Recurrences of multidrug‐resistant tuberculosis: Strains involved, within‐host diversity, and fine‐tuned allocation of reinfections
- Autores
- Pérez Lago, Laura; Monteserin, Johana; Paul, Roxana Elizabeth; Maus, Sandra R.; Yokobori, Noemí; Herranz, Marta; Sicilia, Jon; Acosta, Fermín Eloy; Fajardo, Sandra; Chiner Oms, Álvaro; Matteo, Mario José; Símboli, Norberto Fabián; Comas, Iñaki; Muñoz, Patricia; López, Beatriz; Ritacco, Gloria Viviana; García de Viedma, Darío
- Año de publicación
- 2022
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Recurrent tuberculosis occurs due to exogenous reinfection or reactivation/persistence. We analysed 90 sequential MDR Mtb isolates obtained in Argentina from 27 patients with previously diagnosed MDR-TB that recurred in 2018 (1–10 years, 2–10 isolates per patient). Three long-term predominant strains were responsible for 63% of all MDR-TB recurrences. Most of the remaining patients were infected by strains different from each other. Reactivation/persistence of the same strain caused all but one recurrence, which was due to a reinfection with a predominant strain. One of the prevalent strains showed marked stability in the recurrences, while in another strain higher SNP-based diversity was observed. Comparisons of intra- versus inter-patient SNP distances identified two possible reinfections with closely related variants circulating in the community. Our results show a complex scenario of MDR-TB infections in settings with predominant MDR Mtb strains.
Fil: Pérez Lago, Laura. Hospital General Universitario Gregorio Marañón (hosp Gral Univ G. Marañón); España
Fil: Monteserin, Johana. Administración Nacional de Laboratorio e Institutos de Salud "Dr. Carlos G. Malbrán". Instituto Nacional de Epidemiologia. Departamento de Investigación; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Paul, Roxana Elizabeth. Administración Nacional de Laboratorio e Institutos de Salud "Dr. Carlos G. Malbrán". Instituto Nacional de Epidemiologia. Departamento de Investigación; Argentina
Fil: Maus, Sandra R.. Hospital General Universitario Gregorio Marañón (hosp Gral Univ G. Marañón); España
Fil: Yokobori, Noemí. Administración Nacional de Laboratorio e Institutos de Salud "Dr. Carlos G. Malbrán". Instituto Nacional de Epidemiologia. Departamento de Investigación; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Herranz, Marta. Hospital General Universitario Gregorio Marañón (hosp Gral Univ G. Marañón); España
Fil: Sicilia, Jon. Hospital General Universitario Gregorio Marañón (hosp Gral Univ G. Marañón); España
Fil: Acosta, Fermín Eloy. Hospital General Universitario Gregorio Marañón (hosp Gral Univ G. Marañón); España
Fil: Fajardo, Sandra. Centro Regional de estudios Bioquímicos de la Tuberculosis; Argentina
Fil: Chiner Oms, Álvaro. Consejo Superior de Investigaciones Científicas; España
Fil: Matteo, Mario José. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Tisioneumonología "raúl F. Vaccarezza".; Argentina
Fil: Símboli, Norberto Fabián. Administración Nacional de Laboratorio e Institutos de Salud "Dr. Carlos G. Malbrán". Instituto Nacional de Epidemiologia. Departamento de Investigación; Argentina
Fil: Comas, Iñaki. Consejo Superior de Investigaciones Científicas; España
Fil: Muñoz, Patricia. Hospital General Universitario Gregorio Marañón (hosp Gral Univ G. Marañón); España. Universidad Complutense de Madrid; España
Fil: López, Beatriz. Administración Nacional de Laboratorio e Institutos de Salud "Dr. Carlos G. Malbrán". Instituto Nacional de Epidemiologia. Departamento de Investigación; Argentina
Fil: Ritacco, Gloria Viviana. Administración Nacional de Laboratorio e Institutos de Salud "Dr. Carlos G. Malbrán". Instituto Nacional de Epidemiologia. Departamento de Investigación; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: García de Viedma, Darío. Hospital General Universitario Gregorio Marañón (hosp Gral Univ G. Marañón); España - Materia
-
MDR
Tuberculosis
WGS
Clonal variants
Molecular epidemiology
Recurrences
Reinfection - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/163996
Ver los metadatos del registro completo
