Recurrences of multidrug‐resistant tuberculosis: Strains involved, within‐host diversity, and fine‐tuned allocation of reinfections

Autores
Pérez Lago, Laura; Monteserin, Johana; Paul, Roxana Elizabeth; Maus, Sandra R.; Yokobori, Noemí; Herranz, Marta; Sicilia, Jon; Acosta, Fermín Eloy; Fajardo, Sandra; Chiner Oms, Álvaro; Matteo, Mario José; Símboli, Norberto Fabián; Comas, Iñaki; Muñoz, Patricia; López, Beatriz; Ritacco, Gloria Viviana; García de Viedma, Darío
Año de publicación
2022
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Recurrent tuberculosis occurs due to exogenous reinfection or reactivation/persistence. We analysed 90 sequential MDR Mtb isolates obtained in Argentina from 27 patients with previously diagnosed MDR-TB that recurred in 2018 (1–10 years, 2–10 isolates per patient). Three long-term predominant strains were responsible for 63% of all MDR-TB recurrences. Most of the remaining patients were infected by strains different from each other. Reactivation/persistence of the same strain caused all but one recurrence, which was due to a reinfection with a predominant strain. One of the prevalent strains showed marked stability in the recurrences, while in another strain higher SNP-based diversity was observed. Comparisons of intra- versus inter-patient SNP distances identified two possible reinfections with closely related variants circulating in the community. Our results show a complex scenario of MDR-TB infections in settings with predominant MDR Mtb strains.
Fil: Pérez Lago, Laura. Hospital General Universitario Gregorio Marañón (hosp Gral Univ G. Marañón); España
Fil: Monteserin, Johana. Administración Nacional de Laboratorio e Institutos de Salud "Dr. Carlos G. Malbrán". Instituto Nacional de Epidemiologia. Departamento de Investigación; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Paul, Roxana Elizabeth. Administración Nacional de Laboratorio e Institutos de Salud "Dr. Carlos G. Malbrán". Instituto Nacional de Epidemiologia. Departamento de Investigación; Argentina
Fil: Maus, Sandra R.. Hospital General Universitario Gregorio Marañón (hosp Gral Univ G. Marañón); España
Fil: Yokobori, Noemí. Administración Nacional de Laboratorio e Institutos de Salud "Dr. Carlos G. Malbrán". Instituto Nacional de Epidemiologia. Departamento de Investigación; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Herranz, Marta. Hospital General Universitario Gregorio Marañón (hosp Gral Univ G. Marañón); España
Fil: Sicilia, Jon. Hospital General Universitario Gregorio Marañón (hosp Gral Univ G. Marañón); España
Fil: Acosta, Fermín Eloy. Hospital General Universitario Gregorio Marañón (hosp Gral Univ G. Marañón); España
Fil: Fajardo, Sandra. Centro Regional de estudios Bioquímicos de la Tuberculosis; Argentina
Fil: Chiner Oms, Álvaro. Consejo Superior de Investigaciones Científicas; España
Fil: Matteo, Mario José. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Tisioneumonología "raúl F. Vaccarezza".; Argentina
Fil: Símboli, Norberto Fabián. Administración Nacional de Laboratorio e Institutos de Salud "Dr. Carlos G. Malbrán". Instituto Nacional de Epidemiologia. Departamento de Investigación; Argentina
Fil: Comas, Iñaki. Consejo Superior de Investigaciones Científicas; España
Fil: Muñoz, Patricia. Hospital General Universitario Gregorio Marañón (hosp Gral Univ G. Marañón); España. Universidad Complutense de Madrid; España
Fil: López, Beatriz. Administración Nacional de Laboratorio e Institutos de Salud "Dr. Carlos G. Malbrán". Instituto Nacional de Epidemiologia. Departamento de Investigación; Argentina
Fil: Ritacco, Gloria Viviana. Administración Nacional de Laboratorio e Institutos de Salud "Dr. Carlos G. Malbrán". Instituto Nacional de Epidemiologia. Departamento de Investigación; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: García de Viedma, Darío. Hospital General Universitario Gregorio Marañón (hosp Gral Univ G. Marañón); España
Materia
MDR
Tuberculosis
WGS
Clonal variants
Molecular epidemiology
Recurrences
Reinfection
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/163996

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network_name_str CONICET Digital (CONICET)
