Relationship between neurocognitive functioning and episode recurrences in bipolar disorder

Autores
Martino, Diego Javier; Strejilevich, Sergio; Marengo, Eliana; Igoa, Ana; Fassi, Guillermo; Teitelbaum, Julia; Caravotta, Pablo Gastón
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Background: The relationship between neurocognitive impairments and clinical course in bipolar disorder (BD) is inconclusive. The aim of this study was to compare time to recurrence between patients with and without clinically significant cognitive impairments. Methods: Seventy euthymic patients with BD were included. Based on baseline neurocognitive performance patients were divided as those with (n=49) and without (n=21) clinically significant cognitive impairments. Both groups of patients were prospectivelly assessed by a modified life chart method during a mean of 16.3 months. Results: Patients with some cognitive domain compromised had an increased risk of suffering any recurrence (HR: 3.13; CI95%: 1.64-5.96), hypo/mainc episodes (HR2.42; CI95%:1.13-5.19), or depressive episodes (HR; 3.84; CI95%: 1.66-8.84) compared with those patients without clinically significant cognitive impairments. These associations remained significant after adjust for several potential counfounders such as number of previous episodes, time since last episode, clinical subtype of BD, exposure to antipsychotics, and subclinical symptoms. Limitations: We clasified patients as with or without clinically significant cognitive impairments, although deficits in different cognitive domains may not be equivalent in terms of risk of recurrence. Conclusions: The results did not support the hypothesis that the experience of successive episodes is related to a progressive neurocognitive decline. Contrarily, cognitive impairments could be the cause more than the consequence of poorer clinical course. Alternativelly, a specific subgroup of patients with clinically significant cognitive impairments and a progressive illness in terms of counts of recurrences, and shortening of wellness intervals might explain the association showed in this study.
Fil: Martino, Diego Javier. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro. Facultad de Medicina. Instituto de Neurociencias; Argentina
Fil: Strejilevich, Sergio. Instituto de Neurología Cognitiva; Argentina. Universidad Favaloro. Facultad de Medicina. Instituto de Neurociencias; Argentina
Fil: Marengo, Eliana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro. Facultad de Medicina. Instituto de Neurociencias; Argentina
Fil: Igoa, Ana. Universidad Favaloro. Facultad de Medicina. Instituto de Neurociencias; Argentina
Fil: Fassi, Guillermo. Universidad Favaloro. Facultad de Medicina. Instituto de Neurociencias; Argentina
Fil: Teitelbaum, Julia. Universidad Favaloro. Facultad de Medicina. Instituto de Neurociencias; Argentina
Fil: Caravotta, Pablo Gastón. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro. Facultad de Medicina. Instituto de Neurociencias; Argentina
Materia
RECURRENCES
EPISODES
COGNITIVE IMPAIRMENTS
NEUROCOGNITIVE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/278999
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/278999
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Relationship between neurocognitive functioning and episode recurrences in bipolar disorderMartino, Diego JavierStrejilevich, SergioMarengo, ElianaIgoa, AnaFassi, GuillermoTeitelbaum, JuliaCaravotta, Pablo GastónRECURRENCESEPISODESCOGNITIVE IMPAIRMENTSNEUROCOGNITIVEhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Background: The relationship between neurocognitive impairments and clinical course in bipolar disorder (BD) is inconclusive. The aim of this study was to compare time to recurrence between patients with and without clinically significant cognitive impairments. Methods: Seventy euthymic patients with BD were included. Based on baseline neurocognitive performance patients were divided as those with (n=49) and without (n=21) clinically significant cognitive impairments. Both groups of patients were prospectivelly assessed by a modified life chart method during a mean of 16.3 months. Results: Patients with some cognitive domain compromised had an increased risk of suffering any recurrence (HR: 3.13; CI95%: 1.64-5.96), hypo/mainc episodes (HR2.42; CI95%:1.13-5.19), or depressive episodes (HR; 3.84; CI95%: 1.66-8.84) compared with those patients without clinically significant cognitive impairments. These associations remained significant after adjust for several potential counfounders such as number of previous episodes, time since last episode, clinical subtype of BD, exposure to antipsychotics, and subclinical symptoms. Limitations: We clasified patients as with or without clinically significant cognitive impairments, although deficits in different cognitive domains may not be equivalent in terms of risk of recurrence. Conclusions: The results did not support the hypothesis that the experience of successive episodes is related to a progressive neurocognitive decline. Contrarily, cognitive impairments could be the cause more than the consequence of poorer clinical course. Alternativelly, a specific subgroup of patients with clinically significant cognitive impairments and a progressive illness in terms of counts of recurrences, and shortening of wellness intervals might explain the association showed in this study.Fil: Martino, Diego Javier. