shows the importance of further investigation into potential transmission events and prevalences of S. stercoralis in dogs and humans in South America. The results reported here should also encourage future work that examines different scenarios of infection with S. stercoralis in dogs and humans with the aim of integrating clinical management, diagnosis, treatment and follow-up strategies in the quest for new approaches for the treatment of this disease in animals and humans. The findings support the adoption of a One Health approach, which recognizes the interconnectedness between animal and human health, in addressing parasitic infections such as strongyloidiasis.Fil: Borrás, Pablo. Universidad Maimónides; ArgentinaFil: Pérez, Matías Gastón. University of Glasgow; Reino UnidoFil: Repetto, Silvia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médica; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología; ArgentinaFil: Barrera, Juan Pedro. Universidad Complutense de Madrid; EspañaFil: Risso, Marikena Guadalupe. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médica; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología; ArgentinaFil: Montoya, Ana. Universidad Complutense de Madrid; EspañaFil: Miró, Guadalupe. Universidad Complutense de Madrid; EspañaFil: Fernandez, Federico. Laboratorio Innolab; ArgentinaFil: Telesca, Laura. Veterinario de Practica Privada; ArgentinaFil: Britton, Collette. University of Glasgow; Reino UnidoFil: Ruybal, Paula. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médica; ArgentinaBioMed Central2023-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/227730Borrás, Pablo; Pérez, Matías Gastón; Repetto, Silvia; Barrera, Juan Pedro; Risso, Marikena Guadalupe; et al.; First identification of Strongyloides stercoralis infection in a pet dog in Argentina, using integrated diagnostic approaches; BioMed Central; Parasites and Vectors; 16; 1; 12-2023; 1-91756-3305CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://parasitesandvectors.biomedcentral.com/articles/10.1186/s13071-023-06022-6info:eu-repo/semantics/altIdentifier/doi/10.1186/s13071-023-06022-6info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:24:30Zoai:ri.conicet.gov.ar:11336/227730instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:24:30.553CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv First identification of Strongyloides stercoralis infection in a pet dog in Argentina, using integrated diagnostic approaches
title First identification of Strongyloides stercoralis infection in a pet dog in Argentina, using integrated diagnostic approaches
spellingShingle First identification of Strongyloides stercoralis infection in a pet dog in Argentina, using integrated diagnostic approaches
Borrás, Pablo
DOMESTIC DOG
MOXIDECTIN
ONE HEALTH
PARASITE BIODIVERSITY
STRONGYLOIDES STERCORALIS
title_short First identification of Strongyloides stercoralis infection in a pet dog in Argentina, using integrated diagnostic approaches
title_full First identification of Strongyloides stercoralis infection in a pet dog in Argentina, using integrated diagnostic approaches
title_fullStr First identification of Strongyloides stercoralis infection in a pet dog in Argentina, using integrated diagnostic approaches
title_full_unstemmed First identification of Strongyloides stercoralis infection in a pet dog in Argentina, using integrated diagnostic approaches
title_sort First identification of Strongyloides stercoralis infection in a pet dog in Argentina, using integrated diagnostic approaches
dc.creator.none.fl_str_mv Borrás, Pablo
Pérez, Matías Gastón
Repetto, Silvia
Barrera, Juan Pedro
Risso, Marikena Guadalupe
Montoya, Ana
Miró, Guadalupe
Fernandez, Federico
Telesca, Laura
Britton, Collette
Ruybal, Paula
author Borrás, Pablo
author_facet Borrás, Pablo
Pérez, Matías Gastón
Repetto, Silvia
Barrera, Juan Pedro
Risso, Marikena Guadalupe
Montoya, Ana
Miró, Guadalupe
Fernandez, Federico
Telesca, Laura
Britton, Collette
Ruybal, Paula
author_role author
author2 Pérez, Matías Gastón
Repetto, Silvia
Barrera, Juan Pedro
Risso, Marikena Guadalupe
Montoya, Ana
Miró, Guadalupe
Fernandez, Federico
Telesca, Laura
Britton, Collette
Ruybal, Paula
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv DOMESTIC DOG
MOXIDECTIN
ONE HEALTH
PARASITE BIODIVERSITY
STRONGYLOIDES STERCORALIS
topic DOMESTIC DOG
MOXIDECTIN
ONE HEALTH
PARASITE BIODIVERSITY
STRONGYLOIDES STERCORALIS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Background: Strongyloides stercoralis is a soil-transmitted intestinal nematode with a complex life cycle that primarily affects humans, non-human primates, dogs, and occasionally cats. This study presents, to the best of our knowledge, the first case of S. stercoralis infection and its genotyping in a domestic dog from Argentina. Methods: The patient was a female wired-haired Teckel dog exhibiting recurrent coughing. Coproparasitological analysis using the Baermann technique revealed the presence of rhabditiform larvae morphologically compatible with S. stercoralis. To confirm this finding, molecular diagnosis (18S ribosomal RNA) and analysis of the cox1 gene were performed. Results: We identified a haplotype (HP20) that has previously only been related to S. stercoralis infection in dogs, but was found in the present study to be highly related to the haplotype (HP16) of a zoonotic variant and divergent from those previously described from human patients in Argentina. Furthermore, unlike in human cases following treatment with ivermectin, the dog was negative after moxidectin treatment according to polymerase chain reaction of the sampled faeces. Conclusions: This case report shows the importance of further investigation into potential transmission events and prevalences of S. stercoralis in dogs and humans in South America. The results reported here should also encourage future work that examines different scenarios of infection with S. stercoralis in dogs and humans with the aim of integrating clinical management, diagnosis, treatment and follow-up strategies in the quest for new approaches for the treatment of this disease in animals and humans. The findings support the adoption of a One Health approach, which recognizes the interconnectedness between animal and human health, in addressing parasitic infections such as strongyloidiasis.