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Recurrences of multidrug‐resistant tuberculosis: Strains involved, within‐host diversity, and fine‐tuned allocation of reinfectionsPérez Lago, LauraMonteserin, JohanaPaul, Roxana ElizabethMaus, Sandra R.Yokobori, NoemíHerranz, MartaSicilia, JonAcosta, Fermín EloyFajardo, SandraChiner Oms, ÁlvaroMatteo, Mario JoséSímboli, Norberto FabiánComas, IñakiMuñoz, PatriciaLópez, BeatrizRitacco, Gloria VivianaGarcía de Viedma, DaríoMDRTuberculosisWGSClonal variantsMolecular epidemiologyRecurrencesReinfectionhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Recurrent tuberculosis occurs due to exogenous reinfection or reactivation/persistence. We analysed 90 sequential MDR Mtb isolates obtained in Argentina from 27 patients with previously diagnosed MDR-TB that recurred in 2018 (1–10 years, 2–10 isolates per patient). Three long-term predominant strains were responsible for 63% of all MDR-TB recurrences. Most of the remaining patients were infected by strains different from each other. Reactivation/persistence of the same strain caused all but one recurrence, which was due to a reinfection with a predominant strain. One of the prevalent strains showed marked stability in the recurrences, while in another strain higher SNP-based diversity was observed. Comparisons of intra- versus inter-patient SNP distances identified two possible reinfections with closely related variants circulating in the community. Our results show a complex scenario of MDR-TB infections in settings with predominant MDR Mtb strains.Fil: Pérez Lago, Laura. Hospital General Universitario Gregorio Marañón (hosp Gral Univ G. Marañón); EspañaFil: Monteserin, Johana. Administración Nacional de Laboratorio e Institutos de Salud "Dr. Carlos G. Malbrán". Instituto Nacional de Epidemiologia. Departamento de Investigación; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Paul, Roxana Elizabeth. Administración Nacional de Laboratorio e Institutos de Salud "Dr. Carlos G. Malbrán". Instituto Nacional de Epidemiologia. Departamento de Investigación; ArgentinaFil: Maus, Sandra R.. Hospital General Universitario Gregorio Marañón (hosp Gral Univ G. Marañón); EspañaFil: Yokobori, Noemí. Administración Nacional de Laboratorio e Institutos de Salud "Dr. Carlos G. Malbrán". Instituto Nacional de Epidemiologia. Departamento de Investigación; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Herranz, Marta. Hospital General Universitario Gregorio Marañón (hosp Gral Univ G. Marañón); EspañaFil: Sicilia, Jon. Hospital General Universitario Gregorio Marañón (hosp Gral Univ G. Marañón); EspañaFil: Acosta, Fermín Eloy. Hospital General Universitario Gregorio Marañón (hosp Gral Univ G. Marañón); EspañaFil: Fajardo, Sandra. Centro Regional de estudios Bioquímicos de la Tuberculosis; ArgentinaFil: Chiner Oms, Álvaro. Consejo Superior de Investigaciones Científicas; EspañaFil: Matteo, Mario José. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Tisioneumonología "raúl F. Vaccarezza".; ArgentinaFil: Símboli, Norberto Fabián. Administración Nacional de Laboratorio e Institutos de Salud "Dr. Carlos G. Malbrán". Instituto Nacional de Epidemiologia. Departamento de Investigación; ArgentinaFil: Comas, Iñaki. Consejo Superior de Investigaciones Científicas; EspañaFil: Muñoz, Patricia. Hospital General Universitario Gregorio Marañón (hosp Gral Univ G. Marañón); España. Universidad Complutense de Madrid; EspañaFil: López, Beatriz. Administración Nacional de Laboratorio e Institutos de Salud "Dr. Carlos G. Malbrán". Instituto Nacional de Epidemiologia. Departamento de Investigación; ArgentinaFil: Ritacco, Gloria Viviana. Administración Nacional de Laboratorio e Institutos de Salud "Dr. Carlos G. Malbrán". Instituto Nacional de Epidemiologia. Departamento de Investigación; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: García de Viedma, Darío. Hospital General Universitario Gregorio Marañón (hosp Gral Univ G. Marañón); EspañaWiley Blackwell Publishing, Inc2022-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/163996Pérez Lago, Laura; Monteserin, Johana; Paul, Roxana Elizabeth; Maus, Sandra R.; Yokobori, Noemí; et al.; Recurrences of multidrug‐resistant tuberculosis: Strains involved, within‐host diversity, and fine‐tuned allocation of reinfections; Wiley Blackwell Publishing, Inc; Transboundary And Emerging Diseases; 69; 2; 3-2022; 327-3361865-16741865-1682CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/10.1111/tbed.13982info:eu-repo/semantics/altIdentifier/doi/10.1111/tbed.13982info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:40:06Zoai:ri.conicet.gov.ar:11336/163996instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:40:07.107CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Recurrences of multidrug‐resistant tuberculosis: Strains involved, within‐host diversity, and fine‐tuned allocation of reinfections |
