Diagnostic Accuracy of Five Serologic Tests for Strongyloides stercoralis Infection
- Autores
- Bisoffi, Zeno; Buonfrate, Dora; Sequi, Marco; Mejia, Rojelio; Cimino, Rubén Oscar; Krolewiecki, Alejandro Javier; Albonico, Marco; Gobbo, Maria; Bonafini, Stefania; Angheben, Andrea; Requena-Mendez, Ana; Muñoz, José; Nutman, Thomas B.
- Año de publicación
- 2014
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Background:The diagnosis of Strongyloides stercoralis (S. stercoralis) infection is hampered by the suboptimal sensitivity of fecal-based tests. Serological methods are believed to be more sensitive, although assessing their accuracy is difficult because of the lack of sensitivity of a fecal-based reference ("gold") standard.Methods:The sensitivity and specificity of 5 serologic tests for S. stercoralis (in-house IFAT, NIE-ELISA and NIE-LIPS and the commercially available Bordier-ELISA and IVD-ELISA) were assessed on 399 cryopreserved serum samples. Accuracy was measured using fecal results as the primary reference standard, but also using a composite reference standard (based on a combination of tests).Results:According to the latter standard, the most sensitive test was IFAT, with 94.6% sensitivity (91.2-96.9), followed by IVD-ELISA (92.3%, 87.7-96.9). The most specific test was NIE-LIPS, with specificity 99.6% (98.9-100), followed by IVD-ELISA (97.4%, 95.5-99.3). NIE-LIPS did not cross-react with any of the specimens from subjects with other parasitic infections. NIE-LIPS and the two commercial ELISAs approach 100% specificity at a cut off level that maintains ≥70% sensitivity.Conclusions:NIE-LIPS is the most accurate serologic test for the diagnosis of S. stercoralis infection. IFAT and each of the ELISA tests are sufficiently accurate, above a given cut off, for diagnosis, prevalence studies and inclusion in clinical trials.
Fil: Bisoffi, Zeno. Sacro Cuore Hospital; Italia
Fil: Buonfrate, Dora. Sacro Cuore Hospital; Italia
Fil: Sequi, Marco. Istituto Di Ricerche Farmacologiche Mario Negri; Italia
Fil: Mejia, Rojelio. National Institute Of Allergy And Infectious Diseases; Estados Unidos
Fil: Cimino, Rubén Oscar. Universidad Nacional de Salta. Sede Regional Orán. Instituto de Investigación de Enfermedades Tropicales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Krolewiecki, Alejandro Javier. Universidad Nacional de Salta. Sede Regional Orán. Instituto de Investigación de Enfermedades Tropicales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Albonico, Marco. Sacro Cuore Hospital; Italia
Fil: Gobbo, Maria. Sacro Cuore Hospital; Italia
Fil: Bonafini, Stefania. Sacro Cuore Hospital; Italia
Fil: Angheben, Andrea. Sacro Cuore Hospital; Italia
Fil: Requena-Mendez, Ana. Universidad de Barcelona; España
Fil: Muñoz, José. Universidad de Barcelona; España
Fil: Nutman, Thomas B.. National Institute Of Allergy And Infectious Diseases; Estados Unidos - Materia
-
Strongyloides Stercoralis
Serology
Diagnostics
Lips - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/37122
Ver los metadatos del registro completo
id |
CONICETDig_797db583b3050a2273efeaf75f204702 |
---|---|
oai_identifier_str |
oai:ri.conicet.gov.ar:11336/37122 |
network_acronym_str |
CONICETDig |
repository_id_str |
3498 |
network_name_str |
CONICET Digital (CONICET) |
spelling |
Diagnostic Accuracy of Five Serologic Tests for Strongyloides stercoralis InfectionBisoffi, ZenoBuonfrate, DoraSequi, MarcoMejia, RojelioCimino, Rubén OscarKrolewiecki, Alejandro JavierAlbonico, MarcoGobbo, MariaBonafini, StefaniaAngheben, AndreaRequena-Mendez, AnaMuñoz, JoséNutman, Thomas B.Strongyloides StercoralisSerologyDiagnosticsLipshttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Background:The diagnosis of Strongyloides stercoralis (S. stercoralis) infection is hampered by the suboptimal sensitivity of fecal-based tests. Serological methods are believed to be more sensitive, although assessing their accuracy is difficult because of the lack of sensitivity of a fecal-based reference ("gold") standard.Methods:The sensitivity and specificity of 5 serologic tests for S. stercoralis (in-house IFAT, NIE-ELISA and NIE-LIPS and the commercially available Bordier-ELISA and IVD-ELISA) were assessed on 399 cryopreserved serum samples. Accuracy was measured using fecal results as the primary reference standard, but also using a composite reference standard (based on a combination of tests).Results:According to the latter standard, the most sensitive test was IFAT, with 94.6% sensitivity (91.2-96.9), followed by IVD-ELISA (92.3%, 87.7-96.9). The most specific test was NIE-LIPS, with specificity 99.6% (98.9-100), followed by IVD-ELISA (97.4%, 