Comparative Immunological Effect of Anticoagulant and Antioxidant Therapy in the Prevention of Abortion in Mice

Autores
Junovich, Gisela Yael; Dubinsky, Valeria Rosalía; Gentile, Teresa; Sarto, Adriana; Pasqualini, Sergio; Gutierrez, Gabriela Lidia
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Problem Considering the potential adverse effects of anticoagulation in abortion treatment, we investigate whether antioxidants might exert the same immunoprotection. Although the fertility properties of Vitamin E have been associated with its antioxidant capacity, its effect on cytokine balance during pregnancy is still unknown. Method of study Pregnant females from CBA/J x DBA/2 abortion model were orally supplemented with Vitamin E or inoculated intraperitoneally with enoxaparin. Foeto-placental units were scored at 14.5 days of pregnancy, and abortion rate was calculated. Cytokine placental levels were determined by enzyme-linked immunosorbent assay. Results Vitamin E (15 mg/day) has been able to decrease abortion rate and to increase IL-6 placental levels, while both treatments increased vascular endothelial growth factor (VEGF) placental levels. Conclusion Vitamin E and enoxaparin are able not only to prevent foetal wastage but also to balance IL-6 and VEGF placental levels, presenting a new potential therapeutic alternative for patients with recurrent abortion not associated with thrombophilias.
Fil: Junovich, Gisela Yael. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral "Profesor R. A. Margni"; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Halitus Instituto Medico; Argentina
Fil: Dubinsky, Valeria Rosalía. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral "Profesor R. A. Margni"; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Halitus Instituto Medico; Argentina
Fil: Gentile, Teresa. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral "Profesor R. A. Margni"; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Sarto, Adriana. Halitus Instituto Medico; Argentina
Fil: Pasqualini, Sergio. Halitus Instituto Medico; Argentina
Fil: Gutierrez, Gabriela Lidia. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral "Profesor R. A. Margni"; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Halitus Instituto Medico; Argentina
Materia
Antioxidant Therapy
Prevention of Abortion
Anticoagulant, Il-6, Vegf
Vitamin E
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/15328
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/15328
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Comparative Immunological Effect of Anticoagulant and Antioxidant Therapy in the Prevention of Abortion in MiceJunovich, Gisela YaelDubinsky, Valeria RosalíaGentile, TeresaSarto, AdrianaPasqualini, SergioGutierrez, Gabriela LidiaAntioxidant TherapyPrevention of AbortionAnticoagulant, Il-6, VegfVitamin Ehttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Problem Considering the potential adverse effects of anticoagulation in abortion treatment, we investigate whether antioxidants might exert the same immunoprotection. Although the fertility properties of Vitamin E have been associated with its antioxidant capacity, its effect on cytokine balance during pregnancy is still unknown. Method of study Pregnant females from CBA/J x DBA/2 abortion model were orally supplemented with Vitamin E or inoculated intraperitoneally with enoxaparin. Foeto-placental units were scored at 14.5 days of pregnancy, and abortion rate was calculated. Cytokine placental levels were determined by enzyme-linked immunosorbent assay. Results Vitamin E (15 mg/day) has been able to decrease abortion rate and to increase IL-6 placental levels, while both treatments increased vascular endothelial growth factor (VEGF) placental levels. Conclusion Vitamin E and enoxaparin are able not only to prevent foetal wastage but also to balance IL-6 and VEGF placental levels, presenting a new potential therapeutic alternative for patients with recurrent abortion not associated with thrombophilias.Fil: Junovich, Gisela Yael. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral "Profesor R. A. Margni"; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Halitus Instituto Medico; ArgentinaFil: Dubinsky, Valeria Rosalía. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral "Profesor R. A. Margni"; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Halitus Instituto Medico; ArgentinaFil: Gentile, Teresa. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral "Profesor R. A. Margni"; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; ArgentinaFil: Sarto, Adriana. Halitus Instituto Medico; ArgentinaFil: Pasqualini, Sergio. Halitus Instituto Medico; ArgentinaFil: Gutierrez, Gabriela Lidia. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral "Profesor R. A. Margni"; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Halitus Instituto Medico; ArgentinaWiley2011-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/15328Junovich, Gisela Yael; Dubinsky, Valeria Rosalía; Gentile, Teresa; Sarto, Adriana; Pasqualini, Sergio; et al.; Comparative Immunological Effect of Anticoagulant and Antioxidant Therapy in the Prevention of Abortion in Mice; Wiley; American Journal Of Reproductive Immunology; 65; 2; 2-2011; 104-1091046-7408enginfo:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1111/j.1600-0897.2010.00896.x/abstractinfo:eu-repo/semantics/altIdentifier/doi/10.1111/j.1600-0897.2010.00896.xinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:39:09Zoai:ri.conicet.gov.ar:11336/15328instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:39:09.286CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Comparative Immunological Effect of Anticoagulant and Antioxidant Therapy in the Prevention of Abortion in Mice