title |
Recurrences of multidrug‐resistant tuberculosis: Strains involved, within‐host diversity, and fine‐tuned allocation of reinfections |
spellingShingle |
Recurrences of multidrug‐resistant tuberculosis: Strains involved, within‐host diversity, and fine‐tuned allocation of reinfections Pérez Lago, Laura MDR Tuberculosis WGS Clonal variants Molecular epidemiology Recurrences Reinfection |
title_short |
Recurrences of multidrug‐resistant tuberculosis: Strains involved, within‐host diversity, and fine‐tuned allocation of reinfections |
title_full |
Recurrences of multidrug‐resistant tuberculosis: Strains involved, within‐host diversity, and fine‐tuned allocation of reinfections |
title_fullStr |
Recurrences of multidrug‐resistant tuberculosis: Strains involved, within‐host diversity, and fine‐tuned allocation of reinfections |
title_full_unstemmed |
Recurrences of multidrug‐resistant tuberculosis: Strains involved, within‐host diversity, and fine‐tuned allocation of reinfections |
title_sort |
Recurrences of multidrug‐resistant tuberculosis: Strains involved, within‐host diversity, and fine‐tuned allocation of reinfections |
dc.creator.none.fl_str_mv |
Pérez Lago, Laura Monteserin, Johana Paul, Roxana Elizabeth Maus, Sandra R. Yokobori, Noemí Herranz, Marta Sicilia, Jon Acosta, Fermín Eloy Fajardo, Sandra Chiner Oms, Álvaro Matteo, Mario José Símboli, Norberto Fabián Comas, Iñaki Muñoz, Patricia López, Beatriz Ritacco, Gloria Viviana García de Viedma, Darío |
author |
Pérez Lago, Laura |
author_facet |
Pérez Lago, Laura Monteserin, Johana Paul, Roxana Elizabeth Maus, Sandra R. Yokobori, Noemí Herranz, Marta Sicilia, Jon Acosta, Fermín Eloy Fajardo, Sandra Chiner Oms, Álvaro Matteo, Mario José Símboli, Norberto Fabián Comas, Iñaki Muñoz, Patricia López, Beatriz Ritacco, Gloria Viviana García de Viedma, Darío |
author_role |
author |
author2 |
Monteserin, Johana Paul, Roxana Elizabeth Maus, Sandra R. Yokobori, Noemí Herranz, Marta Sicilia, Jon Acosta, Fermín Eloy Fajardo, Sandra Chiner Oms, Álvaro Matteo, Mario José Símboli, Norberto Fabián Comas, Iñaki Muñoz, Patricia López, Beatriz Ritacco, Gloria Viviana García de Viedma, Darío |
author2_role |
author author author author author author author author author author author author author author author author |
dc.subject.none.fl_str_mv |
MDR Tuberculosis WGS Clonal variants Molecular epidemiology Recurrences Reinfection |
topic |
MDR Tuberculosis WGS Clonal variants Molecular epidemiology Recurrences Reinfection |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.3 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Recurrent tuberculosis occurs due to exogenous reinfection or reactivation/persistence. We analysed 90 sequential MDR Mtb isolates obtained in Argentina from 27 patients with previously diagnosed MDR-TB that recurred in 2018 (1–10 years, 2–10 isolates per patient). Three long-term predominant strains were responsible for 63% of all MDR-TB recurrences. Most of the remaining patients were infected by strains different from each other. Reactivation/persistence of the same strain caused all but one recurrence, which was due to a reinfection with a predominant strain. One of the prevalent strains showed marked stability in the recurrences, while in another strain higher SNP-based diversity was observed. Comparisons of intra- versus inter-patient SNP distances identified two possible reinfections with closely related variants circulating in the community. Our results show a complex scenario of MDR-TB infections in settings with predominant MDR Mtb strains. Fil: Pérez Lago, Laura. Hospital General Universitario Gregorio Marañón (hosp Gral Univ G. Marañón); España Fil: Monteserin, Johana. Administración Nacional de Laboratorio e Institutos de Salud "Dr. Carlos G. Malbrán". Instituto Nacional de Epidemiologia. Departamento de Investigación; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Paul, Roxana