95.5-99.3). NIE-LIPS did not cross-react with any of the specimens from subjects with other parasitic infections. NIE-LIPS and the two commercial ELISAs approach 100% specificity at a cut off level that maintains ≥70% sensitivity.Conclusions:NIE-LIPS is the most accurate serologic test for the diagnosis of S. stercoralis infection. IFAT and each of the ELISA tests are sufficiently accurate, above a given cut off, for diagnosis, prevalence studies and inclusion in clinical trials.Fil: Bisoffi, Zeno. Sacro Cuore Hospital; ItaliaFil: Buonfrate, Dora. Sacro Cuore Hospital; ItaliaFil: Sequi, Marco. Istituto Di Ricerche Farmacologiche Mario Negri; ItaliaFil: Mejia, Rojelio. National Institute Of Allergy And Infectious Diseases; Estados UnidosFil: Cimino, Rubén Oscar. Universidad Nacional de Salta. Sede Regional Orán. Instituto de Investigación de Enfermedades Tropicales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Krolewiecki, Alejandro Javier. Universidad Nacional de Salta. Sede Regional Orán. Instituto de Investigación de Enfermedades Tropicales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Albonico, Marco. Sacro Cuore Hospital; ItaliaFil: Gobbo, Maria. Sacro Cuore Hospital; ItaliaFil: Bonafini, Stefania. Sacro Cuore Hospital; ItaliaFil: Angheben, Andrea. Sacro Cuore Hospital; ItaliaFil: Requena-Mendez, Ana. Universidad de Barcelona; EspañaFil: Muñoz, José. Universidad de Barcelona; EspañaFil: Nutman, Thomas B.. National Institute Of Allergy And Infectious Diseases; Estados UnidosPublic Library of Science2014-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/37122Bisoffi, Zeno; Buonfrate, Dora; Sequi, Marco; Mejia, Rojelio; Cimino, Rubén Oscar; et al.; Diagnostic Accuracy of Five Serologic Tests for Strongyloides stercoralis Infection; Public Library of Science; Neglected Tropical Diseases; 8; 1; 1-2014; 1-8; e26401935-2735CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pntd.0002640info:eu-repo/semantics/altIdentifier/url/http://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0002640info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:47:54Zoai:ri.conicet.gov.ar:11336/37122instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:47:54.88CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Diagnostic Accuracy of Five Serologic Tests for Strongyloides stercoralis Infection |
title |
Diagnostic Accuracy of Five Serologic Tests for Strongyloides stercoralis Infection |
spellingShingle |
Diagnostic Accuracy of Five Serologic Tests for Strongyloides stercoralis Infection Bisoffi, Zeno Strongyloides Stercoralis Serology Diagnostics Lips |
title_short |
Diagnostic Accuracy of Five Serologic Tests for Strongyloides stercoralis Infection |
title_full |
Diagnostic Accuracy of Five Serologic Tests for Strongyloides stercoralis Infection |
title_fullStr |
Diagnostic Accuracy of Five Serologic Tests for Strongyloides stercoralis Infection |
title_full_unstemmed |
Diagnostic Accuracy of Five Serologic Tests for Strongyloides stercoralis Infection |
title_sort |
Diagnostic Accuracy of Five Serologic Tests for Strongyloides stercoralis Infection |
dc.creator.none.fl_str_mv |
Bisoffi, Zeno Buonfrate, Dora Sequi, Marco Mejia, Rojelio Cimino, Rubén Oscar Krolewiecki, Alejandro Javier Albonico, Marco Gobbo, Maria Bonafini, Stefania Angheben, Andrea Requena-Mendez, Ana Muñoz, José Nutman, Thomas B. |
author |
Bisoffi, Zeno |
author_facet |
Bisoffi, Zeno Buonfrate, Dora Sequi, Marco Mejia, Rojelio Cimino, Rubén Oscar Krolewiecki, Alejandro Javier Albonico, Marco Gobbo, Maria Bonafini, Stefania Angheben, Andrea Requena-Mendez, Ana Muñoz, José Nutman, Thomas B. |
author_role |
author |
author2 |
Buonfrate, Dora Sequi, Marco Mejia, Rojelio Cimino, Rubén Oscar Krolewiecki, Alejandro Javier Albonico, Marco Gobbo, Maria Bonafini, Stefania Angheben, Andrea Requena-Mendez, Ana Muñoz, José Nutman, Thomas B. |
author2_role |
author author author author author author author author author author author author |
dc.subject.none.fl_str_mv |
Strongyloides Stercoralis Serology Diagnostics Lips |
topic |