spelling Recurrences of multidrug‐resistant tuberculosis: Strains involved, within‐host diversity, and fine‐tuned allocation of reinfectionsPérez Lago, LauraMonteserin, JohanaPaul, Roxana ElizabethMaus, Sandra R.Yokobori, NoemíHerranz, MartaSicilia, JonAcosta, Fermín EloyFajardo, SandraChiner Oms, ÁlvaroMatteo, Mario JoséSímboli, Norberto FabiánComas, IñakiMuñoz, PatriciaLópez, BeatrizRitacco, Gloria VivianaGarcía de Viedma, DaríoMDRTuberculosisWGSClonal variantsMolecular epidemiologyRecurrencesReinfectionhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Recurrent tuberculosis occurs due to exogenous reinfection or reactivation/persistence. We analysed 90 sequential MDR Mtb isolates obtained in Argentina from 27 patients with previously diagnosed MDR-TB that recurred in 2018 (1–10 years, 2–10 isolates per patient). Three long-term predominant strains were responsible for 63% of all MDR-TB recurrences. Most of the remaining patients were infected by strains different from each other. Reactivation/persistence of the same strain caused all but one recurrence, which was due to a reinfection with a predominant strain. One of the prevalent strains showed marked stability in the recurrences, while in another strain higher SNP-based diversity was observed. Comparisons of intra- versus inter-patient SNP distances identified two possible reinfections with closely related variants circulating in the community. Our results show a complex scenario of MDR-TB infections in settings with predominant MDR Mtb strains.Fil: Pérez Lago, Laura. Hospital General Universitario Gregorio Marañón (hosp Gral Univ G. Marañón); EspañaFil: Monteserin, Johana. Administración Nacional de Laboratorio e Institutos de Salud "Dr. Carlos G. Malbrán". Instituto Nacional de Epidemiologia. Departamento de Investigación; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Paul, Roxana Elizabeth. Administración Nacional de Laboratorio e Institutos de Salud "Dr. Carlos G. Malbrán". Instituto Nacional de Epidemiologia. Departamento de Investigación; ArgentinaFil: Maus, Sandra R.. Hospital General Universitario Gregorio Marañón (hosp Gral Univ G. Marañón); EspañaFil: Yokobori, Noemí. Administración Nacional de Laboratorio e Institutos de Salud "Dr. Carlos G. Malbrán". Instituto Nacional de Epidemiologia. Departamento de Investigación; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Herranz, Marta. Hospital General Universitario Gregorio Marañón (hosp Gral Univ G. Marañón); EspañaFil: Sicilia, Jon. Hospital General Universitario Gregorio Marañón (hosp Gral Univ G. Marañón); EspañaFil: Acosta, Fermín Eloy. Hospital General Universitario Gregorio Marañón (hosp Gral Univ G. Marañón); EspañaFil: Fajardo, Sandra. Centro Regional de estudios Bioquímicos de la Tuberculosis; ArgentinaFil: Chiner Oms, Álvaro. Consejo Superior de Investigaciones Científicas; EspañaFil: Matteo, Mario José. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Tisioneumonología "raúl F. Vaccarezza".; ArgentinaFil: Símboli, Norberto Fabián. Administración Nacional de Laboratorio e Institutos de Salud "Dr. Carlos G. Malbrán". Instituto Nacional de Epidemiologia. Departamento de Investigación; ArgentinaFil: Comas, Iñaki. Consejo Superior de Investigaciones Científicas; EspañaFil: Muñoz, Patricia. Hospital General Universitario Gregorio Marañón (hosp Gral Univ G. Marañón); España. Universidad Complutense de Madrid; EspañaFil: López, Beatriz. Administración Nacional de Laboratorio e Institutos de Salud "Dr. Carlos G. Malbrán". Instituto Nacional de Epidemiologia. Departamento de Investigación; ArgentinaFil: Ritacco, Gloria Viviana. Administración Nacional de Laboratorio e Institutos de Salud "Dr. Carlos G. Malbrán". Instituto Nacional de Epidemiologia. Departamento de Investigación; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: García de Viedma, Darío. Hospital General Universitario Gregorio Marañón (hosp Gral Univ G. Marañón); EspañaWiley Blackwell Publishing, Inc2022-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/163996Pérez Lago, Laura; Monteserin, Johana; Paul, Roxana