Elizabeth. Administración Nacional de Laboratorio e Institutos de Salud "Dr. Carlos G. Malbrán". Instituto Nacional de Epidemiologia. Departamento de Investigación; Argentina Fil: Maus, Sandra R.. Hospital General Universitario Gregorio Marañón (hosp Gral Univ G. Marañón); España Fil: Yokobori, Noemí. Administración Nacional de Laboratorio e Institutos de Salud "Dr. Carlos G. Malbrán". Instituto Nacional de Epidemiologia. Departamento de Investigación; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Herranz, Marta. Hospital General Universitario Gregorio Marañón (hosp Gral Univ G. Marañón); España Fil: Sicilia, Jon. Hospital General Universitario Gregorio Marañón (hosp Gral Univ G. Marañón); España Fil: Acosta, Fermín Eloy. Hospital General Universitario Gregorio Marañón (hosp Gral Univ G. Marañón); España Fil: Fajardo, Sandra. Centro Regional de estudios Bioquímicos de la Tuberculosis; Argentina Fil: Chiner Oms, Álvaro. Consejo Superior de Investigaciones Científicas; España Fil: Matteo, Mario José. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Tisioneumonología "raúl F. Vaccarezza".; Argentina Fil: Símboli, Norberto Fabián. Administración Nacional de Laboratorio e Institutos de Salud "Dr. Carlos G. Malbrán". Instituto Nacional de Epidemiologia. Departamento de Investigación; Argentina Fil: Comas, Iñaki. Consejo Superior de Investigaciones Científicas; España Fil: Muñoz, Patricia. Hospital General Universitario Gregorio Marañón (hosp Gral Univ G. Marañón); España. Universidad Complutense de Madrid; España Fil: López, Beatriz. Administración Nacional de Laboratorio e Institutos de Salud "Dr. Carlos G. Malbrán". Instituto Nacional de Epidemiologia. Departamento de Investigación; Argentina Fil: Ritacco, Gloria Viviana. Administración Nacional de Laboratorio e Institutos de Salud "Dr. Carlos G. Malbrán". Instituto Nacional de Epidemiologia. Departamento de Investigación; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: García de Viedma, Darío. Hospital General Universitario Gregorio Marañón (hosp Gral Univ G. Marañón); España |
description |
Recurrent tuberculosis occurs due to exogenous reinfection or reactivation/persistence. We analysed 90 sequential MDR Mtb isolates obtained in Argentina from 27 patients with previously diagnosed MDR-TB that recurred in 2018 (1–10 years, 2–10 isolates per patient). Three long-term predominant strains were responsible for 63% of all MDR-TB recurrences. Most of the remaining patients were infected by strains different from each other. Reactivation/persistence of the same strain caused all but one recurrence, which was due to a reinfection with a predominant strain. One of the prevalent strains showed marked stability in the recurrences, while in another strain higher SNP-based diversity was observed. Comparisons of intra- versus inter-patient SNP distances identified two possible reinfections with closely related variants circulating in the community. Our results show a complex scenario of MDR-TB infections in settings with predominant MDR Mtb strains. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-03 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/163996 Pérez Lago, Laura; Monteserin, Johana; Paul, Roxana Elizabeth; Maus, Sandra R.; Yokobori, Noemí; et al.; Recurrences of multidrug‐resistant tuberculosis: Strains involved, within‐host diversity, and fine‐tuned allocation of reinfections; Wiley Blackwell Publishing, Inc; Transboundary And Emerging Diseases; 69; 2; 3-2022; 327-336 1865-1674 1865-1682 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/163996 |
identifier_str_mv |
Pérez Lago, Laura; Monteserin, Johana; Paul, Roxana Elizabeth; Maus, Sandra R.; Yokobori, Noemí; et al.; Recurrences of multidrug‐resistant tuberculosis: Strains involved, within‐host diversity, and fine‐tuned allocation of reinfections; Wiley Blackwell Publishing, Inc; Transboundary And Emerging Diseases; 69; 2; 3-2022; 327-336 1865-1674 1865-1682 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/10.1111/tbed.13982 info:eu-repo/semantics/altIdentifier/doi/10.1111/tbed.13982 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Wiley Blackwell Publishing, Inc |
publisher.none.fl_str_mv |
Wiley Blackwell Publishing, Inc |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844613268843266048 |
score |
13.070432 |