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro. Facultad de Medicina. Instituto de Neurociencias; ArgentinaFil: Strejilevich, Sergio. Instituto de Neurología Cognitiva; Argentina. Universidad Favaloro. Facultad de Medicina. Instituto de Neurociencias; ArgentinaFil: Marengo, Eliana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro. Facultad de Medicina. Instituto de Neurociencias; ArgentinaFil: Igoa, Ana. Universidad Favaloro. Facultad de Medicina. Instituto de Neurociencias; ArgentinaFil: Fassi, Guillermo. Universidad Favaloro. Facultad de Medicina. Instituto de Neurociencias; ArgentinaFil: Teitelbaum, Julia. Universidad Favaloro. Facultad de Medicina. Instituto de Neurociencias; ArgentinaFil: Caravotta, Pablo Gastón. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro. Facultad de Medicina. Instituto de Neurociencias; ArgentinaElsevier Science2012-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/278999Martino, Diego Javier; Strejilevich, Sergio; Marengo, Eliana; Igoa, Ana; Fassi, Guillermo; et al.; Relationship between neurocognitive functioning and episode recurrences in bipolar disorder; Elsevier Science; Journal of Affective Disorders; 147; 1-3; 12-2012; 345-3510165-0327CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S016503271200804Xinfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.jad.2012.11.037info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2026-01-14T12:28:59Zoai:ri.conicet.gov.ar:11336/278999instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982026-01-14 12:29:00.09CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Relationship between neurocognitive functioning and episode recurrences in bipolar disorder
title Relationship between neurocognitive functioning and episode recurrences in bipolar disorder
spellingShingle Relationship between neurocognitive functioning and episode recurrences in bipolar disorder
Martino, Diego Javier
RECURRENCES
EPISODES
COGNITIVE IMPAIRMENTS
NEUROCOGNITIVE
title_short Relationship between neurocognitive functioning and episode recurrences in bipolar disorder
title_full Relationship between neurocognitive functioning and episode recurrences in bipolar disorder
title_fullStr Relationship between neurocognitive functioning and episode recurrences in bipolar disorder
title_full_unstemmed Relationship between neurocognitive functioning and episode recurrences in bipolar disorder
title_sort Relationship between neurocognitive functioning and episode recurrences in bipolar disorder
dc.creator.none.fl_str_mv Martino, Diego Javier
Strejilevich, Sergio
Marengo, Eliana
Igoa, Ana
Fassi, Guillermo
Teitelbaum, Julia
Caravotta, Pablo Gastón
author Martino, Diego Javier
author_facet Martino, Diego Javier
Strejilevich, Sergio
Marengo, Eliana
Igoa, Ana
Fassi, Guillermo
Teitelbaum, Julia
Caravotta, Pablo Gastón
author_role author
author2 Strejilevich, Sergio
Marengo, Eliana
Igoa, Ana
Fassi, Guillermo
Teitelbaum, Julia
Caravotta, Pablo Gastón
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv RECURRENCES
EPISODES
COGNITIVE IMPAIRMENTS
NEUROCOGNITIVE
topic RECURRENCES
EPISODES
COGNITIVE IMPAIRMENTS
NEUROCOGNITIVE
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Background: The relationship between neurocognitive impairments and clinical course in bipolar disorder (BD) is inconclusive. The aim of this study was to compare time to recurrence between patients with and without clinically significant cognitive impairments. Methods: Seventy euthymic patients with BD were included. Based on baseline neurocognitive performance patients were divided as those with (n=49) and without (n=21) clinically significant cognitive impairments. Both groups of patients were prospectivelly assessed by a modified life chart method during a mean of 16.3 months. Results: Patients with some cognitive domain compromised had an increased risk of suffering any recurrence (HR: 3.13; CI95%: 1.64-5.96), hypo/mainc episodes (HR2.42; CI95%:1.13-5.19), or depressive episodes (HR; 3.84; CI95%: 1.66-8.84) compared with those patients without clinically significant cognitive impairments. These associations remained significant after adjust for several potential counfounders such as number of previous episodes, time since last episode, clinical subtype of BD, exposure to antipsychotics, and subclinical symptoms. Limitations: We clasified patients as with or without clinically significant cognitive impairments, although deficits in different cognitive domains may not be equivalent in terms of risk of recurrence. Conclusions: The results did not support the hypothesis that the experience of successive episodes is related to a progressive neurocognitive decline. Contrarily, cognitive impairments could be the cause more than the consequence of poorer clinical course. Alternativelly, a specific subgroup of patients with clinically significant cognitive impairments and a progressive illness in terms of counts of recurrences, and shortening of wellness intervals might explain the association showed in this study.