Fil: Borrás, Pablo. Universidad Maimónides; Argentina
Fil: Pérez, Matías Gastón. University of Glasgow; Reino Unido
Fil: Repetto, Silvia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médica; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología; Argentina
Fil: Barrera, Juan Pedro. Universidad Complutense de Madrid; España
Fil: Risso, Marikena Guadalupe. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médica; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología; Argentina
Fil: Montoya, Ana. Universidad Complutense de Madrid; España
Fil: Miró, Guadalupe. Universidad Complutense de Madrid; España
Fil: Fernandez, Federico. Laboratorio Innolab; Argentina
Fil: Telesca, Laura. Veterinario de Practica Privada; Argentina
Fil: Britton, Collette. University of Glasgow; Reino Unido
Fil: Ruybal, Paula. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médica; Argentina
description Background: Strongyloides stercoralis is a soil-transmitted intestinal nematode with a complex life cycle that primarily affects humans, non-human primates, dogs, and occasionally cats. This study presents, to the best of our knowledge, the first case of S. stercoralis infection and its genotyping in a domestic dog from Argentina. Methods: The patient was a female wired-haired Teckel dog exhibiting recurrent coughing. Coproparasitological analysis using the Baermann technique revealed the presence of rhabditiform larvae morphologically compatible with S. stercoralis. To confirm this finding, molecular diagnosis (18S ribosomal RNA) and analysis of the cox1 gene were performed. Results: We identified a haplotype (HP20) that has previously only been related to S. stercoralis infection in dogs, but was found in the present study to be highly related to the haplotype (HP16) of a zoonotic variant and divergent from those previously described from human patients in Argentina. Furthermore, unlike in human cases following treatment with ivermectin, the dog was negative after moxidectin treatment according to polymerase chain reaction of the sampled faeces. Conclusions: This case report shows the importance of further investigation into potential transmission events and prevalences of S. stercoralis in dogs and humans in South America. The results reported here should also encourage future work that examines different scenarios of infection with S. stercoralis in dogs and humans with the aim of integrating clinical management, diagnosis, treatment and follow-up strategies in the quest for new approaches for the treatment of this disease in animals and humans. The findings support the adoption of a One Health approach, which recognizes the interconnectedness between animal and human health, in addressing parasitic infections such as strongyloidiasis.
publishDate 2023
dc.date.none.fl_str_mv 2023-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/227730
Borrás, Pablo; Pérez, Matías Gastón; Repetto, Silvia; Barrera, Juan Pedro; Risso, Marikena Guadalupe; et al.; First identification of Strongyloides stercoralis infection in a pet dog in Argentina, using integrated diagnostic approaches; BioMed Central; Parasites and Vectors; 16; 1; 12-2023; 1-9
1756-3305
CONICET Digital
CONICET
url http://hdl.handle.net/11336/227730
identifier_str_mv Borrás, Pablo; Pérez, Matías Gastón; Repetto, Silvia; Barrera, Juan Pedro; Risso, Marikena Guadalupe; et al.; First identification of Strongyloides stercoralis infection in a pet dog in Argentina, using integrated diagnostic approaches; BioMed Central; Parasites and Vectors; 16; 1; 12-2023; 1-9
1756-3305
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://parasitesandvectors.biomedcentral.com/articles/10.1186/s13071-023-06022-6
info:eu-repo/semantics/altIdentifier/doi/10.1186/s13071-023-06022-6
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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