Elizabeth; Maus, Sandra R.; Yokobori, Noemí; et al.; Recurrences of multidrug‐resistant tuberculosis: Strains involved, within‐host diversity, and fine‐tuned allocation of reinfections; Wiley Blackwell Publishing, Inc; Transboundary And Emerging Diseases; 69; 2; 3-2022; 327-3361865-16741865-1682CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/10.1111/tbed.13982info:eu-repo/semantics/altIdentifier/doi/10.1111/tbed.13982info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:40:06Zoai:ri.conicet.gov.ar:11336/163996instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:40:07.107CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Recurrences of multidrug‐resistant tuberculosis: Strains involved, within‐host diversity, and fine‐tuned allocation of reinfections
title Recurrences of multidrug‐resistant tuberculosis: Strains involved, within‐host diversity, and fine‐tuned allocation of reinfections
spellingShingle Recurrences of multidrug‐resistant tuberculosis: Strains involved, within‐host diversity, and fine‐tuned allocation of reinfections
Pérez Lago, Laura
MDR
Tuberculosis
WGS
Clonal variants
Molecular epidemiology
Recurrences
Reinfection
title_short Recurrences of multidrug‐resistant tuberculosis: Strains involved, within‐host diversity, and fine‐tuned allocation of reinfections
title_full Recurrences of multidrug‐resistant tuberculosis: Strains involved, within‐host diversity, and fine‐tuned allocation of reinfections
title_fullStr Recurrences of multidrug‐resistant tuberculosis: Strains involved, within‐host diversity, and fine‐tuned allocation of reinfections
title_full_unstemmed Recurrences of multidrug‐resistant tuberculosis: Strains involved, within‐host diversity, and fine‐tuned allocation of reinfections
title_sort Recurrences of multidrug‐resistant tuberculosis: Strains involved, within‐host diversity, and fine‐tuned allocation of reinfections
dc.creator.none.fl_str_mv Pérez Lago, Laura
Monteserin, Johana
Paul, Roxana Elizabeth
Maus, Sandra R.
Yokobori, Noemí
Herranz, Marta
Sicilia, Jon
Acosta, Fermín Eloy
Fajardo, Sandra
Chiner Oms, Álvaro
Matteo, Mario José
Símboli, Norberto Fabián
Comas, Iñaki
Muñoz, Patricia
López, Beatriz
Ritacco, Gloria Viviana
García de Viedma, Darío
author Pérez Lago, Laura
author_facet Pérez Lago, Laura
Monteserin, Johana
Paul, Roxana Elizabeth
Maus, Sandra R.
Yokobori, Noemí
Herranz, Marta
Sicilia, Jon
Acosta, Fermín Eloy
Fajardo, Sandra
Chiner Oms, Álvaro
Matteo, Mario José
Símboli, Norberto Fabián
Comas, Iñaki
Muñoz, Patricia
López, Beatriz
Ritacco, Gloria Viviana
García de Viedma, Darío
author_role author
author2 Monteserin, Johana
Paul, Roxana Elizabeth
Maus, Sandra R.
Yokobori, Noemí
Herranz, Marta
Sicilia, Jon
Acosta, Fermín Eloy
Fajardo, Sandra
Chiner Oms, Álvaro
Matteo, Mario José
Símboli, Norberto Fabián
Comas, Iñaki
Muñoz, Patricia
López, Beatriz
Ritacco, Gloria Viviana
García de Viedma, Darío
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv MDR
Tuberculosis
WGS
Clonal variants
Molecular epidemiology
Recurrences
Reinfection
topic MDR
Tuberculosis
WGS
Clonal variants
Molecular epidemiology
Recurrences
Reinfection
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Recurrent tuberculosis occurs due to exogenous reinfection or reactivation/persistence. We analysed 90 sequential MDR Mtb isolates obtained in Argentina from 27 patients with previously diagnosed MDR-TB that recurred in 2018 (1–10 years, 2–10 isolates per patient). Three long-term predominant strains were responsible for 63% of all MDR-TB recurrences. Most of the remaining patients were infected by strains different from each other. Reactivation/persistence of the same strain caused all but one recurrence, which was due to a reinfection with a predominant strain. One of the prevalent strains showed marked stability in the recurrences, while in another strain higher SNP-based diversity was observed. Comparisons of intra- versus inter-patient SNP distances identified two possible reinfections with closely related variants circulating in the community. Our results show a complex scenario of MDR-TB infections in settings with predominant MDR Mtb strains.