Fil: Martino, Diego Javier. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro. Facultad de Medicina. Instituto de Neurociencias; Argentina
Fil: Strejilevich, Sergio. Instituto de Neurología Cognitiva; Argentina. Universidad Favaloro. Facultad de Medicina. Instituto de Neurociencias; Argentina
Fil: Marengo, Eliana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro. Facultad de Medicina. Instituto de Neurociencias; Argentina
Fil: Igoa, Ana. Universidad Favaloro. Facultad de Medicina. Instituto de Neurociencias; Argentina
Fil: Fassi, Guillermo. Universidad Favaloro. Facultad de Medicina. Instituto de Neurociencias; Argentina
Fil: Teitelbaum, Julia. Universidad Favaloro. Facultad de Medicina. Instituto de Neurociencias; Argentina
Fil: Caravotta, Pablo Gastón. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro. Facultad de Medicina. Instituto de Neurociencias; Argentina
description Background: The relationship between neurocognitive impairments and clinical course in bipolar disorder (BD) is inconclusive. The aim of this study was to compare time to recurrence between patients with and without clinically significant cognitive impairments. Methods: Seventy euthymic patients with BD were included. Based on baseline neurocognitive performance patients were divided as those with (n=49) and without (n=21) clinically significant cognitive impairments. Both groups of patients were prospectivelly assessed by a modified life chart method during a mean of 16.3 months. Results: Patients with some cognitive domain compromised had an increased risk of suffering any recurrence (HR: 3.13; CI95%: 1.64-5.96), hypo/mainc episodes (HR2.42; CI95%:1.13-5.19), or depressive episodes (HR; 3.84; CI95%: 1.66-8.84) compared with those patients without clinically significant cognitive impairments. These associations remained significant after adjust for several potential counfounders such as number of previous episodes, time since last episode, clinical subtype of BD, exposure to antipsychotics, and subclinical symptoms. Limitations: We clasified patients as with or without clinically significant cognitive impairments, although deficits in different cognitive domains may not be equivalent in terms of risk of recurrence. Conclusions: The results did not support the hypothesis that the experience of successive episodes is related to a progressive neurocognitive decline. Contrarily, cognitive impairments could be the cause more than the consequence of poorer clinical course. Alternativelly, a specific subgroup of patients with clinically significant cognitive impairments and a progressive illness in terms of counts of recurrences, and shortening of wellness intervals might explain the association showed in this study.
publishDate 2012
dc.date.none.fl_str_mv 2012-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/278999
Martino, Diego Javier; Strejilevich, Sergio; Marengo, Eliana; Igoa, Ana; Fassi, Guillermo; et al.; Relationship between neurocognitive functioning and episode recurrences in bipolar disorder; Elsevier Science; Journal of Affective Disorders; 147; 1-3; 12-2012; 345-351
0165-0327
CONICET Digital
CONICET
url http://hdl.handle.net/11336/278999
identifier_str_mv Martino, Diego Javier; Strejilevich, Sergio; Marengo, Eliana; Igoa, Ana; Fassi, Guillermo; et al.; Relationship between neurocognitive functioning and episode recurrences in bipolar disorder; Elsevier Science; Journal of Affective Disorders; 147; 1-3; 12-2012; 345-351
0165-0327
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S016503271200804X
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jad.2012.11.037
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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