Strongyloides Stercoralis Serology Diagnostics Lips |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.3 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Background:The diagnosis of Strongyloides stercoralis (S. stercoralis) infection is hampered by the suboptimal sensitivity of fecal-based tests. Serological methods are believed to be more sensitive, although assessing their accuracy is difficult because of the lack of sensitivity of a fecal-based reference ("gold") standard.Methods:The sensitivity and specificity of 5 serologic tests for S. stercoralis (in-house IFAT, NIE-ELISA and NIE-LIPS and the commercially available Bordier-ELISA and IVD-ELISA) were assessed on 399 cryopreserved serum samples. Accuracy was measured using fecal results as the primary reference standard, but also using a composite reference standard (based on a combination of tests).Results:According to the latter standard, the most sensitive test was IFAT, with 94.6% sensitivity (91.2-96.9), followed by IVD-ELISA (92.3%, 87.7-96.9). The most specific test was NIE-LIPS, with specificity 99.6% (98.9-100), followed by IVD-ELISA (97.4%, 95.5-99.3). NIE-LIPS did not cross-react with any of the specimens from subjects with other parasitic infections. NIE-LIPS and the two commercial ELISAs approach 100% specificity at a cut off level that maintains ≥70% sensitivity.Conclusions:NIE-LIPS is the most accurate serologic test for the diagnosis of S. stercoralis infection. IFAT and each of the ELISA tests are sufficiently accurate, above a given cut off, for diagnosis, prevalence studies and inclusion in clinical trials. Fil: Bisoffi, Zeno. Sacro Cuore Hospital; Italia Fil: Buonfrate, Dora. Sacro Cuore Hospital; Italia Fil: Sequi, Marco. Istituto Di Ricerche Farmacologiche Mario Negri; Italia Fil: Mejia, Rojelio. National Institute Of Allergy And Infectious Diseases; Estados Unidos Fil: Cimino, Rubén Oscar. Universidad Nacional de Salta. Sede Regional Orán. Instituto de Investigación de Enfermedades Tropicales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Krolewiecki, Alejandro Javier. Universidad Nacional de Salta. Sede Regional Orán. Instituto de Investigación de Enfermedades Tropicales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Albonico, Marco. Sacro Cuore Hospital; Italia Fil: Gobbo, Maria. Sacro Cuore Hospital; Italia Fil: Bonafini, Stefania. Sacro Cuore Hospital; Italia Fil: Angheben, Andrea. Sacro Cuore Hospital; Italia Fil: Requena-Mendez, Ana. Universidad de Barcelona; España Fil: Muñoz, José. Universidad de Barcelona; España Fil: Nutman, Thomas B.. National Institute Of Allergy And Infectious Diseases; Estados Unidos |
description |
Background:The diagnosis of Strongyloides stercoralis (S. stercoralis) infection is hampered by the suboptimal sensitivity of fecal-based tests. Serological methods are believed to be more sensitive, although assessing their accuracy is difficult because of the lack of sensitivity of a fecal-based reference ("gold") standard.Methods:The sensitivity and specificity of 5 serologic tests for S. stercoralis (in-house IFAT, NIE-ELISA and NIE-LIPS and the commercially available Bordier-ELISA and IVD-ELISA) were assessed on 399 cryopreserved serum samples. Accuracy was measured using fecal results as the primary reference standard, but also using a composite reference standard (based on a combination of tests).Results:According to the latter standard, the most sensitive test was IFAT, with 94.6% sensitivity (91.2-96.9), followed by IVD-ELISA (92.3%, 87.7-96.9). The most specific test was NIE-LIPS, with specificity 99.6% (98.9-100), followed by IVD-ELISA (97.4%, 95.5-99.3). NIE-LIPS did not cross-react with any of the specimens from subjects with other parasitic infections. NIE-LIPS and the two commercial ELISAs approach 100% specificity at a cut off level that maintains ≥70% sensitivity.Conclusions:NIE-LIPS is the most accurate serologic test for the diagnosis of S. stercoralis infection. IFAT and each of the ELISA tests are sufficiently accurate, above a given cut off, for diagnosis, prevalence studies and inclusion in clinical trials. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-01 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/37122 Bisoffi, Zeno; Buonfrate, Dora; Sequi, Marco; Mejia, Rojelio; Cimino, Rubén Oscar; et al.; Diagnostic Accuracy of Five Serologic Tests for Strongyloides stercoralis Infection; Public Library of Science; Neglected Tropical Diseases; 8; 1; 1-2014; 1-8; e2640 1935-2735 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/37122 |
identifier_str_mv |
Bisoffi, Zeno; Buonfrate, Dora; Sequi, Marco; Mejia, Rojelio; Cimino, Rubén Oscar; et al.; Diagnostic Accuracy of Five Serologic Tests for Strongyloides stercoralis Infection; Public Library of Science; Neglected Tropical Diseases; 8; 1; 1-2014; 1-8; e2640 1935-2735 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pntd.0002640 info:eu-repo/semantics/altIdentifier/url/http://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0002640 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Public Library of Science |
publisher.none.fl_str_mv |
Public Library of Science |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
_version_ |
1842268889571917824 |
score |
13.13397 |