Fil: Pérez Lago, Laura. Hospital General Universitario Gregorio Marañón (hosp Gral Univ G. Marañón); España
Fil: Monteserin, Johana. Administración Nacional de Laboratorio e Institutos de Salud "Dr. Carlos G. Malbrán". Instituto Nacional de Epidemiologia. Departamento de Investigación; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Paul, Roxana Elizabeth. Administración Nacional de Laboratorio e Institutos de Salud "Dr. Carlos G. Malbrán". Instituto Nacional de Epidemiologia. Departamento de Investigación; Argentina
Fil: Maus, Sandra R.. Hospital General Universitario Gregorio Marañón (hosp Gral Univ G. Marañón); España
Fil: Yokobori, Noemí. Administración Nacional de Laboratorio e Institutos de Salud "Dr. Carlos G. Malbrán". Instituto Nacional de Epidemiologia. Departamento de Investigación; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Herranz, Marta. Hospital General Universitario Gregorio Marañón (hosp Gral Univ G. Marañón); España
Fil: Sicilia, Jon. Hospital General Universitario Gregorio Marañón (hosp Gral Univ G. Marañón); España
Fil: Acosta, Fermín Eloy. Hospital General Universitario Gregorio Marañón (hosp Gral Univ G. Marañón); España
Fil: Fajardo, Sandra. Centro Regional de estudios Bioquímicos de la Tuberculosis; Argentina
Fil: Chiner Oms, Álvaro. Consejo Superior de Investigaciones Científicas; España
Fil: Matteo, Mario José. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Tisioneumonología "raúl F. Vaccarezza".; Argentina
Fil: Símboli, Norberto Fabián. Administración Nacional de Laboratorio e Institutos de Salud "Dr. Carlos G. Malbrán". Instituto Nacional de Epidemiologia. Departamento de Investigación; Argentina
Fil: Comas, Iñaki. Consejo Superior de Investigaciones Científicas; España
Fil: Muñoz, Patricia. Hospital General Universitario Gregorio Marañón (hosp Gral Univ G. Marañón); España. Universidad Complutense de Madrid; España
Fil: López, Beatriz. Administración Nacional de Laboratorio e Institutos de Salud "Dr. Carlos G. Malbrán". Instituto Nacional de Epidemiologia. Departamento de Investigación; Argentina
Fil: Ritacco, Gloria Viviana. Administración Nacional de Laboratorio e Institutos de Salud "Dr. Carlos G. Malbrán". Instituto Nacional de Epidemiologia. Departamento de Investigación; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: García de Viedma, Darío. Hospital General Universitario Gregorio Marañón (hosp Gral Univ G. Marañón); España
description Recurrent tuberculosis occurs due to exogenous reinfection or reactivation/persistence. We analysed 90 sequential MDR Mtb isolates obtained in Argentina from 27 patients with previously diagnosed MDR-TB that recurred in 2018 (1–10 years, 2–10 isolates per patient). Three long-term predominant strains were responsible for 63% of all MDR-TB recurrences. Most of the remaining patients were infected by strains different from each other. Reactivation/persistence of the same strain caused all but one recurrence, which was due to a reinfection with a predominant strain. One of the prevalent strains showed marked stability in the recurrences, while in another strain higher SNP-based diversity was observed. Comparisons of intra- versus inter-patient SNP distances identified two possible reinfections with closely related variants circulating in the community. Our results show a complex scenario of MDR-TB infections in settings with predominant MDR Mtb strains.
publishDate 2022
dc.date.none.fl_str_mv 2022-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
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info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/163996
Pérez Lago, Laura; Monteserin, Johana; Paul, Roxana Elizabeth; Maus, Sandra R.; Yokobori, Noemí; et al.; Recurrences of multidrug‐resistant tuberculosis: Strains involved, within‐host diversity, and fine‐tuned allocation of reinfections; Wiley Blackwell Publishing, Inc; Transboundary And Emerging Diseases; 69; 2; 3-2022; 327-336
1865-1674
1865-1682
CONICET Digital
CONICET
url http://hdl.handle.net/11336/163996
identifier_str_mv Pérez Lago, Laura; Monteserin, Johana; Paul, Roxana Elizabeth; Maus, Sandra R.; Yokobori, Noemí; et al.; Recurrences of multidrug‐resistant tuberculosis: Strains involved, within‐host diversity, and fine‐tuned allocation of reinfections; Wiley Blackwell Publishing, Inc; Transboundary And Emerging Diseases; 69; 2; 3-2022; 327-336
1865-1674
1865-1682
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/10.1111/tbed.13982
info:eu-repo/semantics/altIdentifier/doi/10.1111/tbed.13982
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
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reponame_str CONICET Digital (CONICET)
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instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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