title Comparative Immunological Effect of Anticoagulant and Antioxidant Therapy in the Prevention of Abortion in Mice
spellingShingle Comparative Immunological Effect of Anticoagulant and Antioxidant Therapy in the Prevention of Abortion in Mice
Junovich, Gisela Yael
Antioxidant Therapy
Prevention of Abortion
Anticoagulant, Il-6, Vegf
Vitamin E
title_short Comparative Immunological Effect of Anticoagulant and Antioxidant Therapy in the Prevention of Abortion in Mice
title_full Comparative Immunological Effect of Anticoagulant and Antioxidant Therapy in the Prevention of Abortion in Mice
title_fullStr Comparative Immunological Effect of Anticoagulant and Antioxidant Therapy in the Prevention of Abortion in Mice
title_full_unstemmed Comparative Immunological Effect of Anticoagulant and Antioxidant Therapy in the Prevention of Abortion in Mice
title_sort Comparative Immunological Effect of Anticoagulant and Antioxidant Therapy in the Prevention of Abortion in Mice
dc.creator.none.fl_str_mv Junovich, Gisela Yael
Dubinsky, Valeria Rosalía
Gentile, Teresa
Sarto, Adriana
Pasqualini, Sergio
Gutierrez, Gabriela Lidia
author Junovich, Gisela Yael
author_facet Junovich, Gisela Yael
Dubinsky, Valeria Rosalía
Gentile, Teresa
Sarto, Adriana
Pasqualini, Sergio
Gutierrez, Gabriela Lidia
author_role author
author2 Dubinsky, Valeria Rosalía
Gentile, Teresa
Sarto, Adriana
Pasqualini, Sergio
Gutierrez, Gabriela Lidia
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Antioxidant Therapy
Prevention of Abortion
Anticoagulant, Il-6, Vegf
Vitamin E
topic Antioxidant Therapy
Prevention of Abortion
Anticoagulant, Il-6, Vegf
Vitamin E
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Problem Considering the potential adverse effects of anticoagulation in abortion treatment, we investigate whether antioxidants might exert the same immunoprotection. Although the fertility properties of Vitamin E have been associated with its antioxidant capacity, its effect on cytokine balance during pregnancy is still unknown. Method of study Pregnant females from CBA/J x DBA/2 abortion model were orally supplemented with Vitamin E or inoculated intraperitoneally with enoxaparin. Foeto-placental units were scored at 14.5 days of pregnancy, and abortion rate was calculated. Cytokine placental levels were determined by enzyme-linked immunosorbent assay. Results Vitamin E (15 mg/day) has been able to decrease abortion rate and to increase IL-6 placental levels, while both treatments increased vascular endothelial growth factor (VEGF) placental levels. Conclusion Vitamin E and enoxaparin are able not only to prevent foetal wastage but also to balance IL-6 and VEGF placental levels, presenting a new potential therapeutic alternative for patients with recurrent abortion not associated with thrombophilias.
Fil: Junovich, Gisela Yael. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral "Profesor R. A. Margni"; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Halitus Instituto Medico; Argentina
Fil: Dubinsky, Valeria Rosalía. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral "Profesor R. A. Margni"; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Halitus Instituto Medico; Argentina
Fil: Gentile, Teresa. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral "Profesor R. A. Margni"; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Sarto, Adriana. Halitus Instituto Medico; Argentina
Fil: Pasqualini, Sergio. Halitus Instituto Medico; Argentina
Fil: Gutierrez, Gabriela Lidia. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral "Profesor R. A. Margni"; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Halitus Instituto Medico; Argentina
description Problem Considering the potential adverse effects of anticoagulation in abortion treatment, we investigate whether antioxidants might exert the same immunoprotection. Although the fertility properties of Vitamin E have been associated with its antioxidant capacity, its effect on cytokine balance during pregnancy is still unknown. Method of study Pregnant females from CBA/J x DBA/2 abortion model were orally supplemented with Vitamin E or inoculated intraperitoneally with enoxaparin. Foeto-placental units were scored at 14.5 days of pregnancy, and abortion rate was calculated. Cytokine placental levels were determined by enzyme-linked immunosorbent assay. Results Vitamin E (15 mg/day) has been able to decrease abortion rate and to increase IL-6 placental levels, while both treatments increased vascular endothelial growth factor (VEGF) placental levels. Conclusion Vitamin E and enoxaparin are able not only to prevent foetal wastage but also to balance IL-6 and VEGF placental levels, presenting a new potential therapeutic alternative for patients with recurrent abortion not associated with thrombophilias.
publishDate 2011
dc.date.none.fl_str_mv 2011-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/15328
Junovich, Gisela Yael; Dubinsky, Valeria Rosalía; Gentile, Teresa; Sarto, Adriana; Pasqualini, Sergio; et al.; Comparative Immunological Effect of Anticoagulant and Antioxidant Therapy in the Prevention of Abortion in Mice; Wiley; American Journal Of Reproductive Immunology; 65; 2; 2-2011; 104-109
1046-7408
url http://hdl.handle.net/11336/15328
identifier_str_mv Junovich, Gisela Yael; Dubinsky, Valeria Rosalía; Gentile, Teresa; Sarto, Adriana; Pasqualini, Sergio; et al.; Comparative Immunological Effect of Anticoagulant and Antioxidant Therapy in the Prevention of Abortion in Mice; Wiley; American Journal Of Reproductive Immunology; 65; 2; 2-2011; 104-109
1046-7408
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1111/j.1600-0897.2010.00896.x/abstract
info:eu-repo/semantics/altIdentifier/doi/10.1111/j.1600-0897.2010.00896.x
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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